YJL079C / PRY1

Sterol binding protein involved in the export of acetylated sterols; secreted glycoprotein and member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); sterol export function is redundant with that of PRY2; may be involved in detoxification of hydrophobic compounds; PRY1 has a paralog, PRY2, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL079C / PRY1

Click on Significant Values for Screen Details ID:SGTC_78|Compound:0336-0123|FD-Score:-3.31|P-value:2.12E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:3.38|P-value:8.80E-5 ID:SGTC_273|Compound:hydroxyurea|FD-Score:2.87|P-value:6.92E-4 ID:SGTC_336|Compound:4111-0029|FD-Score:-3.10|P-value:4.77E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:4.15|P-value:2.27E-6 ID:SGTC_502|Compound:l-744,832|FD-Score:2.87|P-value:7.03E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-4.22|P-value:3.09E-6 ID:SGTC_515|Compound:4092-1064|FD-Score:-3.16|P-value:3.84E-4 ID:SGTC_604|Compound:1000-0114|FD-Score:3.82|P-value:1.17E-5 ID:SGTC_663|Compound:1486-0733|FD-Score:2.79|P-value:9.46E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:4.20|P-value:1.67E-6 ID:SGTC_1068|Compound:loratadine|FD-Score:-3.37|P-value:1.62E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:2.83|P-value:8.04E-4 ID:SGTC_1234|Compound:0326-0494|FD-Score:3.00|P-value:4.24E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:3.11|P-value:2.76E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.40|P-value:7.89E-5 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:3.11|P-value:2.73E-4 ID:SGTC_1408|Compound:3909-7976|FD-Score:2.89|P-value:6.45E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:4.08|P-value:3.22E-6 ID:SGTC_1454|Compound:4239-0054|FD-Score:-3.49|P-value:9.68E-5 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.55|P-value:4.08E-5 ID:SGTC_1541|Compound:2',3',6-trimethoxyflavone|FD-Score:3.43|P-value:6.97E-5 ID:SGTC_1571|Compound:st070080|FD-Score:4.07|P-value:3.35E-6 ID:SGTC_1591|Compound:genipin|FD-Score:4.04|P-value:3.87E-6 ID:SGTC_1622|Compound:st003707|FD-Score:-3.10|P-value:4.94E-4 ID:SGTC_1638|Compound:st008370|FD-Score:-4.23|P-value:3.01E-6 ID:SGTC_1657|Compound:st012939|FD-Score:-3.15|P-value:3.97E-4 ID:SGTC_1663|Compound:st014140|FD-Score:2.99|P-value:4.34E-4 ID:SGTC_1676|Compound:st018489|FD-Score:2.83|P-value:8.02E-4 ID:SGTC_1752|Compound:st044819|FD-Score:3.72|P-value:1.87E-5 ID:SGTC_1777|Compound:st045864|FD-Score:-3.30|P-value:2.22E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:-3.83|P-value:2.15E-5 ID:SGTC_1808|Compound:st050063|FD-Score:3.48|P-value:5.73E-5 ID:SGTC_1962|Compound:st076595|FD-Score:2.99|P-value:4.35E-4 ID:SGTC_2011|Compound:4012611|FD-Score:2.90|P-value:6.28E-4 ID:SGTC_2123|Compound:5259487|FD-Score:3.34|P-value:1.04E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.90|P-value:8.06E-6 ID:SGTC_2133|Compound:5320837|FD-Score:-3.53|P-value:8.23E-5 ID:SGTC_2279|Compound:7948423|FD-Score:3.02|P-value:3.88E-4 ID:SGTC_2281|Compound:7943571|FD-Score:3.89|P-value:8.28E-6 ID:SGTC_2290|Compound:7904846|FD-Score:3.36|P-value:9.52E-5 ID:SGTC_2309|Compound:7664088|FD-Score:4.81|P-value:5.70E-8 ID:SGTC_2325|Compound:6158266|FD-Score:3.20|P-value:1.86E-4 ID:SGTC_2329|Compound:6138490|FD-Score:6.08|P-value:1.09E-11 ID:SGTC_2335|Compound:9018011|FD-Score:4.97|P-value:2.16E-8 ID:SGTC_2337|Compound:9009472|FD-Score:3.06|P-value:3.33E-4 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:2.99|P-value:4.41E-4 ID:SGTC_2625|Compound:euphol|FD-Score:3.38|P-value:8.72E-5 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:5.19|P-value:5.15E-9 ID:SGTC_2827|Compound:7993847|FD-Score:3.87|P-value:9.12E-6 ID:SGTC_2828|Compound:7998861|FD-Score:3.38|P-value:8.87E-5 ID:SGTC_2831|Compound:7999036|FD-Score:3.53|P-value:4.57E-5 ID:SGTC_2833|Compound:9001315|FD-Score:-4.50|P-value:6.98E-7 ID:SGTC_2835|Compound:9006588|FD-Score:-4.80|P-value:1.32E-7 ID:SGTC_2842|Compound:9000675|FD-Score:-3.41|P-value:1.39E-4 ID:SGTC_2893|Compound:9048488|FD-Score:-3.15|P-value:4.00E-4 ID:SGTC_2933|Compound:9026794|FD-Score:3.43|P-value:7.14E-5 ID:SGTC_3020|Compound:9089140|FD-Score:-3.79|P-value:2.60E-5 ID:SGTC_3041|Compound:9091929|FD-Score:-3.73|P-value:3.32E-5 ID:SGTC_3205|Compound:9113483|FD-Score:-3.17|P-value:3.68E-4 ID:SGTC_3216|Compound:9129716|FD-Score:4.27|P-value:1.15E-6 ID:SGTC_3224|Compound:9130643|FD-Score:-4.10|P-value:5.74E-6 ID:SGTC_3244|Compound:9134489|FD-Score:3.66|P-value:2.44E-5 ID:SGTC_78|Compound:0336-0123|FD-Score:-3.31|P-value:2.12E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:3.38|P-value:8.80E-5 ID:SGTC_273|Compound:hydroxyurea|FD-Score:2.87|P-value:6.92E-4 ID:SGTC_336|Compound:4111-0029|FD-Score:-3.10|P-value:4.77E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:4.15|P-value:2.27E-6 ID:SGTC_502|Compound:l-744,832|FD-Score:2.87|P-value:7.03E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-4.22|P-value:3.09E-6 ID:SGTC_515|Compound:4092-1064|FD-Score:-3.16|P-value:3.84E-4 ID:SGTC_604|Compound:1000-0114|FD-Score:3.82|P-value:1.17E-5 ID:SGTC_663|Compound:1486-0733|FD-Score:2.79|P-value:9.46E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:4.20|P-value:1.67E-6 ID:SGTC_1068|Compound:loratadine|FD-Score:-3.37|P-value:1.62E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:2.83|P-value:8.04E-4 ID:SGTC_1234|Compound:0326-0494|FD-Score:3.00|P-value:4.24E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:3.11|P-value:2.76E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.40|P-value:7.89E-5 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:3.11|P-value:2.73E-4 ID:SGTC_1408|Compound:3909-7976|FD-Score:2.89|P-value:6.45E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:4.08|P-value:3.22E-6 ID:SGTC_1454|Compound:4239-0054|FD-Score:-3.49|P-value:9.68E-5 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.55|P-value:4.08E-5 ID:SGTC_1541|Compound:2',3',6-trimethoxyflavone|FD-Score:3.43|P-value:6.97E-5 ID:SGTC_1571|Compound:st070080|FD-Score:4.07|P-value:3.35E-6 ID:SGTC_1591|Compound:genipin|FD-Score:4.04|P-value:3.87E-6 ID:SGTC_1622|Compound:st003707|FD-Score:-3.10|P-value:4.94E-4 ID:SGTC_1638|Compound:st008370|FD-Score:-4.23|P-value:3.01E-6 ID:SGTC_1657|Compound:st012939|FD-Score:-3.15|P-value:3.97E-4 ID:SGTC_1663|Compound:st014140|FD-Score:2.99|P-value:4.34E-4 ID:SGTC_1676|Compound:st018489|FD-Score:2.83|P-value:8.02E-4 ID:SGTC_1752|Compound:st044819|FD-Score:3.72|P-value:1.87E-5 ID:SGTC_1777|Compound:st045864|FD-Score:-3.30|P-value:2.22E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:-3.83|P-value:2.15E-5 ID:SGTC_1808|Compound:st050063|FD-Score:3.48|P-value:5.73E-5 ID:SGTC_1962|Compound:st076595|FD-Score:2.99|P-value:4.35E-4 ID:SGTC_2011|Compound:4012611|FD-Score:2.90|P-value:6.28E-4 ID:SGTC_2123|Compound:5259487|FD-Score:3.34|P-value:1.04E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.90|P-value:8.06E-6 ID:SGTC_2133|Compound:5320837|FD-Score:-3.53|P-value:8.23E-5 ID:SGTC_2279|Compound:7948423|FD-Score:3.02|P-value:3.88E-4 ID:SGTC_2281|Compound:7943571|FD-Score:3.89|P-value:8.28E-6 ID:SGTC_2290|Compound:7904846|FD-Score:3.36|P-value:9.52E-5 ID:SGTC_2309|Compound:7664088|FD-Score:4.81|P-value:5.70E-8 ID:SGTC_2325|Compound:6158266|FD-Score:3.20|P-value:1.86E-4 ID:SGTC_2329|Compound:6138490|FD-Score:6.08|P-value:1.09E-11 ID:SGTC_2335|Compound:9018011|FD-Score:4.97|P-value:2.16E-8 ID:SGTC_2337|Compound:9009472|FD-Score:3.06|P-value:3.33E-4 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:2.99|P-value:4.41E-4 ID:SGTC_2625|Compound:euphol|FD-Score:3.38|P-value:8.72E-5 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:5.19|P-value:5.15E-9 ID:SGTC_2827|Compound:7993847|FD-Score:3.87|P-value:9.12E-6 ID:SGTC_2828|Compound:7998861|FD-Score:3.38|P-value:8.87E-5 ID:SGTC_2831|Compound:7999036|FD-Score:3.53|P-value:4.57E-5 ID:SGTC_2833|Compound:9001315|FD-Score:-4.50|P-value:6.98E-7 ID:SGTC_2835|Compound:9006588|FD-Score:-4.80|P-value:1.32E-7 ID:SGTC_2842|Compound:9000675|FD-Score:-3.41|P-value:1.39E-4 ID:SGTC_2893|Compound:9048488|FD-Score:-3.15|P-value:4.00E-4 ID:SGTC_2933|Compound:9026794|FD-Score:3.43|P-value:7.14E-5 ID:SGTC_3020|Compound:9089140|FD-Score:-3.79|P-value:2.60E-5 ID:SGTC_3041|Compound:9091929|FD-Score:-3.73|P-value:3.32E-5 ID:SGTC_3205|Compound:9113483|FD-Score:-3.17|P-value:3.68E-4 ID:SGTC_3216|Compound:9129716|FD-Score:4.27|P-value:1.15E-6 ID:SGTC_3224|Compound:9130643|FD-Score:-4.10|P-value:5.74E-6 ID:SGTC_3244|Compound:9134489|FD-Score:3.66|P-value:2.44E-5

Top fitness defect scores for YJL079C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2329 6138490 6.08 200.0 µM 1.09E-11 7 5.88E-10
2 SGTC_2626 ethyl orsellinate 5.19 100.0 µM 5.15E-9 11 1.03E-7
3 SGTC_2335 9018011 4.97 154.2 µM 2.16E-8 12 3.43E-7
4 SGTC_2309 7664088 4.81 163.9 µM 5.70E-8 12 7.73E-7
5 SGTC_3216 9129716 4.27 49.5 µM 1.15E-6 RPP1 & pyrimidine depletion 18 9.57E-6
6 SGTC_665 3914-0008 4.20 307.0 µM 1.67E-6 16 1.31E-5
7 SGTC_430 0958-0115 4.15 16.4 µM 2.27E-6 25 1.70E-5
8 SGTC_1447 4239-0816 4.08 81.9 µM 3.22E-6 25 2.27E-5
9 SGTC_1571 st070080 4.07 73.4 µM 3.35E-6 13 2.35E-5
10 SGTC_1591 genipin 4.04 88.4 µM 3.87E-6 mitochondrial processes 11 2.65E-5
11 SGTC_2129 girgensonine 3.90 121.0 µM 8.06E-6 heme biosynthesis & mitochondrial translocase 34 4.91E-5
12 SGTC_2281 7943571 3.89 200.0 µM 8.28E-6 13 5.02E-5
13 SGTC_2827 7993847 3.87 71.4 µM 9.12E-6 29 5.44E-5
14 SGTC_604 1000-0114 3.82 314.0 µM 1.17E-5 23 6.71E-5
15 SGTC_1752 st044819 3.72 83.0 µM 1.87E-5 29 9.93E-5
16 SGTC_3244 9134489 3.66 49.5 µM 2.44E-5 24 1.24E-4
17 SGTC_1456 k015-0012 3.55 13.0 µM 4.08E-5 46 1.91E-4
18 SGTC_2831 7999036 3.53 19.5 µM 4.57E-5 60 2.10E-4
19 SGTC_1808 st050063 3.48 61.5 µM 5.73E-5 21 2.54E-4
20 SGTC_1541 2',3',6-trimethoxyflavone 3.43 64.0 µM 6.97E-5 28 2.99E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.141 2.75E-16 YGR112W SHY1 hom Mitochondrial inner membrane protein required for assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes; similar to human SURF1 involved in Leigh Syndrome
0.127 1.45E-13 YBL074C AAR2 het Component of the U5 snRNP, required for splicing of U3 precursors; originally described as a splicing factor specifically required for splicing pre-mRNA of the MATa1 cistron
0.107 4.35E-10 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.103 2.40E-9 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.099 1.08E-8 YJR135W-A TIM8 hom Mitochondrial intermembrane space protein, forms a complex with Tim13p that delivers a subset of hydrophobic proteins to the TIM22 complex for inner membrane insertion; homolog of human TIMM8A, implicated in Mohr-Tranebjaerg syndrome
0.096 2.20E-8 YKL082C RRP14 het Essential protein, constituent of 66S pre-ribosomal particles; interacts with proteins involved in ribosomal biogenesis and cell polarity; member of the SURF-6 family
0.095 3.29E-8 YBL008W-A_p YBL008W-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.095 3.60E-8 YDR454C GUK1 het Guanylate kinase, converts GMP to GDP; required for growth and mannose outer chain elongation of cell wall N-linked glycoproteins
0.095 3.68E-8 YBR258C SHG1 hom Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres
0.095 3.89E-8 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.091 1.49E-7 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.090 1.52E-7 YBL032W HEK2 hom RNA binding protein involved in the asymmetric localization of ASH1 mRNA; represses translation of ASH1 mRNA, an effect reversed by Yck1p-dependent phosphoryation; regulates telomere position effect and length; similarity to hnRNP-K
0.089 2.28E-7 YLR317W_d YLR317W_d het Dubious open reading frame; may be part of a bicistronic transcript with NKP2/YLR315W; overlaps the verified ORF TAD3/YLR316C
0.089 2.30E-7 YDL242W_d YDL242W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.089 2.51E-7 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit