YJL043W_p

Putative protein of unknown function; YJL043W is a non-essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL043W / YJL043W

Click on Significant Values for Screen Details ID:SGTC_292|Compound:k038-0015|FD-Score:-3.19|P-value:2.69E-4 ID:SGTC_320|Compound:4092-0846|FD-Score:-3.04|P-value:4.96E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:-2.93|P-value:7.38E-4 ID:SGTC_420|Compound:mitomycin C|FD-Score:2.87|P-value:5.84E-4 ID:SGTC_480|Compound:am 92016|FD-Score:3.22|P-value:1.36E-4 ID:SGTC_491|Compound:tetrandrine|FD-Score:2.83|P-value:6.68E-4 ID:SGTC_611|Compound:3453-1652|FD-Score:3.22|P-value:1.40E-4 ID:SGTC_884|Compound:0851-0618|FD-Score:3.31|P-value:9.38E-5 ID:SGTC_891|Compound:0929-0073|FD-Score:4.40|P-value:3.73E-7 ID:SGTC_913|Compound:3487-1245|FD-Score:2.81|P-value:7.42E-4 ID:SGTC_1159|Compound:4092-0538|FD-Score:-4.10|P-value:3.95E-6 ID:SGTC_1220|Compound:1838-0075|FD-Score:2.81|P-value:7.26E-4 ID:SGTC_1278|Compound:0874-0585|FD-Score:3.26|P-value:1.18E-4 ID:SGTC_1445|Compound:4239-0156|FD-Score:4.18|P-value:1.30E-6 ID:SGTC_1447|Compound:4239-0816|FD-Score:-3.70|P-value:2.80E-5 ID:SGTC_1457|Compound:k015-0032|FD-Score:5.13|P-value:4.37E-9 ID:SGTC_1561|Compound:5-methoxyflavone|FD-Score:3.45|P-value:5.04E-5 ID:SGTC_1657|Compound:st012939|FD-Score:2.92|P-value:4.75E-4 ID:SGTC_1722|Compound:st034304|FD-Score:-3.66|P-value:3.40E-5 ID:SGTC_1882|Compound:5615643|FD-Score:4.11|P-value:1.95E-6 ID:SGTC_2112|Compound:5488546|FD-Score:3.06|P-value:2.75E-4 ID:SGTC_2147|Compound:5545932|FD-Score:-2.92|P-value:7.86E-4 ID:SGTC_2324|Compound:6149169|FD-Score:2.99|P-value:3.57E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:-4.20|P-value:2.30E-6 ID:SGTC_2584|Compound:androsterone|FD-Score:2.83|P-value:6.82E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:2.80|P-value:7.58E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-8.08|P-value:3.43E-19 ID:SGTC_2692|Compound:st077426|FD-Score:2.86|P-value:5.94E-4 ID:SGTC_2814|Compound:7977482|FD-Score:3.79|P-value:1.01E-5 ID:SGTC_292|Compound:k038-0015|FD-Score:-3.19|P-value:2.69E-4 ID:SGTC_320|Compound:4092-0846|FD-Score:-3.04|P-value:4.96E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:-2.93|P-value:7.38E-4 ID:SGTC_420|Compound:mitomycin C|FD-Score:2.87|P-value:5.84E-4 ID:SGTC_480|Compound:am 92016|FD-Score:3.22|P-value:1.36E-4 ID:SGTC_491|Compound:tetrandrine|FD-Score:2.83|P-value:6.68E-4 ID:SGTC_611|Compound:3453-1652|FD-Score:3.22|P-value:1.40E-4 ID:SGTC_884|Compound:0851-0618|FD-Score:3.31|P-value:9.38E-5 ID:SGTC_891|Compound:0929-0073|FD-Score:4.40|P-value:3.73E-7 ID:SGTC_913|Compound:3487-1245|FD-Score:2.81|P-value:7.42E-4 ID:SGTC_1159|Compound:4092-0538|FD-Score:-4.10|P-value:3.95E-6 ID:SGTC_1220|Compound:1838-0075|FD-Score:2.81|P-value:7.26E-4 ID:SGTC_1278|Compound:0874-0585|FD-Score:3.26|P-value:1.18E-4 ID:SGTC_1445|Compound:4239-0156|FD-Score:4.18|P-value:1.30E-6 ID:SGTC_1447|Compound:4239-0816|FD-Score:-3.70|P-value:2.80E-5 ID:SGTC_1457|Compound:k015-0032|FD-Score:5.13|P-value:4.37E-9 ID:SGTC_1561|Compound:5-methoxyflavone|FD-Score:3.45|P-value:5.04E-5 ID:SGTC_1657|Compound:st012939|FD-Score:2.92|P-value:4.75E-4 ID:SGTC_1722|Compound:st034304|FD-Score:-3.66|P-value:3.40E-5 ID:SGTC_1882|Compound:5615643|FD-Score:4.11|P-value:1.95E-6 ID:SGTC_2112|Compound:5488546|FD-Score:3.06|P-value:2.75E-4 ID:SGTC_2147|Compound:5545932|FD-Score:-2.92|P-value:7.86E-4 ID:SGTC_2324|Compound:6149169|FD-Score:2.99|P-value:3.57E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:-4.20|P-value:2.30E-6 ID:SGTC_2584|Compound:androsterone|FD-Score:2.83|P-value:6.82E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:2.80|P-value:7.58E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-8.08|P-value:3.43E-19 ID:SGTC_2692|Compound:st077426|FD-Score:2.86|P-value:5.94E-4 ID:SGTC_2814|Compound:7977482|FD-Score:3.79|P-value:1.01E-5

Top fitness defect scores for YJL043W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1457 k015-0032 5.13 57.3 µM 4.37E-9 13 1.44E-7
2 SGTC_891 0929-0073 4.40 133.0 µM 3.73E-7 16 5.29E-6
3 SGTC_1445 4239-0156 4.18 97.7 µM 1.30E-6 23 1.46E-5
4 SGTC_1882 5615643 4.11 20.0 µM 1.95E-6 TRP & mitochondrial translation 23 2.02E-5
5 SGTC_2814 7977482 3.79 43.0 µM 1.01E-5 57 7.68E-5
6 SGTC_1561 5-methoxyflavone 3.45 52.9 µM 5.04E-5 11 2.83E-4
7 SGTC_884 0851-0618 3.31 334.0 µM 9.38E-5 38 4.68E-4
8 SGTC_1278 0874-0585 3.26 172.0 µM 1.18E-4 40 5.62E-4
9 SGTC_480 am 92016 3.22 50.0 µM 1.36E-4 41 6.34E-4
10 SGTC_611 3453-1652 3.22 23.7 µM 1.40E-4 53 6.47E-4
11 SGTC_2112 5488546 3.06 200.0 µM 2.75E-4 TSC3-RPN4 56 0.00112
12 SGTC_2324 6149169 2.99 200.0 µM 3.57E-4 49 0.00138
13 SGTC_1657 st012939 2.92 43.4 µM 4.75E-4 43 0.00174
14 SGTC_420 mitomycin C 2.87 81.9 mM 5.84E-4 71 0.00206
15 SGTC_2692 st077426 2.86 47.7 µM 5.94E-4 79 0.00209
16 SGTC_491 tetrandrine 2.83 80.3 µM 6.68E-4 40 0.00230
17 SGTC_2584 androsterone 2.83 48.7 µM 6.82E-4 cell wall 234 0.00234
18 SGTC_1220 1838-0075 2.81 193.0 µM 7.26E-4 67 0.00246
19 SGTC_913 3487-1245 2.81 167.0 µM 7.42E-4 106 0.00251
20 SGTC_2586 curcumin 2.80 80.0 µM 7.58E-4 iron homeostasis 137 0.00255

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.350 2.28E-97 YER066W_p RRT13_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription
0.306 1.36E-73 YLR395C COX8 hom Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
0.293 3.20E-67 YGL146C_p RRT6_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins
0.258 2.61E-52 YGR015C_p YGR015C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
0.218 1.71E-37 YCR102W-A_d YCR102W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.210 7.81E-35 YNL220W ADE12 hom Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence
0.206 2.18E-33 YOR300W_d YOR300W_d hom Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7
0.205 4.33E-33 YEL049W PAU2 hom Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
0.196 2.21E-30 YER068W MOT2 hom Ubiquitin-protein ligase subunit of the CCR4-NOT complex; with Ubc4p, ubiquitinates nascent polypeptide-associated complex subunits and histone demethyase Jhd2p; CCR4-NOT has roles in transcription regulation, mRNA degradation, and post-transcriptional modifications
0.195 5.24E-30 YIL115C NUP159 het FG-nucleoporin component of central core of the nuclear pore complex (NPC); also part of the NPC cytoplasmic filaments; contributes directly to nucleocytoplasmic transport; regulates ADP release from the ATP-dependent RNA helicase Dbp5p; forms a stable association with Nup82p, Gle2p and two other FG-nucleoporins (Nsp1p and Nup116p)
0.193 1.40E-29 YNR067C DSE4 hom Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother
0.176 9.22E-25 YPL100W ATG21 hom Phosphoinositide binding protein required for vesicle formation in the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein
0.175 2.35E-24 YER071C_p TDA2_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; null mutant is sensitive to expression of the top1-T722A allele
0.166 3.54E-22 YAL004W_d YAL004W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene SSA1/YAL005C
0.162 3.91E-21 YHR194W MDM31 hom Mitochondrial protein that may have a role in phospholipid metabolism; inner membrane protein with similarity to Mdm32p; required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MMM2, MDM10, MDM12, and MDM34