HIPHOP chemogenomics database
YJR010W / MET3 
ATP sulfurylase, catalyzes the primary step of intracellular sulfate activation, essential for assimilatory reduction of sulfate to sulfide, involved in methionine metabolism
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YJR010W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.132 | 1.36E-14 | YLL017W | YLL017W | hom | Non-essential Ras guanine nucleotide exchange factor (GEF); localized to the membrane; expressed in poor nutrient conditions and on nonfermentable carbon sources; contains a stop codon in S288C, full-length gene includes YLL016W; SDC25 has a paralog, CDC25, that arose from the whole genome duplication |
| 0.125 | 3.59E-13 | YNL105W_d | RRT16_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene INP52; identified in a screen for mutants with decreased levels of rDNA transcription |
| 0.122 | 1.08E-12 | YDL079C | MRK1 | hom | Glycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress responsive genes and that function in protein degradation |
| 0.114 | 3.32E-11 | YBR052C | RFS1 | hom | Protein of unknown function; member of a flavodoxin-like fold protein family that includes Pst2p and Ycp4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; RFS1 has a paralog, PST2, that arose from the whole genome duplication |
| 0.114 | 3.70E-11 | YBR243C | ALG7 | het | UDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin |
| 0.110 | 1.48E-10 | YGR035W-A_p | YGR035W-A_p | hom | Putative protein of unknown function |
| 0.110 | 1.74E-10 | YLL006W-A_p | YLL006W-A_p | hom | Putative protein of unknown function; identified by fungal homology and RT-PCR |
| 0.110 | 1.96E-10 | YMR221C_p | YMR221C_p | hom | Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; physical interaction with Atg27p suggests a possible role in autophagy |
| 0.108 | 3.76E-10 | YJL208C | NUC1 | hom | Major mitochondrial nuclease, has RNAse and DNA endo- and exonucleolytic activities; has roles in mitochondrial recombination, apoptosis and maintenance of polyploidy |
| 0.105 | 8.83E-10 | YJR055W | HIT1 | hom | Protein of unknown function, required for growth at high temperature |
| 0.101 | 4.92E-9 | YMR020W | FMS1 | hom | Polyamine oxidase, converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis |
| 0.098 | 1.21E-8 | YDR057W | YOS9 | hom | ER quality-control lectin; integral subunit of the HRD ligase; binds to glycans with terminal alpha-1,6 linked mannose on misfolded N-glycosylated proteins and participates in targeting proteins to ERAD; member of the OS-9 protein family |
| 0.097 | 1.75E-8 | YPR002W | PDH1 | hom | Mitochondrial protein that participates in respiration, induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate |
| 0.095 | 3.34E-8 | YLR196W | PWP1 | het | Protein with WD-40 repeats involved in rRNA processing; associates with trans-acting ribosome biogenesis factors; similar to beta-transducin superfamily |
| 0.093 | 6.02E-8 | YER027C | GAL83 | hom | One of three possible beta-subunits of the Snf1 kinase complex, allows nuclear localization of the Snf1 kinase complex in the presence of a nonfermentable carbon source; contains glycogen-binding domain |