HIPHOP chemogenomics database

YJL168C / SET2

Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36, which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p

Zygosity: Homozygous strain

fixedexpanded
Profile for YJL168C / SET2

Click on Significant Values for Screen Details

Top fitness defect scores for YJL168C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_64	000l-0018	14.50	272.1 µM	2.37E-49	ubiquinone biosynthesis & proteasome	22	5.88E-48
2	SGTC_67	0335-0847	14.20	266.0 µM	3.54E-47	ubiquinone biosynthesis & proteasome	12	7.71E-46
3	SGTC_86	0417-1630	11.90	471.9 µM	8.69E-34	ubiquinone biosynthesis & proteasome	29	8.47E-33
4	SGTC_158	k038-0087	9.12	26.4 µM	8.42E-21	ubiquinone biosynthesis & proteasome	34	3.66E-20
5	SGTC_165	k038-0023	7.51	64.4 µM	9.91E-15	ubiquinone biosynthesis & proteasome	9	2.91E-14
6	SGTC_137	0438-0332	7.47	85.4 µM	1.35E-14	ubiquinone biosynthesis & proteasome	43	3.92E-14
7	SGTC_2582	agaric acid	6.33	100.0 µM	5.49E-11	redox potentiating	146	1.25E-10
8	SGTC_142	0335-0849	6.24	62.7 µM	9.76E-11	ubiquinone biosynthesis & proteasome	55	2.19E-10
9	SGTC_1511	0906-3109	5.91	28.5 µM	8.03E-10	excess fatty acid	12	1.69E-9
10	SGTC_221	trifluoperazine	5.85	10.3 µM	1.17E-9	NEO1-PIK1	126	2.43E-9
11	SGTC_36	0335-0881	5.85	14.2 µM	1.20E-9	ubiquinone biosynthesis & proteasome	67	2.50E-9
12	SGTC_216	k038-0035	5.63	28.4 µM	4.59E-9	ubiquinone biosynthesis & proteasome	27	9.17E-9
13	SGTC_200	k038-0079	5.55	37.5 µM	7.41E-9	ubiquinone biosynthesis & proteasome	32	1.46E-8
14	SGTC_1844	rapamycin	5.28	4.0 nM	3.42E-8		106	6.42E-8
15	SGTC_794	k038-0031	5.28	316.0 µM	3.46E-8	ubiquinone biosynthesis & proteasome	74	6.50E-8
16	SGTC_994	3910-0338	5.03	138.0 µM	1.39E-7	calcium & mitochondrial duress	22	2.50E-7
17	SGTC_934	2950-0684	4.95	338.0 µM	2.05E-7		8	3.63E-7
18	SGTC_1754	st042065	4.88	16.1 µM	3.02E-7	NEO1-PIK1	134	5.30E-7
19	SGTC_3152	9099253	4.70	49.5 µM	7.47E-7	NEO1-PIK1	89	1.27E-6
20	SGTC_1529	apigenin	4.58	74.0 µM	1.36E-6		18	2.28E-6

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.581	4.03E-302	YOR254C	SEC63	het	Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.570	5.45E-288	YMR110C	HFD1	hom	Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.544	3.98E-258	YJL169W_d	YJL169W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL168C/SET2
0.523	4.48E-235	YNR042W_d	YNR042W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.515	1.49E-226	YBR003W	COQ1	hom	Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis
0.508	5.27E-220	YPR146C_d	YPR146C_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.490	2.77E-202	YML034C-A_d	YML034C-A_d	hom	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.486	1.54E-198	YLR201C	COQ9	hom	Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.472	4.49E-186	YDR204W	COQ4	hom	Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex
0.460	2.02E-175	YNR041C	COQ2	hom	Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis
0.455	4.94E-171	YGL119W	COQ8	hom	Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.455	6.40E-171	YDL183C	YDL183C	hom	Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene
0.452	1.75E-168	YPR064W_d	YPR064W_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.451	1.14E-167	YPR024W	YME1	hom	Catalytic subunit of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; also has a role in intermembrane space protein folding; mutation causes an elevated rate of mitochondrial turnover
0.451	1.15E-167	YJL155C	FBP26	hom	Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress