YJR147W / HMS2

Protein with similarity to heat shock transcription factors; overexpression suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant; HMS2 has a paralog, SKN7, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR147W / HMS2

Click on Significant Values for Screen Details ID:SGTC_511|Compound:blebbistatin|FD-Score:3.10|P-value:2.41E-4 ID:SGTC_549|Compound:1661-1316|FD-Score:2.78|P-value:8.97E-4 ID:SGTC_553|Compound:k007-0256|FD-Score:3.04|P-value:3.13E-4 ID:SGTC_560|Compound:2332-1943|FD-Score:-3.71|P-value:1.22E-5 ID:SGTC_925|Compound:2064-1272|FD-Score:-3.95|P-value:3.59E-6 ID:SGTC_1093|Compound:fluphenazine|FD-Score:-2.82|P-value:6.61E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.81|P-value:7.27E-6 ID:SGTC_1129|Compound:3453-1384|FD-Score:2.89|P-value:5.65E-4 ID:SGTC_1157|Compound:4092-0394|FD-Score:3.65|P-value:1.99E-5 ID:SGTC_1246|Compound:0422-0085|FD-Score:-3.27|P-value:9.71E-5 ID:SGTC_1283|Compound:0922-0125|FD-Score:4.07|P-value:2.30E-6 ID:SGTC_1432|Compound:4049-0298|FD-Score:3.07|P-value:2.71E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.42|P-value:5.77E-5 ID:SGTC_2032|Compound:5185112|FD-Score:-3.73|P-value:1.08E-5 ID:SGTC_2321|Compound:7390090|FD-Score:-2.89|P-value:5.02E-4 ID:SGTC_2357|Compound:9067248|FD-Score:-4.63|P-value:7.09E-8 ID:SGTC_2415|Compound:st077333|FD-Score:3.37|P-value:7.34E-5 ID:SGTC_2448|Compound:5185112|FD-Score:5.81|P-value:2.78E-11 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-2.82|P-value:6.60E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:3.70|P-value:1.55E-5 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-2.85|P-value:5.74E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:3.87|P-value:6.46E-6 ID:SGTC_2760|Compound:etidronate|FD-Score:-2.85|P-value:5.80E-4 ID:SGTC_3038|Compound:9091290|FD-Score:3.30|P-value:1.02E-4 ID:SGTC_3162|Compound:9099653|FD-Score:2.82|P-value:7.59E-4 ID:SGTC_3178|Compound:9107506|FD-Score:-2.97|P-value:3.64E-4 ID:SGTC_3198|Compound:9112019|FD-Score:2.85|P-value:6.78E-4 ID:SGTC_3200|Compound:9114385|FD-Score:-3.80|P-value:7.68E-6 ID:SGTC_3307|Compound:9126885|FD-Score:-3.49|P-value:3.65E-5 ID:SGTC_511|Compound:blebbistatin|FD-Score:3.10|P-value:2.41E-4 ID:SGTC_549|Compound:1661-1316|FD-Score:2.78|P-value:8.97E-4 ID:SGTC_553|Compound:k007-0256|FD-Score:3.04|P-value:3.13E-4 ID:SGTC_560|Compound:2332-1943|FD-Score:-3.71|P-value:1.22E-5 ID:SGTC_925|Compound:2064-1272|FD-Score:-3.95|P-value:3.59E-6 ID:SGTC_1093|Compound:fluphenazine|FD-Score:-2.82|P-value:6.61E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.81|P-value:7.27E-6 ID:SGTC_1129|Compound:3453-1384|FD-Score:2.89|P-value:5.65E-4 ID:SGTC_1157|Compound:4092-0394|FD-Score:3.65|P-value:1.99E-5 ID:SGTC_1246|Compound:0422-0085|FD-Score:-3.27|P-value:9.71E-5 ID:SGTC_1283|Compound:0922-0125|FD-Score:4.07|P-value:2.30E-6 ID:SGTC_1432|Compound:4049-0298|FD-Score:3.07|P-value:2.71E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.42|P-value:5.77E-5 ID:SGTC_2032|Compound:5185112|FD-Score:-3.73|P-value:1.08E-5 ID:SGTC_2321|Compound:7390090|FD-Score:-2.89|P-value:5.02E-4 ID:SGTC_2357|Compound:9067248|FD-Score:-4.63|P-value:7.09E-8 ID:SGTC_2415|Compound:st077333|FD-Score:3.37|P-value:7.34E-5 ID:SGTC_2448|Compound:5185112|FD-Score:5.81|P-value:2.78E-11 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-2.82|P-value:6.60E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:3.70|P-value:1.55E-5 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-2.85|P-value:5.74E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:3.87|P-value:6.46E-6 ID:SGTC_2760|Compound:etidronate|FD-Score:-2.85|P-value:5.80E-4 ID:SGTC_3038|Compound:9091290|FD-Score:3.30|P-value:1.02E-4 ID:SGTC_3162|Compound:9099653|FD-Score:2.82|P-value:7.59E-4 ID:SGTC_3178|Compound:9107506|FD-Score:-2.97|P-value:3.64E-4 ID:SGTC_3198|Compound:9112019|FD-Score:2.85|P-value:6.78E-4 ID:SGTC_3200|Compound:9114385|FD-Score:-3.80|P-value:7.68E-6 ID:SGTC_3307|Compound:9126885|FD-Score:-3.49|P-value:3.65E-5

Top fitness defect scores for YJR147W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2448 5185112 5.81 27.2 µM 2.78E-11 3 3.15E-9
2 SGTC_1283 0922-0125 4.07 16.4 µM 2.30E-6 19 2.39E-5
3 SGTC_2754 granisetron 3.87 64.0 µM 6.46E-6 34 5.42E-5
4 SGTC_2593 nobiletin 3.70 86.2 µM 1.55E-5 35 1.08E-4
5 SGTC_1157 4092-0394 3.65 27.6 µM 1.99E-5 36 1.32E-4
6 SGTC_1456 k015-0012 3.42 13.0 µM 5.77E-5 51 3.08E-4
7 SGTC_2415 st077333 3.37 57.7 µM 7.34E-5 81 3.74E-4
8 SGTC_3038 9091290 3.30 49.5 µM 1.02E-4 38 4.87E-4
9 SGTC_511 blebbistatin 3.10 171.0 µM 2.41E-4 DNA intercalators 47 9.63E-4
10 SGTC_1432 4049-0298 3.07 68.4 µM 2.71E-4 30 0.00106
11 SGTC_553 k007-0256 3.04 45.7 µM 3.13E-4 heme biosynthesis & mitochondrial translocase 73 0.00119
12 SGTC_1129 3453-1384 2.89 223.0 µM 5.65E-4 103 0.00190
13 SGTC_3198 9112019 2.85 49.5 µM 6.78E-4 mitochondrial processes 65 0.00220
14 SGTC_3162 9099653 2.82 49.5 µM 7.59E-4 37 0.00241
15 SGTC_549 1661-1316 2.78 519.0 µM 8.97E-4 75 0.00275
16 SGTC_823 0417-1665 2.75 178.0 µM 0.00101 100 0.00302
17 SGTC_3042 9091578 2.74 49.5 µM 0.00104 ERG2 44 0.00310
18 SGTC_2678 equilin 2.70 100.0 µM 0.00120 88 0.00348
19 SGTC_3221 9128209 2.70 49.5 µM 0.00122 81 0.00352
20 SGTC_1880 MG-132 2.66 525.0 µM 0.00138 67 0.00389

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.189 2.00E-28 YDL174C DLD1 hom D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane
0.183 1.20E-26 YGR207C CIR1 hom Mitochondrial protein that interacts with frataxin (Yfh1p); putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-beta; may have a role in oxidative stress response
0.156 1.13E-19 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.144 6.44E-17 YKL171W NNK1 hom Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm
0.143 8.60E-17 YBR118W TEF2 hom Translational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes; may also have a role in tRNA re-export from the nucleus; TEF2 has a paralog, TEF1, that arose from the whole genome duplication
0.130 5.15E-14 YDR242W AMD2 hom Putative amidase
0.123 8.77E-13 YER060W-A FCY22 hom Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function
0.120 2.57E-12 YOR245C DGA1 hom Diacylglycerol acyltransferase, catalyzes the terminal step of triacylglycerol (TAG) formation, acylates diacylglycerol using acyl-CoA as an acyl donor, localized to lipid particles
0.119 3.73E-12 YAL061W_p BDH2_p hom Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3
0.119 5.56E-12 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.116 1.48E-11 YBR207W FTH1 hom Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress
0.114 3.48E-11 YGR189C CRH1 hom Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar and functionally redundant to Utr2; localizes to sites of polarized growth; expression induced by cell wall stress
0.112 7.40E-11 YMR147W_p YMR147W_p hom Putative protein of unknown function
0.110 1.92E-10 YDR044W HEM13 het Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)
0.109 2.10E-10 YER030W CHZ1 hom Histone chaperone for Htz1p/H2A-H2B dimer; required for the stabilization of the Chz1p-Htz1-H2B complex; has overlapping function with Nap1p; null mutant displays weak sensitivity to MMS and benomyl; contains a highly conserved CHZ motif; protein abundance increases in response to DNA replication stress