YJR020W_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR020W / YJR020W

Click on Significant Values for Screen Details ID:SGTC_140|Compound:0062-0056|FD-Score:-3.00|P-value:4.93E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:-2.90|P-value:7.22E-4 ID:SGTC_229|Compound:benomyl|FD-Score:3.28|P-value:1.78E-4 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:3.98|P-value:7.48E-6 ID:SGTC_382|Compound:3229-0966|FD-Score:2.92|P-value:7.49E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:3.58|P-value:4.87E-5 ID:SGTC_497|Compound:capsazepine|FD-Score:-2.99|P-value:5.14E-4 ID:SGTC_603|Compound:3794-0023|FD-Score:-2.90|P-value:7.05E-4 ID:SGTC_645|Compound:0845-0943|FD-Score:3.15|P-value:3.05E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:2.90|P-value:8.06E-4 ID:SGTC_1273|Compound:0849-0096|FD-Score:3.80|P-value:1.75E-5 ID:SGTC_1304|Compound:1165-0502|FD-Score:3.45|P-value:8.77E-5 ID:SGTC_1315|Compound:1237-0019|FD-Score:3.80|P-value:1.72E-5 ID:SGTC_1364|Compound:1653-0028|FD-Score:2.88|P-value:8.62E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:-2.91|P-value:6.91E-4 ID:SGTC_1651|Compound:st011928|FD-Score:2.99|P-value:5.83E-4 ID:SGTC_1682|Compound:st012968|FD-Score:3.50|P-value:6.93E-5 ID:SGTC_1684|Compound:st024538|FD-Score:-3.30|P-value:1.46E-4 ID:SGTC_1728|Compound:st035614|FD-Score:3.00|P-value:5.51E-4 ID:SGTC_1920|Compound:st075728|FD-Score:-3.06|P-value:3.80E-4 ID:SGTC_2011|Compound:4012611|FD-Score:2.88|P-value:8.61E-4 ID:SGTC_2201|Compound:6605497|FD-Score:-2.85|P-value:8.57E-4 ID:SGTC_2211|Compound:7117706|FD-Score:4.16|P-value:2.90E-6 ID:SGTC_2217|Compound:6934799|FD-Score:4.07|P-value:4.69E-6 ID:SGTC_2218|Compound:6965428|FD-Score:3.04|P-value:4.69E-4 ID:SGTC_2273|Compound:7815444|FD-Score:3.16|P-value:2.90E-4 ID:SGTC_2310|Compound:7668677|FD-Score:4.16|P-value:3.01E-6 ID:SGTC_2315|Compound:7733312|FD-Score:-2.82|P-value:9.58E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-4.40|P-value:6.71E-7 ID:SGTC_2630|Compound:antimycin a|FD-Score:-3.22|P-value:2.01E-4 ID:SGTC_2729|Compound:fluphenazine|FD-Score:-2.83|P-value:9.25E-4 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:-3.30|P-value:1.45E-4 ID:SGTC_2780|Compound:5215298|FD-Score:-3.36|P-value:1.09E-4 ID:SGTC_2788|Compound:5282734|FD-Score:4.27|P-value:1.61E-6 ID:SGTC_2810|Compound:7959871|FD-Score:2.89|P-value:8.35E-4 ID:SGTC_2892|Compound:9047358|FD-Score:3.38|P-value:1.19E-4 ID:SGTC_2893|Compound:9048488|FD-Score:2.92|P-value:7.38E-4 ID:SGTC_2937|Compound:9044753|FD-Score:3.96|P-value:8.10E-6 ID:SGTC_2976|Compound:9009005|FD-Score:3.11|P-value:3.61E-4 ID:SGTC_3090|Compound:9117696|FD-Score:2.92|P-value:7.59E-4 ID:SGTC_3194|Compound:9111903|FD-Score:3.82|P-value:1.64E-5 ID:SGTC_3195|Compound:9113082|FD-Score:4.33|P-value:1.19E-6 ID:SGTC_3209|Compound:9113616|FD-Score:3.08|P-value:4.13E-4 ID:SGTC_3223|Compound:9129970|FD-Score:3.42|P-value:1.01E-4 ID:SGTC_3304|Compound:9125678|FD-Score:-5.69|P-value:2.12E-10 ID:SGTC_3307|Compound:9126885|FD-Score:4.08|P-value:4.37E-6 ID:SGTC_3340|Compound:9146634|FD-Score:-3.75|P-value:1.89E-5 ID:SGTC_3341|Compound:9147222|FD-Score:-3.70|P-value:2.42E-5 ID:SGTC_3348|Compound:9149464|FD-Score:-2.82|P-value:9.77E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:-3.00|P-value:4.93E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:-2.90|P-value:7.22E-4 ID:SGTC_229|Compound:benomyl|FD-Score:3.28|P-value:1.78E-4 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:3.98|P-value:7.48E-6 ID:SGTC_382|Compound:3229-0966|FD-Score:2.92|P-value:7.49E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:3.58|P-value:4.87E-5 ID:SGTC_497|Compound:capsazepine|FD-Score:-2.99|P-value:5.14E-4 ID:SGTC_603|Compound:3794-0023|FD-Score:-2.90|P-value:7.05E-4 ID:SGTC_645|Compound:0845-0943|FD-Score:3.15|P-value:3.05E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:2.90|P-value:8.06E-4 ID:SGTC_1273|Compound:0849-0096|FD-Score:3.80|P-value:1.75E-5 ID:SGTC_1304|Compound:1165-0502|FD-Score:3.45|P-value:8.77E-5 ID:SGTC_1315|Compound:1237-0019|FD-Score:3.80|P-value:1.72E-5 ID:SGTC_1364|Compound:1653-0028|FD-Score:2.88|P-value:8.62E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:-2.91|P-value:6.91E-4 ID:SGTC_1651|Compound:st011928|FD-Score:2.99|P-value:5.83E-4 ID:SGTC_1682|Compound:st012968|FD-Score:3.50|P-value:6.93E-5 ID:SGTC_1684|Compound:st024538|FD-Score:-3.30|P-value:1.46E-4 ID:SGTC_1728|Compound:st035614|FD-Score:3.00|P-value:5.51E-4 ID:SGTC_1920|Compound:st075728|FD-Score:-3.06|P-value:3.80E-4 ID:SGTC_2011|Compound:4012611|FD-Score:2.88|P-value:8.61E-4 ID:SGTC_2201|Compound:6605497|FD-Score:-2.85|P-value:8.57E-4 ID:SGTC_2211|Compound:7117706|FD-Score:4.16|P-value:2.90E-6 ID:SGTC_2217|Compound:6934799|FD-Score:4.07|P-value:4.69E-6 ID:SGTC_2218|Compound:6965428|FD-Score:3.04|P-value:4.69E-4 ID:SGTC_2273|Compound:7815444|FD-Score:3.16|P-value:2.90E-4 ID:SGTC_2310|Compound:7668677|FD-Score:4.16|P-value:3.01E-6 ID:SGTC_2315|Compound:7733312|FD-Score:-2.82|P-value:9.58E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-4.40|P-value:6.71E-7 ID:SGTC_2630|Compound:antimycin a|FD-Score:-3.22|P-value:2.01E-4 ID:SGTC_2729|Compound:fluphenazine|FD-Score:-2.83|P-value:9.25E-4 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:-3.30|P-value:1.45E-4 ID:SGTC_2780|Compound:5215298|FD-Score:-3.36|P-value:1.09E-4 ID:SGTC_2788|Compound:5282734|FD-Score:4.27|P-value:1.61E-6 ID:SGTC_2810|Compound:7959871|FD-Score:2.89|P-value:8.35E-4 ID:SGTC_2892|Compound:9047358|FD-Score:3.38|P-value:1.19E-4 ID:SGTC_2893|Compound:9048488|FD-Score:2.92|P-value:7.38E-4 ID:SGTC_2937|Compound:9044753|FD-Score:3.96|P-value:8.10E-6 ID:SGTC_2976|Compound:9009005|FD-Score:3.11|P-value:3.61E-4 ID:SGTC_3090|Compound:9117696|FD-Score:2.92|P-value:7.59E-4 ID:SGTC_3194|Compound:9111903|FD-Score:3.82|P-value:1.64E-5 ID:SGTC_3195|Compound:9113082|FD-Score:4.33|P-value:1.19E-6 ID:SGTC_3209|Compound:9113616|FD-Score:3.08|P-value:4.13E-4 ID:SGTC_3223|Compound:9129970|FD-Score:3.42|P-value:1.01E-4 ID:SGTC_3304|Compound:9125678|FD-Score:-5.69|P-value:2.12E-10 ID:SGTC_3307|Compound:9126885|FD-Score:4.08|P-value:4.37E-6 ID:SGTC_3340|Compound:9146634|FD-Score:-3.75|P-value:1.89E-5 ID:SGTC_3341|Compound:9147222|FD-Score:-3.70|P-value:2.42E-5 ID:SGTC_3348|Compound:9149464|FD-Score:-2.82|P-value:9.77E-4

Top fitness defect scores for YJR020W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3195 9113082 4.33 49.5 µM 1.19E-6 12 7.41E-6
2 SGTC_2788 5282734 4.27 71.4 µM 1.61E-6 31 9.57E-6
3 SGTC_2211 7117706 4.16 200.0 µM 2.90E-6 8 1.57E-5
4 SGTC_2310 7668677 4.16 200.0 µM 3.01E-6 23 1.62E-5
5 SGTC_3307 9126885 4.08 69.3 µM 4.37E-6 29 2.22E-5
6 SGTC_2217 6934799 4.07 96.1 µM 4.69E-6 TSC3-RPN4 8 2.36E-5
7 SGTC_239 5hr heat shock (37°C) + mitomycin C 3.98 819.4 µM 7.48E-6 heat shock/prefoldin 34 3.50E-5
8 SGTC_2937 9044753 3.96 11.3 µM 8.10E-6 60S ribosome export 32 3.75E-5
9 SGTC_3194 9111903 3.82 49.5 µM 1.64E-5 27 6.80E-5
10 SGTC_1315 1237-0019 3.80 3.7 µM 1.72E-5 10 7.10E-5
11 SGTC_1273 0849-0096 3.80 14.1 µM 1.75E-5 RPP1 & pyrimidine depletion 21 7.21E-5
12 SGTC_385 1494-0393 3.58 12.4 µM 4.87E-5 34 1.71E-4
13 SGTC_1682 st012968 3.50 530.0 nM 6.93E-5 33 2.31E-4
14 SGTC_1304 1165-0502 3.45 251.0 µM 8.77E-5 83 2.82E-4
15 SGTC_3223 9129970 3.42 49.5 µM 1.01E-4 36 3.17E-4
16 SGTC_2892 9047358 3.38 58.4 µM 1.19E-4 20 3.65E-4
17 SGTC_229 benomyl 3.28 22.9 µM 1.78E-4 tubulin folding & SWR complex 50 5.14E-4
18 SGTC_2273 7815444 3.16 169.1 µM 2.90E-4 60 7.79E-4
19 SGTC_645 0845-0943 3.15 5.4 µM 3.05E-4 60S ribosome export 34 8.13E-4
20 SGTC_2976 9009005 3.11 19.5 µM 3.61E-4 60 9.38E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.132 1.67E-14 YDR249C_p YDR249C_p hom Putative protein of unknown function
0.102 2.72E-9 YPR168W NUT2 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for transcriptional activation and has a role in basal transcription; protein abundance increases in response to DNA replication stress
0.098 1.09E-8 YBR188C NTC20 hom Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs
0.077 8.65E-6 YLR221C RSA3 hom Protein with a likely role in ribosomal maturation, required for accumulation of wild-type levels of large (60S) ribosomal subunits; binds to the helicase Dbp6p in pre-60S ribosomal particles in the nucleolus
0.076 1.22E-5 YJL091C GWT1 het Protein involved in the inositol acylation of glucosaminyl phosphatidylinositol (GlcN-PI) to form glucosaminyl(acyl)phosphatidylinositol (GlcN(acyl)PI), an intermediate in the biosynthesis of glycosylphosphatidylinositol (GPI) anchors
0.075 1.53E-5 YIL128W MET18 hom Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia1p and Cia2p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; ortholog of human MMS19
0.074 1.65E-5 YMR294W-A_d YMR294W-A_d hom Dubious open reading frame unlikely to encode a functional protein, substantially overlaps YMR295C; deletion causes sensitivity to unfolded protein response-inducing agents
0.074 1.72E-5 YDR523C SPS1 hom Putative protein serine/threonine kinase expressed at the end of meiosis and localized to the prospore membrane, required for correct localization of enzymes involved in spore wall synthesis
0.074 1.74E-5 YNR033W ABZ1 hom Para-aminobenzoate (PABA) synthase; has similarity to Escherichia coli PABA synthase components PabA and PabB; required for the synthesis of para-aminobenzoic acid, an important intermediate for folate and ubiquinone Q biosynthesis; protein abundance increases in response to DNA replication stress
0.071 4.07E-5 YCR011C ADP1 hom Putative ATP-dependent permease of the ABC transporter family of proteins
0.070 4.64E-5 YGL140C_p YGL140C_p hom Putative protein of unknown function; non-essential gene; contains multiple predicted transmembrane domains
0.069 5.77E-5 YGL141W HUL5 hom Multiubiquitin chain assembly factor (E4); proteasome processivity factor that elongates polyUb chains on substrates, opposing Ubp6p, a branched polyubiquitin protease; required for retrograde transport of misfolded proteins during ERAD
0.068 7.99E-5 YER007W PAC2 hom Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl
0.067 1.13E-4 YGR063C SPT4 hom Component of the universally conserved Spt4/5 complex (DSIF complex); the complex has multiple roles in concert with RNA polymerases I and II, including regulation of transcription elongation, RNA processing, quality control, and transcription-coupled DNA repair; Spt4p also localizes to kinetochores and heterochromatin and affects chromosome dynamics and silencing; required for transcription through lengthy trinucleotide repeats in ORFs or non-protein coding regions
0.065 1.49E-4 YOL036W_p YOL036W_p hom Protein of unknown function; potential Cdc28p substrate; YOL036W has a paralog, YIR016W, that arose from the whole genome duplication