YJR087W_d

Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified genes STE18 and ECM2

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR087W / YJR087W

Click on Significant Values for Screen Details ID:SGTC_152|Compound:4469-0003|FD-Score:3.25|P-value:3.74E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:4.98|P-value:1.14E-7 ID:SGTC_320|Compound:4092-0846|FD-Score:3.71|P-value:5.86E-5 ID:SGTC_380|Compound:3970-0968|FD-Score:3.08|P-value:7.00E-4 ID:SGTC_510|Compound:ag-490|FD-Score:3.00|P-value:9.31E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:8.04|P-value:3.44E-17 ID:SGTC_717|Compound:1532-0246|FD-Score:-3.48|P-value:1.42E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:3.00|P-value:9.18E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:3.70|P-value:6.03E-5 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:3.54|P-value:1.18E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.96|P-value:1.88E-5 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.75|P-value:4.87E-5 ID:SGTC_1285|Compound:0929-0069|FD-Score:3.02|P-value:8.53E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.18|P-value:4.78E-4 ID:SGTC_1373|Compound:2887-0003|FD-Score:3.73|P-value:5.45E-5 ID:SGTC_1615|Compound:st002656|FD-Score:-3.02|P-value:8.17E-4 ID:SGTC_1712|Compound:st032288|FD-Score:3.63|P-value:8.08E-5 ID:SGTC_1725|Compound:st036284|FD-Score:5.05|P-value:7.77E-8 ID:SGTC_1750|Compound:st081859|FD-Score:6.40|P-value:1.44E-11 ID:SGTC_1842|Compound:st055362|FD-Score:2.99|P-value:9.71E-4 ID:SGTC_1973|Compound:st070275|FD-Score:3.62|P-value:8.57E-5 ID:SGTC_2021|Compound:4019055|FD-Score:5.69|P-value:1.74E-9 ID:SGTC_2024|Compound:5144227|FD-Score:-3.61|P-value:8.56E-5 ID:SGTC_2076|Compound:5212012|FD-Score:3.14|P-value:5.61E-4 ID:SGTC_2081|Compound:5214970|FD-Score:3.32|P-value:2.83E-4 ID:SGTC_2140|Compound:5586273|FD-Score:-3.05|P-value:7.37E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:4.65|P-value:6.89E-7 ID:SGTC_2521|Compound:angolensin|FD-Score:3.16|P-value:5.21E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.70|P-value:6.11E-5 ID:SGTC_2963|Compound:9082507|FD-Score:3.69|P-value:6.46E-5 ID:SGTC_3312|Compound:9133330|FD-Score:3.10|P-value:6.51E-4 ID:SGTC_3333|Compound:9141820|FD-Score:-3.27|P-value:3.24E-4 ID:SGTC_3347|Compound:9188721|FD-Score:3.01|P-value:8.82E-4 ID:SGTC_152|Compound:4469-0003|FD-Score:3.25|P-value:3.74E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:4.98|P-value:1.14E-7 ID:SGTC_320|Compound:4092-0846|FD-Score:3.71|P-value:5.86E-5 ID:SGTC_380|Compound:3970-0968|FD-Score:3.08|P-value:7.00E-4 ID:SGTC_510|Compound:ag-490|FD-Score:3.00|P-value:9.31E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:8.04|P-value:3.44E-17 ID:SGTC_717|Compound:1532-0246|FD-Score:-3.48|P-value:1.42E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:3.00|P-value:9.18E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:3.70|P-value:6.03E-5 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:3.54|P-value:1.18E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.96|P-value:1.88E-5 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.75|P-value:4.87E-5 ID:SGTC_1285|Compound:0929-0069|FD-Score:3.02|P-value:8.53E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.18|P-value:4.78E-4 ID:SGTC_1373|Compound:2887-0003|FD-Score:3.73|P-value:5.45E-5 ID:SGTC_1615|Compound:st002656|FD-Score:-3.02|P-value:8.17E-4 ID:SGTC_1712|Compound:st032288|FD-Score:3.63|P-value:8.08E-5 ID:SGTC_1725|Compound:st036284|FD-Score:5.05|P-value:7.77E-8 ID:SGTC_1750|Compound:st081859|FD-Score:6.40|P-value:1.44E-11 ID:SGTC_1842|Compound:st055362|FD-Score:2.99|P-value:9.71E-4 ID:SGTC_1973|Compound:st070275|FD-Score:3.62|P-value:8.57E-5 ID:SGTC_2021|Compound:4019055|FD-Score:5.69|P-value:1.74E-9 ID:SGTC_2024|Compound:5144227|FD-Score:-3.61|P-value:8.56E-5 ID:SGTC_2076|Compound:5212012|FD-Score:3.14|P-value:5.61E-4 ID:SGTC_2081|Compound:5214970|FD-Score:3.32|P-value:2.83E-4 ID:SGTC_2140|Compound:5586273|FD-Score:-3.05|P-value:7.37E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:4.65|P-value:6.89E-7 ID:SGTC_2521|Compound:angolensin|FD-Score:3.16|P-value:5.21E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.70|P-value:6.11E-5 ID:SGTC_2963|Compound:9082507|FD-Score:3.69|P-value:6.46E-5 ID:SGTC_3312|Compound:9133330|FD-Score:3.10|P-value:6.51E-4 ID:SGTC_3333|Compound:9141820|FD-Score:-3.27|P-value:3.24E-4 ID:SGTC_3347|Compound:9188721|FD-Score:3.01|P-value:8.82E-4

Top fitness defect scores for YJR087W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_562 3772-2733 8.04 112.0 µM 3.44E-17 ERG2 15 4.67E-16
2 SGTC_1750 st081859 6.40 2.4 µM 1.44E-11 endomembrane recycling 98 7.59E-11
3 SGTC_2021 4019055 5.69 173.0 µM 1.74E-9 endomembrane recycling 47 6.47E-9
4 SGTC_1725 st036284 5.05 20.6 µM 7.77E-8 11 2.20E-7
5 SGTC_315 k915-0449 4.98 187.0 µM 1.14E-7 29 3.13E-7
6 SGTC_2514 salinomycin 4.65 42.7 µM 6.89E-7 25 1.67E-6
7 SGTC_1212 0520-0165 3.75 585.0 µM 4.87E-5 38 8.71E-5
8 SGTC_1373 2887-0003 3.73 58.5 µM 5.45E-5 Golgi 24 9.68E-5
9 SGTC_320 4092-0846 3.71 5.3 µM 5.86E-5 ergosterol depletion effects on membrane 59 1.04E-4
10 SGTC_852 0418-0143 3.70 439.0 µM 6.03E-5 calcium & mitochondrial duress 80 1.06E-4
11 SGTC_2690 usnic acid 3.70 100.0 µM 6.11E-5 33 1.08E-4
12 SGTC_2963 9082507 3.69 9.0 µM 6.46E-5 32 1.13E-4
13 SGTC_1712 st032288 3.63 53.4 µM 8.08E-5 calcium & mitochondrial duress 214 1.39E-4
14 SGTC_1973 st070275 3.62 50.2 µM 8.57E-5 20 1.47E-4
15 SGTC_915 methyl methanesulfonate (MMS) 3.54 110.0 mM 1.18E-4 DNA damage response 58 1.98E-4
16 SGTC_2081 5214970 3.32 32.3 µM 2.83E-4 46 4.47E-4
17 SGTC_152 4469-0003 3.25 551.2 µM 3.74E-4 43 5.80E-4
18 SGTC_1360 1598-0022 3.18 39.8 µM 4.78E-4 ERG2 71 7.30E-4
19 SGTC_2521 angolensin 3.16 13.4 µM 5.21E-4 33 7.91E-4
20 SGTC_2076 5212012 3.14 200.0 µM 5.61E-4 18 8.47E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.346 5.14E-95 YJR088C EMC2 hom Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm Y57G7A.10/EMC-2, fly CG17556, human TTC35
0.295 2.24E-68 YLL014W EMC6 hom Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm F33D4.7/EMC-6, fly CG11781, human TMEM93
0.267 7.16E-56 YMR126C_p DLT1_p hom Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA)
0.265 6.00E-55 YKL207W EMC3 hom Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; required for respiratory growth; null mutant displays induction of the unfolded protein response; homologous to worm Y62E10A.10/EMC-3, fly CG6750, human TMEM111
0.247 5.27E-48 YMR007W_d YMR007W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.235 3.47E-43 YGL231C EMC4 hom Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm ZK616.6/EMC-4, fly CG11137, human TMM85
0.232 3.28E-42 YKL051W SFK1 hom Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
0.205 4.16E-33 YNL149C PGA2 het Essential protein required for maturation of Gas1p and Pho8p; involved in protein trafficking; GFP-fusion protein localizes to the ER and YFP-fusion protein to the nuclear envelope-ER network; null mutants have a cell separation defect
0.203 1.21E-32 YCL046W_d YCL046W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YCL045C
0.202 2.50E-32 YCL045C EMC1 hom Member of conserved endoplasmic reticulum membrane complex; involved in efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; interacts with Gal80p; homologous to worm H17B01.4/EMC-1, fly CG2943, and human KIAA0090
0.198 4.48E-31 YPR029C APL4 hom Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport
0.197 9.41E-31 YPR153W YPR153W hom Putative protein of unknown function
0.192 4.49E-29 YGL203C KEX1 hom Protease involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteins
0.180 6.19E-26 YMR230W-A_p YMR230W-A_p hom Putative protein of unknown function
0.177 5.54E-25 YDL138W RGT2 hom Plasma membrane high glucose sensor that regulates glucose transport; contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; RGT2 has a paralog, SNF3, that arose from the whole genome duplication