YJL157C / FAR1

Cyclin-dependent kinase inhibitor; mediates cell cycle arrest in response to pheromone; also forms a complex with Cdc24p, Ste4p, and Ste18p that may specify the direction of polarized growth during mating; potential Cdc28p substrate; relocalizes from nucleus to cytoplasm upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL157C / FAR1

Click on Significant Values for Screen Details ID:SGTC_421|Compound:streptovitacin|FD-Score:3.32|P-value:4.54E-5 ID:SGTC_435|Compound:c-PAF|FD-Score:3.13|P-value:1.09E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:3.07|P-value:1.43E-4 ID:SGTC_624|Compound:k048-0052|FD-Score:-2.97|P-value:3.21E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:5.84|P-value:3.71E-12 ID:SGTC_731|Compound:3966-0296|FD-Score:-2.76|P-value:7.50E-4 ID:SGTC_904|Compound:1141-0088|FD-Score:-3.15|P-value:1.41E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:-2.83|P-value:5.80E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:3.26|P-value:6.07E-5 ID:SGTC_1064|Compound:honokiol|FD-Score:3.01|P-value:1.87E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:2.74|P-value:6.09E-4 ID:SGTC_1153|Compound:4055-0057|FD-Score:-2.91|P-value:4.13E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:3.77|P-value:4.47E-6 ID:SGTC_1237|Compound:0330-0133|FD-Score:-3.08|P-value:1.97E-4 ID:SGTC_1395|Compound:3486-0190|FD-Score:2.91|P-value:2.93E-4 ID:SGTC_1420|Compound:4'-methoxyflavone|FD-Score:3.20|P-value:8.02E-5 ID:SGTC_1520|Compound:flindersine|FD-Score:5.06|P-value:1.44E-9 ID:SGTC_1685|Compound:st024049|FD-Score:3.53|P-value:1.62E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.20|P-value:1.16E-4 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:2.96|P-value:2.38E-4 ID:SGTC_2238|Compound:6671620|FD-Score:-3.62|P-value:1.54E-5 ID:SGTC_2243|Compound:6634756|FD-Score:-3.73|P-value:8.25E-6 ID:SGTC_2279|Compound:7948423|FD-Score:3.36|P-value:3.74E-5 ID:SGTC_2458|Compound:5808907|FD-Score:3.33|P-value:4.33E-5 ID:SGTC_2793|Compound:7325131|FD-Score:2.78|P-value:5.01E-4 ID:SGTC_2796|Compound:7949634|FD-Score:-2.98|P-value:3.00E-4 ID:SGTC_2931|Compound:9014674|FD-Score:-3.13|P-value:1.59E-4 ID:SGTC_2985|Compound:9022375|FD-Score:3.43|P-value:2.61E-5 ID:SGTC_3160|Compound:9100216|FD-Score:2.99|P-value:2.07E-4 ID:SGTC_3212|Compound:9128307|FD-Score:2.82|P-value:4.31E-4 ID:SGTC_3293|Compound:9120939|FD-Score:2.63|P-value:9.23E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:3.32|P-value:4.54E-5 ID:SGTC_435|Compound:c-PAF|FD-Score:3.13|P-value:1.09E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:3.07|P-value:1.43E-4 ID:SGTC_624|Compound:k048-0052|FD-Score:-2.97|P-value:3.21E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:5.84|P-value:3.71E-12 ID:SGTC_731|Compound:3966-0296|FD-Score:-2.76|P-value:7.50E-4 ID:SGTC_904|Compound:1141-0088|FD-Score:-3.15|P-value:1.41E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:-2.83|P-value:5.80E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:3.26|P-value:6.07E-5 ID:SGTC_1064|Compound:honokiol|FD-Score:3.01|P-value:1.87E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:2.74|P-value:6.09E-4 ID:SGTC_1153|Compound:4055-0057|FD-Score:-2.91|P-value:4.13E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:3.77|P-value:4.47E-6 ID:SGTC_1237|Compound:0330-0133|FD-Score:-3.08|P-value:1.97E-4 ID:SGTC_1395|Compound:3486-0190|FD-Score:2.91|P-value:2.93E-4 ID:SGTC_1420|Compound:4'-methoxyflavone|FD-Score:3.20|P-value:8.02E-5 ID:SGTC_1520|Compound:flindersine|FD-Score:5.06|P-value:1.44E-9 ID:SGTC_1685|Compound:st024049|FD-Score:3.53|P-value:1.62E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.20|P-value:1.16E-4 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:2.96|P-value:2.38E-4 ID:SGTC_2238|Compound:6671620|FD-Score:-3.62|P-value:1.54E-5 ID:SGTC_2243|Compound:6634756|FD-Score:-3.73|P-value:8.25E-6 ID:SGTC_2279|Compound:7948423|FD-Score:3.36|P-value:3.74E-5 ID:SGTC_2458|Compound:5808907|FD-Score:3.33|P-value:4.33E-5 ID:SGTC_2793|Compound:7325131|FD-Score:2.78|P-value:5.01E-4 ID:SGTC_2796|Compound:7949634|FD-Score:-2.98|P-value:3.00E-4 ID:SGTC_2931|Compound:9014674|FD-Score:-3.13|P-value:1.59E-4 ID:SGTC_2985|Compound:9022375|FD-Score:3.43|P-value:2.61E-5 ID:SGTC_3160|Compound:9100216|FD-Score:2.99|P-value:2.07E-4 ID:SGTC_3212|Compound:9128307|FD-Score:2.82|P-value:4.31E-4 ID:SGTC_3293|Compound:9120939|FD-Score:2.63|P-value:9.23E-4

Top fitness defect scores for YJL157C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_716 1683-5115 5.84 658.0 µM 3.71E-12 3 2.65E-9
2 SGTC_1520 flindersine 5.06 88.0 µM 1.44E-9 13 2.14E-7
3 SGTC_1179 1021-1431 3.77 9.3 µM 4.47E-6 48 8.11E-5
4 SGTC_1685 st024049 3.53 53.1 µM 1.62E-5 TSC3-RPN4 22 2.10E-4
5 SGTC_2985 9022375 3.43 71.4 µM 2.61E-5 RPP1 & pyrimidine depletion 49 3.00E-4
6 SGTC_2279 7948423 3.36 32.9 µM 3.74E-5 25 3.92E-4
7 SGTC_2458 5808907 3.33 16.4 µM 4.33E-5 12 4.36E-4
8 SGTC_421 streptovitacin 3.32 30.0 mM 4.54E-5 50 4.52E-4
9 SGTC_1055 3448-0672 3.26 86.0 µM 6.07E-5 70 5.61E-4
10 SGTC_1420 4'-methoxyflavone 3.20 42.0 µM 8.02E-5 32 6.89E-4
11 SGTC_435 c-PAF 3.13 6.7 µM 1.09E-4 91 8.66E-4
12 SGTC_567 1080-0542 3.07 68.4 µM 1.43E-4 38 0.00106
13 SGTC_1064 honokiol 3.01 6.8 µM 1.87E-4 63 0.00129
14 SGTC_3160 9100216 2.99 49.5 µM 2.07E-4 23 0.00139
15 SGTC_2039 Aminomethylbenzodioxan 2.96 200.0 µM 2.38E-4 30 0.00155
16 SGTC_1395 3486-0190 2.91 4.3 µM 2.93E-4 64 0.00180
17 SGTC_3212 9128307 2.82 49.5 µM 4.31E-4 109 0.00240
18 SGTC_2793 7325131 2.78 81.8 µM 5.01E-4 67 0.00269
19 SGTC_1124 fisetin 2.74 1.2 µM 6.09E-4 106 0.00311
20 SGTC_3293 9120939 2.63 62.0 µM 9.23E-4 88 0.00424

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.190 1.10E-28 YDR134C YDR134C hom Hypothetical protein; YDR134C has a paralog, CCW12, that arose from the whole genome duplication
0.142 1.08E-16 YMR147W_p YMR147W_p hom Putative protein of unknown function
0.138 9.09E-16 YGR182C_d YGR182C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF TIM13/YGR181W
0.122 1.32E-12 YHR131C_p YHR131C_p hom Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; overexpression causes cell cycle delay or arrest; contains a PH domain and binds phosphatidylinositols and other lipids in a large-scale study
0.114 3.70E-11 YMR244C-A COA6 hom Protein involved in cytochrome c oxidase assembly; also required for efficient formation of respiratory supercomplexes comprised of Complexes III and IV; localizes to the mitochondrial intermembrane space; has a human homolog; transcription is induced in response to the DNA-damaging agent MMS; protein abundance increases in response to DNA replication stress
0.109 2.87E-10 YJR106W ECM27 hom Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants are hypersensitive to Papulacandin B; null mutants have increased plasmid loss; displays a two-hybrid interaction with Pdr5p
0.103 2.60E-9 YMR094W CTF13 het Subunit of the CBF3 complex, which binds to the CDE III element of centromeres, bending the DNA upon binding, and may be involved in sister chromatid cohesion during mitosis
0.102 2.89E-9 YDR273W DON1 hom Meiosis-specific component of the spindle pole body, part of the leading edge protein (LEP) coat, forms a ring-like structure at the leading edge of the prospore membrane during meiosis II
0.102 2.94E-9 YOR238W_p YOR238W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.102 3.56E-9 YBR225W_p YBR225W_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants affected in mannosylphophorylation of cell wall components
0.100 5.78E-9 YGL235W_p YGL235W_p hom Putative protein of unknown function; potential Cdc28p substrate; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
0.095 4.03E-8 YHR073W OSH3 hom Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
0.095 4.14E-8 YBR031W RPL4A hom Ribosomal 60S subunit protein L4A; N-terminally acetylated; homologous to mammalian ribosomal protein L4 and bacterial L4; RPL4A has a paralog, RPL4B, that arose from the whole genome duplication
0.094 4.53E-8 YML059C NTE1 hom Serine esterase, homolog of human neuropathy target esterase (NTE); Nte1p-mediated phosphatidylcholine turnover influences transcription factor Opi1p localization, affecting transcriptional regulation of phospholipid biosynthesis genes
0.092 9.74E-8 YDR210W_p YDR210W_p hom Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery