HIPHOP chemogenomics database
YJL200C / ACO2 
Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol
Zygosity: Homozygous strain
fixedexpanded
  Click on Significant Values for Screen Details |
Top fitness defect scores for YJL200C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.155 | 1.63E-19 | YLR097C | HRT3 | hom | Putative SCF-ubiquitin ligase F-box protein, based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies |
| 0.114 | 3.06E-11 | YPL096W | PNG1 | hom | Conserved peptide N-glycanase required for deglycosylation of misfolded glycoproteins during proteasome-dependent degradation; localizes to the cytoplasm and nucleus; activity is enhanced by interaction with Rad23p |
| 0.110 | 1.69E-10 | YJR080C | AIM24 | hom | Protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays reduced respiratory growth and elevated frequency of mitochondrial genome loss |
| 0.108 | 3.79E-10 | YHR131C_p | YHR131C_p | hom | Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; overexpression causes cell cycle delay or arrest; contains a PH domain and binds phosphatidylinositols and other lipids in a large-scale study |
| 0.107 | 4.71E-10 | YBR052C | RFS1 | hom | Protein of unknown function; member of a flavodoxin-like fold protein family that includes Pst2p and Ycp4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; RFS1 has a paralog, PST2, that arose from the whole genome duplication |
| 0.106 | 8.44E-10 | YKR015C_p | YKR015C_p | hom | Putative protein of unknown function |
| 0.104 | 1.37E-9 | YNL038W | GPI15 | het | Protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-H protein |
| 0.103 | 2.18E-9 | YPR195C_d | YPR195C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
| 0.103 | 2.52E-9 | YJR058C | APS2 | hom | Small subunit of the clathrin-associated adaptor complex AP-2, which is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex |
| 0.099 | 8.49E-9 | YDR020C_p | DAS2_p | hom | Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; weak similarity with uridine kinases and with phosphoribokinases |
| 0.095 | 3.47E-8 | YMR253C_p | YMR253C_p | hom | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YMR253C is not an essential gene |
| 0.093 | 6.88E-8 | YML104C | MDM1 | hom | Intermediate filament protein, required for nuclear and mitochondrial transmission to daughter buds; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P) |
| 0.092 | 8.63E-8 | YPL027W | SMA1 | hom | Protein of unknown function involved in the assembly of the prospore membrane during sporulation; interacts with Spo14p |
| 0.092 | 1.02E-7 | YLL020C_d | YLL020C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene KNS1 |
| 0.091 | 1.40E-7 | YBL081W_p | YBL081W_p | hom | Non-essential protein of unknown function; null mutation results in a decrease in plasma membrane electron transport |