HIPHOP chemogenomics database

YJL179W / PFD1

Subunit of heterohexameric prefoldin, which binds cytosolic chaperonin and transfers target proteins to it; involved in the biogenesis of actin and of alpha- and gamma-tubulin

Zygosity: Homozygous strain

fixedexpanded
Profile for YJL179W / PFD1

Click on Significant Values for Screen Details

Top fitness defect scores for YJL179W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_1643	st009866	14.30	20.2 µM	1.69E-44		4	8.62E-47
2	SGTC_2688	kanamycin b	7.27	96.7 µM	7.18E-13	calcium & mitochondrial duress	95	1.78E-13
3	SGTC_2582	agaric acid	7.02	100.0 µM	4.21E-12	redox potentiating	127	1.15E-12
4	SGTC_1803	st050068	6.81	52.4 µM	1.72E-11	NEO1-PIK1	58	5.04E-12
5	SGTC_212	3807-4682	6.78	38.8 µM	2.06E-11	tubulin folding & SWR complex	20	6.11E-12
6	SGTC_2527	2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone	5.72	63.6 µM	1.28E-8		17	5.31E-9
7	SGTC_163	1327-0036	5.46	7.5 µM	5.18E-8		57	2.32E-8
8	SGTC_1875	nocodazole	5.14	6.0 µM	2.79E-7	tubulin folding & SWR complex	36	1.36E-7
9	SGTC_210	3551-0445	4.86	56.8 µM	1.10E-6		39	5.80E-7
10	SGTC_138	0850-0259	4.83	40.9 µM	1.28E-6	cell wall	153	6.80E-7
11	SGTC_58	0957-0393	4.81	9.0 µM	1.44E-6	cell wall	305	7.68E-7
12	SGTC_2530	3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene	4.61	92.6 µM	3.57E-6		16	2.00E-6
13	SGTC_129	0088-0017	4.31	176.6 µM	1.38E-5		62	8.29E-6
14	SGTC_422	cantharidin	4.29	155.0 µM	1.49E-5	cell wall signaling	47	8.97E-6
15	SGTC_980	1473-0395	4.27	201.0 µM	1.62E-5		8	9.80E-6
16	SGTC_1597	7-benzyloxygramine	4.24	47.5 µM	1.82E-5	calcium & mitochondrial duress	103	1.10E-5
17	SGTC_849	0386-0493	4.17	241.0 µM	2.47E-5		15	1.53E-5
18	SGTC_146	3448-8650	4.12	53.1 µM	2.99E-5	NEO1-PIK1	128	1.86E-5
19	SGTC_2971	9092186	4.12	9.9 µM	3.01E-5	ergosterol biosynthesis	26	1.88E-5
20	SGTC_535	2293-4129	4.01	48.2 µM	4.75E-5	NEO1	58	3.04E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.306	1.85E-73	YLR200W	YKE2	hom	Subunit of the heterohexameric Gim/prefoldin protein complex involved in the folding of alpha-tubulin, beta-tubulin, and actin
0.285	1.17E-63	YML094C-A_d	YML094C-A_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene GIM5/YML094W; deletion confers sensitivity to GSAO
0.237	6.82E-44	YGR078C	PAC10	hom	Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding
0.233	1.25E-42	YDR334W	SWR1	hom	Swi2/Snf2-related ATPase that is the structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
0.225	9.96E-40	YML103C	NUP188	hom	Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.223	6.14E-39	YML121W	GTR1	hom	Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB
0.221	2.24E-38	YNL246W	VPS75	hom	NAP family histone chaperone; binds to histones and Rtt109p, stimulating histone acetyltransferase activity; possesses nucleosome assembly activity in vitro; proposed role in vacuolar protein sorting and in double-strand break repair; protein abundance increases in response to DNA replication stress
0.215	1.70E-36	YBR231C	SWC5	hom	Component of the SWR1 complex; complex exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; protein abundance increases in response to DNA replication stress
0.203	1.70E-32	YKL176C	LST4	hom	Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface
0.199	2.03E-31	YER007W	PAC2	hom	Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl
0.193	1.82E-29	YAL011W	SWC3	hom	Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae
0.192	2.42E-29	YGL043W	DST1	hom	General transcription elongation factor TFIIS, enables RNA polymerase II to read through blocks to elongation by stimulating cleavage of nascent transcripts stalled at transcription arrest sites; maintains RNAPII elongation activity on ribosomal protein genes during conditions of transcriptional stress
0.191	9.91E-29	YML041C	VPS71	hom	Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting
0.190	1.61E-28	YDR335W	MSN5	hom	Karyopherin involved in nuclear import and export of proteins, including import of replication protein A and export of Swi6p, Far1p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm
0.189	2.83E-28	YPL241C	CIN2	hom	GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; deletion complemented by human GAP, retinitis pigmentosa 2