YJR098C_p

Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR098C / YJR098C

Click on Significant Values for Screen Details ID:SGTC_290|Compound:2043-6722|FD-Score:-3.04|P-value:5.66E-4 ID:SGTC_325|Compound:2810-4341|FD-Score:3.01|P-value:5.42E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:-2.96|P-value:7.68E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:-3.19|P-value:3.21E-4 ID:SGTC_648|Compound:0375-0473|FD-Score:-3.43|P-value:1.23E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:3.38|P-value:1.25E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:-3.17|P-value:3.46E-4 ID:SGTC_697|Compound:0508-1955|FD-Score:-3.35|P-value:1.66E-4 ID:SGTC_700|Compound:3453-2283|FD-Score:-3.08|P-value:4.88E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:-3.57|P-value:6.46E-5 ID:SGTC_710|Compound:3448-4187|FD-Score:-3.62|P-value:5.30E-5 ID:SGTC_711|Compound:k292-0785|FD-Score:-5.20|P-value:1.19E-8 ID:SGTC_759|Compound:3486-0358|FD-Score:2.86|P-value:9.33E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:3.29|P-value:1.78E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:3.04|P-value:4.82E-4 ID:SGTC_929|Compound:2805-0021|FD-Score:3.03|P-value:4.97E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:3.29|P-value:1.76E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.11|P-value:5.25E-6 ID:SGTC_1114|Compound:scopoletin|FD-Score:2.92|P-value:7.42E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:-3.27|P-value:2.35E-4 ID:SGTC_1186|Compound:1319-0216|FD-Score:3.51|P-value:7.11E-5 ID:SGTC_1628|Compound:st004252|FD-Score:3.24|P-value:2.22E-4 ID:SGTC_1632|Compound:st005650|FD-Score:2.90|P-value:8.25E-4 ID:SGTC_1638|Compound:st008370|FD-Score:-4.46|P-value:8.75E-7 ID:SGTC_2330|Compound:7979373|FD-Score:-3.58|P-value:6.36E-5 ID:SGTC_2338|Compound:7999974|FD-Score:2.85|P-value:9.63E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.34|P-value:1.42E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-2.97|P-value:7.55E-4 ID:SGTC_2532|Compound:xanthone|FD-Score:-2.92|P-value:9.11E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:2.94|P-value:7.15E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:-3.04|P-value:5.70E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:-3.57|P-value:6.67E-5 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-5.38|P-value:3.91E-9 ID:SGTC_2822|Compound:7994718|FD-Score:3.02|P-value:5.16E-4 ID:SGTC_2825|Compound:7998094|FD-Score:-4.14|P-value:4.64E-6 ID:SGTC_2826|Compound:7992541|FD-Score:3.30|P-value:1.67E-4 ID:SGTC_2849|Compound:9019321|FD-Score:3.02|P-value:5.19E-4 ID:SGTC_2864|Compound:9034755|FD-Score:-3.54|P-value:7.64E-5 ID:SGTC_2874|Compound:9043904|FD-Score:-3.73|P-value:3.29E-5 ID:SGTC_3153|Compound:9100258|FD-Score:-4.02|P-value:8.33E-6 ID:SGTC_3245|Compound:9134821|FD-Score:3.07|P-value:4.21E-4 ID:SGTC_3334|Compound:9142812|FD-Score:-2.99|P-value:6.82E-4 ID:SGTC_290|Compound:2043-6722|FD-Score:-3.04|P-value:5.66E-4 ID:SGTC_325|Compound:2810-4341|FD-Score:3.01|P-value:5.42E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:-2.96|P-value:7.68E-4 ID:SGTC_496|Compound:calpeptin|FD-Score:-3.19|P-value:3.21E-4 ID:SGTC_648|Compound:0375-0473|FD-Score:-3.43|P-value:1.23E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:3.38|P-value:1.25E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:-3.17|P-value:3.46E-4 ID:SGTC_697|Compound:0508-1955|FD-Score:-3.35|P-value:1.66E-4 ID:SGTC_700|Compound:3453-2283|FD-Score:-3.08|P-value:4.88E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:-3.57|P-value:6.46E-5 ID:SGTC_710|Compound:3448-4187|FD-Score:-3.62|P-value:5.30E-5 ID:SGTC_711|Compound:k292-0785|FD-Score:-5.20|P-value:1.19E-8 ID:SGTC_759|Compound:3486-0358|FD-Score:2.86|P-value:9.33E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:3.29|P-value:1.78E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:3.04|P-value:4.82E-4 ID:SGTC_929|Compound:2805-0021|FD-Score:3.03|P-value:4.97E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:3.29|P-value:1.76E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.11|P-value:5.25E-6 ID:SGTC_1114|Compound:scopoletin|FD-Score:2.92|P-value:7.42E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:-3.27|P-value:2.35E-4 ID:SGTC_1186|Compound:1319-0216|FD-Score:3.51|P-value:7.11E-5 ID:SGTC_1628|Compound:st004252|FD-Score:3.24|P-value:2.22E-4 ID:SGTC_1632|Compound:st005650|FD-Score:2.90|P-value:8.25E-4 ID:SGTC_1638|Compound:st008370|FD-Score:-4.46|P-value:8.75E-7 ID:SGTC_2330|Compound:7979373|FD-Score:-3.58|P-value:6.36E-5 ID:SGTC_2338|Compound:7999974|FD-Score:2.85|P-value:9.63E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.34|P-value:1.42E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-2.97|P-value:7.55E-4 ID:SGTC_2532|Compound:xanthone|FD-Score:-2.92|P-value:9.11E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:2.94|P-value:7.15E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:-3.04|P-value:5.70E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:-3.57|P-value:6.67E-5 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-5.38|P-value:3.91E-9 ID:SGTC_2822|Compound:7994718|FD-Score:3.02|P-value:5.16E-4 ID:SGTC_2825|Compound:7998094|FD-Score:-4.14|P-value:4.64E-6 ID:SGTC_2826|Compound:7992541|FD-Score:3.30|P-value:1.67E-4 ID:SGTC_2849|Compound:9019321|FD-Score:3.02|P-value:5.19E-4 ID:SGTC_2864|Compound:9034755|FD-Score:-3.54|P-value:7.64E-5 ID:SGTC_2874|Compound:9043904|FD-Score:-3.73|P-value:3.29E-5 ID:SGTC_3153|Compound:9100258|FD-Score:-4.02|P-value:8.33E-6 ID:SGTC_3245|Compound:9134821|FD-Score:3.07|P-value:4.21E-4 ID:SGTC_3334|Compound:9142812|FD-Score:-2.99|P-value:6.82E-4

Top fitness defect scores for YJR098C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1186 1319-0216 3.51 26.0 µM 7.11E-5 33 2.27E-4
2 SGTC_650 1328-0195 3.38 38.0 µM 1.25E-4 36 3.69E-4
3 SGTC_2419 paclitaxel 3.34 166.5 µM 1.42E-4 79 4.13E-4
4 SGTC_2826 7992541 3.30 19.5 µM 1.67E-4 31 4.75E-4
5 SGTC_996 3970-0799 3.29 1.8 µM 1.76E-4 131 4.96E-4
6 SGTC_815 1582-0027 3.29 36.9 µM 1.78E-4 63 5.01E-4
7 SGTC_1628 st004252 3.24 77.7 µM 2.22E-4 52 6.06E-4
8 SGTC_3245 9134821 3.07 49.5 µM 4.21E-4 55 0.00106
9 SGTC_907 3448-6986 3.04 75.5 µM 4.82E-4 62 0.00119
10 SGTC_929 2805-0021 3.03 398.0 µM 4.97E-4 58 0.00122
11 SGTC_2822 7994718 3.02 71.4 µM 5.16E-4 43 0.00126
12 SGTC_2849 9019321 3.02 13.0 µM 5.19E-4 71 0.00126
13 SGTC_325 2810-4341 3.01 181.0 µM 5.42E-4 amide catabolism 34 0.00131
14 SGTC_2608 thymoquinone 2.94 42.7 µM 7.15E-4 60 0.00167
15 SGTC_1114 scopoletin 2.92 1.7 µM 7.42E-4 48 0.00172
16 SGTC_1632 st005650 2.90 90.0 µM 8.25E-4 75 0.00189
17 SGTC_759 3486-0358 2.86 89.3 µM 9.33E-4 68 0.00210
18 SGTC_2338 7999974 2.85 200.0 µM 9.63E-4 78 0.00216
19 SGTC_1563 conessine 2.83 56.1 µM 0.00107 74 0.00236
20 SGTC_3087 9117406 2.76 49.5 µM 0.00135 75 0.00290

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.240 4.74E-45 YGL146C_p RRT6_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins
0.236 1.23E-43 YER066W_p RRT13_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription
0.231 1.04E-41 YCR102W-A_d YCR102W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.204 1.01E-32 YOR300W_d YOR300W_d hom Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7
0.203 1.99E-32 YKL131W_d YKL131W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.199 1.92E-31 YEL049W PAU2 hom Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
0.199 2.28E-31 YML074C FPR3 hom Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p
0.189 1.73E-28 YLR395C COX8 hom Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
0.186 1.73E-27 YKL094W YJU3 hom Monoglyceride lipase (MGL), functional ortholog of mammalian MGL, localizes to lipid particles and membranes, also member of the eukaryotic serine hydrolase family
0.171 1.66E-23 YBR083W TEC1 hom Transcription factor targeting filamentation genes and Ty1 expression; Ste12p activation of most filamentation gene promoters depends on Tec1p and Tec1p transcriptional activity is dependent on its association with Ste12p; binds to TCS elements upstream of filamentation genes, which are regulated by Tec1p/Ste12p/Dig1p complex; competes with Dig2p for binding to Ste12p/Dig1p; positive regulator of chronological life span; TEA/ATTS DNA-binding domain family member
0.166 4.04E-22 YGR025W_d YGR025W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.162 4.64E-21 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.161 6.02E-21 YER071C_p TDA2_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; null mutant is sensitive to expression of the top1-T722A allele
0.161 8.44E-21 YMR104C YPK2 hom Protein kinase with similarity to serine/threonine protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway required for optimal cell wall integrity; homolog of mammalian kinase SGK; YPK2 has a paralog, YPK1, that arose from the whole genome duplication
0.160 1.39E-20 YGR015C_p YGR015C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion