YJL060W / BNA3

Kynurenine aminotransferase, catalyzes formation of kynurenic acid from kynurenine; potential Cdc28p substrate

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL060W / BNA3

Click on Significant Values for Screen Details ID:SGTC_116|Compound:0155-0182|FD-Score:4.58|P-value:1.54E-6 ID:SGTC_249|Compound:wiskostatin|FD-Score:3.04|P-value:9.78E-4 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:3.24|P-value:4.80E-4 ID:SGTC_381|Compound:3461-2219|FD-Score:-3.08|P-value:7.75E-4 ID:SGTC_495|Compound:decylubiquinone|FD-Score:3.44|P-value:2.30E-4 ID:SGTC_497|Compound:capsazepine|FD-Score:-3.49|P-value:1.69E-4 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:5.08|P-value:1.11E-7 ID:SGTC_535|Compound:2293-4129|FD-Score:4.35|P-value:4.66E-6 ID:SGTC_662|Compound:k832-1615|FD-Score:4.73|P-value:6.95E-7 ID:SGTC_673|Compound:1082-0474|FD-Score:3.16|P-value:6.52E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:4.32|P-value:5.25E-6 ID:SGTC_945|Compound:3381-0768|FD-Score:4.18|P-value:1.01E-5 ID:SGTC_1031|Compound:k035-0009|FD-Score:6.33|P-value:5.21E-11 ID:SGTC_1034|Compound:k072-0165|FD-Score:-3.02|P-value:9.49E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:3.41|P-value:2.58E-4 ID:SGTC_1038|Compound:k292-0204|FD-Score:-3.06|P-value:8.25E-4 ID:SGTC_1112|Compound:tnp00069|FD-Score:3.16|P-value:6.48E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:5.77|P-value:2.00E-9 ID:SGTC_1240|Compound:0356-0016|FD-Score:3.43|P-value:2.38E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:3.12|P-value:7.41E-4 ID:SGTC_1472|Compound:k841-0093|FD-Score:5.18|P-value:6.42E-8 ID:SGTC_1523|Compound:st012844|FD-Score:-3.49|P-value:1.73E-4 ID:SGTC_1672|Compound:st016598|FD-Score:7.60|P-value:4.48E-15 ID:SGTC_1701|Compound:st028638|FD-Score:3.65|P-value:9.88E-5 ID:SGTC_1713|Compound:st033146|FD-Score:4.14|P-value:1.25E-5 ID:SGTC_1714|Compound:st033236|FD-Score:5.56|P-value:7.28E-9 ID:SGTC_1717|Compound:st033143|FD-Score:9.76|P-value:1.11E-23 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.46|P-value:2.14E-4 ID:SGTC_1921|Compound:5740136|FD-Score:5.09|P-value:1.07E-7 ID:SGTC_1923|Compound:st058458|FD-Score:3.45|P-value:2.18E-4 ID:SGTC_1945|Compound:st075991|FD-Score:4.35|P-value:4.65E-6 ID:SGTC_1955|Compound:wogonin|FD-Score:-3.17|P-value:5.62E-4 ID:SGTC_2017|Compound:5132927|FD-Score:5.18|P-value:6.36E-8 ID:SGTC_2019|Compound:4016004|FD-Score:3.55|P-value:1.48E-4 ID:SGTC_2051|Compound:5263410|FD-Score:-3.43|P-value:2.16E-4 ID:SGTC_2054|Compound:5233173|FD-Score:4.43|P-value:3.19E-6 ID:SGTC_2059|Compound:5238311|FD-Score:3.80|P-value:5.54E-5 ID:SGTC_2164|Compound:5685496|FD-Score:4.31|P-value:5.62E-6 ID:SGTC_2199|Compound:6590217|FD-Score:-3.08|P-value:7.78E-4 ID:SGTC_2200|Compound:6600604|FD-Score:4.03|P-value:2.04E-5 ID:SGTC_2203|Compound:7227154|FD-Score:3.67|P-value:9.38E-5 ID:SGTC_2336|Compound:9001819|FD-Score:3.83|P-value:4.79E-5 ID:SGTC_2380|Compound:9035439|FD-Score:3.25|P-value:4.62E-4 ID:SGTC_2381|Compound:9035592|FD-Score:3.79|P-value:5.64E-5 ID:SGTC_2386|Compound:9075165|FD-Score:3.89|P-value:3.77E-5 ID:SGTC_2391|Compound:6285546|FD-Score:-3.93|P-value:2.78E-5 ID:SGTC_2441|Compound:5730946|FD-Score:4.45|P-value:2.83E-6 ID:SGTC_2486|Compound:5283202|FD-Score:5.90|P-value:8.68E-10 ID:SGTC_2517|Compound:totarol|FD-Score:3.24|P-value:4.87E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:3.55|P-value:1.49E-4 ID:SGTC_2641|Compound:levomentholum|FD-Score:3.39|P-value:2.81E-4 ID:SGTC_2646|Compound:retinol|FD-Score:3.14|P-value:7.04E-4 ID:SGTC_2652|Compound:actinonin|FD-Score:-3.06|P-value:8.38E-4 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:3.18|P-value:6.15E-4 ID:SGTC_2663|Compound:amphotericin b|FD-Score:3.08|P-value:8.48E-4 ID:SGTC_2846|Compound:9008642|FD-Score:-4.07|P-value:1.46E-5 ID:SGTC_2884|Compound:9058502|FD-Score:5.19|P-value:6.14E-8 ID:SGTC_3038|Compound:9091290|FD-Score:4.77|P-value:5.87E-7 ID:SGTC_3043|Compound:9092303|FD-Score:3.91|P-value:3.44E-5 ID:SGTC_3103|Compound:9120822|FD-Score:4.04|P-value:1.97E-5 ID:SGTC_3132|Compound:9126706|FD-Score:3.56|P-value:1.47E-4 ID:SGTC_3197|Compound:9113331|FD-Score:3.27|P-value:4.41E-4 ID:SGTC_3214|Compound:9129694|FD-Score:3.85|P-value:4.33E-5 ID:SGTC_3320|Compound:9137005|FD-Score:3.22|P-value:5.26E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:4.58|P-value:1.54E-6 ID:SGTC_249|Compound:wiskostatin|FD-Score:3.04|P-value:9.78E-4 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:3.24|P-value:4.80E-4 ID:SGTC_381|Compound:3461-2219|FD-Score:-3.08|P-value:7.75E-4 ID:SGTC_495|Compound:decylubiquinone|FD-Score:3.44|P-value:2.30E-4 ID:SGTC_497|Compound:capsazepine|FD-Score:-3.49|P-value:1.69E-4 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:5.08|P-value:1.11E-7 ID:SGTC_535|Compound:2293-4129|FD-Score:4.35|P-value:4.66E-6 ID:SGTC_662|Compound:k832-1615|FD-Score:4.73|P-value:6.95E-7 ID:SGTC_673|Compound:1082-0474|FD-Score:3.16|P-value:6.52E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:4.32|P-value:5.25E-6 ID:SGTC_945|Compound:3381-0768|FD-Score:4.18|P-value:1.01E-5 ID:SGTC_1031|Compound:k035-0009|FD-Score:6.33|P-value:5.21E-11 ID:SGTC_1034|Compound:k072-0165|FD-Score:-3.02|P-value:9.49E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:3.41|P-value:2.58E-4 ID:SGTC_1038|Compound:k292-0204|FD-Score:-3.06|P-value:8.25E-4 ID:SGTC_1112|Compound:tnp00069|FD-Score:3.16|P-value:6.48E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:5.77|P-value:2.00E-9 ID:SGTC_1240|Compound:0356-0016|FD-Score:3.43|P-value:2.38E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:3.12|P-value:7.41E-4 ID:SGTC_1472|Compound:k841-0093|FD-Score:5.18|P-value:6.42E-8 ID:SGTC_1523|Compound:st012844|FD-Score:-3.49|P-value:1.73E-4 ID:SGTC_1672|Compound:st016598|FD-Score:7.60|P-value:4.48E-15 ID:SGTC_1701|Compound:st028638|FD-Score:3.65|P-value:9.88E-5 ID:SGTC_1713|Compound:st033146|FD-Score:4.14|P-value:1.25E-5 ID:SGTC_1714|Compound:st033236|FD-Score:5.56|P-value:7.28E-9 ID:SGTC_1717|Compound:st033143|FD-Score:9.76|P-value:1.11E-23 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.46|P-value:2.14E-4 ID:SGTC_1921|Compound:5740136|FD-Score:5.09|P-value:1.07E-7 ID:SGTC_1923|Compound:st058458|FD-Score:3.45|P-value:2.18E-4 ID:SGTC_1945|Compound:st075991|FD-Score:4.35|P-value:4.65E-6 ID:SGTC_1955|Compound:wogonin|FD-Score:-3.17|P-value:5.62E-4 ID:SGTC_2017|Compound:5132927|FD-Score:5.18|P-value:6.36E-8 ID:SGTC_2019|Compound:4016004|FD-Score:3.55|P-value:1.48E-4 ID:SGTC_2051|Compound:5263410|FD-Score:-3.43|P-value:2.16E-4 ID:SGTC_2054|Compound:5233173|FD-Score:4.43|P-value:3.19E-6 ID:SGTC_2059|Compound:5238311|FD-Score:3.80|P-value:5.54E-5 ID:SGTC_2164|Compound:5685496|FD-Score:4.31|P-value:5.62E-6 ID:SGTC_2199|Compound:6590217|FD-Score:-3.08|P-value:7.78E-4 ID:SGTC_2200|Compound:6600604|FD-Score:4.03|P-value:2.04E-5 ID:SGTC_2203|Compound:7227154|FD-Score:3.67|P-value:9.38E-5 ID:SGTC_2336|Compound:9001819|FD-Score:3.83|P-value:4.79E-5 ID:SGTC_2380|Compound:9035439|FD-Score:3.25|P-value:4.62E-4 ID:SGTC_2381|Compound:9035592|FD-Score:3.79|P-value:5.64E-5 ID:SGTC_2386|Compound:9075165|FD-Score:3.89|P-value:3.77E-5 ID:SGTC_2391|Compound:6285546|FD-Score:-3.93|P-value:2.78E-5 ID:SGTC_2441|Compound:5730946|FD-Score:4.45|P-value:2.83E-6 ID:SGTC_2486|Compound:5283202|FD-Score:5.90|P-value:8.68E-10 ID:SGTC_2517|Compound:totarol|FD-Score:3.24|P-value:4.87E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:3.55|P-value:1.49E-4 ID:SGTC_2641|Compound:levomentholum|FD-Score:3.39|P-value:2.81E-4 ID:SGTC_2646|Compound:retinol|FD-Score:3.14|P-value:7.04E-4 ID:SGTC_2652|Compound:actinonin|FD-Score:-3.06|P-value:8.38E-4 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:3.18|P-value:6.15E-4 ID:SGTC_2663|Compound:amphotericin b|FD-Score:3.08|P-value:8.48E-4 ID:SGTC_2846|Compound:9008642|FD-Score:-4.07|P-value:1.46E-5 ID:SGTC_2884|Compound:9058502|FD-Score:5.19|P-value:6.14E-8 ID:SGTC_3038|Compound:9091290|FD-Score:4.77|P-value:5.87E-7 ID:SGTC_3043|Compound:9092303|FD-Score:3.91|P-value:3.44E-5 ID:SGTC_3103|Compound:9120822|FD-Score:4.04|P-value:1.97E-5 ID:SGTC_3132|Compound:9126706|FD-Score:3.56|P-value:1.47E-4 ID:SGTC_3197|Compound:9113331|FD-Score:3.27|P-value:4.41E-4 ID:SGTC_3214|Compound:9129694|FD-Score:3.85|P-value:4.33E-5 ID:SGTC_3320|Compound:9137005|FD-Score:3.22|P-value:5.26E-4

Top fitness defect scores for YJL060W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1717 st033143 9.76 58.0 µM 1.11E-23 5 8.46E-23
2 SGTC_1672 st016598 7.60 6.5 µM 4.48E-15 endomembrane recycling 19 1.51E-14
3 SGTC_1031 k035-0009 6.33 16.0 µM 5.21E-11 3 1.20E-10
4 SGTC_2486 5283202 5.90 22.4 µM 8.68E-10 11 1.78E-9
5 SGTC_1131 3454-3128 5.77 32.3 µM 2.00E-9 6 3.97E-9
6 SGTC_1714 st033236 5.56 13.6 µM 7.28E-9 5 1.37E-8
7 SGTC_2884 9058502 5.19 52.0 µM 6.14E-8 10 1.06E-7
8 SGTC_2017 5132927 5.18 60.6 µM 6.36E-8 8 1.10E-7
9 SGTC_1472 k841-0093 5.18 193.0 µM 6.42E-8 3 1.11E-7
10 SGTC_1921 5740136 5.09 50.0 µM 1.07E-7 TRP & mitochondrial translation 30 1.81E-7
11 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 5.08 150.0 µM 1.11E-7 Golgi 26 1.89E-7
12 SGTC_3038 9091290 4.77 49.5 µM 5.87E-7 7 9.31E-7
13 SGTC_662 k832-1615 4.73 104.0 µM 6.95E-7 8 1.10E-6
14 SGTC_116 0155-0182 4.58 31.8 µM 1.54E-6 mitochondrial response to ROS 52 2.35E-6
15 SGTC_2441 5730946 4.45 39.1 µM 2.83E-6 9 4.22E-6
16 SGTC_2054 5233173 4.43 129.0 µM 3.19E-6 mitochondrial response to ROS 42 4.73E-6
17 SGTC_1945 st075991 4.35 56.6 µM 4.65E-6 60S ribosome export 11 6.80E-6
18 SGTC_535 2293-4129 4.35 48.2 µM 4.66E-6 NEO1 52 6.82E-6
19 SGTC_756 0508-1999 4.32 28.3 µM 5.25E-6 RPP1 & pyrimidine depletion 15 7.64E-6
20 SGTC_2164 5685496 4.31 200.0 µM 5.62E-6 16 8.17E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.226 2.93E-40 YLR401C DUS3 hom Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region; forms nuclear foci upon DNA replication stress
0.119 3.89E-12 YER011W TIR1 hom Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expression is downregulated at acidic pH and induced by cold shock and anaerobiosis; abundance is increased in cells cultured without shaking
0.112 6.80E-11 YMR195W ICY1 hom Protein of unknown function, required for viability in rich media of cells lacking mitochondrial DNA; mutants have an invasive growth defect with elongated morphology; induced by amino acid starvation
0.105 9.19E-10 YJL083W TAX4 hom EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; TAX4 has a paralog, IRS4, that arose from the whole genome duplication
0.092 9.89E-8 YJL210W PEX2 hom RING-finger peroxin and E3 ubiquitin ligase, peroxisomal membrane protein with a C-terminal zinc-binding RING domain, forms translocation subcomplex with Pex10p and Pex12p which functions in peroxisomal matrix protein import
0.092 9.98E-8 YGR161W-C_p YGR161W-C_p hom Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species
0.090 2.04E-7 YIL010W DOT5 hom Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth
0.087 3.91E-7 YKL043W PHD1 hom Transcriptional activator that enhances pseudohyphal growth; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; regulates expression of FLO11, an adhesin required for pseudohyphal filament formation; similar to StuA, an A. nidulans developmental regulator; potential Cdc28p substrate; PHD1 has a paralog, SOK2, that arose from the whole genome duplication
0.084 1.02E-6 YPL047W SGF11 hom Integral subunit of SAGA histone acetyltransferase complex, regulates transcription of a subset of SAGA-regulated genes, required for the Ubp8p association with SAGA and for H2B deubiquitylation
0.083 1.47E-6 YJR005C-A_p YJR005C-A_p hom Putative protein of unknown function; originally identified as a syntenic homolog of an Ashbya gossypii gene; YJR005C-A has a paralog, YGR169C-A, that arose from the whole genome duplication
0.082 1.92E-6 YNL267W PIK1 het Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton
0.079 4.09E-6 YER103W SSA4 hom Heat shock protein that is highly induced upon stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the HSP70 family; cytoplasmic protein that concentrates in nuclei upon starvation; SSA4 has a paralog, SSA3, that arose from the whole genome duplication
0.079 4.31E-6 YEL065W SIT1 hom Ferrioxamine B transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; transcription is induced during iron deprivation and diauxic shift; potentially phosphorylated by Cdc28p
0.079 5.13E-6 YGR258C RAD2 hom Single-stranded DNA endonuclease, cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPG protein
0.077 8.01E-6 YMR201C RAD14 hom Protein that recognizes and binds damaged DNA during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); contains zinc finger motif; homolog of human XPA protein