YJL137C / GLG2

Glycogenin glucosyltransferase; self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin; GLG2 has a paralog, GLG1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL137C / GLG2

Click on Significant Values for Screen Details ID:SGTC_290|Compound:2043-6722|FD-Score:3.80|P-value:6.17E-5 ID:SGTC_306|Compound:1672-3436|FD-Score:3.33|P-value:3.65E-4 ID:SGTC_320|Compound:4092-0846|FD-Score:4.62|P-value:1.58E-6 ID:SGTC_329|Compound:k048-0121|FD-Score:-3.41|P-value:4.18E-4 ID:SGTC_333|Compound:3486-0131|FD-Score:-3.87|P-value:7.09E-5 ID:SGTC_336|Compound:4111-0029|FD-Score:-4.00|P-value:4.23E-5 ID:SGTC_338|Compound:4055-0136|FD-Score:-4.39|P-value:7.65E-6 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:-3.77|P-value:1.06E-4 ID:SGTC_497|Compound:capsazepine|FD-Score:-4.56|P-value:3.52E-6 ID:SGTC_545|Compound:4218-0007|FD-Score:3.15|P-value:6.97E-4 ID:SGTC_594|Compound:1487-1584|FD-Score:-4.13|P-value:2.40E-5 ID:SGTC_606|Compound:k015-0008|FD-Score:4.88|P-value:4.37E-7 ID:SGTC_615|Compound:k087-0205|FD-Score:-4.53|P-value:4.10E-6 ID:SGTC_641|Compound:4092-0595|FD-Score:-3.57|P-value:2.28E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:3.45|P-value:2.43E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:3.25|P-value:4.98E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:4.96|P-value:2.93E-7 ID:SGTC_907|Compound:3448-6986|FD-Score:5.22|P-value:7.35E-8 ID:SGTC_931|Compound:2812-0076|FD-Score:-3.36|P-value:5.03E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:-4.28|P-value:1.26E-5 ID:SGTC_973|Compound:1325-0077|FD-Score:3.42|P-value:2.68E-4 ID:SGTC_981|Compound:1488-1094|FD-Score:-3.88|P-value:6.81E-5 ID:SGTC_1220|Compound:1838-0075|FD-Score:3.33|P-value:3.74E-4 ID:SGTC_1233|Compound:0325-0408|FD-Score:-3.90|P-value:6.32E-5 ID:SGTC_1238|Compound:0333-0287|FD-Score:-3.17|P-value:9.52E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:-5.02|P-value:3.70E-7 ID:SGTC_1362|Compound:1611-0397|FD-Score:-3.44|P-value:3.68E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.35|P-value:3.40E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:4.12|P-value:1.58E-5 ID:SGTC_1602|Compound:st001878|FD-Score:3.53|P-value:1.74E-4 ID:SGTC_1616|Compound:st002734|FD-Score:3.23|P-value:5.23E-4 ID:SGTC_1713|Compound:st033146|FD-Score:3.23|P-value:5.35E-4 ID:SGTC_1723|Compound:st034307|FD-Score:-4.53|P-value:4.06E-6 ID:SGTC_1744|Compound:st037937|FD-Score:3.29|P-value:4.27E-4 ID:SGTC_1849|Compound:st056239|FD-Score:3.24|P-value:5.14E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:3.34|P-value:3.54E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:3.24|P-value:5.19E-4 ID:SGTC_2268|Compound:7933382|FD-Score:-3.48|P-value:3.21E-4 ID:SGTC_2271|Compound:7849410|FD-Score:4.36|P-value:5.31E-6 ID:SGTC_2335|Compound:9018011|FD-Score:3.75|P-value:7.60E-5 ID:SGTC_2384|Compound:9036245|FD-Score:3.96|P-value:3.10E-5 ID:SGTC_2393|Compound:9031399|FD-Score:3.80|P-value:6.02E-5 ID:SGTC_2403|Compound:6032726|FD-Score:-3.51|P-value:2.88E-4 ID:SGTC_2486|Compound:5283202|FD-Score:-4.55|P-value:3.80E-6 ID:SGTC_2564|Compound:betulinic acid|FD-Score:4.44|P-value:3.74E-6 ID:SGTC_2584|Compound:androsterone|FD-Score:3.21|P-value:5.77E-4 ID:SGTC_2795|Compound:7780010|FD-Score:3.90|P-value:3.99E-5 ID:SGTC_2988|Compound:9073640|FD-Score:-4.19|P-value:1.91E-5 ID:SGTC_2990|Compound:9074105|FD-Score:-10.00|P-value:1.51E-23 ID:SGTC_2996|Compound:9066192|FD-Score:3.34|P-value:3.63E-4 ID:SGTC_3201|Compound:9113999|FD-Score:3.37|P-value:3.25E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-3.29|P-value:6.28E-4 ID:SGTC_290|Compound:2043-6722|FD-Score:3.80|P-value:6.17E-5 ID:SGTC_306|Compound:1672-3436|FD-Score:3.33|P-value:3.65E-4 ID:SGTC_320|Compound:4092-0846|FD-Score:4.62|P-value:1.58E-6 ID:SGTC_329|Compound:k048-0121|FD-Score:-3.41|P-value:4.18E-4 ID:SGTC_333|Compound:3486-0131|FD-Score:-3.87|P-value:7.09E-5 ID:SGTC_336|Compound:4111-0029|FD-Score:-4.00|P-value:4.23E-5 ID:SGTC_338|Compound:4055-0136|FD-Score:-4.39|P-value:7.65E-6 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:-3.77|P-value:1.06E-4 ID:SGTC_497|Compound:capsazepine|FD-Score:-4.56|P-value:3.52E-6 ID:SGTC_545|Compound:4218-0007|FD-Score:3.15|P-value:6.97E-4 ID:SGTC_594|Compound:1487-1584|FD-Score:-4.13|P-value:2.40E-5 ID:SGTC_606|Compound:k015-0008|FD-Score:4.88|P-value:4.37E-7 ID:SGTC_615|Compound:k087-0205|FD-Score:-4.53|P-value:4.10E-6 ID:SGTC_641|Compound:4092-0595|FD-Score:-3.57|P-value:2.28E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:3.45|P-value:2.43E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:3.25|P-value:4.98E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:4.96|P-value:2.93E-7 ID:SGTC_907|Compound:3448-6986|FD-Score:5.22|P-value:7.35E-8 ID:SGTC_931|Compound:2812-0076|FD-Score:-3.36|P-value:5.03E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:-4.28|P-value:1.26E-5 ID:SGTC_973|Compound:1325-0077|FD-Score:3.42|P-value:2.68E-4 ID:SGTC_981|Compound:1488-1094|FD-Score:-3.88|P-value:6.81E-5 ID:SGTC_1220|Compound:1838-0075|FD-Score:3.33|P-value:3.74E-4 ID:SGTC_1233|Compound:0325-0408|FD-Score:-3.90|P-value:6.32E-5 ID:SGTC_1238|Compound:0333-0287|FD-Score:-3.17|P-value:9.52E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:-5.02|P-value:3.70E-7 ID:SGTC_1362|Compound:1611-0397|FD-Score:-3.44|P-value:3.68E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.35|P-value:3.40E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:4.12|P-value:1.58E-5 ID:SGTC_1602|Compound:st001878|FD-Score:3.53|P-value:1.74E-4 ID:SGTC_1616|Compound:st002734|FD-Score:3.23|P-value:5.23E-4 ID:SGTC_1713|Compound:st033146|FD-Score:3.23|P-value:5.35E-4 ID:SGTC_1723|Compound:st034307|FD-Score:-4.53|P-value:4.06E-6 ID:SGTC_1744|Compound:st037937|FD-Score:3.29|P-value:4.27E-4 ID:SGTC_1849|Compound:st056239|FD-Score:3.24|P-value:5.14E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:3.34|P-value:3.54E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:3.24|P-value:5.19E-4 ID:SGTC_2268|Compound:7933382|FD-Score:-3.48|P-value:3.21E-4 ID:SGTC_2271|Compound:7849410|FD-Score:4.36|P-value:5.31E-6 ID:SGTC_2335|Compound:9018011|FD-Score:3.75|P-value:7.60E-5 ID:SGTC_2384|Compound:9036245|FD-Score:3.96|P-value:3.10E-5 ID:SGTC_2393|Compound:9031399|FD-Score:3.80|P-value:6.02E-5 ID:SGTC_2403|Compound:6032726|FD-Score:-3.51|P-value:2.88E-4 ID:SGTC_2486|Compound:5283202|FD-Score:-4.55|P-value:3.80E-6 ID:SGTC_2564|Compound:betulinic acid|FD-Score:4.44|P-value:3.74E-6 ID:SGTC_2584|Compound:androsterone|FD-Score:3.21|P-value:5.77E-4 ID:SGTC_2795|Compound:7780010|FD-Score:3.90|P-value:3.99E-5 ID:SGTC_2988|Compound:9073640|FD-Score:-4.19|P-value:1.91E-5 ID:SGTC_2990|Compound:9074105|FD-Score:-10.00|P-value:1.51E-23 ID:SGTC_2996|Compound:9066192|FD-Score:3.34|P-value:3.63E-4 ID:SGTC_3201|Compound:9113999|FD-Score:3.37|P-value:3.25E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-3.29|P-value:6.28E-4

Top fitness defect scores for YJL137C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_907 3448-6986 5.22 75.5 µM 7.35E-8 7 8.95E-8
2 SGTC_794 k038-0031 4.96 316.0 µM 2.93E-7 ubiquinone biosynthesis & proteasome 81 3.54E-7
