YJR078W / BNA2

Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for de novo biosynthesis of NAD from tryptophan via kynurenine; interacts genetically with telomere capping gene CDC13; regulated by Hst1p and Aftp

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR078W / BNA2

Click on Significant Values for Screen Details ID:SGTC_93|Compound:0109-0045|FD-Score:-3.55|P-value:2.98E-5 ID:SGTC_99|Compound:0109-0120|FD-Score:3.12|P-value:2.24E-4 ID:SGTC_144|Compound:4161-2749|FD-Score:-3.52|P-value:3.50E-5 ID:SGTC_148|Compound:3253-0744|FD-Score:-3.63|P-value:2.09E-5 ID:SGTC_288|Compound:1315-0019|FD-Score:-3.18|P-value:1.62E-4 ID:SGTC_307|Compound:1501-1223|FD-Score:-2.97|P-value:3.99E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.37|P-value:7.55E-5 ID:SGTC_556|Compound:4058-0063|FD-Score:3.20|P-value:1.60E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:-2.84|P-value:6.48E-4 ID:SGTC_898|Compound:1000-0849|FD-Score:3.11|P-value:2.33E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:-2.75|P-value:9.43E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:3.23|P-value:1.41E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-4.46|P-value:2.32E-7 ID:SGTC_2053|Compound:5265679|FD-Score:-3.34|P-value:8.15E-5 ID:SGTC_2125|Compound:5246583|FD-Score:4.86|P-value:2.32E-8 ID:SGTC_2126|Compound:5251174|FD-Score:3.12|P-value:2.27E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:-4.35|P-value:4.39E-7 ID:SGTC_2162|Compound:5663267|FD-Score:2.88|P-value:6.13E-4 ID:SGTC_2235|Compound:salicylic acid|FD-Score:-3.06|P-value:2.73E-4 ID:SGTC_2307|Compound:7538926|FD-Score:3.27|P-value:1.16E-4 ID:SGTC_2400|Compound:5203494|FD-Score:-3.33|P-value:8.32E-5 ID:SGTC_2452|Compound:5863136|FD-Score:-2.94|P-value:4.39E-4 ID:SGTC_2487|Compound:5918373|FD-Score:3.01|P-value:3.58E-4 ID:SGTC_2490|Compound:carminic acid|FD-Score:2.88|P-value:6.11E-4 ID:SGTC_2492|Compound:derrusnin|FD-Score:3.68|P-value:1.77E-5 ID:SGTC_2596|Compound:sinensetin|FD-Score:-3.13|P-value:2.04E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:2.96|P-value:4.49E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:-2.87|P-value:5.81E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:3.31|P-value:1.00E-4 ID:SGTC_2691|Compound:st077356|FD-Score:-7.58|P-value:6.04E-18 ID:SGTC_2694|Compound:st077685|FD-Score:-4.32|P-value:5.33E-7 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:4.57|P-value:1.38E-7 ID:SGTC_2701|Compound:st077767|FD-Score:-3.80|P-value:8.57E-6 ID:SGTC_2703|Compound:st077852|FD-Score:3.53|P-value:3.65E-5 ID:SGTC_2704|Compound:st078022|FD-Score:2.88|P-value:6.12E-4 ID:SGTC_2706|Compound:st078239|FD-Score:-3.02|P-value:3.22E-4 ID:SGTC_2715|Compound:st079500|FD-Score:-2.93|P-value:4.57E-4 ID:SGTC_2908|Compound:7930301|FD-Score:-2.92|P-value:4.72E-4 ID:SGTC_2999|Compound:9069765|FD-Score:-2.91|P-value:4.92E-4 ID:SGTC_3001|Compound:9076041|FD-Score:-2.92|P-value:4.90E-4 ID:SGTC_3117|Compound:9124945|FD-Score:-3.24|P-value:1.25E-4 ID:SGTC_3212|Compound:9128307|FD-Score:-2.77|P-value:8.63E-4 ID:SGTC_3213|Compound:9129884|FD-Score:-3.14|P-value:1.89E-4 ID:SGTC_3223|Compound:9129970|FD-Score:2.93|P-value:5.04E-4 ID:SGTC_3251|Compound:9135047|FD-Score:3.33|P-value:9.25E-5 ID:SGTC_3262|Compound:9137218|FD-Score:3.09|P-value:2.59E-4 ID:SGTC_3263|Compound:9137018|FD-Score:-3.46|P-value:4.57E-5 ID:SGTC_3264|Compound:9137442|FD-Score:3.22|P-value:1.45E-4 ID:SGTC_3272|Compound:9137413|FD-Score:-4.18|P-value:1.20E-6 ID:SGTC_3274|Compound:9138298|FD-Score:-3.55|P-value:3.03E-5 ID:SGTC_3329|Compound:9141233|FD-Score:2.82|P-value:7.61E-4 ID:SGTC_93|Compound:0109-0045|FD-Score:-3.55|P-value:2.98E-5 ID:SGTC_99|Compound:0109-0120|FD-Score:3.12|P-value:2.24E-4 ID:SGTC_144|Compound:4161-2749|FD-Score:-3.52|P-value:3.50E-5 ID:SGTC_148|Compound:3253-0744|FD-Score:-3.63|P-value:2.09E-5 ID:SGTC_288|Compound:1315-0019|FD-Score:-3.18|P-value:1.62E-4 ID:SGTC_307|Compound:1501-1223|FD-Score:-2.97|P-value:3.99E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.37|P-value:7.55E-5 ID:SGTC_556|Compound:4058-0063|FD-Score:3.20|P-value:1.60E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:-2.84|P-value:6.48E-4 ID:SGTC_898|Compound:1000-0849|FD-Score:3.11|P-value:2.33E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:-2.75|P-value:9.43E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:3.23|P-value:1.41E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-4.46|P-value:2.32E-7 ID:SGTC_2053|Compound:5265679|FD-Score:-3.34|P-value:8.15E-5 ID:SGTC_2125|Compound:5246583|FD-Score:4.86|P-value:2.32E-8 ID:SGTC_2126|Compound:5251174|FD-Score:3.12|P-value:2.27E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:-4.35|P-value:4.39E-7 ID:SGTC_2162|Compound:5663267|FD-Score:2.88|P-value:6.13E-4 ID:SGTC_2235|Compound:salicylic acid|FD-Score:-3.06|P-value:2.73E-4 ID:SGTC_2307|Compound:7538926|FD-Score:3.27|P-value:1.16E-4 ID:SGTC_2400|Compound:5203494|FD-Score:-3.33|P-value:8.32E-5 ID:SGTC_2452|Compound:5863136|FD-Score:-2.94|P-value:4.39E-4 ID:SGTC_2487|Compound:5918373|FD-Score:3.01|P-value:3.58E-4 ID:SGTC_2490|Compound:carminic acid|FD-Score:2.88|P-value:6.11E-4 ID:SGTC_2492|Compound:derrusnin|FD-Score:3.68|P-value:1.77E-5 ID:SGTC_2596|Compound:sinensetin|FD-Score:-3.13|P-value:2.04E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:2.96|P-value:4.49E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:-2.87|P-value:5.81E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:3.31|P-value:1.00E-4 ID:SGTC_2691|Compound:st077356|FD-Score:-7.58|P-value:6.04E-18 ID:SGTC_2694|Compound:st077685|FD-Score:-4.32|P-value:5.33E-7 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:4.57|P-value:1.38E-7 ID:SGTC_2701|Compound:st077767|FD-Score:-3.80|P-value:8.57E-6 ID:SGTC_2703|Compound:st077852|FD-Score:3.53|P-value:3.65E-5 ID:SGTC_2704|Compound:st078022|FD-Score:2.88|P-value:6.12E-4 ID:SGTC_2706|Compound:st078239|FD-Score:-3.02|P-value:3.22E-4 ID:SGTC_2715|Compound:st079500|FD-Score:-2.93|P-value:4.57E-4 ID:SGTC_2908|Compound:7930301|FD-Score:-2.92|P-value:4.72E-4 ID:SGTC_2999|Compound:9069765|FD-Score:-2.91|P-value:4.92E-4 ID:SGTC_3001|Compound:9076041|FD-Score:-2.92|P-value:4.90E-4 ID:SGTC_3117|Compound:9124945|FD-Score:-3.24|P-value:1.25E-4 ID:SGTC_3212|Compound:9128307|FD-Score:-2.77|P-value:8.63E-4 ID:SGTC_3213|Compound:9129884|FD-Score:-3.14|P-value:1.89E-4 ID:SGTC_3223|Compound:9129970|FD-Score:2.93|P-value:5.04E-4 ID:SGTC_3251|Compound:9135047|FD-Score:3.33|P-value:9.25E-5 ID:SGTC_3262|Compound:9137218|FD-Score:3.09|P-value:2.59E-4 ID:SGTC_3263|Compound:9137018|FD-Score:-3.46|P-value:4.57E-5 ID:SGTC_3264|Compound:9137442|FD-Score:3.22|P-value:1.45E-4 ID:SGTC_3272|Compound:9137413|FD-Score:-4.18|P-value:1.20E-6 ID:SGTC_3274|Compound:9138298|FD-Score:-3.55|P-value:3.03E-5 ID:SGTC_3329|Compound:9141233|FD-Score:2.82|P-value:7.61E-4

Top fitness defect scores for YJR078W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2125 5246583 4.86 200.0 µM 2.32E-8 tubulin folding & SWR complex 27 5.95E-7
2 SGTC_2697 mebhydrolin 4.57 72.4 µM 1.38E-7 NEO1 52 2.45E-6
3 SGTC_2492 derrusnin 3.68 100.0 µM 1.77E-5 8 1.17E-4
4 SGTC_2703 st077852 3.53 53.4 µM 3.65E-5 36 2.10E-4
5 SGTC_453 enantio-paf c16 3.37 10.0 µM 7.55E-5 200 3.74E-4
6 SGTC_3251 9135047 3.33 49.5 µM 9.25E-5 60S ribosome export 18 4.41E-4
7 SGTC_2687 chenodiol 3.31 100.0 µM 1.00E-4 48 4.69E-4
8 SGTC_2307 7538926 3.27 6.3 µM 1.16E-4 69 5.30E-4
9 SGTC_1310 1188-0297 3.23 994.0 nM 1.41E-4 azole & statin 60 6.19E-4
10 SGTC_3264 9137442 3.22 49.5 µM 1.45E-4 26 6.30E-4
11 SGTC_556 4058-0063 3.20 51.5 µM 1.60E-4 50 6.82E-4
12 SGTC_99 0109-0120 3.12 622.8 µM 2.24E-4 44 8.94E-4
13 SGTC_2126 5251174 3.12 33.9 µM 2.27E-4 81 9.05E-4
14 SGTC_898 1000-0849 3.11 28.3 µM 2.33E-4 28 9.23E-4
15 SGTC_3262 9137218 3.09 49.5 µM 2.59E-4 12 0.00100
16 SGTC_2487 5918373 3.01 44.0 µM 3.58E-4 54 0.00130
17 SGTC_2605 digitonin 2.96 300.0 nM 4.49E-4 83 0.00156
18 SGTC_3223 9129970 2.93 49.5 µM 5.04E-4 63 0.00172
19 SGTC_2490 carminic acid 2.88 95.4 µM 6.11E-4 33 0.00200
20 SGTC_2704 st078022 2.88 71.1 µM 6.12E-4 49 0.00200

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.164 1.12E-21 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.160 1.34E-20 YJR058C APS2 hom Small subunit of the clathrin-associated adaptor complex AP-2, which is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex
0.153 5.46E-19 YDL222C FMP45 hom Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C
0.148 5.66E-18 YIL010W DOT5 hom Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth
0.147 1.22E-17 YFR014C CMK1 hom Calmodulin-dependent protein kinase; may play a role in stress response, many Ca++/calmodulin dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK1 has a paralog, CMK2, that arose from the whole genome duplication
0.142 1.62E-16 YGR136W LSB1 hom Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress
0.140 3.97E-16 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.140 4.24E-16 YFR042W KEG1 het Integral membrane protein of the ER; physically interacts with Kre6p; has a role in the synthesis of beta-1,6-glucan in the cell wall; required for cell viability
0.140 4.34E-16 YOR050C_d YOR050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable
0.136 2.85E-15 YEL063C CAN1 hom Plasma membrane arginine permease; requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance; CAN1 has a paralog, ALP1, that arose from the whole genome duplication
0.131 3.27E-14 YOR301W RAX1 hom Protein involved in bud site selection during bipolar budding; localization requires Rax2p; has similarity to members of the insulin-related peptide superfamily
0.129 6.97E-14 YDR169C STB3 hom Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress
0.125 4.21E-13 YER046W SPO73 hom Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensible for both nuclear divisions during meiosis
0.123 7.13E-13 YDL230W PTP1 hom Phosphotyrosine-specific protein phosphatase that dephosphorylates a broad range of substrates in vivo, including Fpr3p; localized to the cytoplasm and the mitochondria; proposed to be a negative regulator of filamentation
0.121 1.90E-12 YFL048C EMP47 hom Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport