HIPHOP chemogenomics database

YJR091C / JSN1

Member of the Puf family of RNA-binding proteins, interacts with mRNAs encoding membrane-associated proteins; involved in localizing the Arp2/3 complex to mitochondria; overexpression causes increased sensitivity to benomyl

Zygosity: Homozygous strain

fixedexpanded
Profile for YJR091C / JSN1

Click on Significant Values for Screen Details

Top fitness defect scores for YJR091C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2582	agaric acid	9.98	100.0 µM	7.45E-30	redox potentiating	62	9.28E-24
2	SGTC_3289	9119912	4.39	71.4 µM	3.25E-7		8	5.59E-6
3	SGTC_397	arbidol	4.17	50.0 µM	1.13E-6	cell wall	16	1.50E-5
4	SGTC_3141	9094609	4.12	49.5 µM	1.56E-6	iron homeostasis	34	1.93E-5
5	SGTC_64	000l-0018	4.06	272.1 µM	2.17E-6	ubiquinone biosynthesis & proteasome	144	2.50E-5
6	SGTC_75	0159-0059	3.88	199.0 µM	5.65E-6	fatty acid desaturase (OLE1)	21	5.32E-5
7	SGTC_1946	st076057	3.64	65.1 µM	1.85E-5		8	1.36E-4
8	SGTC_67	0335-0847	3.47	266.0 µM	4.24E-5	ubiquinone biosynthesis & proteasome	144	2.62E-4
9	SGTC_927	2425-1185	3.28	123.0 µM	1.00E-4		53	5.17E-4
10	SGTC_2341	7987486	3.27	176.7 µM	1.07E-4		41	5.45E-4
11	SGTC_103	0844-0104	3.25	51.8 µM	1.15E-4	ERAD & cell cycle	185	5.79E-4
12	SGTC_2922	7999257	3.21	32.5 µM	1.36E-4		27	6.61E-4
13	SGTC_1006	4099-6547	3.20	255.0 µM	1.44E-4		53	6.92E-4
14	SGTC_777	1315-0167	3.14	517.0 µM	1.82E-4	Golgi	55	8.31E-4
15	SGTC_2584	androsterone	3.14	48.7 µM	1.83E-4	cell wall	198	8.35E-4
16	SGTC_989	1501-0895	3.05	10.3 µM	2.71E-4		28	0.00114
17	SGTC_1526	st051518	3.04	75.0 µM	2.87E-4		54	0.00119
18	SGTC_2632	3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone	3.02	100.0 µM	3.10E-4		51	0.00127
19	SGTC_724	3910-0327	2.96	137.0 µM	3.89E-4	ERG2	63	0.00152
20	SGTC_1348	1493-0373	2.96	93.8 µM	3.90E-4		55	0.00152

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.358	1.38E-101	YNL106C	INP52	hom	Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.312	1.37E-76	YNL105W_d	RRT16_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene INP52; identified in a screen for mutants with decreased levels of rDNA transcription
0.308	3.57E-74	YNL166C	BNI5	hom	Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.301	3.36E-71	YKL130C	SHE2	hom	RNA-binding protein that binds specific mRNAs and interacts with She3p; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud
0.271	1.21E-57	YML052W	SUR7	hom	Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants
0.256	2.84E-51	YML103C	NUP188	hom	Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.250	5.60E-49	YNL027W	CRZ1	hom	Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.241	1.21E-45	YBL017C	PEP1	hom	Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments
0.232	3.56E-42	YPL232W	SSO1	hom	Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p
0.229	5.63E-41	YOR050C_d	YOR050C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable
0.219	1.12E-37	YEL007W	MIT1	hom	Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1
0.218	1.62E-37	YMR109W	MYO5	hom	One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization
0.216	9.52E-37	YIL056W	VHR1	hom	Transcriptional activator; required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations; VHR1 has a paralog, VHR2, that arose from the whole genome duplication
0.211	6.52E-35	YFR008W	FAR7	hom	Protein involved in recovery from pheromone-induced cell cycle arrest; acts in a Far1p-independent pathway; interacts with Far3p, Far8p, Far9p, Far10p, and Far11p; protein abundance increases in response to DNA replication stress
0.209	4.51E-34	YPR180W	AOS1	het	Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability