YJR128W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSF2

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR128W / YJR128W

Click on Significant Values for Screen Details ID:SGTC_66|Compound:0109-0187|FD-Score:-3.32|P-value:2.97E-4 ID:SGTC_264|Compound:promethazine|FD-Score:-3.21|P-value:4.51E-4 ID:SGTC_320|Compound:4092-0846|FD-Score:3.58|P-value:1.00E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:4.38|P-value:2.69E-6 ID:SGTC_476|Compound:mead acid|FD-Score:3.78|P-value:4.36E-5 ID:SGTC_925|Compound:2064-1272|FD-Score:-3.21|P-value:4.55E-4 ID:SGTC_935|Compound:2996-0153|FD-Score:-3.05|P-value:8.10E-4 ID:SGTC_1223|Compound:0764-0573|FD-Score:-3.38|P-value:2.42E-4 ID:SGTC_1231|Compound:0242-0792|FD-Score:-3.60|P-value:9.80E-5 ID:SGTC_1232|Compound:0279-0259|FD-Score:-3.00|P-value:9.71E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.50|P-value:1.37E-4 ID:SGTC_1351|Compound:1496-0003|FD-Score:-3.35|P-value:2.66E-4 ID:SGTC_1705|Compound:st027868|FD-Score:-4.07|P-value:1.28E-5 ID:SGTC_1842|Compound:st055362|FD-Score:2.98|P-value:9.95E-4 ID:SGTC_1911|Compound:st060208|FD-Score:3.94|P-value:2.18E-5 ID:SGTC_1975|Compound:st070967|FD-Score:4.13|P-value:9.27E-6 ID:SGTC_1976|Compound:st070609|FD-Score:4.63|P-value:7.87E-7 ID:SGTC_2708|Compound:st078559|FD-Score:-3.27|P-value:3.71E-4 ID:SGTC_2711|Compound:st079103|FD-Score:-4.51|P-value:1.55E-6 ID:SGTC_2717|Compound:st081029|FD-Score:-4.48|P-value:1.79E-6 ID:SGTC_2856|Compound:9022925|FD-Score:-3.36|P-value:2.56E-4 ID:SGTC_2859|Compound:9028643|FD-Score:-3.64|P-value:8.46E-5 ID:SGTC_2930|Compound:9013230|FD-Score:3.73|P-value:5.45E-5 ID:SGTC_2933|Compound:9026794|FD-Score:-3.07|P-value:7.49E-4 ID:SGTC_2942|Compound:9052777|FD-Score:4.36|P-value:3.04E-6 ID:SGTC_2973|Compound:9094665|FD-Score:-3.15|P-value:5.62E-4 ID:SGTC_2974|Compound:9094440|FD-Score:4.96|P-value:1.30E-7 ID:SGTC_3229|Compound:9132204|FD-Score:3.61|P-value:8.94E-5 ID:SGTC_3240|Compound:9133527|FD-Score:-3.01|P-value:9.31E-4 ID:SGTC_3313|Compound:9133968|FD-Score:3.32|P-value:2.82E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:-3.32|P-value:2.97E-4 ID:SGTC_264|Compound:promethazine|FD-Score:-3.21|P-value:4.51E-4 ID:SGTC_320|Compound:4092-0846|FD-Score:3.58|P-value:1.00E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:4.38|P-value:2.69E-6 ID:SGTC_476|Compound:mead acid|FD-Score:3.78|P-value:4.36E-5 ID:SGTC_925|Compound:2064-1272|FD-Score:-3.21|P-value:4.55E-4 ID:SGTC_935|Compound:2996-0153|FD-Score:-3.05|P-value:8.10E-4 ID:SGTC_1223|Compound:0764-0573|FD-Score:-3.38|P-value:2.42E-4 ID:SGTC_1231|Compound:0242-0792|FD-Score:-3.60|P-value:9.80E-5 ID:SGTC_1232|Compound:0279-0259|FD-Score:-3.00|P-value:9.71E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.50|P-value:1.37E-4 ID:SGTC_1351|Compound:1496-0003|FD-Score:-3.35|P-value:2.66E-4 ID:SGTC_1705|Compound:st027868|FD-Score:-4.07|P-value:1.28E-5 ID:SGTC_1842|Compound:st055362|FD-Score:2.98|P-value:9.95E-4 ID:SGTC_1911|Compound:st060208|FD-Score:3.94|P-value:2.18E-5 ID:SGTC_1975|Compound:st070967|FD-Score:4.13|P-value:9.27E-6 ID:SGTC_1976|Compound:st070609|FD-Score:4.63|P-value:7.87E-7 ID:SGTC_2708|Compound:st078559|FD-Score:-3.27|P-value:3.71E-4 ID:SGTC_2711|Compound:st079103|FD-Score:-4.51|P-value:1.55E-6 ID:SGTC_2717|Compound:st081029|FD-Score:-4.48|P-value:1.79E-6 ID:SGTC_2856|Compound:9022925|FD-Score:-3.36|P-value:2.56E-4 ID:SGTC_2859|Compound:9028643|FD-Score:-3.64|P-value:8.46E-5 ID:SGTC_2930|Compound:9013230|FD-Score:3.73|P-value:5.45E-5 ID:SGTC_2933|Compound:9026794|FD-Score:-3.07|P-value:7.49E-4 ID:SGTC_2942|Compound:9052777|FD-Score:4.36|P-value:3.04E-6 ID:SGTC_2973|Compound:9094665|FD-Score:-3.15|P-value:5.62E-4 ID:SGTC_2974|Compound:9094440|FD-Score:4.96|P-value:1.30E-7 ID:SGTC_3229|Compound:9132204|FD-Score:3.61|P-value:8.94E-5 ID:SGTC_3240|Compound:9133527|FD-Score:-3.01|P-value:9.31E-4 ID:SGTC_3313|Compound:9133968|FD-Score:3.32|P-value:2.82E-4

Top fitness defect scores for YJR128W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2974 9094440 4.96 9.7 µM 1.30E-7 ergosterol biosynthesis 23 3.45E-7
2 SGTC_1976 st070609 4.63 63.5 µM 7.87E-7 2 1.85E-6
3 SGTC_335 4077-0256 4.38 27.6 µM 2.69E-6 13 5.84E-6
4 SGTC_2942 9052777 4.36 62.2 µM 3.04E-6 25 6.53E-6
5 SGTC_1975 st070967 4.13 30.8 µM 9.27E-6 29 1.85E-5
6 SGTC_1911 st060208 3.94 74.3 µM 2.18E-5 35 4.10E-5
7 SGTC_476 mead acid 3.78 10.0 µM 4.36E-5 3 7.86E-5
8 SGTC_2930 9013230 3.73 14.9 µM 5.45E-5 heme biosynthesis & mitochondrial translocase 47 9.68E-5
9 SGTC_3229 9132204 3.61 49.5 µM 8.94E-5 6 1.53E-4
10 SGTC_320 4092-0846 3.58 5.3 µM 1.00E-4 ergosterol depletion effects on membrane 65 1.71E-4
11 SGTC_1262 0737-0114 3.50 49.6 µM 1.37E-4 36 2.29E-4
12 SGTC_3313 9133968 3.32 57.0 µM 2.82E-4 18 4.49E-4
13 SGTC_1842 st055362 2.98 61.2 µM 9.95E-4 59 0.00146
14 SGTC_1208 2323-2347 2.89 50.3 µM 0.00136 48 0.00195
15 SGTC_312 4092-0653 2.88 6.8 µM 0.00138 ergosterol depletion effects on membrane 153 0.00198
16 SGTC_436 n,n-dimethylsphingosine 2.86 3.3 µM 0.00147 76 0.00210
17 SGTC_3022 9087993 2.78 49.5 µM 0.00196 40 0.00275
18 SGTC_3331 9141060 2.71 2.0 µM 0.00244 cell wall 98 0.00337
19 SGTC_2956 9076196 2.65 2.5 µM 0.00294 96 0.00401
20 SGTC_3037 9091026 2.64 49.5 µM 0.00301 NEO1-PIK1 252 0.00410

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.157 5.02E-20 YJR152W DAL5 hom Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression
0.144 4.15E-17 YDR059C UBC5 hom Ubiquitin-conjugating enzyme; mediates selective degradation of short-lived, abnormal, or excess proteins, including histone H3; central component of the cellular stress response; expression is heat inducible; protein abundance increases in response to DNA replication stress; UBC5 has a paralog, UBC4, that arose from the whole genome duplication
0.140 3.54E-16 YKL024C URA6 het Uridylate kinase, catalyzes the seventh enzymatic step in the de novo biosynthesis of pyrimidines, converting uridine monophosphate (UMP) into uridine-5'-diphosphate (UDP)
0.133 1.03E-14 YIL167W SDL1 hom Open reading frame, unlikely to produce a functional protein in S288C; in closely related species and other S. cerevisiae strain backgrounds YIL167W and adjacent ORF, YIL168W, constitute a single ORF encoding L-serine dehydratase
0.131 2.23E-14 YGL004C RPN14 hom Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p
0.129 5.77E-14 YLR405W DUS4 hom Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p
0.125 3.98E-13 YLR414C PUN1 hom Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress
0.122 1.07E-12 YDR169C STB3 hom Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress
0.122 1.17E-12 YER024W YAT2 hom Carnitine acetyltransferase; has similarity to Yat1p, which is a carnitine acetyltransferase associated with the mitochondrial outer membrane
0.121 2.10E-12 YKL205W LOS1 hom Nuclear pore protein involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm
0.117 8.68E-12 YDL091C UBX3 hom Subunit of the DSC ubiquitin ligase complex; UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; ortholog of fission yeast Ucp10
0.116 1.93E-11 YOL024W_p YOL024W_p hom Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site; YOL024W has a paralog, IGD1, that arose from the whole genome duplication
0.115 1.99E-11 YBR199W KTR4 hom Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family
0.115 2.55E-11 YER076C_p YER076C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; analysis of HA-tagged protein suggests a membrane localization
0.114 3.05E-11 YDR497C ITR1 hom Myo-inositol transporter; has strong similarity to the minor myo-inositol transporter Itr2p, member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p; relative distribution to the vacuole increases upon DNA replication stress