YJR091C / JSN1

Member of the Puf family of RNA-binding proteins, interacts with mRNAs encoding membrane-associated proteins; involved in localizing the Arp2/3 complex to mitochondria; overexpression causes increased sensitivity to benomyl

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR091C / JSN1

Click on Significant Values for Screen Details ID:SGTC_43|Compound:0570-0105|FD-Score:-3.64|P-value:2.04E-5 ID:SGTC_64|Compound:000l-0018|FD-Score:4.06|P-value:2.17E-6 ID:SGTC_67|Compound:0335-0847|FD-Score:3.47|P-value:4.24E-5 ID:SGTC_75|Compound:0159-0059|FD-Score:3.88|P-value:5.65E-6 ID:SGTC_76|Compound:0433-0009|FD-Score:2.84|P-value:6.46E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:3.25|P-value:1.15E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:-3.11|P-value:2.27E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:-3.04|P-value:3.15E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:-4.21|P-value:1.02E-6 ID:SGTC_167|Compound:3672-0051|FD-Score:-5.05|P-value:6.16E-9 ID:SGTC_168|Compound:3970-0862|FD-Score:-2.92|P-value:5.02E-4 ID:SGTC_302|Compound:1094-0063|FD-Score:2.75|P-value:9.13E-4 ID:SGTC_397|Compound:arbidol|FD-Score:4.17|P-value:1.13E-6 ID:SGTC_413|Compound:propylparaben|FD-Score:-2.83|P-value:7.18E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-7.68|P-value:2.23E-18 ID:SGTC_626|Compound:0214-0009|FD-Score:2.89|P-value:5.31E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:-3.23|P-value:1.38E-4 ID:SGTC_724|Compound:3910-0327|FD-Score:2.96|P-value:3.89E-4 ID:SGTC_777|Compound:1315-0167|FD-Score:3.14|P-value:1.82E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:-3.76|P-value:1.13E-5 ID:SGTC_927|Compound:2425-1185|FD-Score:3.28|P-value:1.00E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:-3.26|P-value:1.21E-4 ID:SGTC_989|Compound:1501-0895|FD-Score:3.05|P-value:2.71E-4 ID:SGTC_992|Compound:3909-8734|FD-Score:-2.95|P-value:4.42E-4 ID:SGTC_1006|Compound:4099-6547|FD-Score:3.20|P-value:1.44E-4 ID:SGTC_1235|Compound:benzylparaben|FD-Score:2.93|P-value:4.47E-4 ID:SGTC_1348|Compound:1493-0373|FD-Score:2.96|P-value:3.90E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:2.90|P-value:5.05E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-5.07|P-value:5.31E-9 ID:SGTC_1463|Compound:k081-0032|FD-Score:-5.33|P-value:9.19E-10 ID:SGTC_1526|Compound:st051518|FD-Score:3.04|P-value:2.87E-4 ID:SGTC_1753|Compound:st043925|FD-Score:2.78|P-value:8.00E-4 ID:SGTC_1944|Compound:st076371|FD-Score:-3.55|P-value:3.24E-5 ID:SGTC_1945|Compound:st075991|FD-Score:-3.13|P-value:2.07E-4 ID:SGTC_1946|Compound:st076057|FD-Score:3.64|P-value:1.85E-5 ID:SGTC_1947|Compound:st076332|FD-Score:-2.94|P-value:4.62E-4 ID:SGTC_1949|Compound:st076024|FD-Score:-4.07|P-value:2.22E-6 ID:SGTC_2341|Compound:7987486|FD-Score:3.27|P-value:1.07E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-2.95|P-value:4.43E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:9.98|P-value:7.45E-30 ID:SGTC_2584|Compound:androsterone|FD-Score:3.14|P-value:1.83E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-2.79|P-value:8.47E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:3.02|P-value:3.10E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:2.87|P-value:5.57E-4 ID:SGTC_2662|Compound:daunorubicin|FD-Score:-4.37|P-value:4.17E-7 ID:SGTC_2756|Compound:carbadox|FD-Score:2.79|P-value:7.68E-4 ID:SGTC_2908|Compound:7930301|FD-Score:-2.92|P-value:5.12E-4 ID:SGTC_2921|Compound:7974240|FD-Score:-3.05|P-value:2.95E-4 ID:SGTC_2922|Compound:7999257|FD-Score:3.21|P-value:1.36E-4 ID:SGTC_3031|Compound:9088762|FD-Score:-2.80|P-value:8.02E-4 ID:SGTC_3141|Compound:9094609|FD-Score:4.12|P-value:1.56E-6 ID:SGTC_3208|Compound:9114115|FD-Score:-3.76|P-value:1.16E-5 ID:SGTC_3289|Compound:9119912|FD-Score:4.39|P-value:3.25E-7 ID:SGTC_3294|Compound:9122953|FD-Score:-3.77|P-value:1.07E-5 ID:SGTC_3317|Compound:9138495|FD-Score:-2.78|P-value:8.66E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:-3.64|P-value:2.04E-5 ID:SGTC_64|Compound:000l-0018|FD-Score:4.06|P-value:2.17E-6 ID:SGTC_67|Compound:0335-0847|FD-Score:3.47|P-value:4.24E-5 ID:SGTC_75|Compound:0159-0059|FD-Score:3.88|P-value:5.65E-6 ID:SGTC_76|Compound:0433-0009|FD-Score:2.84|P-value:6.46E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:3.25|P-value:1.15E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:-3.11|P-value:2.27E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:-3.04|P-value:3.15E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:-4.21|P-value:1.02E-6 ID:SGTC_167|Compound:3672-0051|FD-Score:-5.05|P-value:6.16E-9 ID:SGTC_168|Compound:3970-0862|FD-Score:-2.92|P-value:5.02E-4 ID:SGTC_302|Compound:1094-0063|FD-Score:2.75|P-value:9.13E-4 ID:SGTC_397|Compound:arbidol|FD-Score:4.17|P-value:1.13E-6 ID:SGTC_413|Compound:propylparaben|FD-Score:-2.83|P-value:7.18E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-7.68|P-value:2.23E-18 ID:SGTC_626|Compound:0214-0009|FD-Score:2.89|P-value:5.31E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:-3.23|P-value:1.38E-4 ID:SGTC_724|Compound:3910-0327|FD-Score:2.96|P-value:3.89E-4 ID:SGTC_777|Compound:1315-0167|FD-Score:3.14|P-value:1.82E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:-3.76|P-value:1.13E-5 ID:SGTC_927|Compound:2425-1185|FD-Score:3.28|P-value:1.00E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:-3.26|P-value:1.21E-4 ID:SGTC_989|Compound:1501-0895|FD-Score:3.05|P-value:2.71E-4 ID:SGTC_992|Compound:3909-8734|FD-Score:-2.95|P-value:4.42E-4 ID:SGTC_1006|Compound:4099-6547|FD-Score:3.20|P-value:1.44E-4 ID:SGTC_1235|Compound:benzylparaben|FD-Score:2.93|P-value:4.47E-4 ID:SGTC_1348|Compound:1493-0373|FD-Score:2.96|P-value:3.90E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:2.90|P-value:5.05E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-5.07|P-value:5.31E-9 ID:SGTC_1463|Compound:k081-0032|FD-Score:-5.33|P-value:9.19E-10 ID:SGTC_1526|Compound:st051518|FD-Score:3.04|P-value:2.87E-4 ID:SGTC_1753|Compound:st043925|FD-Score:2.78|P-value:8.00E-4 ID:SGTC_1944|Compound:st076371|FD-Score:-3.55|P-value:3.24E-5 ID:SGTC_1945|Compound:st075991|FD-Score:-3.13|P-value:2.07E-4 ID:SGTC_1946|Compound:st076057|FD-Score:3.64|P-value:1.85E-5 ID:SGTC_1947|Compound:st076332|FD-Score:-2.94|P-value:4.62E-4 ID:SGTC_1949|Compound:st076024|FD-Score:-4.07|P-value:2.22E-6 ID:SGTC_2341|Compound:7987486|FD-Score:3.27|P-value:1.07E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-2.95|P-value:4.43E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:9.98|P-value:7.45E-30 ID:SGTC_2584|Compound:androsterone|FD-Score:3.14|P-value:1.83E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-2.79|P-value:8.47E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:3.02|P-value:3.10E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:2.87|P-value:5.57E-4 ID:SGTC_2662|Compound:daunorubicin|FD-Score:-4.37|P-value:4.17E-7 ID:SGTC_2756|Compound:carbadox|FD-Score:2.79|P-value:7.68E-4 ID:SGTC_2908|Compound:7930301|FD-Score:-2.92|P-value:5.12E-4 ID:SGTC_2921|Compound:7974240|FD-Score:-3.05|P-value:2.95E-4 ID:SGTC_2922|Compound:7999257|FD-Score:3.21|P-value:1.36E-4 ID:SGTC_3031|Compound:9088762|FD-Score:-2.80|P-value:8.02E-4 ID:SGTC_3141|Compound:9094609|FD-Score:4.12|P-value:1.56E-6 ID:SGTC_3208|Compound:9114115|FD-Score:-3.76|P-value:1.16E-5 ID:SGTC_3289|Compound:9119912|FD-Score:4.39|P-value:3.25E-7 ID:SGTC_3294|Compound:9122953|FD-Score:-3.77|P-value:1.07E-5 ID:SGTC_3317|Compound:9138495|FD-Score:-2.78|P-value:8.66E-4

Top fitness defect scores for YJR091C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2582 agaric acid 9.98 100.0 µM 7.45E-30 redox potentiating 62 9.28E-24
2 SGTC_3289 9119912 4.39 71.4 µM 3.25E-7 8 5.59E-6
3 SGTC_397 arbidol 4.17 50.0 µM 1.13E-6 cell wall 16 1.50E-5
4 SGTC_3141 9094609 4.12 49.5 µM 1.56E-6 iron homeostasis 34 1.93E-5
5 SGTC_64 000l-0018 4.06 272.1 µM 2.17E-6 ubiquinone biosynthesis & proteasome 144 2.50E-5
6 SGTC_75 0159-0059 3.88 199.0 µM 5.65E-6 fatty acid desaturase (OLE1) 21 5.32E-5
7 SGTC_1946 st076057 3.64 65.1 µM 1.85E-5 8 1.36E-4
8 SGTC_67 0335-0847 3.47 266.0 µM 4.24E-5 ubiquinone biosynthesis & proteasome 144 2.62E-4
9 SGTC_927 2425-1185 3.28 123.0 µM 1.00E-4 53 5.17E-4
10 SGTC_2341 7987486 3.27 176.7 µM 1.07E-4 41 5.45E-4
11 SGTC_103 0844-0104 3.25 51.8 µM 1.15E-4 ERAD & cell cycle 185 5.79E-4
12 SGTC_2922 7999257 3.21 32.5 µM 1.36E-4 27 6.61E-4
13 SGTC_1006 4099-6547 3.20 255.0 µM 1.44E-4 53 6.92E-4
14 SGTC_777 1315-0167 3.14 517.0 µM 1.82E-4 Golgi 55 8.31E-4
15 SGTC_2584 androsterone 3.14 48.7 µM 1.83E-4 cell wall 198 8.35E-4
16 SGTC_989 1501-0895 3.05 10.3 µM 2.71E-4 28 0.00114
17 SGTC_1526 st051518 3.04 75.0 µM 2.87E-4 54 0.00119
18 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 3.02 100.0 µM 3.10E-4 51 0.00127
19 SGTC_724 3910-0327 2.96 137.0 µM 3.89E-4 ERG2 63 0.00152
20 SGTC_1348 1493-0373 2.96 93.8 µM 3.90E-4 55 0.00152

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.358 1.38E-101 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.312 1.37E-76 YNL105W_d RRT16_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene INP52; identified in a screen for mutants with decreased levels of rDNA transcription
0.308 3.57E-74 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.301 3.36E-71 YKL130C SHE2 hom RNA-binding protein that binds specific mRNAs and interacts with She3p; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud
0.271 1.21E-57 YML052W SUR7 hom Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants
0.256 2.84E-51 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.250 5.60E-49 YNL027W CRZ1 hom Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.241 1.21E-45 YBL017C PEP1 hom Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments
0.232 3.56E-42 YPL232W SSO1 hom Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p
0.229 5.63E-41 YOR050C_d YOR050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable
0.219 1.12E-37 YEL007W MIT1 hom Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1
0.218 1.62E-37 YMR109W MYO5 hom One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization
0.216 9.52E-37 YIL056W VHR1 hom Transcriptional activator; required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations; VHR1 has a paralog, VHR2, that arose from the whole genome duplication
0.211 6.52E-35 YFR008W FAR7 hom Protein involved in recovery from pheromone-induced cell cycle arrest; acts in a Far1p-independent pathway; interacts with Far3p, Far8p, Far9p, Far10p, and Far11p; protein abundance increases in response to DNA replication stress
0.209 4.51E-34 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability