HIPHOP chemogenomics database

YJL182C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YJL181W

Zygosity: Homozygous strain

fixedexpanded
Profile for YJL182C / YJL182C

Click on Significant Values for Screen Details

Top fitness defect scores for YJL182C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_1798	st045719	8.10	61.0 µM	1.04E-16		1	2.66E-16
2	SGTC_1790	st045711	5.77	43.5 µM	2.50E-9		2	4.00E-9
3	SGTC_869	0564-0080	5.12	44.1 µM	1.05E-7		7	1.51E-7
4	SGTC_2565	isoliquiritigenin	4.83	100.0 µM	4.87E-7		20	6.73E-7
5	SGTC_2944	9067346	4.59	25.6 µM	1.64E-6		13	2.20E-6
6	SGTC_3106	9121286	4.58	49.5 µM	1.72E-6		6	2.30E-6
7	SGTC_1764	st044502	4.55	93.5 µM	2.06E-6		21	2.73E-6
8	SGTC_3222	9128301	4.47	49.5 µM	2.99E-6	60S ribosome export	14	3.94E-6
9	SGTC_1010	4112-3296	4.23	15.2 µM	9.04E-6		13	1.16E-5
10	SGTC_2888	9058547	4.22	13.0 µM	9.52E-6		4	1.22E-5
11	SGTC_3281	9140613	4.05	49.5 µM	2.06E-5	RPP1 & pyrimidine depletion	19	2.57E-5
12	SGTC_3204	9114183	4.03	49.5 µM	2.26E-5		30	2.82E-5
13	SGTC_1721	st082152	3.92	9.3 µM	3.54E-5	60S ribosome export	20	4.36E-5
14	SGTC_1106	tegaserod maleate	3.89	11.7 µM	4.04E-5		18	4.97E-5
15	SGTC_1528	arabinosylhypoxanthine	3.85	74.6 µM	4.86E-5		26	5.94E-5
16	SGTC_1778	st046819	3.85	58.9 µM	4.93E-5		28	6.03E-5
17	SGTC_871	0574-0004	3.81	149.0 µM	5.68E-5		52	6.91E-5
18	SGTC_1519	esterone	3.78	74.0 µM	6.35E-5	DNA intercalators	19	7.72E-5
19	SGTC_1523	st012844	3.77	44.7 µM	6.67E-5	60S ribosome export	27	8.09E-5
20	SGTC_943	3253-1379	3.72	105.0 µM	8.16E-5		31	9.85E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.105	1.08E-9	YKL101W	HSL1	hom	Nim1p-related protein kinase that regulates the morphogenesis and septin checkpoints; associates with the assembled septin filament; required along with Hsl7p for bud neck recruitment, phosphorylation, and degradation of Swe1p
0.103	2.29E-9	YBL098W	BNA4	hom	Kynurenine 3-mono oxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p; putative therapeutic target for Huntington disease
0.082	1.72E-6	YLR361C	DCR2	hom	Phosphoesterase involved in downregulation of the unfolded protein response, at least in part via dephosphorylation of Ire1p; dosage-dependent positive regulator of the G1/S phase transition through control of the timing of START
0.082	2.08E-6	YDL161W	ENT1	hom	Epsin-like protein involved in endocytosis and actin patch assembly; functionally redundant with Ent2p; binds clathrin via a clathrin-binding domain motif at C-terminus; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.082	2.28E-6	YBL106C	SRO77	hom	Protein with roles in exocytosis and cation homeostasis; functions in docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Drosophila lethal giant larvae tumor suppressor; interacts with SNARE protein Sec9p; SRO77 has a paralog, SRO7, that arose from the whole genome duplication
0.074	1.58E-5	YGR001C_p	YGR001C_p	hom	Putative protein of unknown function with similarity to methyltransferase family members; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; required for replication of Brome mosaic virus in S. cerevisiae
0.074	1.60E-5	YNL010W_p	YNL010W_p	hom	Putative protein of unknown function with similarity to phosphoserine phosphatases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; homozygous diploid mutant shows an increase in glycogen accumulation
0.073	2.37E-5	YOR149C	SMP3	het	Alpha 1,2-mannosyltransferase involved in glycosyl phosphatidyl inositol (GPI) biosynthesis; required for addition of the fourth, side branching mannose to the GPI core structure
0.067	9.27E-5	YPL037C	EGD1	hom	Subunit beta1 of the nascent polypeptide-associated complex (NAC) involved in protein targeting, associated with cytoplasmic ribosomes; enhances DNA binding of the Gal4p activator; homolog of human BTF3b
0.066	1.16E-4	YIL092W_p	YIL092W_p	hom	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus
0.065	1.50E-4	YPR052C	NHP6A	hom	High-mobility group (HMG) protein, binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to chromosomes; functionally redundant with Nhp6Bp; homologous to mammalian HMGB1 and HMGB2; NHP6A has a paralog, NHP6B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.064	1.90E-4	YGL099W	LSG1	het	Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm
0.064	2.17E-4	YML023C	NSE5	het	Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair
0.064	2.25E-4	YBR046C	ZTA1	hom	NADPH-dependent quinone reductase, GFP-tagged protein localizes to the cytoplasm and nucleus; has similarity to E. coli quinone oxidoreductase and to human zeta-crystallin
0.063	2.48E-4	YGR210C_p	YGR210C_p	hom	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm