YJL212C / OPT1

Proton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT family

Zygosity: Homozygous strain
fixedexpanded
Profile for YJL212C / OPT1

Click on Significant Values for Screen Details ID:SGTC_13|Compound:0199-0087|FD-Score:3.07|P-value:8.88E-4 ID:SGTC_208|Compound:k072-0098|FD-Score:4.98|P-value:2.07E-7 ID:SGTC_577|Compound:r071-0003|FD-Score:-3.08|P-value:8.53E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:3.68|P-value:9.15E-5 ID:SGTC_734|Compound:2023-0417|FD-Score:3.94|P-value:3.02E-5 ID:SGTC_847|Compound:0342-0274|FD-Score:5.30|P-value:3.40E-8 ID:SGTC_1012|Compound:4112-3522|FD-Score:5.45|P-value:1.47E-8 ID:SGTC_1014|Compound:4130-3005|FD-Score:3.80|P-value:5.61E-5 ID:SGTC_1061|Compound:3448-9325|FD-Score:-3.42|P-value:2.47E-4 ID:SGTC_1121|Compound:fusaric acid|FD-Score:4.81|P-value:4.90E-7 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-3.11|P-value:7.76E-4 ID:SGTC_1280|Compound:0880-0253|FD-Score:3.12|P-value:7.46E-4 ID:SGTC_1441|Compound:4106-0040|FD-Score:3.09|P-value:8.43E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:3.62|P-value:1.17E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.44|P-value:2.33E-4 ID:SGTC_1863|Compound:st057641|FD-Score:3.13|P-value:7.19E-4 ID:SGTC_1921|Compound:5740136|FD-Score:3.69|P-value:8.69E-5 ID:SGTC_1930|Compound:st074634|FD-Score:4.52|P-value:2.13E-6 ID:SGTC_1939|Compound:st074455|FD-Score:4.32|P-value:5.47E-6 ID:SGTC_2207|Compound:7258803|FD-Score:3.23|P-value:5.04E-4 ID:SGTC_2301|Compound:7769476|FD-Score:5.40|P-value:2.01E-8 ID:SGTC_2323|Compound:6148992|FD-Score:-3.56|P-value:1.49E-4 ID:SGTC_2384|Compound:9036245|FD-Score:6.67|P-value:5.64E-12 ID:SGTC_2396|Compound:5342950|FD-Score:-4.11|P-value:1.45E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:4.11|P-value:1.43E-5 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:3.62|P-value:1.14E-4 ID:SGTC_2624|Compound:nerol|FD-Score:3.61|P-value:1.18E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:5.53|P-value:9.19E-9 ID:SGTC_2691|Compound:st077356|FD-Score:8.91|P-value:6.26E-20 ID:SGTC_2694|Compound:st077685|FD-Score:3.27|P-value:4.36E-4 ID:SGTC_2713|Compound:st079149|FD-Score:3.47|P-value:2.06E-4 ID:SGTC_2837|Compound:9008476|FD-Score:3.06|P-value:9.39E-4 ID:SGTC_2854|Compound:9024559|FD-Score:5.67|P-value:4.12E-9 ID:SGTC_2884|Compound:9058502|FD-Score:3.69|P-value:8.60E-5 ID:SGTC_2936|Compound:9038235|FD-Score:3.26|P-value:4.53E-4 ID:SGTC_3030|Compound:9087619|FD-Score:3.67|P-value:9.36E-5 ID:SGTC_3056|Compound:9094900|FD-Score:-3.85|P-value:4.50E-5 ID:SGTC_3058|Compound:9093861|FD-Score:-3.26|P-value:4.56E-4 ID:SGTC_3063|Compound:1327-0034|FD-Score:-3.36|P-value:3.11E-4 ID:SGTC_3173|Compound:9105693|FD-Score:4.11|P-value:1.47E-5 ID:SGTC_3222|Compound:9128301|FD-Score:3.12|P-value:7.59E-4 ID:SGTC_3307|Compound:9126885|FD-Score:3.07|P-value:8.84E-4 ID:SGTC_13|Compound:0199-0087|FD-Score:3.07|P-value:8.88E-4 ID:SGTC_208|Compound:k072-0098|FD-Score:4.98|P-value:2.07E-7 ID:SGTC_577|Compound:r071-0003|FD-Score:-3.08|P-value:8.53E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:3.68|P-value:9.15E-5 ID:SGTC_734|Compound:2023-0417|FD-Score:3.94|P-value:3.02E-5 ID:SGTC_847|Compound:0342-0274|FD-Score:5.30|P-value:3.40E-8 ID:SGTC_1012|Compound:4112-3522|FD-Score:5.45|P-value:1.47E-8 ID:SGTC_1014|Compound:4130-3005|FD-Score:3.80|P-value:5.61E-5 ID:SGTC_1061|Compound:3448-9325|FD-Score:-3.42|P-value:2.47E-4 ID:SGTC_1121|Compound:fusaric acid|FD-Score:4.81|P-value:4.90E-7 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-3.11|P-value:7.76E-4 ID:SGTC_1280|Compound:0880-0253|FD-Score:3.12|P-value:7.46E-4 ID:SGTC_1441|Compound:4106-0040|FD-Score:3.09|P-value:8.43E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:3.62|P-value:1.17E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.44|P-value:2.33E-4 ID:SGTC_1863|Compound:st057641|FD-Score:3.13|P-value:7.19E-4 ID:SGTC_1921|Compound:5740136|FD-Score:3.69|P-value:8.69E-5 ID:SGTC_1930|Compound:st074634|FD-Score:4.52|P-value:2.13E-6 ID:SGTC_1939|Compound:st074455|FD-Score:4.32|P-value:5.47E-6 ID:SGTC_2207|Compound:7258803|FD-Score:3.23|P-value:5.04E-4 ID:SGTC_2301|Compound:7769476|FD-Score:5.40|P-value:2.01E-8 ID:SGTC_2323|Compound:6148992|FD-Score:-3.56|P-value:1.49E-4 ID:SGTC_2384|Compound:9036245|FD-Score:6.67|P-value:5.64E-12 ID:SGTC_2396|Compound:5342950|FD-Score:-4.11|P-value:1.45E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:4.11|P-value:1.43E-5 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:3.62|P-value:1.14E-4 ID:SGTC_2624|Compound:nerol|FD-Score:3.61|P-value:1.18E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:5.53|P-value:9.19E-9 ID:SGTC_2691|Compound:st077356|FD-Score:8.91|P-value:6.26E-20 ID:SGTC_2694|Compound:st077685|FD-Score:3.27|P-value:4.36E-4 ID:SGTC_2713|Compound:st079149|FD-Score:3.47|P-value:2.06E-4 ID:SGTC_2837|Compound:9008476|FD-Score:3.06|P-value:9.39E-4 ID:SGTC_2854|Compound:9024559|FD-Score:5.67|P-value:4.12E-9 ID:SGTC_2884|Compound:9058502|FD-Score:3.69|P-value:8.60E-5 ID:SGTC_2936|Compound:9038235|FD-Score:3.26|P-value:4.53E-4 ID:SGTC_3030|Compound:9087619|FD-Score:3.67|P-value:9.36E-5 ID:SGTC_3056|Compound:9094900|FD-Score:-3.85|P-value:4.50E-5 ID:SGTC_3058|Compound:9093861|FD-Score:-3.26|P-value:4.56E-4 ID:SGTC_3063|Compound:1327-0034|FD-Score:-3.36|P-value:3.11E-4 ID:SGTC_3173|Compound:9105693|FD-Score:4.11|P-value:1.47E-5 ID:SGTC_3222|Compound:9128301|FD-Score:3.12|P-value:7.59E-4 ID:SGTC_3307|Compound:9126885|FD-Score:3.07|P-value:8.84E-4

Top fitness defect scores for YJL212C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2691 st077356 8.91 60.2 µM 6.26E-20 1 2.56E-19
2 SGTC_2384 9036245 6.67 200.0 µM 5.64E-12 12 1.25E-11
3 SGTC_2854 9024559 5.67 71.4 µM 4.12E-9 6 7.35E-9
4 SGTC_2687 chenodiol 5.53 100.0 µM 9.19E-9 3 1.60E-8
5 SGTC_1012 4112-3522 5.45 18.0 µM 1.47E-8 6 2.52E-8
6 SGTC_2301 7769476 5.40 200.0 µM 2.01E-8 13 3.41E-8
7 SGTC_847 0342-0274 5.30 5.5 µM 3.40E-8 8 5.67E-8
8 SGTC_208 k072-0098 4.98 12.4 µM 2.07E-7 heme biosynthesis & mitochondrial translocase 25 3.24E-7
9 SGTC_1121 fusaric acid 4.81 630.5 nM 4.90E-7 19 7.48E-7
10 SGTC_1930 st074634 4.52 34.3 µM 2.13E-6 RNA pol III & RNase P/MRP 23 3.10E-6
11 SGTC_1939 st074455 4.32 53.6 µM 5.47E-6 22 7.72E-6
12 SGTC_2405 ticlatone 4.11 3.5 µM 1.43E-5 64 1.95E-5
13 SGTC_3173 9105693 4.11 49.5 µM 1.47E-5 17 2.01E-5
14 SGTC_734 2023-0417 3.94 80.0 µM 3.02E-5 ergosterol biosynthesis 16 4.02E-5
15 SGTC_1014 4130-3005 3.80 69.3 µM 5.61E-5 23 7.33E-5
16 SGTC_2884 9058502 3.69 52.0 µM 8.60E-5 35 1.11E-4
17 SGTC_1921 5740136 3.69 50.0 µM 8.69E-5 TRP & mitochondrial translation 69 1.12E-4
18 SGTC_627 1391-0720 3.68 175.0 µM 9.15E-5 19 1.18E-4
19 SGTC_3030 9087619 3.67 49.5 µM 9.36E-5 17 1.20E-4
20 SGTC_2501 sodium tetradecyl sulfate 3.62 13.4 µM 1.14E-4 41 1.45E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.141 2.70E-16 YCR012W PGK1 het 3-phosphoglycerate kinase, catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1,3-bisphosphoglycerate to ADP to produce ATP; key enzyme in glycolysis and gluconeogenesis
0.136 2.34E-15 YKL221W MCH2 hom Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
0.133 1.30E-14 YOR282W_d YOR282W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C
0.123 9.77E-13 YKR041W YKR041W hom Protein of unknown function; localizes to the mitotic spindle; overexpression of YKR041W affects endocytic protein trafficking
0.117 9.15E-12 YDR181C SAS4 hom Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; required for the HAT activity of Sas2p
0.117 1.23E-11 YJR041C URB2 het Nucleolar protein required for normal metabolism of the rRNA primary transcript, proposed to be involved in ribosome biogenesis
0.116 1.64E-11 YMR163C INP2 hom Peroxisome-specific receptor important for peroxisome inheritance; co-fractionates with peroxisome membranes and co-localizes with peroxisomes in vivo; physically interacts with the myosin V motor Myo2p; INP2 is not an essential gene
0.116 1.85E-11 YDR444W_p YDR444W_p hom Putative hydrolase acting on ester bonds
0.114 4.24E-11 YMR133W REC114 hom Protein involved in early stages of meiotic recombination; possibly involved in the coordination of recombination and meiotic division; mutations lead to premature initiation of the first meiotic division
0.106 8.38E-10 YKR027W BCH2 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; BCH2 has a paralog, CHS6, that arose from the whole genome duplication
0.097 1.76E-8 YGL263W COS12 hom Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
0.096 2.16E-8 YJL210W PEX2 hom RING-finger peroxin and E3 ubiquitin ligase, peroxisomal membrane protein with a C-terminal zinc-binding RING domain, forms translocation subcomplex with Pex10p and Pex12p which functions in peroxisomal matrix protein import
0.096 2.58E-8 YLR307W CDA1 hom Chitin deacetylase, together with Cda2p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall
0.095 3.87E-8 YDR440W DOT1 hom Nucleosomal histone H3-Lys79 methylase; methylation is required for telomeric silencing, meiotic checkpoint control, and DNA damage response
0.095 3.70E-8 YOR179C SYC1 hom Subunit of the APT subcomplex of cleavage and polyadenylation factor; may have a role in 3' end formation of both polyadenylated and non-polyadenylated RNAs; SYC1 has a paralog, YSH1, that arose from the whole genome duplication