YJL009W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps CCT8/YJL008C, a verified gene encoding a subunit of the cytosolic chaperonin Cct ring complex

Zygosity: Heterozygous strain
fixedexpanded
Profile for YJL009W / YJL009W

Click on Significant Values for Screen Details ID:SGTC_212|Compound:3807-4682|FD-Score:5.23|P-value:2.78E-5 ID:SGTC_435|Compound:c-PAF|FD-Score:6.15|P-value:9.86E-7 ID:SGTC_441|Compound:propafenone|FD-Score:4.40|P-value:3.68E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.80|P-value:1.10E-4 ID:SGTC_455|Compound:paf C-16|FD-Score:4.23|P-value:5.93E-4 ID:SGTC_1010|Compound:4112-3296|FD-Score:-4.01|P-value:6.05E-4 ID:SGTC_1174|Compound:0739-0097|FD-Score:-3.88|P-value:8.60E-4 ID:SGTC_1189|Compound:1431-2119|FD-Score:4.11|P-value:8.20E-4 ID:SGTC_1209|Compound:2323-2347|FD-Score:-4.19|P-value:3.60E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:4.06|P-value:9.23E-4 ID:SGTC_1773|Compound:st048542|FD-Score:4.49|P-value:2.78E-4 ID:SGTC_1786|Compound:berberine|FD-Score:-5.47|P-value:5.76E-6 ID:SGTC_1827|Compound:berberine|FD-Score:-3.99|P-value:6.33E-4 ID:SGTC_1829|Compound:berberine|FD-Score:-5.18|P-value:1.63E-5 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:-4.90|P-value:4.17E-5 ID:SGTC_1863|Compound:st057641|FD-Score:4.63|P-value:1.84E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:16.80|P-value:1.41E-39 ID:SGTC_1916|Compound:st067606|FD-Score:4.66|P-value:1.70E-4 ID:SGTC_2035|Compound:5154463|FD-Score:4.15|P-value:7.31E-4 ID:SGTC_2151|Compound:5563267|FD-Score:4.91|P-value:7.85E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:5.07|P-value:4.75E-5 ID:SGTC_2413|Compound:inermin|FD-Score:-4.50|P-value:1.46E-4 ID:SGTC_2423|Compound:st077119|FD-Score:4.09|P-value:8.51E-4 ID:SGTC_2451|Compound:5856223|FD-Score:4.73|P-value:1.40E-4 ID:SGTC_2601|Compound:securinine|FD-Score:7.62|P-value:1.66E-9 ID:SGTC_2620|Compound:irigenin|FD-Score:-3.86|P-value:9.13E-4 ID:SGTC_2781|Compound:5567276|FD-Score:-3.97|P-value:6.71E-4 ID:SGTC_2783|Compound:7738165|FD-Score:10.00|P-value:3.61E-15 ID:SGTC_2858|Compound:9025781|FD-Score:-5.73|P-value:2.23E-6 ID:SGTC_2880|Compound:9042983|FD-Score:5.02|P-value:5.58E-5 ID:SGTC_2883|Compound:9059145|FD-Score:4.67|P-value:1.64E-4 ID:SGTC_2981|Compound:9013952|FD-Score:4.47|P-value:3.01E-4 ID:SGTC_3146|Compound:9095609|FD-Score:4.73|P-value:1.37E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:5.23|P-value:2.78E-5 ID:SGTC_435|Compound:c-PAF|FD-Score:6.15|P-value:9.86E-7 ID:SGTC_441|Compound:propafenone|FD-Score:4.40|P-value:3.68E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.80|P-value:1.10E-4 ID:SGTC_455|Compound:paf C-16|FD-Score:4.23|P-value:5.93E-4 ID:SGTC_1010|Compound:4112-3296|FD-Score:-4.01|P-value:6.05E-4 ID:SGTC_1174|Compound:0739-0097|FD-Score:-3.88|P-value:8.60E-4 ID:SGTC_1189|Compound:1431-2119|FD-Score:4.11|P-value:8.20E-4 ID:SGTC_1209|Compound:2323-2347|FD-Score:-4.19|P-value:3.60E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:4.06|P-value:9.23E-4 ID:SGTC_1773|Compound:st048542|FD-Score:4.49|P-value:2.78E-4 ID:SGTC_1786|Compound:berberine|FD-Score:-5.47|P-value:5.76E-6 ID:SGTC_1827|Compound:berberine|FD-Score:-3.99|P-value:6.33E-4 ID:SGTC_1829|Compound:berberine|FD-Score:-5.18|P-value:1.63E-5 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:-4.90|P-value:4.17E-5 ID:SGTC_1863|Compound:st057641|FD-Score:4.63|P-value:1.84E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:16.80|P-value:1.41E-39 ID:SGTC_1916|Compound:st067606|FD-Score:4.66|P-value:1.70E-4 ID:SGTC_2035|Compound:5154463|FD-Score:4.15|P-value:7.31E-4 ID:SGTC_2151|Compound:5563267|FD-Score:4.91|P-value:7.85E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:5.07|P-value:4.75E-5 ID:SGTC_2413|Compound:inermin|FD-Score:-4.50|P-value:1.46E-4 ID:SGTC_2423|Compound:st077119|FD-Score:4.09|P-value:8.51E-4 ID:SGTC_2451|Compound:5856223|FD-Score:4.73|P-value:1.40E-4 ID:SGTC_2601|Compound:securinine|FD-Score:7.62|P-value:1.66E-9 ID:SGTC_2620|Compound:irigenin|FD-Score:-3.86|P-value:9.13E-4 ID:SGTC_2781|Compound:5567276|FD-Score:-3.97|P-value:6.71E-4 ID:SGTC_2783|Compound:7738165|FD-Score:10.00|P-value:3.61E-15 ID:SGTC_2858|Compound:9025781|FD-Score:-5.73|P-value:2.23E-6 ID:SGTC_2880|Compound:9042983|FD-Score:5.02|P-value:5.58E-5 ID:SGTC_2883|Compound:9059145|FD-Score:4.67|P-value:1.64E-4 ID:SGTC_2981|Compound:9013952|FD-Score:4.47|P-value:3.01E-4 ID:SGTC_3146|Compound:9095609|FD-Score:4.73|P-value:1.37E-4

Top fitness defect scores for YJL009W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1875 nocodazole 16.80 6.0 µM 1.41E-39 tubulin folding & SWR complex 4 1.85E-63 0.40
2 SGTC_2783 7738165 10.00 71.4 µM 3.61E-15 1 7.86E-24 5.14
3 SGTC_2601 securinine 7.62 100.0 µM 1.66E-9 3 1.22E-14 0.90
4 SGTC_435 c-PAF 6.15 6.7 µM 9.86E-7 7 3.82E-10 0.11
5 SGTC_212 3807-4682 5.23 38.8 µM 2.78E-5 tubulin folding & SWR complex 16 8.48E-8 0.25
6 SGTC_2405 ticlatone 5.07 3.5 µM 4.75E-5 14 2.02E-7 0.01
7 SGTC_2880 9042983 5.02 58.4 µM 5.58E-5 fatty acid desaturase (OLE1) 6 2.61E-7 0.27
8 SGTC_2151 5563267 4.91 85.4 µM 7.85E-5 11 4.54E-7 0.04
9 SGTC_453 enantio-paf c16 4.80 10.0 µM 1.10E-4 13 7.82E-7 0.05
10 SGTC_3146 9095609 4.73 49.5 µM 1.37E-4 2 1.11E-6 0.30
11 SGTC_2451 5856223 4.73 45.7 µM 1.40E-4 5 1.15E-6 0.06
12 SGTC_2883 9059145 4.67 45.5 µM 1.64E-4 2 1.50E-6 0.37
13 SGTC_1916 st067606 4.66 49.2 µM 1.70E-4 3 1.57E-6 0.28
14 SGTC_1863 st057641 4.63 20.1 µM 1.84E-4 2 1.80E-6 0.47
15 SGTC_1773 st048542 4.49 73.6 µM 2.78E-4 18 3.49E-6 0.04
16 SGTC_2981 9013952 4.47 39.0 µM 3.01E-4 5 3.98E-6 0.23
17 SGTC_441 propafenone 4.40 146.0 µM 3.68E-4 2 5.49E-6 0.46
18 SGTC_455 paf C-16 4.23 10.0 µM 5.93E-4 6 1.18E-5 0.29
19 SGTC_2035 5154463 4.15 94.6 µM 7.31E-4 9 1.66E-5 0.06
20 SGTC_1189 1431-2119 4.11 7.3 µM 8.20E-4 9 1.99E-5 0.23

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.332 4.42E-87 YJL014W CCT3 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.329 1.03E-85 YJL008C CCT8 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.312 1.78E-76 YGL094C PAN2 hom Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
0.303 4.05E-72 YJR064W CCT5 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.296 9.36E-69 YDR212W TCP1 het Alpha subunit of chaperonin-containing T-complex, which mediates protein folding in the cytosol; involved in actin cytoskeleton maintenance; overexpression in neurons suppresses formation of pathogenic conformations of huntingtin protein
0.256 1.81E-51 YDL143W CCT4 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.239 8.14E-45 YIL142W CCT2 het Subunit beta of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.223 4.77E-39 YDR187C_d YDR187C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF CCT6/YDR188W
0.184 6.63E-27 YJL111W CCT7 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo; mutant has increased aneuploidy tolerance
0.174 3.19E-24 YDR188W CCT6 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, essential protein that is required for the assembly of actin and tubulins in vivo; contains an ATP-binding motif
0.160 1.30E-20 YPL241C CIN2 hom GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; deletion complemented by human GAP, retinitis pigmentosa 2
0.157 5.54E-20 YKL025C PAN3 hom Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
0.152 8.20E-19 YJL015C_d YJL015C_d het Dubious open reading frame unlikely to encode a functional protein; expression if heat-inducible; located in promoter region of essential CCT3 gene encoding a subunit of the cytosolic chaperonin Cct ring complex, overlaps ORF YJL016W
0.143 9.77E-17 YER007W PAC2 hom Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl
0.143 1.04E-16 YOR349W CIN1 hom Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl