YJR127C / RSF2

Zinc-finger protein; involved in transcriptional control of both nuclear and mitochondrial genes, many of which specify products required for glycerol-based growth, respiration, and other functions; RSF2 has a paralog, TDA9, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasm upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR127C / RSF2

Click on Significant Values for Screen Details ID:SGTC_405|Compound:ebelactone b|FD-Score:-3.21|P-value:1.31E-4 ID:SGTC_413|Compound:propylparaben|FD-Score:-3.12|P-value:1.94E-4 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:3.69|P-value:8.70E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.04|P-value:2.72E-4 ID:SGTC_486|Compound:niguldipine|FD-Score:3.24|P-value:7.74E-5 ID:SGTC_613|Compound:3914-0030|FD-Score:-3.13|P-value:1.90E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.31|P-value:8.44E-5 ID:SGTC_822|Compound:1487-0950|FD-Score:2.75|P-value:6.57E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:3.31|P-value:5.78E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-7.06|P-value:3.01E-16 ID:SGTC_1125|Compound:tnp00248|FD-Score:4.11|P-value:8.56E-7 ID:SGTC_1128|Compound:3448-9350|FD-Score:-2.81|P-value:7.24E-4 ID:SGTC_1195|Compound:1502-0147|FD-Score:-2.75|P-value:8.86E-4 ID:SGTC_1199|Compound:1638-0010|FD-Score:-3.02|P-value:3.00E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:3.22|P-value:8.63E-5 ID:SGTC_1205|Compound:4161-2785|FD-Score:-2.97|P-value:3.68E-4 ID:SGTC_1291|Compound:0993-0025|FD-Score:2.79|P-value:5.61E-4 ID:SGTC_1333|Compound:1482-0047|FD-Score:4.12|P-value:8.31E-7 ID:SGTC_1385|Compound:3091-4834|FD-Score:-2.81|P-value:7.05E-4 ID:SGTC_1392|Compound:3455-1037|FD-Score:-3.05|P-value:2.69E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:-3.10|P-value:2.10E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-4.58|P-value:8.47E-8 ID:SGTC_1465|Compound:k213-0056|FD-Score:-2.83|P-value:6.67E-4 ID:SGTC_1999|Compound:st074831|FD-Score:-2.75|P-value:9.14E-4 ID:SGTC_2001|Compound:4023502|FD-Score:-2.84|P-value:6.32E-4 ID:SGTC_2254|Compound:7938975|FD-Score:2.76|P-value:6.21E-4 ID:SGTC_2305|Compound:7443522|FD-Score:3.00|P-value:2.25E-4 ID:SGTC_2375|Compound:9072683|FD-Score:4.11|P-value:8.77E-7 ID:SGTC_2376|Compound:9072922|FD-Score:2.68|P-value:8.77E-4 ID:SGTC_2384|Compound:9036245|FD-Score:2.82|P-value:4.89E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:2.67|P-value:8.83E-4 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:-2.78|P-value:8.08E-4 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:3.23|P-value:8.25E-5 ID:SGTC_2693|Compound:st077581|FD-Score:3.29|P-value:6.11E-5 ID:SGTC_2763|Compound:lisinopril|FD-Score:3.02|P-value:2.14E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:3.51|P-value:2.12E-5 ID:SGTC_2813|Compound:7971799|FD-Score:-4.76|P-value:2.67E-8 ID:SGTC_2831|Compound:7999036|FD-Score:3.13|P-value:1.31E-4 ID:SGTC_2848|Compound:9016370|FD-Score:3.53|P-value:1.93E-5 ID:SGTC_2849|Compound:9019321|FD-Score:5.41|P-value:1.71E-10 ID:SGTC_2856|Compound:9022925|FD-Score:2.75|P-value:6.58E-4 ID:SGTC_2859|Compound:9028643|FD-Score:3.03|P-value:2.03E-4 ID:SGTC_2918|Compound:7977171|FD-Score:3.02|P-value:2.10E-4 ID:SGTC_2919|Compound:7978188|FD-Score:2.96|P-value:2.73E-4 ID:SGTC_3124|Compound:9127567|FD-Score:3.38|P-value:4.08E-5 ID:SGTC_3336|Compound:9143619|FD-Score:3.30|P-value:5.94E-5 ID:SGTC_3343|Compound:9148379|FD-Score:2.93|P-value:3.14E-4 ID:SGTC_3352|Compound:9151559|FD-Score:-4.28|P-value:5.17E-7 ID:SGTC_3354|Compound:9151612|FD-Score:3.62|P-value:1.23E-5 ID:SGTC_405|Compound:ebelactone b|FD-Score:-3.21|P-value:1.31E-4 ID:SGTC_413|Compound:propylparaben|FD-Score:-3.12|P-value:1.94E-4 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:3.69|P-value:8.70E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.04|P-value:2.72E-4 ID:SGTC_486|Compound:niguldipine|FD-Score:3.24|P-value:7.74E-5 ID:SGTC_613|Compound:3914-0030|FD-Score:-3.13|P-value:1.90E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.31|P-value:8.44E-5 ID:SGTC_822|Compound:1487-0950|FD-Score:2.75|P-value:6.57E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:3.31|P-value:5.78E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-7.06|P-value:3.01E-16 ID:SGTC_1125|Compound:tnp00248|FD-Score:4.11|P-value:8.56E-7 ID:SGTC_1128|Compound:3448-9350|FD-Score:-2.81|P-value:7.24E-4 ID:SGTC_1195|Compound:1502-0147|FD-Score:-2.75|P-value:8.86E-4 ID:SGTC_1199|Compound:1638-0010|FD-Score:-3.02|P-value:3.00E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:3.22|P-value:8.63E-5 ID:SGTC_1205|Compound:4161-2785|FD-Score:-2.97|P-value:3.68E-4 ID:SGTC_1291|Compound:0993-0025|FD-Score:2.79|P-value:5.61E-4 ID:SGTC_1333|Compound:1482-0047|FD-Score:4.12|P-value:8.31E-7 ID:SGTC_1385|Compound:3091-4834|FD-Score:-2.81|P-value:7.05E-4 ID:SGTC_1392|Compound:3455-1037|FD-Score:-3.05|P-value:2.69E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:-3.10|P-value:2.10E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-4.58|P-value:8.47E-8 ID:SGTC_1465|Compound:k213-0056|FD-Score:-2.83|P-value:6.67E-4 ID:SGTC_1999|Compound:st074831|FD-Score:-2.75|P-value:9.14E-4 ID:SGTC_2001|Compound:4023502|FD-Score:-2.84|P-value:6.32E-4 ID:SGTC_2254|Compound:7938975|FD-Score:2.76|P-value:6.21E-4 ID:SGTC_2305|Compound:7443522|FD-Score:3.00|P-value:2.25E-4 ID:SGTC_2375|Compound:9072683|FD-Score:4.11|P-value:8.77E-7 ID:SGTC_2376|Compound:9072922|FD-Score:2.68|P-value:8.77E-4 ID:SGTC_2384|Compound:9036245|FD-Score:2.82|P-value:4.89E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:2.67|P-value:8.83E-4 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:-2.78|P-value:8.08E-4 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:3.23|P-value:8.25E-5 ID:SGTC_2693|Compound:st077581|FD-Score:3.29|P-value:6.11E-5 ID:SGTC_2763|Compound:lisinopril|FD-Score:3.02|P-value:2.14E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:3.51|P-value:2.12E-5 ID:SGTC_2813|Compound:7971799|FD-Score:-4.76|P-value:2.67E-8 ID:SGTC_2831|Compound:7999036|FD-Score:3.13|P-value:1.31E-4 ID:SGTC_2848|Compound:9016370|FD-Score:3.53|P-value:1.93E-5 ID:SGTC_2849|Compound:9019321|FD-Score:5.41|P-value:1.71E-10 ID:SGTC_2856|Compound:9022925|FD-Score:2.75|P-value:6.58E-4 ID:SGTC_2859|Compound:9028643|FD-Score:3.03|P-value:2.03E-4 ID:SGTC_2918|Compound:7977171|FD-Score:3.02|P-value:2.10E-4 ID:SGTC_2919|Compound:7978188|FD-Score:2.96|P-value:2.73E-4 ID:SGTC_3124|Compound:9127567|FD-Score:3.38|P-value:4.08E-5 ID:SGTC_3336|Compound:9143619|FD-Score:3.30|P-value:5.94E-5 ID:SGTC_3343|Compound:9148379|FD-Score:2.93|P-value:3.14E-4 ID:SGTC_3352|Compound:9151559|FD-Score:-4.28|P-value:5.17E-7 ID:SGTC_3354|Compound:9151612|FD-Score:3.62|P-value:1.23E-5

Top fitness defect scores for YJR127C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2849 9019321 5.41 13.0 µM 1.71E-10 12 3.17E-8
2 SGTC_1333 1482-0047 4.12 286.0 µM 8.31E-7 15 1.91E-5
3 SGTC_1125 tnp00248 4.11 1.3 µM 8.56E-7 22 1.96E-5
4 SGTC_2375 9072683 4.11 200.0 µM 8.77E-7 mitochondrial processes 15 1.99E-5
5 SGTC_437 s-farnesyl-l-cysteine methyl ester 3.69 6.7 µM 8.70E-6 16 1.13E-4
6 SGTC_3354 9151612 3.62 71.4 µM 1.23E-5 20 1.47E-4
7 SGTC_2848 9016370 3.53 26.0 µM 1.93E-5 39 2.07E-4
8 SGTC_2770 toltrazuril 3.51 17.5 µM 2.12E-5 40 2.21E-4
9 SGTC_3124 9127567 3.38 49.5 µM 4.08E-5 DNA damage response 32 3.64E-4
10 SGTC_996 3970-0799 3.31 1.8 µM 5.78E-5 129 4.74E-4
11 SGTC_3336 9143619 3.30 71.4 µM 5.94E-5 42 4.83E-4
12 SGTC_2693 st077581 3.29 40.7 µM 6.11E-5 66 4.94E-4
13 SGTC_486 niguldipine 3.24 82.0 µM 7.74E-5 amide catabolism 35 5.91E-4
14 SGTC_2574 2',4'-dihydroxychalcone 3.23 14.6 µM 8.25E-5 42 6.20E-4
15 SGTC_1204 4049-0315 3.22 18.3 µM 8.63E-5 62 6.42E-4
16 SGTC_2831 7999036 3.13 19.5 µM 1.31E-4 92 8.83E-4
17 SGTC_2859 9028643 3.03 45.5 µM 2.03E-4 44 0.00123
18 SGTC_2918 7977171 3.02 22.1 µM 2.10E-4 57 0.00126
19 SGTC_2763 lisinopril 3.02 49.3 µM 2.14E-4 37 0.00128
20 SGTC_2305 7443522 3.00 69.2 µM 2.25E-4 47 0.00133

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.255 9.51E-51 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.240 2.42E-45 YDR411C DFM1 hom Endoplasmic reticulum (ER) localized protein involved in ER-associated protein degradation (ERAD), ER stress and homeostasis; interacts with components of ERAD-L and ERAD-C and Cdc48p; derlin-like family member similar to Der1p
0.238 1.65E-44 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.238 2.25E-44 YMR104C YPK2 hom Protein kinase with similarity to serine/threonine protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway required for optimal cell wall integrity; homolog of mammalian kinase SGK; YPK2 has a paralog, YPK1, that arose from the whole genome duplication
0.231 6.36E-42 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.224 2.56E-39 YER060W-A FCY22 hom Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function
0.222 6.91E-39 YNL042W-B_p YNL042W-B_p hom Putative protein of unknown function
0.214 3.83E-36 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.212 1.61E-35 YLR353W BUD8 hom Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole
0.211 5.57E-35 YKR023W_p YKR023W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.210 8.63E-35 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.209 1.89E-34 YLR205C HMX1 hom ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.203 1.45E-32 YDL174C DLD1 hom D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane
0.202 3.13E-32 YKL179C COY1 hom Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function
0.199 3.41E-31 YBR262C AIM5 hom Mitochondrial inner membrane protein; subunit of the mitochondrial inner membrane organizing system (MitOS, MICOS, or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture