YJL007C_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL007C / YJL007C

Click on Significant Values for Screen Details ID:SGTC_136|Compound:0097-0015|FD-Score:-4.53|P-value:1.26E-6 ID:SGTC_140|Compound:0062-0056|FD-Score:-3.72|P-value:5.60E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:4.28|P-value:4.81E-6 ID:SGTC_247|Compound:mechlorethamine|FD-Score:-3.24|P-value:3.73E-4 ID:SGTC_589|Compound:1227-0070|FD-Score:-3.43|P-value:1.80E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:3.29|P-value:3.37E-4 ID:SGTC_730|Compound:1436-0052|FD-Score:-3.44|P-value:1.73E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:-7.79|P-value:3.04E-16 ID:SGTC_818|Compound:4072-2707|FD-Score:3.01|P-value:9.67E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:-4.13|P-value:8.79E-6 ID:SGTC_824|Compound:1304-0008|FD-Score:-3.07|P-value:7.00E-4 ID:SGTC_828|Compound:2074-0507|FD-Score:-6.05|P-value:1.71E-10 ID:SGTC_833|Compound:3852-0053|FD-Score:-5.42|P-value:8.80E-9 ID:SGTC_838|Compound:0109-0203|FD-Score:4.40|P-value:2.78E-6 ID:SGTC_1162|Compound:k048-0130|FD-Score:-3.18|P-value:4.71E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:-3.42|P-value:1.87E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:3.79|P-value:4.60E-5 ID:SGTC_1378|Compound:2093-0007|FD-Score:-5.72|P-value:1.45E-9 ID:SGTC_1605|Compound:st000082|FD-Score:3.73|P-value:5.78E-5 ID:SGTC_1628|Compound:st004252|FD-Score:3.48|P-value:1.66E-4 ID:SGTC_1674|Compound:st016616|FD-Score:3.19|P-value:5.05E-4 ID:SGTC_1842|Compound:st055362|FD-Score:3.35|P-value:2.73E-4 ID:SGTC_1935|Compound:st074532|FD-Score:-3.14|P-value:5.43E-4 ID:SGTC_1957|Compound:st077035|FD-Score:4.74|P-value:4.77E-7 ID:SGTC_1986|Compound:st071812|FD-Score:3.32|P-value:3.11E-4 ID:SGTC_2062|Compound:5245942|FD-Score:3.13|P-value:6.10E-4 ID:SGTC_2098|Compound:5376439|FD-Score:3.08|P-value:7.46E-4 ID:SGTC_2100|Compound:5377183|FD-Score:3.16|P-value:5.55E-4 ID:SGTC_2290|Compound:7904846|FD-Score:3.37|P-value:2.48E-4 ID:SGTC_2372|Compound:9071633|FD-Score:3.13|P-value:6.30E-4 ID:SGTC_2449|Compound:5812982|FD-Score:3.17|P-value:5.36E-4 ID:SGTC_2480|Compound:5767542|FD-Score:3.74|P-value:5.69E-5 ID:SGTC_2555|Compound:cholic acid|FD-Score:-3.21|P-value:4.12E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.08|P-value:7.41E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:-4.55|P-value:1.15E-6 ID:SGTC_2610|Compound:ononetin|FD-Score:5.13|P-value:5.67E-8 ID:SGTC_2638|Compound:epoxomicin|FD-Score:-2.98|P-value:9.52E-4 ID:SGTC_3022|Compound:9087993|FD-Score:3.69|P-value:7.07E-5 ID:SGTC_3046|Compound:9092212|FD-Score:3.06|P-value:7.92E-4 ID:SGTC_3336|Compound:9143619|FD-Score:-4.55|P-value:1.12E-6 ID:SGTC_3352|Compound:9151559|FD-Score:4.61|P-value:9.46E-7 ID:SGTC_136|Compound:0097-0015|FD-Score:-4.53|P-value:1.26E-6 ID:SGTC_140|Compound:0062-0056|FD-Score:-3.72|P-value:5.60E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:4.28|P-value:4.81E-6 ID:SGTC_247|Compound:mechlorethamine|FD-Score:-3.24|P-value:3.73E-4 ID:SGTC_589|Compound:1227-0070|FD-Score:-3.43|P-value:1.80E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:3.29|P-value:3.37E-4 ID:SGTC_730|Compound:1436-0052|FD-Score:-3.44|P-value:1.73E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:-7.79|P-value:3.04E-16 ID:SGTC_818|Compound:4072-2707|FD-Score:3.01|P-value:9.67E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:-4.13|P-value:8.79E-6 ID:SGTC_824|Compound:1304-0008|FD-Score:-3.07|P-value:7.00E-4 ID:SGTC_828|Compound:2074-0507|FD-Score:-6.05|P-value:1.71E-10 ID:SGTC_833|Compound:3852-0053|FD-Score:-5.42|P-value:8.80E-9 ID:SGTC_838|Compound:0109-0203|FD-Score:4.40|P-value:2.78E-6 ID:SGTC_1162|Compound:k048-0130|FD-Score:-3.18|P-value:4.71E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:-3.42|P-value:1.87E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:3.79|P-value:4.60E-5 ID:SGTC_1378|Compound:2093-0007|FD-Score:-5.72|P-value:1.45E-9 ID:SGTC_1605|Compound:st000082|FD-Score:3.73|P-value:5.78E-5 ID:SGTC_1628|Compound:st004252|FD-Score:3.48|P-value:1.66E-4 ID:SGTC_1674|Compound:st016616|FD-Score:3.19|P-value:5.05E-4 ID:SGTC_1842|Compound:st055362|FD-Score:3.35|P-value:2.73E-4 ID:SGTC_1935|Compound:st074532|FD-Score:-3.14|P-value:5.43E-4 ID:SGTC_1957|Compound:st077035|FD-Score:4.74|P-value:4.77E-7 ID:SGTC_1986|Compound:st071812|FD-Score:3.32|P-value:3.11E-4 ID:SGTC_2062|Compound:5245942|FD-Score:3.13|P-value:6.10E-4 ID:SGTC_2098|Compound:5376439|FD-Score:3.08|P-value:7.46E-4 ID:SGTC_2100|Compound:5377183|FD-Score:3.16|P-value:5.55E-4 ID:SGTC_2290|Compound:7904846|FD-Score:3.37|P-value:2.48E-4 ID:SGTC_2372|Compound:9071633|FD-Score:3.13|P-value:6.30E-4 ID:SGTC_2449|Compound:5812982|FD-Score:3.17|P-value:5.36E-4 ID:SGTC_2480|Compound:5767542|FD-Score:3.74|P-value:5.69E-5 ID:SGTC_2555|Compound:cholic acid|FD-Score:-3.21|P-value:4.12E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.08|P-value:7.41E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:-4.55|P-value:1.15E-6 ID:SGTC_2610|Compound:ononetin|FD-Score:5.13|P-value:5.67E-8 ID:SGTC_2638|Compound:epoxomicin|FD-Score:-2.98|P-value:9.52E-4 ID:SGTC_3022|Compound:9087993|FD-Score:3.69|P-value:7.07E-5 ID:SGTC_3046|Compound:9092212|FD-Score:3.06|P-value:7.92E-4 ID:SGTC_3336|Compound:9143619|FD-Score:-4.55|P-value:1.12E-6 ID:SGTC_3352|Compound:9151559|FD-Score:4.61|P-value:9.46E-7

Top fitness defect scores for YJL007C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2610 ononetin 5.13 44.2 µM 5.67E-8 15 1.43E-7
2 SGTC_1957 st077035 4.74 62.4 µM 4.77E-7 8 1.05E-6
3 SGTC_3352 9151559 4.61 45.6 µM 9.46E-7 5 2.00E-6
4 SGTC_838 0109-0203 4.40 71.4 µM 2.78E-6 10 5.48E-6
5 SGTC_158 k038-0087 4.28 26.4 µM 4.81E-6 ubiquinone biosynthesis & proteasome 119 9.16E-6
6 SGTC_1349 flufenamic acid 3.79 69.0 µM 4.60E-5 15 7.60E-5
7 SGTC_2480 5767542 3.74 37.2 µM 5.69E-5 13 9.28E-5
8 SGTC_1605 st000082 3.73 49.1 µM 5.78E-5 60S ribosome export 22 9.42E-5
9 SGTC_3022 9087993 3.69 49.5 µM 7.07E-5 10 1.14E-4
10 SGTC_1628 st004252 3.48 77.7 µM 1.66E-4 35 2.53E-4
11 SGTC_2290 7904846 3.37 200.0 µM 2.48E-4 48 3.69E-4
12 SGTC_1842 st055362 3.35 61.2 µM 2.73E-4 30 4.04E-4
13 SGTC_1986 st071812 3.32 45.0 µM 3.11E-4 19 4.56E-4
14 SGTC_638 3970-0837 3.29 4.1 µM 3.37E-4 71 4.93E-4
15 SGTC_1674 st016616 3.19 23.6 µM 5.05E-4 62 7.21E-4
16 SGTC_2449 5812982 3.17 45.8 µM 5.36E-4 29 7.61E-4
17 SGTC_2100 5377183 3.16 190.0 µM 5.55E-4 60S ribosome export 39 7.87E-4
18 SGTC_2062 5245942 3.13 200.0 µM 6.10E-4 46 8.61E-4
19 SGTC_2372 9071633 3.13 200.0 µM 6.30E-4 36 8.87E-4
20 SGTC_2568 diosmetin 3.08 100.0 µM 7.41E-4 65 0.00103

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.167 2.36E-22 YIR010W DSN1 het Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; important for chromosome segregation
0.134 5.69E-15 YJL175W_d YJL175W_d hom Dubious open reading frame unlikely to encode a functional protein; deletion confers resistance to cisplatin, hypersensitivity to 5-fluorouracil, and growth defect at high pH with high calcium; overlaps gene for SWI3 transcription factor
0.123 9.83E-13 YDR215C_d YDR215C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein
0.114 3.69E-11 YJL146W IDS2 hom Protein involved in modulation of Ime2p activity during meiosis, appears to act indirectly to promote Ime2p-mediated late meiotic functions; found in growing cells and degraded during sporulation
0.103 2.42E-9 YLR115W CFT2 het Subunit of the mRNA cleavage and polyadenlylation factor (CPF); required for pre-mRNA cleavage, polyadenylation and poly(A) site recognition, 43% similarity with the mammalian CPSF-100 protein.
0.102 3.37E-9 YMR040W YET2 hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein
0.101 4.37E-9 YOL151W GRE2 hom 3-methylbutanal reductase and NADPH-dependent methylglyoxal reductase (D-lactaldehyde dehydrogenase); stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway; protein abundance increases in response to DNA replication stress
0.100 6.11E-9 YMR272W-B_p YMR272W-B_p hom Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.099 7.96E-9 YJL050W MTR4 het ATP-dependent 3'-5' RNA helicase of the DExD/H family; involved in nuclear RNA processing and degradation both as a component of TRAMP complex and in TRAMP-independent processes; TRAMP unwinds RNA duplexes, with Mtr4p unwinding activity stimulated by Pap2p/Air2p but not dependent on ongoing polyadenylation; contains an arch domain, with two coiled-coil arms/stalks and a globular fist/KOW domain, which has RNA binding activity and is required for 5.8S rRNA processing
0.091 1.51E-7 YOR226C ISU2 hom Protein required for synthesis of iron-sulfur proteins; localized to the mitochondrial matrix; performs a scaffolding function in mitochondria during Fe/S cluster assembly; involved in Fe-S cluster assembly for both mitochondrial and cytosolic proteins; isu1 isu2 double mutant is inviable; protein abundance increases in response to DNA replication stress; evolutionarily conserved
0.090 1.66E-7 YDR287W INM2 hom Inositol monophosphatase, involved in biosynthesis of inositol; enzymatic activity requires magnesium ions and is inhibited by lithium and sodium ions; inm1 inm2 double mutant lacks inositol auxotrophy
0.090 1.79E-7 YPL071C_p YPL071C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
0.087 4.08E-7 YGL231C EMC4 hom Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm ZK616.6/EMC-4, fly CG11137, human TMM85
0.082 2.19E-6 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.081 2.70E-6 YGL101W_p YGL101W_p hom Putative protein of unknown function; non-essential gene with similarity to YBR242W; interacts with the DNA helicase Hpr5p