HIPHOP chemogenomics database

YJL031C / BET4

Alpha subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p

Zygosity: Heterozygous strain

fixedexpanded
Profile for YJL031C / BET4

Click on Significant Values for Screen Details

Top fitness defect scores for YJL031C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value	Screen Clearance
1	SGTC_2930	9013230	12.80	14.9 µM	9.87E-31	heme biosynthesis & mitochondrial translocase	3	4.64E-38	2.37
2	SGTC_745	0469-0705	12.00	296.0 µM	3.94E-27	mitochondrial processes	2	1.59E-33	2.36
3	SGTC_173	1273-0061	11.90	2.7 µM	1.56E-26	mitochondrial stress	3	9.02E-33	0.63
4	SGTC_1453	4237-0541	11.50	195.0 µM	3.87E-25	heme biosynthesis & mitochondrial translocase	1	5.12E-31	2.26
5	SGTC_2336	9001819	9.55	198.7 µM	6.60E-18	heme biosynthesis & mitochondrial translocase	10	6.33E-22	0.25
6	SGTC_2418	pentamidine	8.56	31.7 µM	9.21E-15	mitochondrial processes	4	5.61E-18	0.95
7	SGTC_743	1275-0778	8.28	158.0 µM	6.27E-14	excess fatty acid	2	6.21E-17	0.56
8	SGTC_851	0394-0702	8.18	453.0 µM	1.21E-13	mitochondrial processes	4	1.42E-16	1.62
9	SGTC_70	0141-0289	6.91	43.3 µM	2.99E-10	mitochondrial stress	8	2.51E-12	0.21
10	SGTC_2645	abamectin	6.81	100.0 µM	5.10E-10	heme requiring	2	4.89E-12	0.68
11	SGTC_1568	digitonin	6.78	820.0 nM	6.02E-10	sphingolipid biosynthesis & PDR1	2	6.01E-12	0.20
12	SGTC_236	1509-0011	6.77	5.3 µM	6.49E-10		7	6.60E-12	0.12
13	SGTC_1785	bathophenanthroline	6.74	24.0 µM	7.57E-10	heme requiring	5	8.00E-12	0.03
14	SGTC_81	0411-0046	6.68	10.0 µM	1.05E-9		17	1.20E-11	0.21
15	SGTC_2640	pentamidine	6.65	10.4 µM	1.24E-9	mitochondrial processes	5	1.48E-11	0.35
16	SGTC_1797	st048695	6.65	56.8 µM	1.24E-9	NEO1	6	1.49E-11	0.97
17	SGTC_2905	7799065	6.65	20.1 µM	1.26E-9		1	1.51E-11	0.88
18	SGTC_808	0711-0032	6.51	135.0 µM	2.57E-9		2	3.68E-11	1.71
19	SGTC_368	fentichlor	6.41	4.6 µM	4.39E-9		1	7.19E-11	0.81
20	SGTC_3081	9117243	6.28	49.5 µM	8.51E-9	fatty acid desaturase (OLE1)	11	1.64E-10	0.21

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.278	2.88E-60	YBR192W	RIM2	het	Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family
0.248	5.27E-48	YMR203W	TOM40	het	Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore
0.242	6.50E-46	YDR047W	HEM12	het	Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; a hem12 mutant has phenotypes similar to patients with porphyria cutanea tarda
0.239	1.27E-44	YKL195W	MIA40	het	Oxidoreductase that mediates mitochondrial intermembrane space import; substrates include small proteins containing twin cysteine motifs; acts in concert with Erv1p, which oxidizes the cysteine residues of Mia40p to comprise a disulfide relay system that catalyzes import; also mediates folding of Atp23p
0.234	7.08E-43	YDL205C	HEM3	het	Porphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in heme biosynthesis; localizes to the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p, but not by levels of heme
0.201	7.65E-32	YML091C	RPM2	het	Protein subunit of mitochondrial RNase P, has roles in nuclear transcription, cytoplasmic and mitochondrial RNA processing, and mitochondrial translation; distributed to mitochondria, cytoplasmic processing bodies, and the nucleus
0.192	5.37E-29	YEL034W	HYP2	het	Translation elongation factor eIF-5A; may function in translation initiation; structural homolog of bacterial EF-P; undergoes an essential hypusination modification; HYP2 has a paralog, ANB1, that arose from the whole genome duplication
0.187	1.15E-27	YBL105C	PKC1	het	Protein serine/threonine kinase essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC)
0.183	1.15E-26	YNL112W	DBP2	het	ATP-dependent RNA helicase of the DEAD-box protein family; has a strong preference for dsRNA; involved mRNA decay and rRNA processing; may be involved in suppression of transcription from cryptic initiation sites
0.178	3.88E-25	YER021W	RPN3	het	Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to the p58 subunit of the human 26S proteasome; temperature-sensitive alleles cause metaphase arrest, suggesting a role for the proteasome in cell cycle control
0.165	9.34E-22	YEL035C_p	UTR5_p	het	Protein of unknown function; transcription may be regulated by Gcr1p; essential for growth under standard (aerobic) conditions but not under anaerobic conditions
0.164	1.20E-21	YLR355C	ILV5	het	Bifunctional acetohydroxyacid reductoisomerase and mtDNA binding protein; involved in branched-chain amino acid biosynthesis and maintenance of wild-type mitochondrial DNA; found in mitochondrial nucleoids
0.161	6.51E-21	YJL086C_d	YJL086C_d	het	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL085W/EXO70 and YJL087C/TRL1
0.161	8.59E-21	YDL196W_d	YDL196W_d	het	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame is located in promoter region of essential gene SEC31
0.160	1.34E-20	YIL126W	STH1	het	ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p