YJR080C / AIM24

Protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays reduced respiratory growth and elevated frequency of mitochondrial genome loss

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR080C / AIM24

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:-3.14|P-value:5.65E-4 ID:SGTC_33|Compound:0986-0033|FD-Score:3.13|P-value:3.37E-4 ID:SGTC_88|Compound:0180-0332|FD-Score:3.48|P-value:8.45E-5 ID:SGTC_106|Compound:0092-0003|FD-Score:2.85|P-value:9.83E-4 ID:SGTC_133|Compound:0724-0033|FD-Score:4.16|P-value:3.54E-6 ID:SGTC_139|Compound:0099-0334|FD-Score:-3.19|P-value:4.81E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:-3.32|P-value:2.87E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:3.37|P-value:1.34E-4 ID:SGTC_189|Compound:3970-0742|FD-Score:-3.18|P-value:4.92E-4 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:3.66|P-value:3.84E-5 ID:SGTC_257|Compound:daunorubicin|FD-Score:-3.63|P-value:8.04E-5 ID:SGTC_270|Compound:tamoxifen|FD-Score:4.49|P-value:6.53E-7 ID:SGTC_362|Compound:0310-0100|FD-Score:3.50|P-value:7.59E-5 ID:SGTC_368|Compound:fentichlor|FD-Score:4.01|P-value:7.57E-6 ID:SGTC_581|Compound:0958-0271|FD-Score:3.65|P-value:3.94E-5 ID:SGTC_751|Compound:0833-0568|FD-Score:3.28|P-value:1.89E-4 ID:SGTC_784|Compound:4579-0127|FD-Score:3.24|P-value:2.20E-4 ID:SGTC_806|Compound:3966-4455|FD-Score:3.21|P-value:2.47E-4 ID:SGTC_854|Compound:0422-0053|FD-Score:-3.11|P-value:6.42E-4 ID:SGTC_890|Compound:0929-0006|FD-Score:-3.32|P-value:2.93E-4 ID:SGTC_903|Compound:1134-0042|FD-Score:-3.25|P-value:3.72E-4 ID:SGTC_1004|Compound:4084-0029|FD-Score:4.54|P-value:4.95E-7 ID:SGTC_1072|Compound:oxiconazole|FD-Score:3.17|P-value:2.93E-4 ID:SGTC_1182|Compound:1222-0449|FD-Score:-3.25|P-value:3.85E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:7.56|P-value:3.05E-16 ID:SGTC_1212|Compound:0520-0165|FD-Score:-3.20|P-value:4.58E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:6.26|P-value:9.40E-12 ID:SGTC_1248|Compound:0469-0687|FD-Score:2.88|P-value:8.82E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:3.33|P-value:1.54E-4 ID:SGTC_1293|Compound:1000-1278|FD-Score:3.20|P-value:2.64E-4 ID:SGTC_1391|Compound:3442-0225|FD-Score:-3.96|P-value:1.87E-5 ID:SGTC_1766|Compound:st045414|FD-Score:2.99|P-value:5.77E-4 ID:SGTC_1770|Compound:st043884|FD-Score:3.71|P-value:2.97E-5 ID:SGTC_1908|Compound:st060353|FD-Score:3.98|P-value:8.77E-6 ID:SGTC_2018|Compound:5133068|FD-Score:-3.32|P-value:2.89E-4 ID:SGTC_2019|Compound:4016004|FD-Score:2.90|P-value:8.09E-4 ID:SGTC_2024|Compound:5144227|FD-Score:3.26|P-value:2.01E-4 ID:SGTC_2041|Compound:5107442|FD-Score:3.66|P-value:3.73E-5 ID:SGTC_2044|Compound:5102272|FD-Score:3.06|P-value:4.50E-4 ID:SGTC_2263|Compound:7948595|FD-Score:3.84|P-value:1.66E-5 ID:SGTC_2376|Compound:9072922|FD-Score:3.47|P-value:8.71E-5 ID:SGTC_2442|Compound:5158906|FD-Score:2.87|P-value:9.20E-4 ID:SGTC_2547|Compound:epiafzelechin trimethyl ether|FD-Score:2.87|P-value:9.13E-4 ID:SGTC_2550|Compound:chrysin dimethyl ether|FD-Score:2.98|P-value:5.96E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:3.19|P-value:2.69E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:3.77|P-value:2.26E-5 ID:SGTC_2625|Compound:euphol|FD-Score:2.86|P-value:9.38E-4 ID:SGTC_2834|Compound:9001755|FD-Score:3.79|P-value:2.10E-5 ID:SGTC_2847|Compound:9005661|FD-Score:3.00|P-value:5.62E-4 ID:SGTC_3056|Compound:9094900|FD-Score:4.35|P-value:1.36E-6 ID:SGTC_7|Compound:0192-1582|FD-Score:-3.14|P-value:5.65E-4 ID:SGTC_33|Compound:0986-0033|FD-Score:3.13|P-value:3.37E-4 ID:SGTC_88|Compound:0180-0332|FD-Score:3.48|P-value:8.45E-5 ID:SGTC_106|Compound:0092-0003|FD-Score:2.85|P-value:9.83E-4 ID:SGTC_133|Compound:0724-0033|FD-Score:4.16|P-value:3.54E-6 ID:SGTC_139|Compound:0099-0334|FD-Score:-3.19|P-value:4.81E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:-3.32|P-value:2.87E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:3.37|P-value:1.34E-4 ID:SGTC_189|Compound:3970-0742|FD-Score:-3.18|P-value:4.92E-4 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:3.66|P-value:3.84E-5 ID:SGTC_257|Compound:daunorubicin|FD-Score:-3.63|P-value:8.04E-5 ID:SGTC_270|Compound:tamoxifen|FD-Score:4.49|P-value:6.53E-7 ID:SGTC_362|Compound:0310-0100|FD-Score:3.50|P-value:7.59E-5 ID:SGTC_368|Compound:fentichlor|FD-Score:4.01|P-value:7.57E-6 ID:SGTC_581|Compound:0958-0271|FD-Score:3.65|P-value:3.94E-5 ID:SGTC_751|Compound:0833-0568|FD-Score:3.28|P-value:1.89E-4 ID:SGTC_784|Compound:4579-0127|FD-Score:3.24|P-value:2.20E-4 ID:SGTC_806|Compound:3966-4455|FD-Score:3.21|P-value:2.47E-4 ID:SGTC_854|Compound:0422-0053|FD-Score:-3.11|P-value:6.42E-4 ID:SGTC_890|Compound:0929-0006|FD-Score:-3.32|P-value:2.93E-4 ID:SGTC_903|Compound:1134-0042|FD-Score:-3.25|P-value:3.72E-4 ID:SGTC_1004|Compound:4084-0029|FD-Score:4.54|P-value:4.95E-7 ID:SGTC_1072|Compound:oxiconazole|FD-Score:3.17|P-value:2.93E-4 ID:SGTC_1182|Compound:1222-0449|FD-Score:-3.25|P-value:3.85E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:7.56|P-value:3.05E-16 ID:SGTC_1212|Compound:0520-0165|FD-Score:-3.20|P-value:4.58E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:6.26|P-value:9.40E-12 ID:SGTC_1248|Compound:0469-0687|FD-Score:2.88|P-value:8.82E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:3.33|P-value:1.54E-4 ID:SGTC_1293|Compound:1000-1278|FD-Score:3.20|P-value:2.64E-4 ID:SGTC_1391|Compound:3442-0225|FD-Score:-3.96|P-value:1.87E-5 ID:SGTC_1766|Compound:st045414|FD-Score:2.99|P-value:5.77E-4 ID:SGTC_1770|Compound:st043884|FD-Score:3.71|P-value:2.97E-5 ID:SGTC_1908|Compound:st060353|FD-Score:3.98|P-value:8.77E-6 ID:SGTC_2018|Compound:5133068|FD-Score:-3.32|P-value:2.89E-4 ID:SGTC_2019|Compound:4016004|FD-Score:2.90|P-value:8.09E-4 ID:SGTC_2024|Compound:5144227|FD-Score:3.26|P-value:2.01E-4 ID:SGTC_2041|Compound:5107442|FD-Score:3.66|P-value:3.73E-5 ID:SGTC_2044|Compound:5102272|FD-Score:3.06|P-value:4.50E-4 ID:SGTC_2263|Compound:7948595|FD-Score:3.84|P-value:1.66E-5 ID:SGTC_2376|Compound:9072922|FD-Score:3.47|P-value:8.71E-5 ID:SGTC_2442|Compound:5158906|FD-Score:2.87|P-value:9.20E-4 ID:SGTC_2547|Compound:epiafzelechin trimethyl ether|FD-Score:2.87|P-value:9.13E-4 ID:SGTC_2550|Compound:chrysin dimethyl ether|FD-Score:2.98|P-value:5.96E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:3.19|P-value:2.69E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:3.77|P-value:2.26E-5 ID:SGTC_2625|Compound:euphol|FD-Score:2.86|P-value:9.38E-4 ID:SGTC_2834|Compound:9001755|FD-Score:3.79|P-value:2.10E-5 ID:SGTC_2847|Compound:9005661|FD-Score:3.00|P-value:5.62E-4 ID:SGTC_3056|Compound:9094900|FD-Score:4.35|P-value:1.36E-6

Top fitness defect scores for YJR080C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1206 3978-0017 7.56 132.0 µM 3.05E-16 ERG2 6 2.08E-14
2 SGTC_1246 0422-0085 6.26 105.0 µM 9.40E-12 4 1.91E-10
3 SGTC_1004 4084-0029 4.54 199.0 µM 4.95E-7 7 2.77E-6
4 SGTC_270 tamoxifen 4.49 5.5 µM 6.53E-7 NEO1 18 3.53E-6
5 SGTC_3056 9094900 4.35 49.5 µM 1.36E-6 14 6.72E-6
6 SGTC_133 0724-0033 4.16 378.9 µM 3.54E-6 23 1.57E-5
7 SGTC_368 fentichlor 4.01 4.6 µM 7.57E-6 24 3.06E-5
8 SGTC_1908 st060353 3.98 56.5 µM 8.77E-6 RPP1 & pyrimidine depletion 33 3.48E-5
9 SGTC_2263 7948595 3.84 193.3 µM 1.66E-5 7 6.08E-5
10 SGTC_2834 9001755 3.79 58.4 µM 2.10E-5 43 7.49E-5
11 SGTC_2605 digitonin 3.77 300.0 nM 2.26E-5 36 8.01E-5
12 SGTC_1770 st043884 3.71 66.3 µM 2.97E-5 16 1.02E-4
13 SGTC_2041 5107442 3.66 45.3 µM 3.73E-5 RSC complex & mRNA processing 33 1.24E-4
14 SGTC_243 5hr heat shock (37°C) + splitomicin 3.66 1.0 µM 3.84E-5 heat shock/prefoldin 61 1.27E-4
15 SGTC_581 0958-0271 3.65 211.0 µM 3.94E-5 61 1.31E-4
16 SGTC_362 0310-0100 3.50 9.0 µM 7.59E-5 RPP1 & pyrimidine depletion 47 2.32E-4
17 SGTC_88 0180-0332 3.48 8.7 µM 8.45E-5 36 2.55E-4
18 SGTC_2376 9072922 3.47 81.3 µM 8.71E-5 49 2.62E-4
19 SGTC_142 0335-0849 3.37 62.7 µM 1.34E-4 ubiquinone biosynthesis & proteasome 167 3.82E-4
20 SGTC_1259 0671-0132 3.33 43.0 µM 1.54E-4 48 4.34E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.175 2.00E-24 YNL129W NRK1 hom Nicotinamide riboside kinase, catalyzes the phosphorylation of nicotinamide riboside and nicotinic acid riboside in salvage pathways for NAD+ biosynthesis
0.110 1.69E-10 YJL200C ACO2 hom Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol
0.109 2.76E-10 YDL204W RTN2 hom Reticulon protein; stabilizes membrane curvature; involved in nuclear pore assembly and maintenance of tubular ER morphology; interacts with exocyst subunit Sec6p, Yip3p, and Sbh1p; much less abundant than Rtn1p; rtn1 rtn2 yop1 triple mutant lacks tubular ER; member of RTNLA (reticulon-like A) subfamily; protein increases in abundance and relocalizes to plasma membrane upon DNA replication stress; RTN2 has a paralog, RTN1, that arose from the whole genome duplication
0.108 2.95E-10 YBR264C YPT10 hom Rab family GTP-binding protein that contains the PEST signal sequence specific for proteolytic enzymes; may be involved in vesicular transport; overexpression leads to accumulation of Golgi-like cisternae with budding vesicles
0.103 1.98E-9 YMR213W CEF1 het Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association, evolutionarily conserved and homologous to S. pombe Cdc5p
0.103 2.31E-9 YJL104W PAM16 het Constituent of the import motor (PAM complex) component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); forms a 1:1 subcomplex with Pam18p and inhibits its cochaperone activity; contains a J-like domain
0.094 4.81E-8 YER049W TPA1 hom Poly(rA)-binding protein involved in translation termination efficiency, mRNA poly(A) tail length and mRNA stability; interacts with Sup45p (eRF1), Sup35p (eRF3) and Pab1p; similar to prolyl 4-hydroxylases; binds Fe(III) and 2-oxoglutarate
0.094 5.54E-8 YMR127C SAS2 hom Histone acetyltransferase (HAT) catalytic subunit of the SAS complex (Sas2p-Sas4p-Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; member of the MYSTacetyltransferase family
0.092 8.69E-8 YHR061C GIC1 hom Protein involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain; relocalizes from bud neck to nucleus upon DNA replication stress
0.092 8.73E-8 YGL074C_d YGL074C_d het Dubious open reading frame unlikely to encode a functional protein; overlaps 5' end of essential HSF1 gene encoding heat shock transcription factor
0.089 2.09E-7 YGL110C CUE3 hom Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination
0.083 1.52E-6 YPL178W CBC2 hom Small subunit of the heterodimeric cap binding complex that also contains Sto1p, component of the spliceosomal commitment complex; interacts with Npl3p, possibly to package mRNA for export from the nucleus; contains an RNA-binding motif
0.082 1.94E-6 YOR125C CAT5 hom Protein required for ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; required for gluconeogenic gene activation
0.081 2.99E-6 YIR014W_p YIR014W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; YIR014W is a non-essential gene
0.080 3.71E-6 YOR052C YOR052C hom Nuclear protein of unknown function; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner and by weak acid; transcriptionally regulated by Rpn4p along with proteasome subunit genes; putative ortholog of human AIRAP, which stimulates proteasome activity in response to arsenic; protein abundance increases in response to DNA replication stress