YJL127C-B_p

Putative protein of unknown function; identified based on homology to the filamentous fungus, Ashbya gossypii

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL127C-B / YJL127C-B

Click on Significant Values for Screen Details ID:SGTC_236|Compound:1509-0011|FD-Score:6.50|P-value:1.89E-12 ID:SGTC_264|Compound:promethazine|FD-Score:3.42|P-value:1.24E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-2.97|P-value:7.79E-4 ID:SGTC_419|Compound:nsc-638432|FD-Score:3.02|P-value:6.17E-4 ID:SGTC_420|Compound:mitomycin C|FD-Score:3.11|P-value:4.32E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:-3.32|P-value:2.02E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:3.04|P-value:5.70E-4 ID:SGTC_441|Compound:propafenone|FD-Score:3.09|P-value:4.78E-4 ID:SGTC_538|Compound:2922-0838|FD-Score:3.12|P-value:4.25E-4 ID:SGTC_594|Compound:1487-1584|FD-Score:3.46|P-value:1.08E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:3.86|P-value:1.85E-5 ID:SGTC_769|Compound:0302-0231|FD-Score:3.05|P-value:5.40E-4 ID:SGTC_820|Compound:1582-0060|FD-Score:-3.09|P-value:5.02E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:3.77|P-value:2.77E-5 ID:SGTC_1458|Compound:k015-0034|FD-Score:2.89|P-value:9.78E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:-3.48|P-value:1.03E-4 ID:SGTC_1513|Compound:0337-0559|FD-Score:-2.91|P-value:9.65E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.26|P-value:2.43E-4 ID:SGTC_1616|Compound:st002734|FD-Score:-3.17|P-value:3.66E-4 ID:SGTC_1635|Compound:st007035|FD-Score:5.16|P-value:1.73E-8 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.41|P-value:1.42E-4 ID:SGTC_1908|Compound:st060353|FD-Score:3.72|P-value:3.51E-5 ID:SGTC_2327|Compound:6189656|FD-Score:4.12|P-value:5.29E-6 ID:SGTC_2650|Compound:prasterone|FD-Score:2.96|P-value:7.73E-4 ID:SGTC_2676|Compound:harmalol|FD-Score:3.04|P-value:5.75E-4 ID:SGTC_2678|Compound:equilin|FD-Score:2.91|P-value:9.13E-4 ID:SGTC_2961|Compound:9083290|FD-Score:-3.27|P-value:2.48E-4 ID:SGTC_3000|Compound:9075062|FD-Score:-3.16|P-value:3.78E-4 ID:SGTC_3002|Compound:9075603|FD-Score:-4.41|P-value:1.32E-6 ID:SGTC_3210|Compound:9128157|FD-Score:3.22|P-value:2.86E-4 ID:SGTC_3292|Compound:9120825|FD-Score:3.60|P-value:5.83E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:6.50|P-value:1.89E-12 ID:SGTC_264|Compound:promethazine|FD-Score:3.42|P-value:1.24E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-2.97|P-value:7.79E-4 ID:SGTC_419|Compound:nsc-638432|FD-Score:3.02|P-value:6.17E-4 ID:SGTC_420|Compound:mitomycin C|FD-Score:3.11|P-value:4.32E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:-3.32|P-value:2.02E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:3.04|P-value:5.70E-4 ID:SGTC_441|Compound:propafenone|FD-Score:3.09|P-value:4.78E-4 ID:SGTC_538|Compound:2922-0838|FD-Score:3.12|P-value:4.25E-4 ID:SGTC_594|Compound:1487-1584|FD-Score:3.46|P-value:1.08E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:3.86|P-value:1.85E-5 ID:SGTC_769|Compound:0302-0231|FD-Score:3.05|P-value:5.40E-4 ID:SGTC_820|Compound:1582-0060|FD-Score:-3.09|P-value:5.02E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:3.77|P-value:2.77E-5 ID:SGTC_1458|Compound:k015-0034|FD-Score:2.89|P-value:9.78E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:-3.48|P-value:1.03E-4 ID:SGTC_1513|Compound:0337-0559|FD-Score:-2.91|P-value:9.65E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.26|P-value:2.43E-4 ID:SGTC_1616|Compound:st002734|FD-Score:-3.17|P-value:3.66E-4 ID:SGTC_1635|Compound:st007035|FD-Score:5.16|P-value:1.73E-8 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.41|P-value:1.42E-4 ID:SGTC_1908|Compound:st060353|FD-Score:3.72|P-value:3.51E-5 ID:SGTC_2327|Compound:6189656|FD-Score:4.12|P-value:5.29E-6 ID:SGTC_2650|Compound:prasterone|FD-Score:2.96|P-value:7.73E-4 ID:SGTC_2676|Compound:harmalol|FD-Score:3.04|P-value:5.75E-4 ID:SGTC_2678|Compound:equilin|FD-Score:2.91|P-value:9.13E-4 ID:SGTC_2961|Compound:9083290|FD-Score:-3.27|P-value:2.48E-4 ID:SGTC_3000|Compound:9075062|FD-Score:-3.16|P-value:3.78E-4 ID:SGTC_3002|Compound:9075603|FD-Score:-4.41|P-value:1.32E-6 ID:SGTC_3210|Compound:9128157|FD-Score:3.22|P-value:2.86E-4 ID:SGTC_3292|Compound:9120825|FD-Score:3.60|P-value:5.83E-5

Top fitness defect scores for YJL127C-B deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 6.50 5.3 µM 1.89E-12 277 4.03E-11
2 SGTC_1635 st007035 5.16 42.4 µM 1.73E-8 163 1.23E-7
3 SGTC_2327 6189656 4.12 200.0 µM 5.29E-6 20 1.90E-5
4 SGTC_743 1275-0778 3.86 158.0 µM 1.85E-5 excess fatty acid 34 5.73E-5
5 SGTC_922 1866-0035 3.77 480.0 µM 2.77E-5 excess fatty acid 69 8.19E-5
6 SGTC_1908 st060353 3.72 56.5 µM 3.51E-5 RPP1 & pyrimidine depletion 44 1.01E-4
7 SGTC_3292 9120825 3.60 59.8 µM 5.83E-5 18 1.58E-4
8 SGTC_594 1487-1584 3.46 10.8 µM 1.08E-4 39 2.71E-4
9 SGTC_264 promethazine 3.42 12.5 mM 1.24E-4 DNA intercalators 78 3.08E-4
10 SGTC_1525 8-methoxypsoralen 3.26 92.5 µM 2.43E-4 DNA damage response 60 5.56E-4
11 SGTC_3210 9128157 3.22 49.5 µM 2.86E-4 86 6.42E-4
12 SGTC_538 2922-0838 3.12 53.3 µM 4.25E-4 Golgi 69 9.11E-4
13 SGTC_420 mitomycin C 3.11 81.9 mM 4.32E-4 49 9.24E-4
14 SGTC_441 propafenone 3.09 146.0 µM 4.78E-4 16 0.00101
15 SGTC_769 0302-0231 3.05 76.0 µM 5.40E-4 107 0.00113
16 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 3.04 8.0 µM 5.70E-4 66 0.00118
17 SGTC_2676 harmalol 3.04 100.0 µM 5.75E-4 mitochondrial processes 41 0.00119
18 SGTC_419 nsc-638432 3.02 893.0 µM 6.17E-4 DNA damage response 41 0.00127
19 SGTC_2650 prasterone 2.96 100.0 µM 7.73E-4 28 0.00155
20 SGTC_2678 equilin 2.91 100.0 µM 9.13E-4 64 0.00179

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.426 6.37E-148 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.413 8.27E-138 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.409 3.90E-135 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.384 5.26E-118 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.381 5.42E-116 YGR183C QCR9 hom Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
0.380 1.21E-115 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.377 3.81E-113 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.366 1.03E-106 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.364 1.03E-105 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.362 4.09E-104 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.356 1.10E-100 YOR065W CYT1 hom Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
0.355 2.96E-100 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.354 1.47E-99 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.349 1.14E-96 YKL087C CYT2 hom Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1
0.348 5.27E-96 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p