YJL049W_p

Putative protein of unknown function; YJL049W is a non-essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL049W / YJL049W

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:-2.84|P-value:8.55E-4 ID:SGTC_135|Compound:0933-0004|FD-Score:3.19|P-value:1.18E-4 ID:SGTC_199|Compound:4063-0024|FD-Score:3.52|P-value:2.47E-5 ID:SGTC_234|Compound:nsc-17383|FD-Score:3.10|P-value:1.73E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:2.84|P-value:5.05E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:2.70|P-value:8.77E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:2.68|P-value:9.72E-4 ID:SGTC_646|Compound:4092-0839|FD-Score:3.25|P-value:9.04E-5 ID:SGTC_663|Compound:1486-0733|FD-Score:3.08|P-value:1.86E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:-4.20|P-value:1.47E-6 ID:SGTC_829|Compound:1635-0120|FD-Score:2.75|P-value:7.43E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:3.07|P-value:2.00E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:2.69|P-value:9.26E-4 ID:SGTC_1029|Compound:k015-0030|FD-Score:-2.90|P-value:6.84E-4 ID:SGTC_1220|Compound:1838-0075|FD-Score:-3.12|P-value:2.75E-4 ID:SGTC_1232|Compound:0279-0259|FD-Score:3.21|P-value:1.07E-4 ID:SGTC_1261|Compound:0712-0010|FD-Score:3.98|P-value:2.36E-6 ID:SGTC_1264|Compound:0783-0040|FD-Score:-3.19|P-value:2.01E-4 ID:SGTC_1291|Compound:0993-0025|FD-Score:2.72|P-value:8.33E-4 ID:SGTC_1414|Compound:3917-0015|FD-Score:3.66|P-value:1.27E-5 ID:SGTC_1457|Compound:k015-0032|FD-Score:3.53|P-value:2.44E-5 ID:SGTC_1510|Compound:1123-0200|FD-Score:2.67|P-value:9.82E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:-2.81|P-value:9.40E-4 ID:SGTC_1529|Compound:apigenin|FD-Score:-3.18|P-value:2.12E-4 ID:SGTC_1609|Compound:st001574|FD-Score:-3.91|P-value:6.88E-6 ID:SGTC_1616|Compound:st002734|FD-Score:2.85|P-value:4.95E-4 ID:SGTC_1694|Compound:st024011|FD-Score:3.29|P-value:7.45E-5 ID:SGTC_1696|Compound:st025591|FD-Score:3.06|P-value:2.07E-4 ID:SGTC_1701|Compound:st028638|FD-Score:5.05|P-value:3.66E-9 ID:SGTC_1835|Compound:st008666|FD-Score:3.60|P-value:1.75E-5 ID:SGTC_2127|Compound:5253358|FD-Score:2.72|P-value:8.19E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.33|P-value:6.17E-5 ID:SGTC_2319|Compound:6033012|FD-Score:-3.30|P-value:1.25E-4 ID:SGTC_2382|Compound:9035899|FD-Score:3.06|P-value:2.03E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:-3.65|P-value:2.55E-5 ID:SGTC_2821|Compound:7996764|FD-Score:3.27|P-value:8.30E-5 ID:SGTC_2907|Compound:7721985|FD-Score:-2.95|P-value:5.42E-4 ID:SGTC_3008|Compound:9078912|FD-Score:-3.78|P-value:1.32E-5 ID:SGTC_36|Compound:0335-0881|FD-Score:-2.84|P-value:8.55E-4 ID:SGTC_135|Compound:0933-0004|FD-Score:3.19|P-value:1.18E-4 ID:SGTC_199|Compound:4063-0024|FD-Score:3.52|P-value:2.47E-5 ID:SGTC_234|Compound:nsc-17383|FD-Score:3.10|P-value:1.73E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:2.84|P-value:5.05E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:2.70|P-value:8.77E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:2.68|P-value:9.72E-4 ID:SGTC_646|Compound:4092-0839|FD-Score:3.25|P-value:9.04E-5 ID:SGTC_663|Compound:1486-0733|FD-Score:3.08|P-value:1.86E-4 ID:SGTC_825|Compound:1988-2224|FD-Score:-4.20|P-value:1.47E-6 ID:SGTC_829|Compound:1635-0120|FD-Score:2.75|P-value:7.43E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:3.07|P-value:2.00E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:2.69|P-value:9.26E-4 ID:SGTC_1029|Compound:k015-0030|FD-Score:-2.90|P-value:6.84E-4 ID:SGTC_1220|Compound:1838-0075|FD-Score:-3.12|P-value:2.75E-4 ID:SGTC_1232|Compound:0279-0259|FD-Score:3.21|P-value:1.07E-4 ID:SGTC_1261|Compound:0712-0010|FD-Score:3.98|P-value:2.36E-6 ID:SGTC_1264|Compound:0783-0040|FD-Score:-3.19|P-value:2.01E-4 ID:SGTC_1291|Compound:0993-0025|FD-Score:2.72|P-value:8.33E-4 ID:SGTC_1414|Compound:3917-0015|FD-Score:3.66|P-value:1.27E-5 ID:SGTC_1457|Compound:k015-0032|FD-Score:3.53|P-value:2.44E-5 ID:SGTC_1510|Compound:1123-0200|FD-Score:2.67|P-value:9.82E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:-2.81|P-value:9.40E-4 ID:SGTC_1529|Compound:apigenin|FD-Score:-3.18|P-value:2.12E-4 ID:SGTC_1609|Compound:st001574|FD-Score:-3.91|P-value:6.88E-6 ID:SGTC_1616|Compound:st002734|FD-Score:2.85|P-value:4.95E-4 ID:SGTC_1694|Compound:st024011|FD-Score:3.29|P-value:7.45E-5 ID:SGTC_1696|Compound:st025591|FD-Score:3.06|P-value:2.07E-4 ID:SGTC_1701|Compound:st028638|FD-Score:5.05|P-value:3.66E-9 ID:SGTC_1835|Compound:st008666|FD-Score:3.60|P-value:1.75E-5 ID:SGTC_2127|Compound:5253358|FD-Score:2.72|P-value:8.19E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.33|P-value:6.17E-5 ID:SGTC_2319|Compound:6033012|FD-Score:-3.30|P-value:1.25E-4 ID:SGTC_2382|Compound:9035899|FD-Score:3.06|P-value:2.03E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:-3.65|P-value:2.55E-5 ID:SGTC_2821|Compound:7996764|FD-Score:3.27|P-value:8.30E-5 ID:SGTC_2907|Compound:7721985|FD-Score:-2.95|P-value:5.42E-4 ID:SGTC_3008|Compound:9078912|FD-Score:-3.78|P-value:1.32E-5

Top fitness defect scores for YJL049W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1701 st028638 5.05 40.4 µM 3.66E-9 2 2.20E-7
2 SGTC_1261 0712-0010 3.98 12.7 µM 2.36E-6 RNA processing & uracil transport 22 3.40E-5
3 SGTC_1414 3917-0015 3.66 5.4 µM 1.27E-5 14 1.26E-4
4 SGTC_1835 st008666 3.60 49.2 µM 1.75E-5 32 1.62E-4
5 SGTC_1457 k015-0032 3.53 57.3 µM 2.44E-5 51 2.10E-4
6 SGTC_199 4063-0024 3.52 41.6 µM 2.47E-5 8 2.12E-4
7 SGTC_2129 girgensonine 3.33 121.0 µM 6.17E-5 heme biosynthesis & mitochondrial translocase 63 4.32E-4
8 SGTC_1694 st024011 3.29 44.9 µM 7.45E-5 ERG2 65 5.01E-4
9 SGTC_2821 7996764 3.27 71.4 µM 8.30E-5 68 5.45E-4
10 SGTC_646 4092-0839 3.25 27.3 µM 9.04E-5 plasma membrane duress 50 5.82E-4
11 SGTC_1232 0279-0259 3.21 161.0 µM 1.07E-4 54 6.67E-4
12 SGTC_135 0933-0004 3.19 26.4 µM 1.18E-4 60S ribosome export 54 7.19E-4
13 SGTC_234 nsc-17383 3.10 10.7 µM 1.73E-4 ERG2 46 9.66E-4
14 SGTC_663 1486-0733 3.08 13.9 µM 1.86E-4 cell wall signaling 92 0.00102
15 SGTC_871 0574-0004 3.07 149.0 µM 2.00E-4 92 0.00108
16 SGTC_2382 9035899 3.06 200.0 µM 2.03E-4 60S ribosome export 38 0.00109
17 SGTC_1696 st025591 3.06 34.8 µM 2.07E-4 SWF1 & branched chain AA biosynthesis 66 0.00111
18 SGTC_1616 st002734 2.85 56.1 µM 4.95E-4 92 0.00220
