HIPHOP chemogenomics database
YJL025W / RRN7 
Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p
Zygosity: Heterozygous strain
fixedexpanded
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Top fitness defect scores for YJL025W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.440 | 5.08E-159 | YMR166C_p | YMR166C_p | hom | Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene |
| 0.440 | 2.43E-158 | YOR133W | EFT1 | hom | Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT1 has a paralog, EFT2, that arose from the whole genome duplication |
| 0.430 | 1.18E-150 | YHL039W | EFM1 | hom | Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm |
| 0.419 | 1.13E-142 | YMR168C | CEP3 | het | Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain |
| 0.393 | 1.09E-123 | YDL223C | HBT1 | hom | Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis |
| 0.387 | 2.58E-120 | YGL118C_d | YGL118C_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| 0.385 | 1.37E-118 | YMR289W | ABZ2 | hom | Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis |
| 0.345 | 1.52E-94 | YGR065C | VHT1 | het | High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin |
| 0.336 | 7.21E-89 | YEL032W | MCM3 | het | Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex |
| 0.329 | 2.33E-85 | YGL041C_d | YGL041C_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| 0.285 | 1.87E-63 | YGL200C | EMP24 | hom | Component of the p24 complex; binds to GPI anchor proteins and mediates their efficient transport from the ER to the Golgi; integral membrane protein that associates with endoplasmic reticulum-derived COPII-coated vesicles |
| 0.273 | 1.53E-58 | YMR262W_p | YMR262W_p | hom | Protein of unknown function; interacts weakly with Knr4p; YMR262W is not an essential gene |
| 0.261 | 4.05E-53 | YHR172W | SPC97 | het | Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque |
| 0.250 | 8.42E-49 | YPL157W | TGS1 | hom | Trimethyl guanosine synthase, conserved nucleolar methyl transferase that converts the m(7)G cap structure of snRNAs, snoRNAs, and telomerase TLC1 RNA to m(2,2,7)G; also required for nucleolar assembly and splicing of meiotic pre-mRNAs |
| 0.248 | 2.96E-48 | YLR133W | CKI1 | hom | Choline kinase; catalyzes the first step in phosphatidylcholine synthesis via the CDP-choline (Kennedy pathway); exhibits some ethanolamine kinase activity contributing to phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; CKI1 has a paralog, EKI1, that arose from the whole genome duplication |