YJR092W / BUD4

Anillin-like protein involved in bud-site selection; required for the axial budding pattern; localizes with septins to the bud neck in mitosis and may constitute an axial landmark for the next round of budding; required for the formation and disassembly of the double septin ring structure, and generally for septin organization; in vivo substrate of Cdc28p/Clb2p

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR092W / BUD4

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.53|P-value:6.42E-5 ID:SGTC_141|Compound:0443-0274|FD-Score:-2.87|P-value:8.13E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:-2.82|P-value:9.87E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.10|P-value:3.32E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:2.91|P-value:8.09E-4 ID:SGTC_742|Compound:0kpi-0133|FD-Score:3.07|P-value:4.34E-4 ID:SGTC_1008|Compound:4106-0037|FD-Score:2.90|P-value:8.23E-4 ID:SGTC_1039|Compound:k821-0043|FD-Score:3.04|P-value:4.91E-4 ID:SGTC_1076|Compound:itraconazole|FD-Score:-2.83|P-value:9.37E-4 ID:SGTC_1089|Compound:terbinafine|FD-Score:3.11|P-value:3.65E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.94|P-value:4.04E-11 ID:SGTC_1123|Compound:mangostin|FD-Score:2.91|P-value:8.00E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:-3.49|P-value:6.63E-5 ID:SGTC_1240|Compound:0356-0016|FD-Score:4.21|P-value:2.36E-6 ID:SGTC_1783|Compound:st039459|FD-Score:3.10|P-value:3.83E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:-4.26|P-value:1.51E-6 ID:SGTC_2150|Compound:5556613|FD-Score:4.26|P-value:1.87E-6 ID:SGTC_2161|Compound:5662504|FD-Score:-3.33|P-value:1.31E-4 ID:SGTC_2163|Compound:5671233|FD-Score:2.87|P-value:9.21E-4 ID:SGTC_2305|Compound:7443522|FD-Score:3.14|P-value:3.29E-4 ID:SGTC_2425|Compound:5628681|FD-Score:2.91|P-value:8.05E-4 ID:SGTC_2556|Compound:citropten|FD-Score:-3.17|P-value:2.53E-4 ID:SGTC_2644|Compound:guaiazulene|FD-Score:3.28|P-value:1.84E-4 ID:SGTC_2693|Compound:st077581|FD-Score:3.20|P-value:2.61E-4 ID:SGTC_2694|Compound:st077685|FD-Score:3.19|P-value:2.73E-4 ID:SGTC_2796|Compound:7949634|FD-Score:-3.17|P-value:2.59E-4 ID:SGTC_3025|Compound:9087895|FD-Score:3.05|P-value:4.66E-4 ID:SGTC_3031|Compound:9088762|FD-Score:-2.95|P-value:6.00E-4 ID:SGTC_3042|Compound:9091578|FD-Score:2.89|P-value:8.47E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-2.95|P-value:6.09E-4 ID:SGTC_3264|Compound:9137442|FD-Score:3.35|P-value:1.36E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:3.53|P-value:6.42E-5 ID:SGTC_141|Compound:0443-0274|FD-Score:-2.87|P-value:8.13E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:-2.82|P-value:9.87E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.10|P-value:3.32E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:2.91|P-value:8.09E-4 ID:SGTC_742|Compound:0kpi-0133|FD-Score:3.07|P-value:4.34E-4 ID:SGTC_1008|Compound:4106-0037|FD-Score:2.90|P-value:8.23E-4 ID:SGTC_1039|Compound:k821-0043|FD-Score:3.04|P-value:4.91E-4 ID:SGTC_1076|Compound:itraconazole|FD-Score:-2.83|P-value:9.37E-4 ID:SGTC_1089|Compound:terbinafine|FD-Score:3.11|P-value:3.65E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.94|P-value:4.04E-11 ID:SGTC_1123|Compound:mangostin|FD-Score:2.91|P-value:8.00E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:-3.49|P-value:6.63E-5 ID:SGTC_1240|Compound:0356-0016|FD-Score:4.21|P-value:2.36E-6 ID:SGTC_1783|Compound:st039459|FD-Score:3.10|P-value:3.83E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:-4.26|P-value:1.51E-6 ID:SGTC_2150|Compound:5556613|FD-Score:4.26|P-value:1.87E-6 ID:SGTC_2161|Compound:5662504|FD-Score:-3.33|P-value:1.31E-4 ID:SGTC_2163|Compound:5671233|FD-Score:2.87|P-value:9.21E-4 ID:SGTC_2305|Compound:7443522|FD-Score:3.14|P-value:3.29E-4 ID:SGTC_2425|Compound:5628681|FD-Score:2.91|P-value:8.05E-4 ID:SGTC_2556|Compound:citropten|FD-Score:-3.17|P-value:2.53E-4 ID:SGTC_2644|Compound:guaiazulene|FD-Score:3.28|P-value:1.84E-4 ID:SGTC_2693|Compound:st077581|FD-Score:3.20|P-value:2.61E-4 ID:SGTC_2694|Compound:st077685|FD-Score:3.19|P-value:2.73E-4 ID:SGTC_2796|Compound:7949634|FD-Score:-3.17|P-value:2.59E-4 ID:SGTC_3025|Compound:9087895|FD-Score:3.05|P-value:4.66E-4 ID:SGTC_3031|Compound:9088762|FD-Score:-2.95|P-value:6.00E-4 ID:SGTC_3042|Compound:9091578|FD-Score:2.89|P-value:8.47E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-2.95|P-value:6.09E-4 ID:SGTC_3264|Compound:9137442|FD-Score:3.35|P-value:1.36E-4

Top fitness defect scores for YJR092W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2150 5556613 4.26 200.0 µM 1.87E-6 13 1.04E-5
2 SGTC_1240 0356-0016 4.21 42.1 µM 2.36E-6 mitochondrial response to ROS 32 1.26E-5
3 SGTC_6 0844-0013 3.53 19.8 µM 6.42E-5 138 2.10E-4
4 SGTC_3264 9137442 3.35 49.5 µM 1.36E-4 24 3.98E-4
5 SGTC_2644 guaiazulene 3.28 100.0 µM 1.84E-4 13 5.15E-4
6 SGTC_2693 st077581 3.20 40.7 µM 2.61E-4 73 6.93E-4
7 SGTC_2694 st077685 3.19 81.9 µM 2.73E-4 endomembrane recycling 59 7.21E-4
8 SGTC_2305 7443522 3.14 69.2 µM 3.29E-4 38 8.46E-4
9 SGTC_1089 terbinafine 3.11 2.2 µM 3.65E-4 43 9.25E-4
10 SGTC_1783 st039459 3.10 87.5 µM 3.83E-4 Golgi 54 9.63E-4
11 SGTC_742 0kpi-0133 3.07 140.0 µM 4.34E-4 ERG2 55 0.00107
12 SGTC_3025 9087895 3.05 49.5 µM 4.66E-4 PDR1 67 0.00114
13 SGTC_1039 k821-0043 3.04 94.0 µM 4.91E-4 Golgi 66 0.00119
14 SGTC_1123 mangostin 2.91 811.3 nM 8.00E-4 mitochondrial response to ROS 85 0.00181
15 SGTC_2425 5628681 2.91 7.8 µM 8.05E-4 84 0.00182
16 SGTC_669 0108-0021 2.91 26.2 µM 8.09E-4 fatty acid desaturase (OLE1) 161 0.00183
17 SGTC_1008 4106-0037 2.90 6.0 µM 8.23E-4 PDR1 54 0.00185
18 SGTC_3042 9091578 2.89 49.5 µM 8.47E-4 ERG2 32 0.00190
19 SGTC_2163 5671233 2.87 125.0 µM 9.21E-4 85 0.00204
20 SGTC_2119 5528445 2.85 120.6 µM 0.00100 65 0.00219

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.229 5.28E-41 YDL174C DLD1 hom D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane
0.204 6.46E-33 YGL017W ATE1 hom Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway
0.203 1.16E-32 YBR207W FTH1 hom Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress
0.195 3.62E-30 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.193 2.19E-29 YDR122W KIN1 hom Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p
0.179 1.37E-25 YJR127C RSF2 hom Zinc-finger protein; involved in transcriptional control of both nuclear and mitochondrial genes, many of which specify products required for glycerol-based growth, respiration, and other functions; RSF2 has a paralog, TDA9, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.177 4.63E-25 YCL035C GRX1 hom Glutathione-dependent disulfide oxidoreductase; hydroperoxide and superoxide-radical responsive, heat-stable, with active site cysteine pair; protects cells from oxidative damage; GRX1 has a paralog, GRX2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.177 6.20E-25 YER067C-A_d YER067C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W
0.169 6.30E-23 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.168 1.43E-22 YKL122C SRP21 het Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm
0.167 1.61E-22 YAL060W BDH1 hom NAD-dependent (R,R)-butanediol dehydrogenase, catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of 2,3-butanediol as an aerobic carbon source
0.166 3.98E-22 YER030W CHZ1 hom Histone chaperone for Htz1p/H2A-H2B dimer; required for the stabilization of the Chz1p-Htz1-H2B complex; has overlapping function with Nap1p; null mutant displays weak sensitivity to MMS and benomyl; contains a highly conserved CHZ motif; protein abundance increases in response to DNA replication stress
0.165 5.14E-22 YBL066C SEF1 hom Putative transcription factor, has homolog in Kluyveromyces lactis
0.163 1.86E-21 YJL058C BIT61 hom Subunit of TORC2 membrane-associated complex; involved in regulation of cell cycle-dependent actin cytoskeletal dynamics during polarized growth and cell wall integrity; BIT61 has a paralog, BIT2, that arose from the whole genome duplication
0.163 2.48E-21 YKL131W_d YKL131W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data