YJR106W / ECM27

Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants are hypersensitive to Papulacandin B; null mutants have increased plasmid loss; displays a two-hybrid interaction with Pdr5p

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR106W / ECM27

Click on Significant Values for Screen Details ID:SGTC_66|Compound:0109-0187|FD-Score:-5.44|P-value:1.57E-9 ID:SGTC_72|Compound:0744-0168|FD-Score:-4.76|P-value:1.11E-7 ID:SGTC_74|Compound:000s-0487|FD-Score:-3.78|P-value:2.00E-5 ID:SGTC_111|Compound:0083-0039|FD-Score:2.86|P-value:8.12E-4 ID:SGTC_125|Compound:0133-0007|FD-Score:-3.29|P-value:1.76E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:3.88|P-value:9.90E-6 ID:SGTC_303|Compound:1348-1668|FD-Score:-3.00|P-value:5.65E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:3.95|P-value:6.81E-6 ID:SGTC_556|Compound:4058-0063|FD-Score:-3.79|P-value:1.88E-5 ID:SGTC_560|Compound:2332-1943|FD-Score:3.15|P-value:2.59E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-3.30|P-value:1.68E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:-4.20|P-value:2.49E-6 ID:SGTC_692|Compound:k241-0027|FD-Score:2.93|P-value:6.17E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:-3.10|P-value:3.81E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:3.87|P-value:1.01E-5 ID:SGTC_789|Compound:1309-1135|FD-Score:-3.24|P-value:2.15E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:2.85|P-value:8.29E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-6.20|P-value:7.19E-12 ID:SGTC_1214|Compound:0358-0031|FD-Score:2.98|P-value:5.09E-4 ID:SGTC_1245|Compound:0418-0076|FD-Score:-3.69|P-value:3.04E-5 ID:SGTC_1246|Compound:0422-0085|FD-Score:4.50|P-value:3.71E-7 ID:SGTC_1325|Compound:1431-0015|FD-Score:-2.94|P-value:7.03E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:-3.13|P-value:3.35E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:4.37|P-value:7.72E-7 ID:SGTC_1603|Compound:st002045|FD-Score:2.96|P-value:5.58E-4 ID:SGTC_1627|Compound:st003713|FD-Score:2.91|P-value:6.68E-4 ID:SGTC_1633|Compound:st005664|FD-Score:-3.43|P-value:9.96E-5 ID:SGTC_1770|Compound:st043884|FD-Score:-3.02|P-value:5.27E-4 ID:SGTC_1783|Compound:st039459|FD-Score:2.82|P-value:9.25E-4 ID:SGTC_1924|Compound:st058459|FD-Score:2.83|P-value:8.93E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-4.47|P-value:5.81E-7 ID:SGTC_1936|Compound:st074407|FD-Score:-3.67|P-value:3.38E-5 ID:SGTC_1947|Compound:st076332|FD-Score:-3.01|P-value:5.42E-4 ID:SGTC_2005|Compound:4024620|FD-Score:-3.55|P-value:5.83E-5 ID:SGTC_2014|Compound:4013930|FD-Score:3.37|P-value:1.02E-4 ID:SGTC_2095|Compound:5432005|FD-Score:5.65|P-value:2.68E-10 ID:SGTC_2103|Compound:5378138|FD-Score:2.95|P-value:5.79E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.55|P-value:4.72E-5 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:3.64|P-value:3.01E-5 ID:SGTC_2570|Compound:licareol|FD-Score:-3.05|P-value:4.74E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:5.84|P-value:7.24E-11 ID:SGTC_2584|Compound:androsterone|FD-Score:3.02|P-value:4.27E-4 ID:SGTC_2716|Compound:st080858|FD-Score:3.26|P-value:1.62E-4 ID:SGTC_2724|Compound:maprotiline|FD-Score:3.42|P-value:8.23E-5 ID:SGTC_2736|Compound:butenafine|FD-Score:3.06|P-value:3.78E-4 ID:SGTC_2887|Compound:9044784|FD-Score:-3.07|P-value:4.25E-4 ID:SGTC_2898|Compound:9056270|FD-Score:3.31|P-value:1.30E-4 ID:SGTC_2909|Compound:7941780|FD-Score:2.85|P-value:8.20E-4 ID:SGTC_2978|Compound:9011784|FD-Score:3.02|P-value:4.39E-4 ID:SGTC_3139|Compound:9095020|FD-Score:3.41|P-value:8.58E-5 ID:SGTC_3144|Compound:9087057|FD-Score:3.16|P-value:2.51E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:-5.44|P-value:1.57E-9 ID:SGTC_72|Compound:0744-0168|FD-Score:-4.76|P-value:1.11E-7 ID:SGTC_74|Compound:000s-0487|FD-Score:-3.78|P-value:2.00E-5 ID:SGTC_111|Compound:0083-0039|FD-Score:2.86|P-value:8.12E-4 ID:SGTC_125|Compound:0133-0007|FD-Score:-3.29|P-value:1.76E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:3.88|P-value:9.90E-6 ID:SGTC_303|Compound:1348-1668|FD-Score:-3.00|P-value:5.65E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:3.95|P-value:6.81E-6 ID:SGTC_556|Compound:4058-0063|FD-Score:-3.79|P-value:1.88E-5 ID:SGTC_560|Compound:2332-1943|FD-Score:3.15|P-value:2.59E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-3.30|P-value:1.68E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:-4.20|P-value:2.49E-6 ID:SGTC_692|Compound:k241-0027|FD-Score:2.93|P-value:6.17E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:-3.10|P-value:3.81E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:3.87|P-value:1.01E-5 ID:SGTC_789|Compound:1309-1135|FD-Score:-3.24|P-value:2.15E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:2.85|P-value:8.29E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-6.20|P-value:7.19E-12 ID:SGTC_1214|Compound:0358-0031|FD-Score:2.98|P-value:5.09E-4 ID:SGTC_1245|Compound:0418-0076|FD-Score:-3.69|P-value:3.04E-5 ID:SGTC_1246|Compound:0422-0085|FD-Score:4.50|P-value:3.71E-7 ID:SGTC_1325|Compound:1431-0015|FD-Score:-2.94|P-value:7.03E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:-3.13|P-value:3.35E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:4.37|P-value:7.72E-7 ID:SGTC_1603|Compound:st002045|FD-Score:2.96|P-value:5.58E-4 ID:SGTC_1627|Compound:st003713|FD-Score:2.91|P-value:6.68E-4 ID:SGTC_1633|Compound:st005664|FD-Score:-3.43|P-value:9.96E-5 ID:SGTC_1770|Compound:st043884|FD-Score:-3.02|P-value:5.27E-4 ID:SGTC_1783|Compound:st039459|FD-Score:2.82|P-value:9.25E-4 ID:SGTC_1924|Compound:st058459|FD-Score:2.83|P-value:8.93E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-4.47|P-value:5.81E-7 ID:SGTC_1936|Compound:st074407|FD-Score:-3.67|P-value:3.38E-5 ID:SGTC_1947|Compound:st076332|FD-Score:-3.01|P-value:5.42E-4 ID:SGTC_2005|Compound:4024620|FD-Score:-3.55|P-value:5.83E-5 ID:SGTC_2014|Compound:4013930|FD-Score:3.37|P-value:1.02E-4 ID:SGTC_2095|Compound:5432005|FD-Score:5.65|P-value:2.68E-10 ID:SGTC_2103|Compound:5378138|FD-Score:2.95|P-value:5.79E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.55|P-value:4.72E-5 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:3.64|P-value:3.01E-5 ID:SGTC_2570|Compound:licareol|FD-Score:-3.05|P-value:4.74E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:5.84|P-value:7.24E-11 ID:SGTC_2584|Compound:androsterone|FD-Score:3.02|P-value:4.27E-4 ID:SGTC_2716|Compound:st080858|FD-Score:3.26|P-value:1.62E-4 ID:SGTC_2724|Compound:maprotiline|FD-Score:3.42|P-value:8.23E-5 ID:SGTC_2736|Compound:butenafine|FD-Score:3.06|P-value:3.78E-4 ID:SGTC_2887|Compound:9044784|FD-Score:-3.07|P-value:4.25E-4 ID:SGTC_2898|Compound:9056270|FD-Score:3.31|P-value:1.30E-4 ID:SGTC_2909|Compound:7941780|FD-Score:2.85|P-value:8.20E-4 ID:SGTC_2978|Compound:9011784|FD-Score:3.02|P-value:4.39E-4 ID:SGTC_3139|Compound:9095020|FD-Score:3.41|P-value:8.58E-5 ID:SGTC_3144|Compound:9087057|FD-Score:3.16|P-value:2.51E-4

Top fitness defect scores for YJR106W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_2583 asiatic acid 5.84 100.0 µM 7.24E-11 14 2.67E-9
2 SGTC_2095 5432005 5.65 200.0 µM 2.68E-10 1 7.96E-9
3 SGTC_1246 0422-0085 4.50 105.0 µM 3.71E-7 15 3.38E-6
4 SGTC_1520 flindersine 4.37 88.0 µM 7.72E-7 22 6.24E-6
5 SGTC_358 0075-0058 3.95 9.4 µM 6.81E-6 62 3.87E-5
6 SGTC_299 1273-0059 3.88 1.4 µM 9.90E-6 26 5.29E-5
7 SGTC_774 k060-0086 3.87 136.0 µM 1.01E-5 20 5.40E-5
8 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 3.64 100.0 µM 3.01E-5 31 1.34E-4
9 SGTC_2514 salinomycin 3.55 42.7 µM 4.72E-5 69 1.96E-4
10 SGTC_2724 maprotiline 3.42 69.6 µM 8.23E-5 ERG2 27 3.13E-4
11 SGTC_3139 9095020 3.41 49.5 µM 8.58E-5 19 3.24E-4
12 SGTC_2014 4013930 3.37 200.0 µM 1.02E-4 65 3.74E-4
13 SGTC_2898 9056270 3.31 58.4 µM 1.30E-4 11 4.59E-4
14 SGTC_2716 st080858 3.26 38.6 µM 1.62E-4 60S ribosome export 38 5.52E-4
15 SGTC_3144 9087057 3.16 49.5 µM 2.51E-4 39 7.97E-4
16 SGTC_560 2332-1943 3.15 155.0 µM 2.59E-4 33 8.18E-4
17 SGTC_2736 butenafine 3.06 14.7 µM 3.78E-4 67 0.00113
18 SGTC_2584 androsterone 3.02 48.7 µM 4.27E-4 cell wall 214 0.00125
19 SGTC_2978 9011784 3.02 43.0 µM 4.39E-4 82 0.00128
20 SGTC_1214 0358-0031 2.98 63.7 µM 5.09E-4 55 0.00144

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.251 2.63E-49 YDR122W KIN1 hom Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p
0.244 1.11E-46 YPR151C SUE1 hom Mitochondrial protein required for degradation of unstable forms of cytochrome c
0.235 1.97E-43 YLR205C HMX1 hom ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.235 2.77E-43 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.222 1.20E-38 YLR414C PUN1 hom Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress
0.200 1.53E-31 YKL131W_d YKL131W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.195 5.15E-30 YDL012C YDL012C hom Tail-anchored plasma membrane protein with a conserved CYSTM module; possibly involved in response to stress; may contribute to non-homologous end-joining (NHEJ) based on ydl012c htz1 double null phenotype; YDL012C has a paralog, YBR016W, that arose from the whole genome duplication
0.175 1.93E-24 YGL149W_d YGL149W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF INO80/YGL150C.
0.174 2.55E-24 YNR044W AGA1 hom Anchorage subunit of a-agglutinin of a-cells, highly O-glycosylated protein with N-terminal secretion signal and C-terminal signal for addition of GPI anchor to cell wall, linked to adhesion subunit Aga2p via two disulfide bonds
0.174 3.74E-24 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.172 8.79E-24 YLR346C_p YLR346C_p hom Putative protein of unknown function found in mitochondria; expression is regulated by transcription factors involved in pleiotropic drug resistance, Pdr1p and Yrr1p; YLR346C is not an essential gene
0.169 7.67E-23 YNL042W-B_p YNL042W-B_p hom Putative protein of unknown function
0.168 1.30E-22 YDR242W AMD2 hom Putative amidase
0.167 1.66E-22 YML083C YML083C hom Protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions
0.166 2.90E-22 YJL058C BIT61 hom Subunit of TORC2 membrane-associated complex; involved in regulation of cell cycle-dependent actin cytoskeletal dynamics during polarized growth and cell wall integrity; BIT61 has a paralog, BIT2, that arose from the whole genome duplication