HIPHOP chemogenomics database

YJL099W / CHS6

Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication

Zygosity: Homozygous strain

fixedexpanded
Profile for YJL099W / CHS6

Click on Significant Values for Screen Details

Top fitness defect scores for YJL099W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_863	0466-0191	22.10	129.0 µM	1.75E-94	cell wall	2	3.76E-108
2	SGTC_2912	7964298	20.00	10.9 µM	2.55E-78	cell wall	4	1.27E-89
3	SGTC_138	0850-0259	19.30	40.9 µM	4.02E-73	cell wall	6	1.16E-83
4	SGTC_3311	9131146	15.80	2.9 µM	1.23E-49	cell wall	4	9.81E-57
5	SGTC_2584	androsterone	14.20	48.7 µM	1.96E-40	cell wall	6	3.51E-46
6	SGTC_3321	9137793	14.00	26.8 µM	3.23E-39	cell wall	4	8.71E-45
7	SGTC_586	0957-0265	12.70	8.2 µM	1.54E-32	cell wall	2	3.96E-37
8	SGTC_2582	agaric acid	11.30	100.0 µM	3.93E-26	redox potentiating	49	8.83E-30
9	SGTC_354	2783-3500	8.63	4.9 µM	4.50E-16	cell wall	8	3.03E-18
10	SGTC_304	1310-0298	8.43	97.0 µM	2.02E-15	cell wall	5	1.70E-17
11	SGTC_351	caspofungin	8.39	25.0 nM	2.81E-15	cell wall	15	2.47E-17
12	SGTC_514	4466-0038	8.25	2.6 nM	7.62E-15	cell wall	36	7.77E-17
13	SGTC_3266	9136860	8.23	49.5 µM	8.94E-15	cell wall	12	9.33E-17
14	SGTC_58	0957-0393	7.96	9.0 µM	6.11E-14	cell wall	124	8.44E-16
15	SGTC_916	4466-0038	7.48	42.0 nM	1.67E-12	cell wall	14	3.75E-14
16	SGTC_928	2764-0428	6.51	58.7 µM	6.83E-10	cell wall	11	3.70E-11
17	SGTC_951	1171-0579	6.10	82.7 µM	7.03E-9	cell wall	33	5.37E-10
18	SGTC_964	1287-0107	5.76	19.4 µM	4.29E-8	cell wall	15	4.27E-9
19	SGTC_1465	k213-0056	5.50	144.0 µM	1.57E-7	DNA intercalators	5	1.88E-8
20	SGTC_2619	obliquin	5.03	87.9 µM	1.46E-6	cell wall	98	2.43E-7

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.615	0	YBR023C	CHS3	hom	Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan
0.587	1.12E-309	YLR331C_d	JIP3_d	hom	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.569	4.78E-287	YDL203C	ACK1	hom	Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.501	6.47E-213	YBL006C	LDB7	hom	Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions
0.498	2.43E-209	YPL115C	BEM3	hom	Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly
0.490	1.59E-202	YDL066W	IDP1	hom	Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes
0.464	2.62E-178	YBL061C	SKT5	hom	Activator of Chs3p (chitin synthase III) during vegetative growth; recruits Chs3p to the bud neck via interaction with Bni4p; SKT5 has a paralog, SHC1, that arose from the whole genome duplication
0.462	3.26E-177	YBL062W_d	YBL062W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.456	5.61E-172	YLL032C	YLL032C	hom	Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.454	4.69E-170	YJR142W_p	YJR142W_p	hom	Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.451	2.71E-167	YKL076C_d	PSY1_d	hom	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C
0.443	5.34E-161	YMR124W_p	YMR124W_p	hom	Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization
0.438	1.51E-157	YDR348C	PAL1	hom	Protein of unknown function thought to be involved in endocytosis; Pal1p physically interacts with Ede1p and is found at endocytic sites at the cell periphery during the early stages of endocytosis; green fluorescent protein (GFP)-fusion protein also localizes to the bud neck; potential Cdc28p substrate; similar to the S. pombe Pal1 protein; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.436	6.86E-156	YOL003C	PFA4	hom	Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.427	4.98E-149	YLL043W	FPS1	hom	Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress