HIPHOP chemogenomics database

YJL081C / ARP4

Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes

Zygosity: Heterozygous strain

fixedexpanded
Profile for YJL081C / ARP4

Click on Significant Values for Screen Details

Top fitness defect scores for YJL081C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value	Screen Clearance
1	SGTC_1652	st011932	21.90	78.0 µM	6.26E-72	RSC complex & mRNA processing	2	7.04E-107	2.89
2	SGTC_2912	7964298	18.60	10.9 µM	1.25E-52	cell wall	2	7.25E-78	2.50
3	SGTC_1374	2889-5571	15.70	141.0 µM	6.54E-38	RSC complex & mRNA processing	2	9.21E-56	0.36
4	SGTC_2109	5483026	13.10	200.0 µM	6.41E-27	RSC complex & mRNA processing	5	2.80E-39	2.44
5	SGTC_138	0850-0259	13.00	40.9 µM	1.23E-26	cell wall	9	7.45E-39	1.97
6	SGTC_312	4092-0653	12.90	6.8 µM	2.59E-26	ergosterol depletion effects on membrane	3	2.27E-38	1.98
7	SGTC_1754	st042065	12.70	16.1 µM	9.99E-26	NEO1-PIK1	3	1.72E-37	1.19
8	SGTC_320	4092-0846	12.20	5.3 µM	1.05E-23	ergosterol depletion effects on membrane	3	1.83E-34	1.63
9	SGTC_2567	aureobasidin a	12.10	60.0 nM	2.85E-23		9	8.16E-34	1.14
10	SGTC_2582	agaric acid	11.60	100.0 µM	1.64E-21	redox potentiating	6	3.52E-31	2.23
11	SGTC_2041	5107442	11.30	45.3 µM	1.08E-20	RSC complex & mRNA processing	4	5.94E-30	0.55
12	SGTC_178	4092-0806	10.90	87.5 µM	2.71E-19	ergosterol depletion effects on membrane	1	7.31E-28	1.60
13	SGTC_1707	st032323	10.60	6.3 µM	2.11E-18	DNA damage response	5	1.58E-26	0.10
14	SGTC_586	0957-0265	10.30	8.2 µM	1.49E-17	cell wall	4	2.92E-25	0.28
15	SGTC_673	1082-0474	10.30	110.0 µM	1.66E-17	RSC complex & mRNA processing	9	3.43E-25	0.07
16	SGTC_1818	st052136	10.30	56.3 µM	1.72E-17	NEO1-PIK1	1	3.60E-25	2.66
17	SGTC_871	0574-0004	10.20	149.0 µM	4.09E-17		4	1.32E-24	0.50
18	SGTC_3037	9091026	10.00	49.5 µM	1.32E-16	NEO1-PIK1	6	7.62E-24	0.22
19	SGTC_1800	st050079	9.90	29.1 µM	2.51E-16	NEO1-PIK1	4	1.99E-23	1.84
20	SGTC_928	2764-0428	9.59	58.7 µM	1.98E-15	cell wall	4	4.34E-22	2.99

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.512	6.61E-223	YBR091C	TIM12	het	Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins
0.495	6.71E-207	YER165W	PAB1	het	Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G
0.463	8.06E-178	YOR236W	DFR1	het	Dihydrofolate reductase involved in tetrahydrofolate biosynthesis; required for respiratory metabolism
0.446	2.55E-163	YNR016C	ACC1	het	Acetyl-CoA carboxylase, biotin containing enzyme; catalyzes the carboxylation of cytosolic acetyl-CoA to form malonyl-CoA and regulates histone acetylation by regulating the availablity of acetyl-CoA; required for de novo biosynthesis of long-chain fatty acids;
0.446	7.57E-163	YML127W	RSC9	het	Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway
0.440	8.23E-159	YPR034W	ARP7	het	Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
0.438	1.66E-156	YBL026W	LSM2	het	Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.437	7.54E-156	YFR037C	RSC8	het	Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters
0.421	2.19E-143	YLR033W	RSC58	het	Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance
0.408	7.07E-134	YBL092W	RPL32	het	Ribosomal 60S subunit protein L32; overexpression disrupts telomeric silencing; homologous to mammalian ribosomal protein L32, no bacterial homolog
0.383	5.31E-117	YLR321C	SFH1	het	Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression and maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog
0.372	3.56E-110	YPR104C	FHL1	het	Regulator of ribosomal protein (RP) transcription; has forkhead associated domain that binds phosphorylated proteins; recruits coactivator Ifh1p or corepressor Crf1p to RP gene promoters; also has forkhead DNA-binding domain though in vitro DNA binding assays give inconsistent results; computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p motifs at others; suppresses RNA pol III and splicing factor prp4 mutants
0.351	2.05E-97	YAL001C	TFC3	het	Largest of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauB domain of TFIIIC that binds DNA at the BoxB promoter sites of tRNA and similar genes; cooperates with Tfc6p in DNA binding
0.349	1.93E-96	YMR033W	ARP9	het	Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
0.347	2.01E-95	YLL043W	FPS1	hom	Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress