YJL211C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL210W/PEX2

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL211C / YJL211C

Click on Significant Values for Screen Details ID:SGTC_61|Compound:0978-8327|FD-Score:-3.17|P-value:6.70E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:3.62|P-value:1.27E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-4.03|P-value:2.25E-5 ID:SGTC_573|Compound:3702-0553|FD-Score:3.30|P-value:4.26E-4 ID:SGTC_646|Compound:4092-0839|FD-Score:3.64|P-value:1.18E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:4.20|P-value:1.09E-5 ID:SGTC_955|Compound:1216-0110|FD-Score:-3.64|P-value:1.14E-4 ID:SGTC_968|Compound:1309-0633|FD-Score:-3.90|P-value:3.94E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:-4.10|P-value:1.68E-5 ID:SGTC_1195|Compound:1502-0147|FD-Score:4.34|P-value:5.84E-6 ID:SGTC_1416|Compound:3966-0321|FD-Score:3.58|P-value:1.49E-4 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:-3.12|P-value:7.88E-4 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:3.19|P-value:6.37E-4 ID:SGTC_1610|Compound:st001799|FD-Score:-3.41|P-value:2.74E-4 ID:SGTC_1668|Compound:st014914|FD-Score:-3.12|P-value:7.99E-4 ID:SGTC_1728|Compound:st035614|FD-Score:3.84|P-value:5.41E-5 ID:SGTC_1729|Compound:st035615|FD-Score:5.14|P-value:1.05E-7 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.29|P-value:4.44E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:4.40|P-value:4.46E-6 ID:SGTC_1905|Compound:st060207|FD-Score:3.83|P-value:5.54E-5 ID:SGTC_1919|Compound:st067113|FD-Score:3.51|P-value:1.97E-4 ID:SGTC_1922|Compound:5578187|FD-Score:3.10|P-value:8.83E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-7.52|P-value:1.44E-14 ID:SGTC_1936|Compound:st074407|FD-Score:3.33|P-value:3.86E-4 ID:SGTC_1955|Compound:wogonin|FD-Score:3.49|P-value:2.12E-4 ID:SGTC_1975|Compound:st070967|FD-Score:3.85|P-value:5.01E-5 ID:SGTC_2084|Compound:5306078|FD-Score:-3.76|P-value:6.95E-5 ID:SGTC_2095|Compound:5432005|FD-Score:3.12|P-value:8.14E-4 ID:SGTC_2699|Compound:st077704|FD-Score:3.85|P-value:5.19E-5 ID:SGTC_2711|Compound:st079103|FD-Score:-3.09|P-value:8.66E-4 ID:SGTC_2812|Compound:7970281|FD-Score:-3.76|P-value:6.97E-5 ID:SGTC_2966|Compound:9084041|FD-Score:3.54|P-value:1.75E-4 ID:SGTC_3134|Compound:9127454|FD-Score:3.11|P-value:8.52E-4 ID:SGTC_3135|Compound:9127742|FD-Score:3.34|P-value:3.80E-4 ID:SGTC_3327|Compound:9140648|FD-Score:-3.75|P-value:7.24E-5 ID:SGTC_61|Compound:0978-8327|FD-Score:-3.17|P-value:6.70E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:3.62|P-value:1.27E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-4.03|P-value:2.25E-5 ID:SGTC_573|Compound:3702-0553|FD-Score:3.30|P-value:4.26E-4 ID:SGTC_646|Compound:4092-0839|FD-Score:3.64|P-value:1.18E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:4.20|P-value:1.09E-5 ID:SGTC_955|Compound:1216-0110|FD-Score:-3.64|P-value:1.14E-4 ID:SGTC_968|Compound:1309-0633|FD-Score:-3.90|P-value:3.94E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:-4.10|P-value:1.68E-5 ID:SGTC_1195|Compound:1502-0147|FD-Score:4.34|P-value:5.84E-6 ID:SGTC_1416|Compound:3966-0321|FD-Score:3.58|P-value:1.49E-4 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:-3.12|P-value:7.88E-4 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:3.19|P-value:6.37E-4 ID:SGTC_1610|Compound:st001799|FD-Score:-3.41|P-value:2.74E-4 ID:SGTC_1668|Compound:st014914|FD-Score:-3.12|P-value:7.99E-4 ID:SGTC_1728|Compound:st035614|FD-Score:3.84|P-value:5.41E-5 ID:SGTC_1729|Compound:st035615|FD-Score:5.14|P-value:1.05E-7 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.29|P-value:4.44E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:4.40|P-value:4.46E-6 ID:SGTC_1905|Compound:st060207|FD-Score:3.83|P-value:5.54E-5 ID:SGTC_1919|Compound:st067113|FD-Score:3.51|P-value:1.97E-4 ID:SGTC_1922|Compound:5578187|FD-Score:3.10|P-value:8.83E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-7.52|P-value:1.44E-14 ID:SGTC_1936|Compound:st074407|FD-Score:3.33|P-value:3.86E-4 ID:SGTC_1955|Compound:wogonin|FD-Score:3.49|P-value:2.12E-4 ID:SGTC_1975|Compound:st070967|FD-Score:3.85|P-value:5.01E-5 ID:SGTC_2084|Compound:5306078|FD-Score:-3.76|P-value:6.95E-5 ID:SGTC_2095|Compound:5432005|FD-Score:3.12|P-value:8.14E-4 ID:SGTC_2699|Compound:st077704|FD-Score:3.85|P-value:5.19E-5 ID:SGTC_2711|Compound:st079103|FD-Score:-3.09|P-value:8.66E-4 ID:SGTC_2812|Compound:7970281|FD-Score:-3.76|P-value:6.97E-5 ID:SGTC_2966|Compound:9084041|FD-Score:3.54|P-value:1.75E-4 ID:SGTC_3134|Compound:9127454|FD-Score:3.11|P-value:8.52E-4 ID:SGTC_3135|Compound:9127742|FD-Score:3.34|P-value:3.80E-4 ID:SGTC_3327|Compound:9140648|FD-Score:-3.75|P-value:7.24E-5

Top fitness defect scores for YJL211C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1729 st035615 5.14 46.0 µM 1.05E-7 15 1.37E-7
2 SGTC_1883 5-benzylidenerhodanine 4.40 20.0 µM 4.46E-6 TRP & mitochondrial translation 52 5.43E-6
3 SGTC_1195 1502-0147 4.34 41.1 µM 5.84E-6 14 7.07E-6
4 SGTC_690 glyoxal 4.20 20.3 µM 1.09E-5 73 1.31E-5
5 SGTC_1975 st070967 3.85 30.8 µM 5.01E-5 38 5.82E-5
6 SGTC_2699 st077704 3.85 54.6 µM 5.19E-5 endomembrane recycling 54 6.02E-5
7 SGTC_1728 st035614 3.84 33.8 µM 5.41E-5 58 6.28E-5
8 SGTC_1905 st060207 3.83 84.5 µM 5.54E-5 14 6.42E-5
9 SGTC_646 4092-0839 3.64 27.3 µM 1.18E-4 plasma membrane duress 32 1.35E-4
10 SGTC_422 cantharidin 3.62 155.0 µM 1.27E-4 cell wall signaling 71 1.45E-4
11 SGTC_1416 3966-0321 3.58 25.3 µM 1.49E-4 29 1.70E-4
12 SGTC_2966 9084041 3.54 48.0 µM 1.75E-4 47 1.99E-4
13 SGTC_1919 st067113 3.51 52.3 µM 1.97E-4 TSC3-RPN4 45 2.23E-4
14 SGTC_1955 wogonin 3.49 32.4 µM 2.12E-4 26 2.40E-4
15 SGTC_3135 9127742 3.34 49.5 µM 3.80E-4 40 4.25E-4
16 SGTC_1936 st074407 3.33 74.3 µM 3.86E-4 DNA damage response 62 4.32E-4
17 SGTC_573 3702-0553 3.30 84.7 µM 4.26E-4 29 4.75E-4
18 SGTC_1785 bathophenanthroline 3.29 24.0 µM 4.44E-4 heme requiring 83 4.95E-4
19 SGTC_1557 sumaresinolic acid 3.19 42.3 µM 6.37E-4 48 7.05E-4
20 SGTC_2095 5432005 3.12 200.0 µM 8.14E-4 37 8.97E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.139 5.59E-16 YNL097C-B_p YNL097C-B_p hom Putative protein of unknown function
0.127 1.53E-13 YJL068C YJL068C hom Non-essential intracellular esterase that can function as an S-formylglutathione hydrolase; may be involved in the detoxification of formaldehyde, which can be metabolized to S-formylglutathione; similar to human esterase D
0.121 2.46E-12 YGR097W ASK10 hom Component of RNA polymerase II holoenzyme; phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; proposed to function in activation of the glycerol channel Fps1p; ASK10 has a paralog, RGC1, that arose from the whole genome duplication
0.117 1.25E-11 YNR031C SSK2 hom MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; interacts with Ssk1p, leading to autophosphorylation and activation of Ssk2p which phosphorylates Pbs2p; also mediates actin cytoskeleton recovery from osmotic stress
0.116 1.52E-11 YML042W CAT2 hom Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes
0.113 5.14E-11 YKL151C YKL151C hom NADHX dehydratase; converts (S)-NADHX to NADH in an ATP-dependent manner; homologous to Carkd in mammals, and the C-terminal domain of YjeF in E.coli; enzyme is widespread in eukaryotes, prokaryotes and archaea; YKL151C promoter contains STREs (stress response elements) and expression is induced by heat shock or methyl methanesulfonate; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress
0.112 7.00E-11 YIR004W DJP1 hom Cytosolic J-domain-containing protein, required for peroxisomal protein import and involved in peroxisome assembly, homologous to E. coli DnaJ
0.109 2.25E-10 YNL062C GCD10 het Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression
0.109 2.52E-10 YML084W_d YML084W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.109 2.67E-10 YOR364W_d YOR364W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR365C
0.107 5.40E-10 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.106 7.74E-10 YGR190C_d YGR190C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HIP1/YGR191W
0.105 1.23E-9 YGR023W MTL1 hom Putative plasma membrane sensor, involved in cell integrity signaling and stress response during glucose starvation and oxidative stress; has structural and functional similarity to Mid2p
0.104 1.57E-9 YER068C-A_d YER068C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.103 2.02E-9 YLR203C MSS51 hom Specific translational activator for the mitochondrial COX1 mRNA; loosely associated with the matrix face of the mitochondrial inner membrane; influences both COX1 mRNA translation and Cox1p assembly into cytochrome c oxidase; binds to heme B, which may be a mechanism for sensing oxygen levels in order to regulate cytochrome c oxidase biogenesis