19 SGTC_353 1988-1175 2.84 58.3 µM 5.05E-4 unfolded protein response 84 0.00223
20 SGTC_829 1635-0120 2.75 117.0 µM 7.43E-4 DNA damage response 113 0.00302

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.155 1.48E-19 YBR225W_p YBR225W_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants affected in mannosylphophorylation of cell wall components
0.114 4.30E-11 YBR258C SHG1 hom Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres
0.113 4.95E-11 YNL035C YNL035C hom Protein of unknown function; contains WD-40 domains; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YNL035C is not an essential gene; protein abundance increases in response to DNA replication stress
0.112 8.54E-11 YGR162W TIF4631 hom Translation initiation factor eIF4G; subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); interacts with Pab1p and with eIF4A (Tif1p); also has a role in biogenesis of the large ribosomal subunit; TIF4631 has a paralog, TIF4632, that arose from the whole genome duplication
0.099 1.06E-8 YDR087C RRP1 het Essential evolutionarily conserved nucleolar protein necessary for biogenesis of 60S ribosomal subunits and processing of pre-rRNAs to mature rRNAs, associated with several distinct 66S pre-ribosomal particles
0.095 3.26E-8 YNL097C PHO23 hom Probable component of the Rpd3 histone deacetylase complex, involved in transcriptional regulation of PHO5; affects termination of snoRNAs and cryptic unstable transcripts (CUTs); C-terminus has similarity to human candidate tumor suppressor p33(ING1) and its isoform ING3
0.092 9.79E-8 YBR301W PAU24 hom Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anaerobic conditions, completely repressed during aerobic growth
0.092 1.00E-7 YKL009W MRT4 hom Protein involved in mRNA turnover and ribosome assembly, localizes to the nucleolus
0.089 2.28E-7 YNL318C HXT14 hom Protein with similarity to hexose transporter family members, expression is induced in low glucose and repressed in high glucose; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.079 4.51E-6 YOR263C_d YOR263C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF DES3/YOR264W
0.077 7.66E-6 YKL108W SLD2 het Single-stranded DNA origin-binding and annealing protein; required for the initiation of DNA replication; phosphorylated in S phase by cyclin-dependent kinases (Cdks), promoting origin binding, DNA replication and Dpb11p complex formation; component of the preloading complex; unphosphorylated or CDK-phosphorylated Sld2p binds to the MCM2-7 complex;required for the S phase checkpoint; relative distribution to the nucleus increases upon DNA replication stress
0.074 2.01E-5 YFR029W PTR3 het Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes
0.073 2.32E-5 YGL146C_p RRT6_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins
0.068 7.22E-5 YMR055C BUB2 hom Mitotic exit network regulator, forms GTPase-activating Bfa1p-Bub2p complex that binds Tem1p and spindle pole bodies, blocks cell cycle progression before anaphase in response to spindle and kinetochore damage
0.068 7.31E-5 YAL067W-A_p YAL067W-A_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching