YJR149W_p

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm

Zygosity: Homozygous strain
fixedexpanded
Profile for YJR149W / YJR149W

Click on Significant Values for Screen Details ID:SGTC_77|Compound:0828-0286|FD-Score:-2.80|P-value:9.57E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.30|P-value:9.28E-5 ID:SGTC_308|Compound:4092-1169|FD-Score:-2.80|P-value:9.72E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:-3.69|P-value:2.11E-5 ID:SGTC_529|Compound:4076-0302|FD-Score:3.17|P-value:1.70E-4 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:3.11|P-value:2.19E-4 ID:SGTC_667|Compound:1498-1044|FD-Score:-3.55|P-value:4.00E-5 ID:SGTC_699|Compound:0375-0592|FD-Score:3.51|P-value:3.68E-5 ID:SGTC_702|Compound:1488-0190|FD-Score:2.96|P-value:4.06E-4 ID:SGTC_784|Compound:4579-0127|FD-Score:3.33|P-value:8.20E-5 ID:SGTC_809|Compound:3998-0021|FD-Score:2.97|P-value:3.82E-4 ID:SGTC_1294|Compound:1000-1494|FD-Score:-3.57|P-value:3.75E-5 ID:SGTC_1300|Compound:1094-0077|FD-Score:-3.03|P-value:3.89E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-2.89|P-value:6.81E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-2.81|P-value:9.46E-4 ID:SGTC_1626|Compound:st003712|FD-Score:3.37|P-value:6.84E-5 ID:SGTC_1630|Compound:st005209|FD-Score:3.28|P-value:1.05E-4 ID:SGTC_1716|Compound:st033144|FD-Score:2.82|P-value:7.00E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:4.05|P-value:2.36E-6 ID:SGTC_1739|Compound:st037196|FD-Score:4.01|P-value:3.02E-6 ID:SGTC_1744|Compound:st037937|FD-Score:3.68|P-value:1.56E-5 ID:SGTC_1779|Compound:st039427|FD-Score:3.15|P-value:1.85E-4 ID:SGTC_1812|Compound:st052057|FD-Score:-3.29|P-value:1.29E-4 ID:SGTC_1914|Compound:st062367|FD-Score:-4.70|P-value:8.74E-8 ID:SGTC_2062|Compound:5245942|FD-Score:-2.81|P-value:9.39E-4 ID:SGTC_2102|Compound:5377816|FD-Score:2.81|P-value:7.18E-4 ID:SGTC_2239|Compound:6685329|FD-Score:-2.87|P-value:7.24E-4 ID:SGTC_2789|Compound:5281112|FD-Score:-2.87|P-value:7.49E-4 ID:SGTC_2830|Compound:7992007|FD-Score:-2.90|P-value:6.48E-4 ID:SGTC_2985|Compound:9022375|FD-Score:2.76|P-value:8.88E-4 ID:SGTC_3173|Compound:9105693|FD-Score:3.34|P-value:8.01E-5 ID:SGTC_3187|Compound:9109394|FD-Score:-3.15|P-value:2.38E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:-2.80|P-value:9.57E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.30|P-value:9.28E-5 ID:SGTC_308|Compound:4092-1169|FD-Score:-2.80|P-value:9.72E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:-3.69|P-value:2.11E-5 ID:SGTC_529|Compound:4076-0302|FD-Score:3.17|P-value:1.70E-4 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:3.11|P-value:2.19E-4 ID:SGTC_667|Compound:1498-1044|FD-Score:-3.55|P-value:4.00E-5 ID:SGTC_699|Compound:0375-0592|FD-Score:3.51|P-value:3.68E-5 ID:SGTC_702|Compound:1488-0190|FD-Score:2.96|P-value:4.06E-4 ID:SGTC_784|Compound:4579-0127|FD-Score:3.33|P-value:8.20E-5 ID:SGTC_809|Compound:3998-0021|FD-Score:2.97|P-value:3.82E-4 ID:SGTC_1294|Compound:1000-1494|FD-Score:-3.57|P-value:3.75E-5 ID:SGTC_1300|Compound:1094-0077|FD-Score:-3.03|P-value:3.89E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-2.89|P-value:6.81E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-2.81|P-value:9.46E-4 ID:SGTC_1626|Compound:st003712|FD-Score:3.37|P-value:6.84E-5 ID:SGTC_1630|Compound:st005209|FD-Score:3.28|P-value:1.05E-4 ID:SGTC_1716|Compound:st033144|FD-Score:2.82|P-value:7.00E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:4.05|P-value:2.36E-6 ID:SGTC_1739|Compound:st037196|FD-Score:4.01|P-value:3.02E-6 ID:SGTC_1744|Compound:st037937|FD-Score:3.68|P-value:1.56E-5 ID:SGTC_1779|Compound:st039427|FD-Score:3.15|P-value:1.85E-4 ID:SGTC_1812|Compound:st052057|FD-Score:-3.29|P-value:1.29E-4 ID:SGTC_1914|Compound:st062367|FD-Score:-4.70|P-value:8.74E-8 ID:SGTC_2062|Compound:5245942|FD-Score:-2.81|P-value:9.39E-4 ID:SGTC_2102|Compound:5377816|FD-Score:2.81|P-value:7.18E-4 ID:SGTC_2239|Compound:6685329|FD-Score:-2.87|P-value:7.24E-4 ID:SGTC_2789|Compound:5281112|FD-Score:-2.87|P-value:7.49E-4 ID:SGTC_2830|Compound:7992007|FD-Score:-2.90|P-value:6.48E-4 ID:SGTC_2985|Compound:9022375|FD-Score:2.76|P-value:8.88E-4 ID:SGTC_3173|Compound:9105693|FD-Score:3.34|P-value:8.01E-5 ID:SGTC_3187|Compound:9109394|FD-Score:-3.15|P-value:2.38E-4

Top fitness defect scores for YJR149W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1718 roemerine 4.05 11.9 µM 2.36E-6 redox potentiating 52 2.53E-5
2 SGTC_1739 st037196 4.01 92.5 µM 3.02E-6 20 3.08E-5
3 SGTC_1744 st037937 3.68 38.9 µM 1.56E-5 38 1.14E-4
4 SGTC_699 0375-0592 3.51 111.0 µM 3.68E-5 iron homeostasis 34 2.27E-4
5 SGTC_1626 st003712 3.37 1.8 µM 6.84E-5 43 3.73E-4
6 SGTC_3173 9105693 3.34 49.5 µM 8.01E-5 45 4.23E-4
7 SGTC_784 4579-0127 3.33 173.0 µM 8.20E-5 44 4.31E-4
8 SGTC_270 tamoxifen 3.30 5.5 µM 9.28E-5 NEO1 62 4.76E-4
9 SGTC_1630 st005209 3.28 31.3 µM 1.05E-4 55 5.26E-4
10 SGTC_529 4076-0302 3.17 30.3 µM 1.70E-4 mitochondrial processes 40 7.75E-4
11 SGTC_1779 st039427 3.15 55.0 µM 1.85E-4 61 8.27E-4
12 SGTC_546 peri-Naphthalide 3.11 147.0 µM 2.19E-4 DNA damage response 45 9.47E-4
13 SGTC_809 3998-0021 2.97 90.0 µM 3.82E-4 RNA processing & uracil transport 33 0.00148
14 SGTC_702 1488-0190 2.96 94.0 µM 4.06E-4 amide catabolism 47 0.00155
15 SGTC_1716 st033144 2.82 30.6 µM 7.00E-4 72 0.00241
16 SGTC_2102 5377816 2.81 72.8 µM 7.18E-4 79 0.00246
17 SGTC_2985 9022375 2.76 71.4 µM 8.88E-4 RPP1 & pyrimidine depletion 98 0.00291
18 SGTC_3218 9131285 2.69 49.5 µM 0.00115 endomembrane recycling 135 0.00358
19 SGTC_2803 7707263 2.62 71.4 µM 0.00149 105 0.00440
20 SGTC_895 0964-0006 2.60 13.7 µM 0.00159 85 0.00464

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.147 8.96E-18 YDL242W_d YDL242W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.116 1.72E-11 YDR513W GRX2 hom Cytoplasmic glutaredoxin; thioltransferase, glutathione-dependent disulfide oxidoreductase involved in maintaining redox state of target proteins, also exhibits glutathione peroxidase activity, expression induced in response to stress; GRX2 has a paralog, GRX1, that arose from the whole genome duplication
0.116 1.75E-11 YFR021W ATG18 hom Phosphoinositide binding protein; required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein; relocalizes from vacuole to cytoplasm upon DNA replication stress; has 4 mammalian homologs WIPI1, WIPI2, WIPI3 and WIPI4/WDR45; mutations in human WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood
0.116 2.00E-11 YDL237W AIM6 hom Putative protein of unknown function, required for respiratory growth; YDL237W is not an essential gene
0.115 2.03E-11 YDR376W ARH1 het Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability
0.112 6.66E-11 YHR042W NCP1 het NADP-cytochrome P450 reductase; involved in ergosterol biosynthesis; associated and coordinately regulated with Erg11p
0.110 1.79E-10 YDL224C WHI4 hom Putative RNA binding protein; regulates the cell size requirement for passage through Start and commitment to cell division; WHI4 has a paralog, WHI3, that arose from the whole genome duplication
0.107 5.04E-10 YIL032C_d YIL032C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.102 2.81E-9 YBR145W ADH5 hom Alcohol dehydrogenase isoenzyme V; involved in ethanol production; ADH5 has a paralog, ADH1, that arose from the whole genome duplication
0.100 7.06E-9 YDR224C HTB1 het Histone H2B, core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB2; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation
0.099 1.03E-8 YMR326C_d YMR326C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the telomere on the right arm of chromosome 13
0.098 1.40E-8 YOR375C GDH1 hom NADP(+)-dependent glutamate dehydrogenase; synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh3p; expression regulated by nitrogen and carbon sources; GDH1 has a paralog, GDH3, that arose from the whole genome duplication
0.092 1.00E-7 YER059W PCL6 hom Pho85p cyclin of the Pho80p subfamily; forms the major Glc8p kinase together with Pcl7p and Pho85p; involved in the control of glycogen storage by Pho85p; stabilized by Elongin C binding
0.090 1.63E-7 YHR127W YHR127W hom Protein of unknown function; localizes to the nucleus; required for asymmetric localization of Kar9p during mitosis
0.088 3.28E-7 YDR284C DPP1 hom Diacylglycerol pyrophosphate (DGPP) phosphatase, zinc-regulated vacuolar membrane-associated lipid phosphatase, dephosphorylates DGPP to phosphatidate (PA) and Pi, then PA to diacylglycerol; involved in lipid signaling and cell metabolism