HIPHOP chemogenomics database
YJR007W / SUI2 
Alpha subunit of the translation initiation factor eIF2; eIF2 is involved in identification of the start codon; phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP; protein abundance increases in response to DNA replication stress
Zygosity: Heterozygous strain
fixedexpanded
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Top fitness defect scores for YJR007W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.336 | 2.20E-89 | YPL238C_d | YPL238C_d | het | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified essential gene SUI3/YPL237W |
| 0.325 | 2.91E-83 | YPL237W | SUI3 | het | Beta subunit of the translation initiation factor eIF2, involved in the identification of the start codon; proposed to be involved in mRNA binding |
| 0.228 | 7.87E-41 | YER025W | GCD11 | het | Gamma subunit of the translation initiation factor eIF2, involved in the identification of the start codon; binds GTP when forming the ternary complex with GTP and tRNAi-Met |
| 0.221 | 1.88E-38 | YDL150W | RPC53 | het | RNA polymerase III subunit C53 |
| 0.209 | 1.75E-34 | YBR257W | POP4 | het | Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P |
| 0.194 | 8.40E-30 | YCR053W | THR4 | hom | Threonine synthase, conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway |
| 0.189 | 2.12E-28 | YBR190W_d | YBR190W_d | het | Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified ribosomal protein gene RPL21A/YBR191W |
| 0.181 | 6.71E-26 | YPL131W | RPL5 | het | Ribosomal 60S subunit protein L5; homologous to mammalian ribosomal protein L5 and bacterial L18; binds 5S rRNA and is required for 60S subunit assembly |
| 0.180 | 7.90E-26 | YKL052C | ASK1 | het | Essential subunit of the Dam1 complex (aka DASH complex); couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; phosphorylated during the cell cycle by cyclin-dependent kinases; protein abundance increases in response to DNA replication stress |
| 0.173 | 7.15E-24 | YGL123W | RPS2 | het | Protein component of the small (40S) subunit; essential for control of translational accuracy; phosphorylation by C-terminal domain kinase I (CTDK-I) enhances translational accuracy; methylated on one or more arginine residues by Hmt1p; homologous to mammalian ribosomal protein S2 and bacterial S5 |
| 0.169 | 6.45E-23 | YOR146W_d | YOR146W_d | het | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene PNO1/YOR145C |
| 0.165 | 7.72E-22 | YPR137W | RRP9 | het | Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein |
| 0.165 | 7.76E-22 | YOL040C | RPS15 | het | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15 and bacterial S19 |
| 0.164 | 1.50E-21 | YLR044C | PDC1 | hom | Major of three pyruvate decarboxylase isozymes, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde; subject to glucose-, ethanol-, and autoregulation; involved in amino acid catabolism |
| 0.161 | 6.37E-21 | YFL037W | TUB2 | het | Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria |