YKL006W / RPL14A

Ribosomal 60S subunit protein L14A; N-terminally acetylated; homologous to mammalian ribosomal protein L14, no bacterial homolog; RPL14A has a paralog, RPL14B, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL006W / RPL14A

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:3.77|P-value:2.59E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:7.63|P-value:9.41E-13 ID:SGTC_118|Compound:0083-0097|FD-Score:5.05|P-value:1.62E-6 ID:SGTC_140|Compound:0062-0056|FD-Score:4.22|P-value:4.99E-5 ID:SGTC_194|Compound:1486-1323|FD-Score:5.22|P-value:7.44E-7 ID:SGTC_246|Compound:cycloheximide|FD-Score:3.68|P-value:3.56E-4 ID:SGTC_654|Compound:1124-0271|FD-Score:3.52|P-value:6.00E-4 ID:SGTC_683|Compound:panaxydol|FD-Score:3.60|P-value:4.55E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:10.70|P-value:3.62E-23 ID:SGTC_800|Compound:3448-7362|FD-Score:3.39|P-value:8.97E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:4.16|P-value:6.37E-5 ID:SGTC_864|Compound:0469-0573|FD-Score:3.89|P-value:1.72E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:3.65|P-value:3.85E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:3.78|P-value:2.51E-4 ID:SGTC_932|Compound:2857-0803|FD-Score:4.90|P-value:3.15E-6 ID:SGTC_1118|Compound:chelidonine|FD-Score:5.61|P-value:1.15E-7 ID:SGTC_1126|Compound:isoteolin|FD-Score:3.80|P-value:2.35E-4 ID:SGTC_1140|Compound:3229-1848|FD-Score:4.07|P-value:8.85E-5 ID:SGTC_1174|Compound:0739-0097|FD-Score:4.37|P-value:2.83E-5 ID:SGTC_1179|Compound:1021-1431|FD-Score:7.16|P-value:1.94E-11 ID:SGTC_1218|Compound:1348-1416|FD-Score:-4.17|P-value:5.27E-5 ID:SGTC_1223|Compound:0764-0573|FD-Score:-3.79|P-value:2.08E-4 ID:SGTC_1231|Compound:0242-0792|FD-Score:5.13|P-value:1.11E-6 ID:SGTC_1266|Compound:0828-0227|FD-Score:-3.45|P-value:6.59E-4 ID:SGTC_1426|Compound:4048-4480|FD-Score:3.70|P-value:3.33E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:3.64|P-value:4.02E-4 ID:SGTC_1477|Compound:0139-0234|FD-Score:4.72|P-value:6.68E-6 ID:SGTC_1499|Compound:4480-0877|FD-Score:3.50|P-value:6.35E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:4.84|P-value:4.13E-6 ID:SGTC_1547|Compound:harmine|FD-Score:-3.76|P-value:2.32E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.95|P-value:2.12E-6 ID:SGTC_1730|Compound:st033808|FD-Score:4.79|P-value:5.10E-6 ID:SGTC_1747|Compound:st037496|FD-Score:3.37|P-value:9.67E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.77|P-value:2.24E-4 ID:SGTC_1809|Compound:st050081|FD-Score:3.37|P-value:9.67E-4 ID:SGTC_1850|Compound:st056238|FD-Score:4.02|P-value:1.06E-4 ID:SGTC_1881|Compound:5652484|FD-Score:-3.88|P-value:1.54E-4 ID:SGTC_1916|Compound:st067606|FD-Score:3.89|P-value:1.72E-4 ID:SGTC_1999|Compound:st074831|FD-Score:4.16|P-value:6.41E-5 ID:SGTC_2032|Compound:5185112|FD-Score:5.51|P-value:1.90E-7 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:6.80|P-value:1.78E-10 ID:SGTC_2044|Compound:5102272|FD-Score:3.66|P-value:3.80E-4 ID:SGTC_2064|Compound:5220758|FD-Score:4.07|P-value:8.84E-5 ID:SGTC_2068|Compound:5226020|FD-Score:-3.93|P-value:1.28E-4 ID:SGTC_2084|Compound:5306078|FD-Score:4.41|P-value:2.43E-5 ID:SGTC_2087|Compound:5276107|FD-Score:-4.01|P-value:9.66E-5 ID:SGTC_2088|Compound:5278280|FD-Score:5.00|P-value:2.00E-6 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:-3.58|P-value:4.26E-4 ID:SGTC_2097|Compound:5376186|FD-Score:9.06|P-value:2.86E-17 ID:SGTC_2099|Compound:5377090|FD-Score:7.46|P-value:2.92E-12 ID:SGTC_2104|Compound:5389443|FD-Score:3.80|P-value:2.32E-4 ID:SGTC_2166|Compound:5933061|FD-Score:-4.51|P-value:1.36E-5 ID:SGTC_2167|Compound:5876490|FD-Score:3.91|P-value:1.60E-4 ID:SGTC_2238|Compound:6671620|FD-Score:4.61|P-value:1.09E-5 ID:SGTC_2314|Compound:7727897|FD-Score:-3.59|P-value:4.15E-4 ID:SGTC_2321|Compound:7390090|FD-Score:3.39|P-value:9.12E-4 ID:SGTC_2414|Compound:st077232|FD-Score:-3.32|P-value:9.92E-4 ID:SGTC_2447|Compound:5741742|FD-Score:3.36|P-value:9.88E-4 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:3.55|P-value:5.37E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:3.50|P-value:6.42E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:-4.16|P-value:5.46E-5 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:4.03|P-value:1.02E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:-3.39|P-value:8.03E-4 ID:SGTC_2816|Compound:7982706|FD-Score:-6.35|P-value:1.86E-9 ID:SGTC_2820|Compound:7989630|FD-Score:3.85|P-value:1.99E-4 ID:SGTC_2821|Compound:7996764|FD-Score:-4.89|P-value:2.74E-6 ID:SGTC_2998|Compound:9066762|FD-Score:-3.74|P-value:2.48E-4 ID:SGTC_3045|Compound:9092950|FD-Score:5.76|P-value:5.34E-8 ID:SGTC_3046|Compound:9092212|FD-Score:-3.32|P-value:9.95E-4 ID:SGTC_3058|Compound:9093861|FD-Score:3.62|P-value:4.34E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:3.77|P-value:2.59E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:7.63|P-value:9.41E-13 ID:SGTC_118|Compound:0083-0097|FD-Score:5.05|P-value:1.62E-6 ID:SGTC_140|Compound:0062-0056|FD-Score:4.22|P-value:4.99E-5 ID:SGTC_194|Compound:1486-1323|FD-Score:5.22|P-value:7.44E-7 ID:SGTC_246|Compound:cycloheximide|FD-Score:3.68|P-value:3.56E-4 ID:SGTC_654|Compound:1124-0271|FD-Score:3.52|P-value:6.00E-4 ID:SGTC_683|Compound:panaxydol|FD-Score:3.60|P-value:4.55E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:10.70|P-value:3.62E-23 ID:SGTC_800|Compound:3448-7362|FD-Score:3.39|P-value:8.97E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:4.16|P-value:6.37E-5 ID:SGTC_864|Compound:0469-0573|FD-Score:3.89|P-value:1.72E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:3.65|P-value:3.85E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:3.78|P-value:2.51E-4 ID:SGTC_932|Compound:2857-0803|FD-Score:4.90|P-value:3.15E-6 ID:SGTC_1118|Compound:chelidonine|FD-Score:5.61|P-value:1.15E-7 ID:SGTC_1126|Compound:isoteolin|FD-Score:3.80|P-value:2.35E-4 ID:SGTC_1140|Compound:3229-1848|FD-Score:4.07|P-value:8.85E-5 ID:SGTC_1174|Compound:0739-0097|FD-Score:4.37|P-value:2.83E-5 ID:SGTC_1179|Compound:1021-1431|FD-Score:7.16|P-value:1.94E-11 ID:SGTC_1218|Compound:1348-1416|FD-Score:-4.17|P-value:5.27E-5 ID:SGTC_1223|Compound:0764-0573|FD-Score:-3.79|P-value:2.08E-4 ID:SGTC_1231|Compound:0242-0792|FD-Score:5.13|P-value:1.11E-6 ID:SGTC_1266|Compound:0828-0227|FD-Score:-3.45|P-value:6.59E-4 ID:SGTC_1426|Compound:4048-4480|FD-Score:3.70|P-value:3.33E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:3.64|P-value:4.02E-4 ID:SGTC_1477|Compound:0139-0234|FD-Score:4.72|P-value:6.68E-6 ID:SGTC_1499|Compound:4480-0877|FD-Score:3.50|P-value:6.35E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:4.84|P-value:4.13E-6 ID:SGTC_1547|Compound:harmine|FD-Score:-3.76|P-value:2.32E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.95|P-value:2.12E-6 ID:SGTC_1730|Compound:st033808|FD-Score:4.79|P-value:5.10E-6 ID:SGTC_1747|Compound:st037496|FD-Score:3.37|P-value:9.67E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.77|P-value:2.24E-4 ID:SGTC_1809|Compound:st050081|FD-Score:3.37|P-value:9.67E-4 ID:SGTC_1850|Compound:st056238|FD-Score:4.02|P-value:1.06E-4 ID:SGTC_1881|Compound:5652484|FD-Score:-3.88|P-value:1.54E-4 ID:SGTC_1916|Compound:st067606|FD-Score:3.89|P-value:1.72E-4 ID:SGTC_1999|Compound:st074831|FD-Score:4.16|P-value:6.41E-5 ID:SGTC_2032|Compound:5185112|FD-Score:5.51|P-value:1.90E-7 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:6.80|P-value:1.78E-10 ID:SGTC_2044|Compound:5102272|FD-Score:3.66|P-value:3.80E-4 ID:SGTC_2064|Compound:5220758|FD-Score:4.07|P-value:8.84E-5 ID:SGTC_2068|Compound:5226020|FD-Score:-3.93|P-value:1.28E-4 ID:SGTC_2084|Compound:5306078|FD-Score:4.41|P-value:2.43E-5 ID:SGTC_2087|Compound:5276107|FD-Score:-4.01|P-value:9.66E-5 ID:SGTC_2088|Compound:5278280|FD-Score:5.00|P-value:2.00E-6 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:-3.58|P-value:4.26E-4 ID:SGTC_2097|Compound:5376186|FD-Score:9.06|P-value:2.86E-17 ID:SGTC_2099|Compound:5377090|FD-Score:7.46|P-value:2.92E-12 ID:SGTC_2104|Compound:5389443|FD-Score:3.80|P-value:2.32E-4 ID:SGTC_2166|Compound:5933061|FD-Score:-4.51|P-value:1.36E-5 ID:SGTC_2167|Compound:5876490|FD-Score:3.91|P-value:1.60E-4 ID:SGTC_2238|Compound:6671620|FD-Score:4.61|P-value:1.09E-5 ID:SGTC_2314|Compound:7727897|FD-Score:-3.59|P-value:4.15E-4 ID:SGTC_2321|Compound:7390090|FD-Score:3.39|P-value:9.12E-4 ID:SGTC_2414|Compound:st077232|FD-Score:-3.32|P-value:9.92E-4 ID:SGTC_2447|Compound:5741742|FD-Score:3.36|P-value:9.88E-4 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:3.55|P-value:5.37E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:3.50|P-value:6.42E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:-4.16|P-value:5.46E-5 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:4.03|P-value:1.02E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:-3.39|P-value:8.03E-4 ID:SGTC_2816|Compound:7982706|FD-Score:-6.35|P-value:1.86E-9 ID:SGTC_2820|Compound:7989630|FD-Score:3.85|P-value:1.99E-4 ID:SGTC_2821|Compound:7996764|FD-Score:-4.89|P-value:2.74E-6 ID:SGTC_2998|Compound:9066762|FD-Score:-3.74|P-value:2.48E-4 ID:SGTC_3045|Compound:9092950|FD-Score:5.76|P-value:5.34E-8 ID:SGTC_3046|Compound:9092212|FD-Score:-3.32|P-value:9.95E-4 ID:SGTC_3058|Compound:9093861|FD-Score:3.62|P-value:4.34E-4

Top fitness defect scores for YKL006W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_747 3448-8087 10.70 38.7 µM 3.62E-23 1 8.34E-27
2 SGTC_2097 5376186 9.06 200.0 µM 2.86E-17 1 6.38E-20
3 SGTC_103 0844-0104 7.63 51.8 µM 9.41E-13 ERAD & cell cycle 52 1.19E-14
4 SGTC_2099 5377090 7.46 177.4 µM 2.92E-12 1 4.47E-14
5 SGTC_1179 1021-1431 7.16 9.3 µM 1.94E-11 8 4.07E-13
6 SGTC_2042 p-Dimethylaminoacetophenone 6.80 200.0 µM 1.78E-10 2 5.40E-12
7 SGTC_3045 9092950 5.76 49.5 µM 5.34E-8 3 4.18E-9
8 SGTC_1118 chelidonine 5.61 707.5 nM 1.15E-7 4 1.02E-8
9 SGTC_2032 5185112 5.51 26.0 µM 1.90E-7 4 1.83E-8
10 SGTC_194 1486-1323 5.22 56.9 µM 7.44E-7 5 9.00E-8
11 SGTC_1231 0242-0792 5.13 125.0 µM 1.11E-6 6 1.43E-7
12 SGTC_118 0083-0097 5.05 135.3 µM 1.62E-6 translation 54 2.22E-7
13 SGTC_2088 5278280 5.00 127.4 µM 2.00E-6 9 2.84E-7
14 SGTC_932 2857-0803 4.90 154.0 µM 3.15E-6 15 4.84E-7
15 SGTC_1506 4226-2149 4.84 212.0 µM 4.13E-6 15 6.62E-7
16 SGTC_1730 st033808 4.79 45.1 µM 5.10E-6 14 8.47E-7
17 SGTC_1477 0139-0234 4.72 16.0 µM 6.68E-6 4 1.16E-6
18 SGTC_2238 6671620 4.61 73.2 µM 1.09E-5 16 2.04E-6
19 SGTC_2084 5306078 4.41 60.6 µM 2.43E-5 10 5.22E-6
20 SGTC_1174 0739-0097 4.37 51.1 µM 2.83E-5 redox potentiating 17 6.21E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.135 4.76E-15 YBR031W RPL4A hom Ribosomal 60S subunit protein L4A; N-terminally acetylated; homologous to mammalian ribosomal protein L4 and bacterial L4; RPL4A has a paralog, RPL4B, that arose from the whole genome duplication
0.133 1.29E-14 YGL246C RAI1 hom Nuclear protein with decapping endonuclease activity targeted toward mRNAs with unmethylated 7-methylguanosine cap structures; binds to and stabilizes the exoribonuclease Rat1p; required for pre-rRNA processing; homologous to human DOM3Z
0.125 3.63E-13 YDL148C NOP14 het Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
0.118 7.78E-12 YOR309C_d YOR309C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP58
0.115 2.25E-11 YNL179C_d YNL179C_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance
0.113 5.60E-11 YEL054C RPL12A hom Ribosomal 60S subunit protein L12A; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12A has a paralog, RPL12B, that arose from the whole genome duplication
0.103 2.15E-9 YML016C PPZ1 hom Serine/threonine protein phosphatase Z, isoform of Ppz2p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance
0.098 1.20E-8 YNL227C JJJ1 hom Co-chaperone that stimulates the ATPase activity of Ssa1p, required for a late step of ribosome biogenesis; associated with the cytosolic large ribosomal subunit; contains a J-domain; mutation causes defects in fluid-phase endocytosis
0.096 2.25E-8 YPL019C VTC3 hom Subunit of the vacuolar transporter chaperone (VTC) complex involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion
0.095 3.79E-8 YPR132W RPS23B hom Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; homologous to mammalian ribosomal protein S23 and bacterial S12; RPS23B has a paralog, RPS23A, that arose from the whole genome duplication; deletion of both RPS23A and RPS23B is lethal
0.093 6.72E-8 YJR145C RPS4A hom Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4A has a paralog, RPS4B, that arose from the whole genome duplication
0.092 9.72E-8 YJL188C_d BUD19_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay
0.090 1.85E-7 YMR276W DSK2 hom Nuclear-enriched ubiquitin-like polyubiquitin-binding protein; required for spindle pole body (SPB) duplication and for transit through the G2/M phase of the cell cycle; involved in proteolysis; interacts with the proteasome; protein abundance increases in response to DNA replication stress
0.089 2.18E-7 YDR241W_d BUD26_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 1% of ORF overlaps the verified gene SNU56; diploid mutant displays a weak budding pattern phenotype in a systematic assay
0.089 2.51E-7 YOR363C PIP2 hom Autoregulatory oleate-specific transcriptional activator of peroxisome proliferation, contains Zn(2)-Cys(6) cluster domain, forms heterodimer with Oaf1p, binds oleate response elements (OREs), activates beta-oxidation genes; PIP2 has a paralog, OAF1, that arose from the whole genome duplication