HIPHOP chemogenomics database

YJL094C / KHA1

Putative K+/H+ antiporter with a probable role in intracellular cation homeostasis, localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies

Zygosity: Homozygous strain

fixedexpanded
Profile for YJL094C / KHA1

Click on Significant Values for Screen Details

Top fitness defect scores for YJL094C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_157	1348-1695	18.60	65.8 µM	4.13E-91	iron homeostasis	6	3.39E-77
2	SGTC_2688	kanamycin b	12.70	96.7 µM	1.15E-43	calcium & mitochondrial duress	8	3.66E-37
3	SGTC_2389	9091542	12.50	195.5 µM	8.98E-43	iron homeostasis	1	2.07E-36
4	SGTC_2275	7947463	10.70	200.0 µM	1.02E-31	iron homeostasis	4	4.45E-27
5	SGTC_2586	curcumin	10.60	80.0 µM	4.28E-31	iron homeostasis	1	1.50E-26
6	SGTC_263	alizarin	9.70	107.9 µM	2.45E-26	iron homeostasis	4	1.57E-22
7	SGTC_2021	4019055	9.35	173.0 µM	1.23E-24	endomembrane recycling	13	4.26E-21
8	SGTC_1230	0170-0365	9.05	3.8 µM	3.30E-23	endomembrane recycling	6	6.90E-20
9	SGTC_2249	haloperidol	8.14	116.4 µM	4.01E-19	ergosterol depletion effects on membrane	22	1.95E-16
10	SGTC_649	1123-0311	7.38	367.0 µM	4.68E-16	endomembrane recycling	17	7.67E-14
11	SGTC_1658	st012944	6.53	20.0 µM	6.24E-13	iron homeostasis	24	3.38E-11
12	SGTC_2619	obliquin	6.05	87.9 µM	2.30E-11	cell wall	72	7.17E-10
13	SGTC_1161	k007-0610	6.03	110.0 µM	2.64E-11	ERAD & cell cycle	60	8.05E-10
14	SGTC_1712	st032288	5.99	53.4 µM	3.53E-11	calcium & mitochondrial duress	75	1.03E-9
15	SGTC_1163	k060-0048	5.89	49.9 µM	7.47E-11		4	1.95E-9
16	SGTC_178	4092-0806	5.70	87.5 µM	2.73E-10	ergosterol depletion effects on membrane	45	5.83E-9
17	SGTC_2006	4011487	5.66	200.0 µM	3.67E-10	endomembrane recycling	47	7.51E-9
18	SGTC_2597	laccaic acid a	5.66	100.0 µM	3.80E-10		9	7.72E-9
19	SGTC_1110	3-hydroxy-3'-methoxyflavone	5.24	1.2 µM	6.08E-9	iron homeostasis	22	8.10E-8
20	SGTC_1145	3546-0597	5.16	10.2 µM	9.86E-9	mitochondrial processes	6	1.22E-7

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.594	1.25E-318	YDR269C_d	YDR269C_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.575	6.20E-294	YJR040W	GEF1	hom	Voltage-gated chloride channel localized to the golgi, the endosomal system, and plasma membrane, and involved in cation homeostasis; highly homologous to vertebrate voltage-gated chloride channels; modulates TBSV model (+) RNA virus replication by regulating copper metabolism
0.480	2.15E-192	YDR270W	CCC2	hom	Cu(+2)-transporting P-type ATPase; required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases; protein abundance increases in response to DNA replication stress; affects TBSV model (+)RNA virus replication by regulating copper metabolism
0.411	1.32E-136	YDR271C_d	YDR271C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CCC2/YDR270W
0.388	1.45E-120	YNL259C	ATX1	hom	Cytosolic copper metallochaperone that transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptake
0.356	7.85E-101	YMR058W	FET3	hom	Ferro-O2-oxidoreductase; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress
0.315	4.20E-78	YER145C	FTR1	hom	High affinity iron permease; involved in the transport of iron across the plasma membrane; forms complex with Fet3p; expression is regulated by iron; protein abundance increases in response to DNA replication stress
0.306	9.53E-74	YDR203W_d	YDR203W_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.253	6.71E-50	YJR033C	RAV1	hom	Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate
0.241	1.32E-45	YEL022W	GEA2	hom	Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs); involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; GEA2 has a paralog, GEA1, that arose from the whole genome duplication
0.238	3.36E-44	YMR057C_d	YMR057C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF AAC1
0.223	4.81E-39	YPL120W	VPS30	hom	Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II; Complex I is essential in autophagy and Complex II is required for vacuolar protein sorting; required for overflow degradation of misfolded proteins when ERAD is saturated; ortholog of the higher eukaryotic gene Beclin 1
0.223	5.74E-39	YKL135C	APL2	hom	Beta-adaptin subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; protein abundance increases in response to DNA replication stress
0.219	1.22E-37	YAL002W	VPS8	hom	Membrane-binding component of the CORVET complex; involved in endosomal vesicle tethering and fusion in the endosome to vacuole protein targeting pathway; interacts with Vps21p; contains RING finger motif
0.214	4.72E-36	YGR261C	APL6	hom	Beta3-like subunit of the yeast AP-3 complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; exists in both cytosolic and peripherally associated membrane-bound pools