3 SGTC_606 k015-0008 4.88 38.6 µM 4.37E-7 2 5.29E-7
4 SGTC_320 4092-0846 4.62 5.3 µM 1.58E-6 ergosterol depletion effects on membrane 33 1.91E-6
5 SGTC_2564 betulinic acid 4.44 100.0 µM 3.74E-6 23 4.49E-6
6 SGTC_2271 7849410 4.36 118.6 µM 5.31E-6 9 6.36E-6
7 SGTC_1453 4237-0541 4.12 195.0 µM 1.58E-5 heme biosynthesis & mitochondrial translocase 22 1.88E-5
8 SGTC_2384 9036245 3.96 200.0 µM 3.10E-5 29 3.69E-5
9 SGTC_2795 7780010 3.90 54.5 µM 3.99E-5 31 4.73E-5
10 SGTC_2393 9031399 3.80 185.9 µM 6.02E-5 RNA processing & uracil transport 32 7.12E-5
11 SGTC_290 2043-6722 3.80 48.1 µM 6.17E-5 13 7.30E-5
12 SGTC_2335 9018011 3.75 154.2 µM 7.60E-5 31 8.98E-5
13 SGTC_1602 st001878 3.53 87.6 µM 1.74E-4 27 2.05E-4
14 SGTC_663 1486-0733 3.45 13.9 µM 2.43E-4 cell wall signaling 79 2.84E-4
15 SGTC_973 1325-0077 3.42 65.9 µM 2.68E-4 22 3.14E-4
16 SGTC_3201 9113999 3.37 49.5 µM 3.25E-4 58 3.80E-4
17 SGTC_1377 2944-0135 3.35 198.0 µM 3.40E-4 calcium & mitochondrial duress 60 3.97E-4
18 SGTC_2130 NSC 7 3.34 2.5 µM 3.54E-4 copper-dependent oxidative stress 59 4.13E-4
19 SGTC_2996 9066192 3.34 71.4 µM 3.63E-4 63 4.24E-4
20 SGTC_306 1672-3436 3.33 11.6 µM 3.65E-4 Golgi 31 4.27E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.122 1.11E-12 YJR038C_d YJR038C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.118 8.06E-12 YNL209W SSB2 hom Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in the folding of newly-synthesized polypeptide chains; member of the HSP70 family; SSB2 has a paralog, SSB1, that arose from the whole genome duplication
0.118 7.89E-12 YBR050C REG2 hom Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteolysis of maltose permease
0.115 2.36E-11 YER066C-A_d YER066C-A_d hom Dubious open reading frame unlikely to encode a protein, partially overlaps uncharacterized ORF YER067W
0.112 7.26E-11 YNL187W SWT21 hom Protein involved in mRNA splicing; contains a consensus nuclear export signal (NES) sequence similar to the consensus sequence recognized by Crm1p; interacts genetically with Prp40p and Tgs1p; contains WD40 repeats
0.101 5.15E-9 YHL016C DUR3 hom Plasma membrane transporter for both urea and polyamines, expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway
0.099 8.53E-9 YLL039C UBI4 hom Ubiquitin; becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats; protein abundance increases in response to DNA replication stress
0.099 9.68E-9 YMR006C PLB2 hom Phospholipase B (lysophospholipase) involved in phospholipid metabolism; displays transacylase activity in vitro; overproduction confers resistance to lysophosphatidylcholine
0.099 1.08E-8 YHR078W_p YHR078W_p hom High osmolarity-regulated gene of unknown function
0.096 2.56E-8 YML119W_p YML119W_p hom Putative protein of unknown function; YML119W is not an essential gene; potential Cdc28p substrate
0.089 2.45E-7 YLL019C KNS1 hom Protein kinase involved in negative regulation of PolIII transcription; effector kinase of the TOR signaling pathway and phosphorylates Rpc53p to regulate ribosome and tRNA biosynthesis; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues; capable of autophosphorylation
0.085 7.90E-7 YDR336W_p YDR336W_p hom Putative protein of unknown function; sumoylated under stress conditions in a genome wide study; YDR336W is not an essential gene
0.081 2.49E-6 YGR161W-C_p YGR161W-C_p hom Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species
0.079 4.15E-6 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.078 6.10E-6 YBL037W APL3 hom Alpha-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport