YJR003C_p

Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; predicted to be involved in ribosome biogenesis

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR003C / YJR003C

Click on Significant Values for Screen Details ID:SGTC_129|Compound:0088-0017|FD-Score:-3.25|P-value:6.23E-4 ID:SGTC_197|Compound:4544-0043|FD-Score:3.14|P-value:9.10E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:-3.36|P-value:4.11E-4 ID:SGTC_271|Compound:rotenone|FD-Score:-3.66|P-value:1.39E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:3.68|P-value:1.26E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:-3.48|P-value:2.69E-4 ID:SGTC_472|Compound:calcifediol|FD-Score:3.12|P-value:9.59E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:3.63|P-value:1.54E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:5.17|P-value:1.39E-7 ID:SGTC_604|Compound:1000-0114|FD-Score:3.46|P-value:2.97E-4 ID:SGTC_680|Compound:0417-1641|FD-Score:3.95|P-value:4.28E-5 ID:SGTC_746|Compound:1095-0025|FD-Score:3.34|P-value:4.52E-4 ID:SGTC_827|Compound:3253-0474|FD-Score:3.17|P-value:8.11E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:-3.33|P-value:4.66E-4 ID:SGTC_872|Compound:0588-0139|FD-Score:-6.05|P-value:9.26E-10 ID:SGTC_881|Compound:0833-0569|FD-Score:-3.59|P-value:1.76E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:3.50|P-value:2.51E-4 ID:SGTC_936|Compound:3005-4620|FD-Score:-3.56|P-value:2.04E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:3.73|P-value:1.07E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:-3.30|P-value:5.14E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:3.69|P-value:1.24E-4 ID:SGTC_1801|Compound:st050089|FD-Score:3.50|P-value:2.52E-4 ID:SGTC_1846|Compound:st056244|FD-Score:3.50|P-value:2.57E-4 ID:SGTC_1909|Compound:st060837|FD-Score:5.22|P-value:1.05E-7 ID:SGTC_1936|Compound:st074407|FD-Score:3.20|P-value:7.26E-4 ID:SGTC_1937|Compound:st074714|FD-Score:3.52|P-value:2.36E-4 ID:SGTC_1967|Compound:st070177|FD-Score:3.39|P-value:3.84E-4 ID:SGTC_1970|Compound:st070122|FD-Score:3.45|P-value:3.09E-4 ID:SGTC_2054|Compound:5233173|FD-Score:3.40|P-value:3.65E-4 ID:SGTC_2092|Compound:5303694|FD-Score:3.25|P-value:6.16E-4 ID:SGTC_2093|Compound:5331342|FD-Score:-3.34|P-value:4.47E-4 ID:SGTC_2149|Compound:5554786|FD-Score:4.42|P-value:5.63E-6 ID:SGTC_2317|Compound:5986382|FD-Score:3.27|P-value:5.88E-4 ID:SGTC_2444|Compound:5485484|FD-Score:4.72|P-value:1.37E-6 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:3.81|P-value:7.54E-5 ID:SGTC_2602|Compound:kawain|FD-Score:-3.12|P-value:9.69E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-3.49|P-value:2.60E-4 ID:SGTC_2773|Compound:thioridazine|FD-Score:-3.55|P-value:2.06E-4 ID:SGTC_2815|Compound:7968870|FD-Score:-3.81|P-value:7.58E-5 ID:SGTC_2821|Compound:7996764|FD-Score:3.30|P-value:5.14E-4 ID:SGTC_2836|Compound:9010338|FD-Score:4.54|P-value:3.21E-6 ID:SGTC_2842|Compound:9000675|FD-Score:4.54|P-value:3.25E-6 ID:SGTC_2846|Compound:9008642|FD-Score:7.57|P-value:2.68E-14 ID:SGTC_3067|Compound:9117431|FD-Score:-3.32|P-value:4.78E-4 ID:SGTC_3124|Compound:9127567|FD-Score:3.86|P-value:6.30E-5 ID:SGTC_129|Compound:0088-0017|FD-Score:-3.25|P-value:6.23E-4 ID:SGTC_197|Compound:4544-0043|FD-Score:3.14|P-value:9.10E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:-3.36|P-value:4.11E-4 ID:SGTC_271|Compound:rotenone|FD-Score:-3.66|P-value:1.39E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:3.68|P-value:1.26E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:-3.48|P-value:2.69E-4 ID:SGTC_472|Compound:calcifediol|FD-Score:3.12|P-value:9.59E-4 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:3.63|P-value:1.54E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:5.17|P-value:1.39E-7 ID:SGTC_604|Compound:1000-0114|FD-Score:3.46|P-value:2.97E-4 ID:SGTC_680|Compound:0417-1641|FD-Score:3.95|P-value:4.28E-5 ID:SGTC_746|Compound:1095-0025|FD-Score:3.34|P-value:4.52E-4 ID:SGTC_827|Compound:3253-0474|FD-Score:3.17|P-value:8.11E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:-3.33|P-value:4.66E-4 ID:SGTC_872|Compound:0588-0139|FD-Score:-6.05|P-value:9.26E-10 ID:SGTC_881|Compound:0833-0569|FD-Score:-3.59|P-value:1.76E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:3.50|P-value:2.51E-4 ID:SGTC_936|Compound:3005-4620|FD-Score:-3.56|P-value:2.04E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:3.73|P-value:1.07E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:-3.30|P-value:5.14E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:3.69|P-value:1.24E-4 ID:SGTC_1801|Compound:st050089|FD-Score:3.50|P-value:2.52E-4 ID:SGTC_1846|Compound:st056244|FD-Score:3.50|P-value:2.57E-4 ID:SGTC_1909|Compound:st060837|FD-Score:5.22|P-value:1.05E-7 ID:SGTC_1936|Compound:st074407|FD-Score:3.20|P-value:7.26E-4 ID:SGTC_1937|Compound:st074714|FD-Score:3.52|P-value:2.36E-4 ID:SGTC_1967|Compound:st070177|FD-Score:3.39|P-value:3.84E-4 ID:SGTC_1970|Compound:st070122|FD-Score:3.45|P-value:3.09E-4 ID:SGTC_2054|Compound:5233173|FD-Score:3.40|P-value:3.65E-4 ID:SGTC_2092|Compound:5303694|FD-Score:3.25|P-value:6.16E-4 ID:SGTC_2093|Compound:5331342|FD-Score:-3.34|P-value:4.47E-4 ID:SGTC_2149|Compound:5554786|FD-Score:4.42|P-value:5.63E-6 ID:SGTC_2317|Compound:5986382|FD-Score:3.27|P-value:5.88E-4 ID:SGTC_2444|Compound:5485484|FD-Score:4.72|P-value:1.37E-6 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:3.81|P-value:7.54E-5 ID:SGTC_2602|Compound:kawain|FD-Score:-3.12|P-value:9.69E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-3.49|P-value:2.60E-4 ID:SGTC_2773|Compound:thioridazine|FD-Score:-3.55|P-value:2.06E-4 ID:SGTC_2815|Compound:7968870|FD-Score:-3.81|P-value:7.58E-5 ID:SGTC_2821|Compound:7996764|FD-Score:3.30|P-value:5.14E-4 ID:SGTC_2836|Compound:9010338|FD-Score:4.54|P-value:3.21E-6 ID:SGTC_2842|Compound:9000675|FD-Score:4.54|P-value:3.25E-6 ID:SGTC_2846|Compound:9008642|FD-Score:7.57|P-value:2.68E-14 ID:SGTC_3067|Compound:9117431|FD-Score:-3.32|P-value:4.78E-4 ID:SGTC_3124|Compound:9127567|FD-Score:3.86|P-value:6.30E-5

Top fitness defect scores for YJR003C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2846 9008642 7.57 19.5 µM 2.68E-14 1 1.87E-14
2 SGTC_1909 st060837 5.22 51.5 µM 1.05E-7 25 8.77E-8
3 SGTC_517 1365-0151 5.17 113.0 µM 1.39E-7 15 1.17E-7
4 SGTC_2444 5485484 4.72 36.4 µM 1.37E-6 17 1.19E-6
5 SGTC_2836 9010338 4.54 19.5 µM 3.21E-6 RPP1 & pyrimidine depletion 17 2.80E-6
6 SGTC_2842 9000675 4.54 19.5 µM 3.25E-6 11 2.83E-6
7 SGTC_2149 5554786 4.42 194.8 µM 5.63E-6 cell wall signaling 24 4.95E-6
8 SGTC_680 0417-1641 3.95 114.0 µM 4.28E-5 RPP1 & pyrimidine depletion 13 3.85E-5
9 SGTC_3124 9127567 3.86 49.5 µM 6.30E-5 DNA damage response 16 5.70E-5
10 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 3.81 66.7 µM 7.54E-5 29 6.83E-5
11 SGTC_1136 pergolide 3.73 1.1 µM 1.07E-4 45 9.70E-5
12 SGTC_1266 0828-0227 3.69 32.9 µM 1.24E-4 24 1.13E-4
13 SGTC_367 0335-0881 3.68 7.1 µM 1.26E-4 ubiquinone biosynthesis & proteasome 93 1.15E-4
14 SGTC_474 dl-dihydrosphingosine 3.63 5.0 µM 1.54E-4 34 1.41E-4
15 SGTC_1937 st074714 3.52 47.2 µM 2.36E-4 53 2.17E-4
16 SGTC_927 2425-1185 3.50 123.0 µM 2.51E-4 44 2.31E-4
17 SGTC_1801 st050089 3.50 28.4 µM 2.52E-4 NEO1-PIK1 145 2.32E-4
18 SGTC_1846 st056244 3.50 14.8 µM 2.57E-4 50 2.37E-4
19 SGTC_604 1000-0114 3.46 314.0 µM 2.97E-4 41 2.74E-4
20 SGTC_1970 st070122 3.45 35.8 µM 3.09E-4 TSC3-RPN4 39 2.85E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.111 1.11E-10 YIL136W OM45 hom Mitochondrial outer membrane protein of unknown function; major constituent of the outer membrane, located on the outer (cytosolic) face; protein abundance increases in response to DNA replication stress
0.094 4.55E-8 YOR142W LSC1 hom Alpha subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate; phosphorylated
0.092 1.06E-7 YPR004C AIM45 hom Putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-alpha; interacts with frataxin, Yfh1p; null mutant displays elevated frequency of mitochondrial genome loss; may have a role in oxidative stress response
0.090 2.03E-7 YOR355W GDS1 hom Protein of unknown function, required for growth on glycerol as a carbon source; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.085 9.09E-7 YPL256C CLN2 hom G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)
0.082 1.95E-6 YKR103W NFT1 hom Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds.
0.079 4.43E-6 YOL122C SMF1 hom Divalent metal ion transporter with a broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins
0.079 4.90E-6 YIL131C FKH1 hom Forkhead family transcription factor; has a minor role in the expression of G2/M phase genes; negatively regulates transcriptional elongation; positive role in chromatin silencing at HML and HMR; binds to the recombination enhancer near HML, and regulates donor preference during mating-type switching by positioning HML near the MAT locus through FHA-domain mediated interactions with proteins near the DSB; FKH1 has a paralog, FKH2, that arose from the whole genome duplication
0.077 7.37E-6 YJL116C NCA3 hom Protein involved in mitochondrion organization; functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase; member of the SUN family; expression induced in cells treated with the mycotoxin patulin; NCA3 has a paralog, UTH1, that arose from the whole genome duplication
0.077 7.62E-6 YOR350C MNE1 hom Mitochondrial matrix protein involved in splicing Group I aI5-beta intron from COX1 mRNA
0.077 7.87E-6 YJL147C_p YJL147C_p hom Mitochondrial protein of unknown function; homozygous diploid deletion strain has a sporulation defect characterized by elevated dityrosine in the soluble fraction; expression induced by calcium shortage; YJL147W is a non-essential gene
0.076 9.67E-6 YJR094W-A RPL43B hom Ribosomal 60S subunit protein L43B; homologous to mammalian ribosomal protein L37A, no bacterial homolog; RPL43B has a paralog, RPL43A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.075 1.34E-5 YDR168W CDC37 het Essential Hsp90p co-chaperone; necessary for passage through the START phase of the cell cycle; stabilizes protein kinase nascent chains and participates along with Hsp90p in their folding
0.074 1.80E-5 YDL157C_p YDL157C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.071 3.46E-5 YCR066W RAD18 hom E3 ubiquitin ligase; forms heterodimer with Rad6p to monoubiquitinate PCNA-K164; heterodimer binds single-stranded DNA and has single-stranded DNA dependent ATPase activity; required for postreplication repair; SUMO-targeted ubiquitin ligase (STUbl) that contains a SUMO-interacting motif (SIM) which stimulates its ubiquitin ligase activity towards the sumoylated form of PCNA