YJR062C / NTA1

Amidase, removes the amide group from N-terminal asparagine and glutamine residues to generate proteins with N-terminal aspartate and glutamate residues that are targets of ubiquitin-mediated degradation

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR062C / NTA1

Click on Significant Values for Screen Details ID:SGTC_88|Compound:0180-0332|FD-Score:2.98|P-value:7.42E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:3.62|P-value:6.05E-5 ID:SGTC_160|Compound:3453-0671|FD-Score:2.99|P-value:7.14E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:3.14|P-value:4.20E-4 ID:SGTC_172|Compound:1112-0046|FD-Score:-4.23|P-value:5.32E-6 ID:SGTC_181|Compound:1447-1644|FD-Score:-4.40|P-value:2.37E-6 ID:SGTC_190|Compound:3970-0790|FD-Score:3.01|P-value:6.63E-4 ID:SGTC_192|Compound:3455-0609|FD-Score:3.61|P-value:6.24E-5 ID:SGTC_273|Compound:hydroxyurea|FD-Score:-3.18|P-value:4.84E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:3.87|P-value:2.00E-5 ID:SGTC_542|Compound:3381-0244|FD-Score:4.87|P-value:1.25E-7 ID:SGTC_672|Compound:1441-0018|FD-Score:3.39|P-value:1.55E-4 ID:SGTC_685|Compound:1278-0033|FD-Score:3.30|P-value:2.21E-4 ID:SGTC_959|Compound:1222-0044|FD-Score:3.85|P-value:2.19E-5 ID:SGTC_969|Compound:1313-0238|FD-Score:3.60|P-value:6.56E-5 ID:SGTC_970|Compound:1315-0089|FD-Score:-3.05|P-value:7.76E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:2.94|P-value:8.70E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:3.23|P-value:2.99E-4 ID:SGTC_1068|Compound:loratadine|FD-Score:3.22|P-value:3.04E-4 ID:SGTC_1198|Compound:1612-1005|FD-Score:-3.32|P-value:2.86E-4 ID:SGTC_1223|Compound:0764-0573|FD-Score:3.73|P-value:3.73E-5 ID:SGTC_1240|Compound:0356-0016|FD-Score:-3.40|P-value:2.06E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:-3.05|P-value:7.93E-4 ID:SGTC_1518|Compound:st038567|FD-Score:-3.32|P-value:2.82E-4 ID:SGTC_1527|Compound:coumarin|FD-Score:-5.98|P-value:2.20E-10 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:3.07|P-value:5.46E-4 ID:SGTC_1722|Compound:st034304|FD-Score:2.94|P-value:8.74E-4 ID:SGTC_1726|Compound:st035556|FD-Score:-3.50|P-value:1.40E-4 ID:SGTC_1737|Compound:st035557|FD-Score:3.10|P-value:4.91E-4 ID:SGTC_1761|Compound:st044296|FD-Score:3.26|P-value:2.61E-4 ID:SGTC_1884|Compound:5633444|FD-Score:-3.14|P-value:5.63E-4 ID:SGTC_1886|Compound:st057356|FD-Score:3.01|P-value:6.74E-4 ID:SGTC_2377|Compound:9073351|FD-Score:3.17|P-value:3.68E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:3.31|P-value:2.16E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:4.86|P-value:1.29E-7 ID:SGTC_2793|Compound:7325131|FD-Score:3.00|P-value:7.06E-4 ID:SGTC_2800|Compound:7887935|FD-Score:4.07|P-value:7.92E-6 ID:SGTC_2802|Compound:7925815|FD-Score:2.99|P-value:7.19E-4 ID:SGTC_2866|Compound:9034245|FD-Score:3.23|P-value:2.94E-4 ID:SGTC_2875|Compound:9039966|FD-Score:-3.38|P-value:2.23E-4 ID:SGTC_2900|Compound:5328528|FD-Score:2.91|P-value:9.83E-4 ID:SGTC_2981|Compound:9013952|FD-Score:2.92|P-value:9.21E-4 ID:SGTC_3003|Compound:9075612|FD-Score:3.42|P-value:1.40E-4 ID:SGTC_3146|Compound:9095609|FD-Score:-3.94|P-value:2.10E-5 ID:SGTC_3154|Compound:9100113|FD-Score:-3.07|P-value:7.44E-4 ID:SGTC_3318|Compound:9139014|FD-Score:3.65|P-value:5.25E-5 ID:SGTC_88|Compound:0180-0332|FD-Score:2.98|P-value:7.42E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:3.62|P-value:6.05E-5 ID:SGTC_160|Compound:3453-0671|FD-Score:2.99|P-value:7.14E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:3.14|P-value:4.20E-4 ID:SGTC_172|Compound:1112-0046|FD-Score:-4.23|P-value:5.32E-6 ID:SGTC_181|Compound:1447-1644|FD-Score:-4.40|P-value:2.37E-6 ID:SGTC_190|Compound:3970-0790|FD-Score:3.01|P-value:6.63E-4 ID:SGTC_192|Compound:3455-0609|FD-Score:3.61|P-value:6.24E-5 ID:SGTC_273|Compound:hydroxyurea|FD-Score:-3.18|P-value:4.84E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:3.87|P-value:2.00E-5 ID:SGTC_542|Compound:3381-0244|FD-Score:4.87|P-value:1.25E-7 ID:SGTC_672|Compound:1441-0018|FD-Score:3.39|P-value:1.55E-4 ID:SGTC_685|Compound:1278-0033|FD-Score:3.30|P-value:2.21E-4 ID:SGTC_959|Compound:1222-0044|FD-Score:3.85|P-value:2.19E-5 ID:SGTC_969|Compound:1313-0238|FD-Score:3.60|P-value:6.56E-5 ID:SGTC_970|Compound:1315-0089|FD-Score:-3.05|P-value:7.76E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:2.94|P-value:8.70E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:3.23|P-value:2.99E-4 ID:SGTC_1068|Compound:loratadine|FD-Score:3.22|P-value:3.04E-4 ID:SGTC_1198|Compound:1612-1005|FD-Score:-3.32|P-value:2.86E-4 ID:SGTC_1223|Compound:0764-0573|FD-Score:3.73|P-value:3.73E-5 ID:SGTC_1240|Compound:0356-0016|FD-Score:-3.40|P-value:2.06E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:-3.05|P-value:7.93E-4 ID:SGTC_1518|Compound:st038567|FD-Score:-3.32|P-value:2.82E-4 ID:SGTC_1527|Compound:coumarin|FD-Score:-5.98|P-value:2.20E-10 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:3.07|P-value:5.46E-4 ID:SGTC_1722|Compound:st034304|FD-Score:2.94|P-value:8.74E-4 ID:SGTC_1726|Compound:st035556|FD-Score:-3.50|P-value:1.40E-4 ID:SGTC_1737|Compound:st035557|FD-Score:3.10|P-value:4.91E-4 ID:SGTC_1761|Compound:st044296|FD-Score:3.26|P-value:2.61E-4 ID:SGTC_1884|Compound:5633444|FD-Score:-3.14|P-value:5.63E-4 ID:SGTC_1886|Compound:st057356|FD-Score:3.01|P-value:6.74E-4 ID:SGTC_2377|Compound:9073351|FD-Score:3.17|P-value:3.68E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:3.31|P-value:2.16E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:4.86|P-value:1.29E-7 ID:SGTC_2793|Compound:7325131|FD-Score:3.00|P-value:7.06E-4 ID:SGTC_2800|Compound:7887935|FD-Score:4.07|P-value:7.92E-6 ID:SGTC_2802|Compound:7925815|FD-Score:2.99|P-value:7.19E-4 ID:SGTC_2866|Compound:9034245|FD-Score:3.23|P-value:2.94E-4 ID:SGTC_2875|Compound:9039966|FD-Score:-3.38|P-value:2.23E-4 ID:SGTC_2900|Compound:5328528|FD-Score:2.91|P-value:9.83E-4 ID:SGTC_2981|Compound:9013952|FD-Score:2.92|P-value:9.21E-4 ID:SGTC_3003|Compound:9075612|FD-Score:3.42|P-value:1.40E-4 ID:SGTC_3146|Compound:9095609|FD-Score:-3.94|P-value:2.10E-5 ID:SGTC_3154|Compound:9100113|FD-Score:-3.07|P-value:7.44E-4 ID:SGTC_3318|Compound:9139014|FD-Score:3.65|P-value:5.25E-5

Top fitness defect scores for YJR062C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_542 3381-0244 4.87 89.3 µM 1.25E-7 20 5.62E-7
2 SGTC_2583 asiatic acid 4.86 100.0 µM 1.29E-7 22 5.80E-7
3 SGTC_2800 7887935 4.07 81.8 µM 7.92E-6 RPP1 & pyrimidine depletion 30 2.37E-5
4 SGTC_530 4358-1714 3.87 28.0 µM 2.00E-5 47 5.46E-5
5 SGTC_959 1222-0044 3.85 107.0 µM 2.19E-5 23 5.93E-5
6 SGTC_1223 0764-0573 3.73 147.0 µM 3.73E-5 26 9.58E-5
7 SGTC_3318 9139014 3.65 38.6 µM 5.25E-5 21 1.30E-4
8 SGTC_142 0335-0849 3.62 62.7 µM 6.05E-5 ubiquinone biosynthesis & proteasome 148 1.48E-4
9 SGTC_192 3455-0609 3.61 60.9 µM 6.24E-5 17 1.53E-4
10 SGTC_969 1313-0238 3.60 134.0 µM 6.56E-5 mitochondrial processes 34 1.60E-4
11 SGTC_3003 9075612 3.42 71.4 µM 1.40E-4 36 3.16E-4
12 SGTC_672 1441-0018 3.39 53.7 µM 1.55E-4 30 3.47E-4
13 SGTC_2549 cedrol 3.31 20.9 µM 2.16E-4 30 4.67E-4
14 SGTC_685 1278-0033 3.30 54.9 µM 2.21E-4 60S ribosome export 50 4.76E-4
15 SGTC_1761 st044296 3.26 37.0 µM 2.61E-4 26 5.55E-4
16 SGTC_2866 9034245 3.23 58.4 µM 2.94E-4 24 6.18E-4
17 SGTC_1051 3253-3903 3.23 78.0 µM 2.99E-4 49 6.27E-4
18 SGTC_1068 loratadine 3.22 26.9 µM 3.04E-4 57 6.36E-4
19 SGTC_2377 9073351 3.17 62.6 µM 3.68E-4 ergosterol biosynthesis 56 7.56E-4
20 SGTC_167 3672-0051 3.14 66.2 µM 4.20E-4 79 8.52E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.118 8.26E-12 YOR021C SFM1 hom SPOUT methyltransferase; catalyzes omega-monomethylation of Rps3p on Arg-146; not an essential gene; predicted to be involved in rRNA processing and ribosome biogenesis and in biopolymer catabolism
0.091 1.29E-7 YER051W JHD1 hom JmjC domain family histone demethylase specific for H3-K36, similar to proteins found in human, mouse, drosophila, X. laevis, C. elegans, and S. pombe
0.091 1.40E-7 YFL009W CDC4 het F-box protein required for G1/S and G2/M transition, associates with Skp1p and Cdc53p to form a complex, SCFCdc4, which acts as ubiquitin-protein ligase directing ubiquitination of the phosphorylated CDK inhibitor Sic1p
0.090 2.01E-7 YOL066C RIB2 het Bifunctional enzyme with DRAP deaminase and tRNA:pseudouridine synthase activity; the deaminase catalyzes the third step in riboflavin biosynthesis and the synthase catalyzes formation of pseudouridine at position 32 in cytoplasmic tRNAs
0.087 5.25E-7 YNL231C PDR16 hom Phosphatidylinositol transfer protein (PITP); controlled by the multiple drug resistance regulator Pdr1p; localizes to lipid particles and microsomes; controls levels of various lipids, may regulate lipid synthesis; homologous to Pdr17p; protein abundance increases in response to DNA replication stress
0.086 5.85E-7 YGL130W CEG1 het Alpha (guanylyltransferase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CET1, an RNA 5'-triphosphatase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide
0.080 3.06E-6 YJR015W_p YJR015W_p hom Putative protein of unknown function; localizes to the endoplasmic reticulum and cytoplasm; predicted to encode a membrane transporter based on phylogenetic analysis; YJR015W is a non-essential gene
0.080 3.39E-6 YGR082W TOM20 het Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins
0.078 6.79E-6 YMR254C_d YMR254C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.076 1.09E-5 YPL181W CTI6 hom Protein that relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter; contains a PHD finger domain
0.075 1.24E-5 YJL193W_p YJL193W_p hom Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
0.075 1.37E-5 YIL141W_d YIL141W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.073 2.10E-5 YBR276C PPS1 hom Protein phosphatase with specificity for serine, threonine, and tyrosine residues; has a role in the DNA synthesis phase of the cell cycle
0.073 2.23E-5 YOR292C_p YOR292C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YOR292C is not an essential gene
0.072 2.96E-5 YNL159C ASI2 hom Integral inner nuclear membrane protein that acts with Asi1p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals