YJL205C / NCE101

Protein of unknown function, involved in secretion of proteins that lack classical secretory signal sequences

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL205C / NCE101

Click on Significant Values for Screen Details ID:SGTC_23|Compound:0213-0011|FD-Score:-3.17|P-value:7.38E-4 ID:SGTC_237|Compound:nikkomycin|FD-Score:3.45|P-value:1.71E-4 ID:SGTC_282|Compound:k297-0036|FD-Score:-3.40|P-value:3.13E-4 ID:SGTC_406|Compound:estrone|FD-Score:-3.18|P-value:7.11E-4 ID:SGTC_501|Compound:nsc-95397|FD-Score:3.83|P-value:3.64E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:-3.10|P-value:9.45E-4 ID:SGTC_584|Compound:0986-0246|FD-Score:3.08|P-value:6.72E-4 ID:SGTC_656|Compound:4090-1979|FD-Score:2.97|P-value:9.94E-4 ID:SGTC_713|Compound:1488-1073|FD-Score:-3.21|P-value:6.34E-4 ID:SGTC_729|Compound:4092-0585|FD-Score:-3.78|P-value:7.10E-5 ID:SGTC_731|Compound:3966-0296|FD-Score:3.14|P-value:5.51E-4 ID:SGTC_898|Compound:1000-0849|FD-Score:-3.74|P-value:8.39E-5 ID:SGTC_906|Compound:1165-0455|FD-Score:3.96|P-value:2.00E-5 ID:SGTC_1145|Compound:3546-0597|FD-Score:4.91|P-value:1.89E-7 ID:SGTC_1156|Compound:4092-0367|FD-Score:3.33|P-value:2.72E-4 ID:SGTC_1164|Compound:k060-0068|FD-Score:3.70|P-value:6.14E-5 ID:SGTC_1225|Compound:1216-0074|FD-Score:-3.18|P-value:6.96E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:4.34|P-value:3.48E-6 ID:SGTC_1288|Compound:0973-0013|FD-Score:-3.15|P-value:7.79E-4 ID:SGTC_1621|Compound:st003705|FD-Score:-3.22|P-value:6.22E-4 ID:SGTC_1764|Compound:st044502|FD-Score:4.30|P-value:4.27E-6 ID:SGTC_1797|Compound:st048695|FD-Score:-3.62|P-value:1.33E-4 ID:SGTC_1820|Compound:st053765|FD-Score:3.11|P-value:6.17E-4 ID:SGTC_1887|Compound:st057648|FD-Score:4.02|P-value:1.52E-5 ID:SGTC_1889|Compound:st059080|FD-Score:-3.36|P-value:3.72E-4 ID:SGTC_1908|Compound:st060353|FD-Score:-3.59|P-value:1.55E-4 ID:SGTC_2260|Compound:7964312|FD-Score:-3.16|P-value:7.57E-4 ID:SGTC_2388|Compound:9080168|FD-Score:3.44|P-value:1.80E-4 ID:SGTC_2411|Compound:st077133|FD-Score:3.47|P-value:1.58E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:-3.12|P-value:8.74E-4 ID:SGTC_2526|Compound:patulin|FD-Score:-3.59|P-value:1.54E-4 ID:SGTC_2703|Compound:st077852|FD-Score:2.97|P-value:9.86E-4 ID:SGTC_2795|Compound:7780010|FD-Score:3.02|P-value:8.49E-4 ID:SGTC_3075|Compound:9116269|FD-Score:3.47|P-value:1.56E-4 ID:SGTC_3151|Compound:9099821|FD-Score:3.16|P-value:5.03E-4 ID:SGTC_3181|Compound:9108277|FD-Score:3.62|P-value:8.66E-5 ID:SGTC_3185|Compound:9108267|FD-Score:4.48|P-value:1.75E-6 ID:SGTC_3207|Compound:9114163|FD-Score:3.25|P-value:3.62E-4 ID:SGTC_3208|Compound:9114115|FD-Score:3.60|P-value:9.25E-5 ID:SGTC_3300|Compound:9124615|FD-Score:-3.94|P-value:3.63E-5 ID:SGTC_3349|Compound:9149703|FD-Score:3.09|P-value:6.58E-4 ID:SGTC_3351|Compound:9150312|FD-Score:3.30|P-value:2.97E-4 ID:SGTC_23|Compound:0213-0011|FD-Score:-3.17|P-value:7.38E-4 ID:SGTC_237|Compound:nikkomycin|FD-Score:3.45|P-value:1.71E-4 ID:SGTC_282|Compound:k297-0036|FD-Score:-3.40|P-value:3.13E-4 ID:SGTC_406|Compound:estrone|FD-Score:-3.18|P-value:7.11E-4 ID:SGTC_501|Compound:nsc-95397|FD-Score:3.83|P-value:3.64E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:-3.10|P-value:9.45E-4 ID:SGTC_584|Compound:0986-0246|FD-Score:3.08|P-value:6.72E-4 ID:SGTC_656|Compound:4090-1979|FD-Score:2.97|P-value:9.94E-4 ID:SGTC_713|Compound:1488-1073|FD-Score:-3.21|P-value:6.34E-4 ID:SGTC_729|Compound:4092-0585|FD-Score:-3.78|P-value:7.10E-5 ID:SGTC_731|Compound:3966-0296|FD-Score:3.14|P-value:5.51E-4 ID:SGTC_898|Compound:1000-0849|FD-Score:-3.74|P-value:8.39E-5 ID:SGTC_906|Compound:1165-0455|FD-Score:3.96|P-value:2.00E-5 ID:SGTC_1145|Compound:3546-0597|FD-Score:4.91|P-value:1.89E-7 ID:SGTC_1156|Compound:4092-0367|FD-Score:3.33|P-value:2.72E-4 ID:SGTC_1164|Compound:k060-0068|FD-Score:3.70|P-value:6.14E-5 ID:SGTC_1225|Compound:1216-0074|FD-Score:-3.18|P-value:6.96E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:4.34|P-value:3.48E-6 ID:SGTC_1288|Compound:0973-0013|FD-Score:-3.15|P-value:7.79E-4 ID:SGTC_1621|Compound:st003705|FD-Score:-3.22|P-value:6.22E-4 ID:SGTC_1764|Compound:st044502|FD-Score:4.30|P-value:4.27E-6 ID:SGTC_1797|Compound:st048695|FD-Score:-3.62|P-value:1.33E-4 ID:SGTC_1820|Compound:st053765|FD-Score:3.11|P-value:6.17E-4 ID:SGTC_1887|Compound:st057648|FD-Score:4.02|P-value:1.52E-5 ID:SGTC_1889|Compound:st059080|FD-Score:-3.36|P-value:3.72E-4 ID:SGTC_1908|Compound:st060353|FD-Score:-3.59|P-value:1.55E-4 ID:SGTC_2260|Compound:7964312|FD-Score:-3.16|P-value:7.57E-4 ID:SGTC_2388|Compound:9080168|FD-Score:3.44|P-value:1.80E-4 ID:SGTC_2411|Compound:st077133|FD-Score:3.47|P-value:1.58E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:-3.12|P-value:8.74E-4 ID:SGTC_2526|Compound:patulin|FD-Score:-3.59|P-value:1.54E-4 ID:SGTC_2703|Compound:st077852|FD-Score:2.97|P-value:9.86E-4 ID:SGTC_2795|Compound:7780010|FD-Score:3.02|P-value:8.49E-4 ID:SGTC_3075|Compound:9116269|FD-Score:3.47|P-value:1.56E-4 ID:SGTC_3151|Compound:9099821|FD-Score:3.16|P-value:5.03E-4 ID:SGTC_3181|Compound:9108277|FD-Score:3.62|P-value:8.66E-5 ID:SGTC_3185|Compound:9108267|FD-Score:4.48|P-value:1.75E-6 ID:SGTC_3207|Compound:9114163|FD-Score:3.25|P-value:3.62E-4 ID:SGTC_3208|Compound:9114115|FD-Score:3.60|P-value:9.25E-5 ID:SGTC_3300|Compound:9124615|FD-Score:-3.94|P-value:3.63E-5 ID:SGTC_3349|Compound:9149703|FD-Score:3.09|P-value:6.58E-4 ID:SGTC_3351|Compound:9150312|FD-Score:3.30|P-value:2.97E-4

Top fitness defect scores for YJL205C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1145 3546-0597 4.91 10.2 µM 1.89E-7 mitochondrial processes 8 4.45E-7
2 SGTC_3185 9108267 4.48 49.5 µM 1.75E-6 60S ribosome export 8 3.68E-6
3 SGTC_1252 0493-0875 4.34 34.8 µM 3.48E-6 21 7.04E-6
4 SGTC_1764 st044502 4.30 93.5 µM 4.27E-6 25 8.55E-6
5 SGTC_1887 st057648 4.02 70.8 µM 1.52E-5 13 2.85E-5
6 SGTC_906 1165-0455 3.96 526.0 µM 2.00E-5 11 3.70E-5
7 SGTC_501 nsc-95397 3.83 161.0 µM 3.64E-5 16 6.52E-5
8 SGTC_1164 k060-0068 3.70 93.7 µM 6.14E-5 37 1.07E-4
9 SGTC_3181 9108277 3.62 49.5 µM 8.66E-5 iron homeostasis 25 1.48E-4
10 SGTC_3208 9114115 3.60 49.5 µM 9.25E-5 53 1.58E-4
11 SGTC_3075 9116269 3.47 49.5 µM 1.56E-4 34 2.59E-4
12 SGTC_2411 st077133 3.47 39.9 µM 1.58E-4 RNA pol III & RNase P/MRP 49 2.62E-4
13 SGTC_237 nikkomycin 3.45 200.0 µM 1.71E-4 RSC complex & mRNA processing 28 2.82E-4
14 SGTC_2388 9080168 3.44 200.0 µM 1.80E-4 12 2.96E-4
15 SGTC_1156 4092-0367 3.33 4.9 µM 2.72E-4 47 4.37E-4
16 SGTC_3351 9150312 3.30 21.6 µM 2.97E-4 cell wall 56 4.75E-4
17 SGTC_3207 9114163 3.25 49.5 µM 3.62E-4 63 5.73E-4
18 SGTC_3151 9099821 3.16 49.5 µM 5.03E-4 47 7.83E-4
19 SGTC_731 3966-0296 3.14 387.0 µM 5.51E-4 45 8.53E-4
20 SGTC_1820 st053765 3.11 18.6 µM 6.17E-4 RPP1 & pyrimidine depletion 55 9.51E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.113 6.47E-11 YPL127C HHO1 hom Histone H1, linker histone with roles in meiosis and sporulation; decreasing levels early in sporulation may promote meiosis, and increasing levels during sporulation facilitate compaction of spore chromatin; binds to promoters and within genes in mature spores; may be recruited by Ume6p to promoter regions, contributing to transcriptional repression outside of meiosis; suppresses DNA repair involving homologous recombination
0.112 6.76E-11 YNL244C SUI1 het Translation initiation factor eIF1; component of a complex involved in recognition of the initiator codon; modulates translation accuracy at the initiation phase
0.090 1.77E-7 YPR201W ARR3 hom Plasma membrane metalloid/H+ antiporter; transports arsenite and antimonite; required for resistance to arsenic compounds; transcription is activated by Arr1p in the presence of arsenite
0.086 5.65E-7 YDR196C CAB5 het Probable dephospho-CoA kinase (DPCK) that catalyzes the last step in coenzyme A biosynthesis; null mutant lethality is complemented by E. coli coaE (encoding DPCK); detected in purified mitochondria in high-throughput studies
0.083 1.55E-6 YML060W OGG1 hom Mitochondrial glycosylase/lyase that specifically excises 7,8-dihydro-8-oxoguanine residues located opposite cytosine or thymine residues in DNA, repairs oxidative damage to mitochondrial DNA, contributes to UVA resistance
0.081 2.83E-6 YNL221C POP1 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P
0.076 1.15E-5 YPL205C_d YPL205C_d hom Hypothetical protein; deletion of locus affects telomere length
0.073 2.18E-5 YLR264C-A_p YLR264C-A_p hom Putative protein of unknown function
0.072 2.66E-5 YMR279C YMR279C hom Putative boron transporter involved in boron efflux and resistance; overexpression mutant but not null mutant displays boron tolerance phenotype; identified as a heat-induced gene in a high-throughout screen; YMR279C is not an essential gene; YMR279C has a paralog, ATR1, that arose from the whole genome duplication
0.072 2.88E-5 YFL017W-A SMX2 het Core Sm protein Sm G; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx3p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm G
0.070 4.64E-5 YPL037C EGD1 hom Subunit beta1 of the nascent polypeptide-associated complex (NAC) involved in protein targeting, associated with cytoplasmic ribosomes; enhances DNA binding of the Gal4p activator; homolog of human BTF3b
0.070 5.33E-5 YNL316C PHA2 hom Prephenate dehydratase, catalyzes the conversion of prephanate to phenylpyruvate, which is a step in the phenylalanine biosynthesis pathway
0.067 1.04E-4 YOR260W GCD1 het Gamma subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
0.067 1.13E-4 YIL108W YIL108W hom Putative metalloendopeptidase; forms cytoplasmic foci upon DNA replication stress
0.066 1.25E-4 YDR218C SPR28 hom Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; meiotic septin expressed at high levels during meiotic divisions and ascospore formation