YJL082W / IML2

Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; IML2 has a paralog, YKR018C, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL082W / IML2

Click on Significant Values for Screen Details ID:SGTC_50|Compound:0929-0078|FD-Score:3.49|P-value:2.41E-4 ID:SGTC_60|Compound:0986-0278|FD-Score:3.10|P-value:9.42E-4 ID:SGTC_135|Compound:0933-0004|FD-Score:5.48|P-value:2.44E-8 ID:SGTC_142|Compound:0335-0849|FD-Score:3.36|P-value:3.83E-4 ID:SGTC_258|Compound:haloperidol|FD-Score:3.37|P-value:3.70E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:5.99|P-value:1.36E-9 ID:SGTC_354|Compound:2783-3500|FD-Score:-3.85|P-value:9.73E-5 ID:SGTC_355|Compound:1311-2252|FD-Score:-4.55|P-value:5.07E-6 ID:SGTC_359|Compound:0081-0058|FD-Score:7.24|P-value:3.43E-13 ID:SGTC_537|Compound:1334-0398|FD-Score:3.47|P-value:2.60E-4 ID:SGTC_539|Compound:4859-0462|FD-Score:3.39|P-value:3.36E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:3.14|P-value:8.07E-4 ID:SGTC_683|Compound:panaxydol|FD-Score:3.37|P-value:3.62E-4 ID:SGTC_728|Compound:3030-5151|FD-Score:3.37|P-value:3.72E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:3.23|P-value:5.94E-4 ID:SGTC_849|Compound:0386-0493|FD-Score:-3.83|P-value:1.08E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:-4.11|P-value:3.52E-5 ID:SGTC_1172|Compound:0370-0043|FD-Score:4.48|P-value:3.90E-6 ID:SGTC_1370|Compound:2001-0092|FD-Score:7.00|P-value:1.88E-12 ID:SGTC_1547|Compound:harmine|FD-Score:5.76|P-value:5.07E-9 ID:SGTC_1645|Compound:Cervolide|FD-Score:3.24|P-value:5.81E-4 ID:SGTC_1729|Compound:st035615|FD-Score:3.17|P-value:7.43E-4 ID:SGTC_1820|Compound:st053765|FD-Score:3.22|P-value:6.26E-4 ID:SGTC_1845|Compound:st056753|FD-Score:-4.10|P-value:3.56E-5 ID:SGTC_1848|Compound:st056003|FD-Score:4.95|P-value:4.02E-7 ID:SGTC_1888|Compound:azatryptophan|FD-Score:3.73|P-value:9.58E-5 ID:SGTC_1901|Compound:st060216|FD-Score:3.51|P-value:2.20E-4 ID:SGTC_1940|Compound:st075990|FD-Score:3.39|P-value:3.36E-4 ID:SGTC_2056|Compound:5235370|FD-Score:8.04|P-value:8.24E-16 ID:SGTC_2060|Compound:5238662|FD-Score:6.66|P-value:1.89E-11 ID:SGTC_2127|Compound:5253358|FD-Score:3.61|P-value:1.50E-4 ID:SGTC_2147|Compound:5545932|FD-Score:3.11|P-value:9.04E-4 ID:SGTC_2231|Compound:micatex|FD-Score:3.40|P-value:3.28E-4 ID:SGTC_2304|Compound:7443016|FD-Score:-4.13|P-value:3.15E-5 ID:SGTC_2310|Compound:7668677|FD-Score:3.93|P-value:4.30E-5 ID:SGTC_2569|Compound:tetrandrine|FD-Score:-5.94|P-value:3.79E-9 ID:SGTC_2575|Compound:plumbagin|FD-Score:-4.37|P-value:1.17E-5 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-3.36|P-value:5.88E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:3.09|P-value:9.55E-4 ID:SGTC_2963|Compound:9082507|FD-Score:-3.51|P-value:3.49E-4 ID:SGTC_3050|Compound:9093513|FD-Score:3.18|P-value:7.03E-4 ID:SGTC_3054|Compound:9094397|FD-Score:-3.38|P-value:5.62E-4 ID:SGTC_3055|Compound:9094636|FD-Score:-3.27|P-value:8.08E-4 ID:SGTC_3138|Compound:9097216|FD-Score:3.34|P-value:4.13E-4 ID:SGTC_3152|Compound:9099253|FD-Score:3.52|P-value:2.16E-4 ID:SGTC_3159|Compound:9100096|FD-Score:3.56|P-value:1.81E-4 ID:SGTC_3224|Compound:9130643|FD-Score:-4.49|P-value:6.68E-6 ID:SGTC_3346|Compound:9158254|FD-Score:-3.52|P-value:3.43E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:3.49|P-value:2.41E-4 ID:SGTC_60|Compound:0986-0278|FD-Score:3.10|P-value:9.42E-4 ID:SGTC_135|Compound:0933-0004|FD-Score:5.48|P-value:2.44E-8 ID:SGTC_142|Compound:0335-0849|FD-Score:3.36|P-value:3.83E-4 ID:SGTC_258|Compound:haloperidol|FD-Score:3.37|P-value:3.70E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:5.99|P-value:1.36E-9 ID:SGTC_354|Compound:2783-3500|FD-Score:-3.85|P-value:9.73E-5 ID:SGTC_355|Compound:1311-2252|FD-Score:-4.55|P-value:5.07E-6 ID:SGTC_359|Compound:0081-0058|FD-Score:7.24|P-value:3.43E-13 ID:SGTC_537|Compound:1334-0398|FD-Score:3.47|P-value:2.60E-4 ID:SGTC_539|Compound:4859-0462|FD-Score:3.39|P-value:3.36E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:3.14|P-value:8.07E-4 ID:SGTC_683|Compound:panaxydol|FD-Score:3.37|P-value:3.62E-4 ID:SGTC_728|Compound:3030-5151|FD-Score:3.37|P-value:3.72E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:3.23|P-value:5.94E-4 ID:SGTC_849|Compound:0386-0493|FD-Score:-3.83|P-value:1.08E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:-4.11|P-value:3.52E-5 ID:SGTC_1172|Compound:0370-0043|FD-Score:4.48|P-value:3.90E-6 ID:SGTC_1370|Compound:2001-0092|FD-Score:7.00|P-value:1.88E-12 ID:SGTC_1547|Compound:harmine|FD-Score:5.76|P-value:5.07E-9 ID:SGTC_1645|Compound:Cervolide|FD-Score:3.24|P-value:5.81E-4 ID:SGTC_1729|Compound:st035615|FD-Score:3.17|P-value:7.43E-4 ID:SGTC_1820|Compound:st053765|FD-Score:3.22|P-value:6.26E-4 ID:SGTC_1845|Compound:st056753|FD-Score:-4.10|P-value:3.56E-5 ID:SGTC_1848|Compound:st056003|FD-Score:4.95|P-value:4.02E-7 ID:SGTC_1888|Compound:azatryptophan|FD-Score:3.73|P-value:9.58E-5 ID:SGTC_1901|Compound:st060216|FD-Score:3.51|P-value:2.20E-4 ID:SGTC_1940|Compound:st075990|FD-Score:3.39|P-value:3.36E-4 ID:SGTC_2056|Compound:5235370|FD-Score:8.04|P-value:8.24E-16 ID:SGTC_2060|Compound:5238662|FD-Score:6.66|P-value:1.89E-11 ID:SGTC_2127|Compound:5253358|FD-Score:3.61|P-value:1.50E-4 ID:SGTC_2147|Compound:5545932|FD-Score:3.11|P-value:9.04E-4 ID:SGTC_2231|Compound:micatex|FD-Score:3.40|P-value:3.28E-4 ID:SGTC_2304|Compound:7443016|FD-Score:-4.13|P-value:3.15E-5 ID:SGTC_2310|Compound:7668677|FD-Score:3.93|P-value:4.30E-5 ID:SGTC_2569|Compound:tetrandrine|FD-Score:-5.94|P-value:3.79E-9 ID:SGTC_2575|Compound:plumbagin|FD-Score:-4.37|P-value:1.17E-5 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-3.36|P-value:5.88E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:3.09|P-value:9.55E-4 ID:SGTC_2963|Compound:9082507|FD-Score:-3.51|P-value:3.49E-4 ID:SGTC_3050|Compound:9093513|FD-Score:3.18|P-value:7.03E-4 ID:SGTC_3054|Compound:9094397|FD-Score:-3.38|P-value:5.62E-4 ID:SGTC_3055|Compound:9094636|FD-Score:-3.27|P-value:8.08E-4 ID:SGTC_3138|Compound:9097216|FD-Score:3.34|P-value:4.13E-4 ID:SGTC_3152|Compound:9099253|FD-Score:3.52|P-value:2.16E-4 ID:SGTC_3159|Compound:9100096|FD-Score:3.56|P-value:1.81E-4 ID:SGTC_3224|Compound:9130643|FD-Score:-4.49|P-value:6.68E-6 ID:SGTC_3346|Compound:9158254|FD-Score:-3.52|P-value:3.43E-4

Top fitness defect scores for YJL082W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2056 5235370 8.04 200.0 µM 8.24E-16 5 4.61E-16
2 SGTC_359 0081-0058 7.24 15.9 µM 3.43E-13 60S ribosome export 7 2.24E-13
3 SGTC_1370 2001-0092 7.00 44.6 µM 1.88E-12 4 1.28E-12
4 SGTC_2060 5238662 6.66 140.0 µM 1.89E-11 1 1.36E-11
5 SGTC_346 4513-0042 5.99 7.2 µM 1.36E-9 azole & statin 10 1.08E-9
6 SGTC_1547 harmine 5.76 94.2 µM 5.07E-9 ergosterol biosynthesis 19 4.16E-9
7 SGTC_135 0933-0004 5.48 26.4 µM 2.44E-8 60S ribosome export 3 2.07E-8
8 SGTC_1848 st056003 4.95 16.4 µM 4.02E-7 4 3.62E-7
9 SGTC_1172 0370-0043 4.48 85.0 µM 3.90E-6 10 3.69E-6
10 SGTC_2310 7668677 3.93 200.0 µM 4.30E-5 30 4.25E-5
11 SGTC_1888 azatryptophan 3.73 97.5 µM 9.58E-5 25 9.59E-5
12 SGTC_2127 5253358 3.61 187.9 µM 1.50E-4 32 1.51E-4
13 SGTC_3159 9100096 3.56 49.5 µM 1.81E-4 31 1.84E-4
14 SGTC_3152 9099253 3.52 49.5 µM 2.16E-4 NEO1-PIK1 158 2.19E-4
15 SGTC_1901 st060216 3.51 58.6 µM 2.20E-4 35 2.23E-4
16 SGTC_50 0929-0078 3.49 56.4 µM 2.41E-4 66 2.45E-4
17 SGTC_537 1334-0398 3.47 209.0 µM 2.60E-4 44 2.65E-4
18 SGTC_2231 micatex 3.40 6.8 µM 3.28E-4 25 3.34E-4
19 SGTC_1940 st075990 3.39 51.1 µM 3.36E-4 60S ribosome export 41 3.43E-4
20 SGTC_539 4859-0462 3.39 2.5 µM 3.36E-4 RNA pol III & RNase P/MRP 47 3.44E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.127 1.50E-13 YLR349W_d YLR349W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified ORF DIC1/YLR348C
0.124 5.25E-13 YJR017C ESS1 het Peptidylprolyl-cis/trans-isomerase (PPIase); specific for phosphorylated serine and threonine residues N-terminal to proline; regulates phosphorylation of the RNAP II large subunit (Rpo21p) C-terminal domain (CTD); associates with phospho-Ser5 form of RNAP II in vivo; regulates phosphorylation of Ser7 within CTD; present along entire coding length of genes; represses initiation of CUTs; required for efficient termination of mRNA transcription and trimethylation of histone H3
0.115 2.13E-11 YLR390W-A CCW14 hom Covalently linked cell wall glycoprotein, present in the inner layer of the cell wall
0.108 3.49E-10 YAL014C SYN8 hom Endosomal SNARE related to mammalian syntaxin 8
0.108 3.72E-10 YKL189W HYM1 het Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with Kic1p and Sog2p, localizes to sites of polarized growth during budding and during the mating response
0.106 8.16E-10 YLL005C SPO75 hom Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis
0.104 1.65E-9 YOR136W IDH2 hom Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle; phosphorylated
0.096 2.95E-8 YMR103C_d YMR103C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.091 1.36E-7 YDL197C ASF2 hom Anti-silencing protein that causes derepression of silent loci when overexpressed
0.088 3.20E-7 YHL032C GUT1 hom Glycerol kinase, converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p
0.088 3.31E-7 YKL046C DCW1 hom Putative mannosidase, GPI-anchored membrane protein required for cell wall biosynthesis in bud formation;homologous to Dfg5p
0.088 3.46E-7 YOR329C SCD5 het Protein required for normal actin organization and endocytosis; targeting subunit for protein phosphatase type 1; undergoes Crm1p-dependent nuclear-cytoplasmic shuttling; multicopy suppressor of clathrin deficiency
0.087 4.21E-7 YNL004W HRB1 hom Poly(A+) RNA-binding protein; involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Npl3p; HRB1 has a paralog, GBP2, that arose from the whole genome duplication
0.086 6.68E-7 YOR162C YRR1 hom Zn2-Cys6 zinc-finger transcription factor; activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes; YRR1 has a paralog, PDR8, that arose from the whole genome duplication
0.086 6.90E-7 YER118C SHO1 hom Transmembrane osmosensor involved in activation of the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol response pathway; phosphorylated by Hog1p; interacts with Pbs2p, Msb2p, Hkr1p, and Ste11p