YKL033W / TTI1

Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1; similar to S. pombe Tti1p; detected in highly purified mitochondria in high-throughput studies

Zygosity: Heterozygous strain
fixedexpanded
Profile for YKL033W / TTI1

Click on Significant Values for Screen Details ID:SGTC_27|Compound:0485-0001|FD-Score:-3.36|P-value:5.14E-4 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:3.85|P-value:1.09E-4 ID:SGTC_80|Compound:0159-0065|FD-Score:-3.36|P-value:5.12E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-4.66|P-value:2.75E-6 ID:SGTC_210|Compound:3551-0445|FD-Score:3.41|P-value:5.48E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:-3.21|P-value:8.57E-4 ID:SGTC_319|Compound:1348-1596|FD-Score:-3.21|P-value:8.44E-4 ID:SGTC_321|Compound:4534-3890|FD-Score:-3.23|P-value:7.90E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-5.26|P-value:1.51E-7 ID:SGTC_910|Compound:3454-3003|FD-Score:-4.28|P-value:1.47E-5 ID:SGTC_916|Compound:4466-0038|FD-Score:-3.85|P-value:8.49E-5 ID:SGTC_926|Compound:2268-1401|FD-Score:3.91|P-value:8.86E-5 ID:SGTC_1131|Compound:3454-3128|FD-Score:3.34|P-value:6.88E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:-3.77|P-value:1.15E-4 ID:SGTC_1138|Compound:3761-0006|FD-Score:-3.36|P-value:5.01E-4 ID:SGTC_1270|Compound:0831-1170|FD-Score:-4.55|P-value:4.58E-6 ID:SGTC_1273|Compound:0849-0096|FD-Score:4.53|P-value:6.82E-6 ID:SGTC_1451|Compound:4152-0210|FD-Score:-3.88|P-value:7.64E-5 ID:SGTC_1503|Compound:4585-0012|FD-Score:-3.54|P-value:2.68E-4 ID:SGTC_1507|Compound:4075-3230|FD-Score:-3.23|P-value:7.97E-4 ID:SGTC_1508|Compound:1080-0625|FD-Score:-4.66|P-value:2.71E-6 ID:SGTC_2329|Compound:6138490|FD-Score:-4.72|P-value:2.13E-6 ID:SGTC_2629|Compound:bisabolol|FD-Score:-5.78|P-value:9.19E-9 ID:SGTC_2638|Compound:epoxomicin|FD-Score:-4.37|P-value:1.00E-5 ID:SGTC_2693|Compound:st077581|FD-Score:-3.58|P-value:2.33E-4 ID:SGTC_2946|Compound:9065502|FD-Score:-3.30|P-value:6.25E-4 ID:SGTC_3191|Compound:9110352|FD-Score:4.26|P-value:2.13E-5 ID:SGTC_3192|Compound:9110362|FD-Score:4.79|P-value:2.06E-6 ID:SGTC_3195|Compound:9113082|FD-Score:-4.30|P-value:1.38E-5 ID:SGTC_3196|Compound:9111891|FD-Score:4.10|P-value:4.14E-5 ID:SGTC_3199|Compound:9111318|FD-Score:-3.41|P-value:4.22E-4 ID:SGTC_3297|Compound:9117502|FD-Score:-3.92|P-value:6.43E-5 ID:SGTC_3314|Compound:9135860|FD-Score:-3.27|P-value:7.00E-4 ID:SGTC_3342|Compound:9147791|FD-Score:-3.30|P-value:6.19E-4 ID:SGTC_3354|Compound:9151612|FD-Score:-3.77|P-value:1.16E-4 ID:SGTC_27|Compound:0485-0001|FD-Score:-3.36|P-value:5.14E-4 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:3.85|P-value:1.09E-4 ID:SGTC_80|Compound:0159-0065|FD-Score:-3.36|P-value:5.12E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-4.66|P-value:2.75E-6 ID:SGTC_210|Compound:3551-0445|FD-Score:3.41|P-value:5.48E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:-3.21|P-value:8.57E-4 ID:SGTC_319|Compound:1348-1596|FD-Score:-3.21|P-value:8.44E-4 ID:SGTC_321|Compound:4534-3890|FD-Score:-3.23|P-value:7.90E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-5.26|P-value:1.51E-7 ID:SGTC_910|Compound:3454-3003|FD-Score:-4.28|P-value:1.47E-5 ID:SGTC_916|Compound:4466-0038|FD-Score:-3.85|P-value:8.49E-5 ID:SGTC_926|Compound:2268-1401|FD-Score:3.91|P-value:8.86E-5 ID:SGTC_1131|Compound:3454-3128|FD-Score:3.34|P-value:6.88E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:-3.77|P-value:1.15E-4 ID:SGTC_1138|Compound:3761-0006|FD-Score:-3.36|P-value:5.01E-4 ID:SGTC_1270|Compound:0831-1170|FD-Score:-4.55|P-value:4.58E-6 ID:SGTC_1273|Compound:0849-0096|FD-Score:4.53|P-value:6.82E-6 ID:SGTC_1451|Compound:4152-0210|FD-Score:-3.88|P-value:7.64E-5 ID:SGTC_1503|Compound:4585-0012|FD-Score:-3.54|P-value:2.68E-4 ID:SGTC_1507|Compound:4075-3230|FD-Score:-3.23|P-value:7.97E-4 ID:SGTC_1508|Compound:1080-0625|FD-Score:-4.66|P-value:2.71E-6 ID:SGTC_2329|Compound:6138490|FD-Score:-4.72|P-value:2.13E-6 ID:SGTC_2629|Compound:bisabolol|FD-Score:-5.78|P-value:9.19E-9 ID:SGTC_2638|Compound:epoxomicin|FD-Score:-4.37|P-value:1.00E-5 ID:SGTC_2693|Compound:st077581|FD-Score:-3.58|P-value:2.33E-4 ID:SGTC_2946|Compound:9065502|FD-Score:-3.30|P-value:6.25E-4 ID:SGTC_3191|Compound:9110352|FD-Score:4.26|P-value:2.13E-5 ID:SGTC_3192|Compound:9110362|FD-Score:4.79|P-value:2.06E-6 ID:SGTC_3195|Compound:9113082|FD-Score:-4.30|P-value:1.38E-5 ID:SGTC_3196|Compound:9111891|FD-Score:4.10|P-value:4.14E-5 ID:SGTC_3199|Compound:9111318|FD-Score:-3.41|P-value:4.22E-4 ID:SGTC_3297|Compound:9117502|FD-Score:-3.92|P-value:6.43E-5 ID:SGTC_3314|Compound:9135860|FD-Score:-3.27|P-value:7.00E-4 ID:SGTC_3342|Compound:9147791|FD-Score:-3.30|P-value:6.19E-4 ID:SGTC_3354|Compound:9151612|FD-Score:-3.77|P-value:1.16E-4

Top fitness defect scores for YKL033W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_3192 9110362 4.79 49.5 µM 2.06E-6 mitochondrial processes 3 8.35E-7 0.65
2 SGTC_1273 0849-0096 4.53 14.1 µM 6.82E-6 RPP1 & pyrimidine depletion 4 3.01E-6 0.38
3 SGTC_3191 9110352 4.26 49.5 µM 2.13E-5 2 1.02E-5 1.09
4 SGTC_3196 9111891 4.10 49.5 µM 4.14E-5 mitochondrial processes 3 2.08E-5 0.24
5 SGTC_926 2268-1401 3.91 59.4 µM 8.86E-5 TSC3-RPN4 10 4.69E-5 0.16
6 SGTC_28 pentachloropyridine N-oxide 3.85 1.6 µM 1.09E-4 TSC3-RPN4 4 5.85E-5 0.49
7 SGTC_210 3551-0445 3.41 56.8 µM 5.48E-4 19 3.30E-4 0.12
8 SGTC_1131 3454-3128 3.34 32.3 µM 6.88E-4 24 4.22E-4 0.21
9 SGTC_1733 st037357 3.21 54.9 µM 0.00106 60S ribosome export 14 6.74E-4 0.03
10 SGTC_92 0063-0024 3.19 660.9 µM 0.00112 6 7.11E-4 0.20
11 SGTC_420 mitomycin C 3.17 81.9 mM 0.00119 11 7.62E-4 0.02
12 SGTC_1269 0831-0796 3.06 3.0 µM 0.00169 60S ribosome export 15 0.00111 0.06
13 SGTC_560 2332-1943 2.83 155.0 µM 0.00343 15 0.00236 0.08
14 SGTC_820 1582-0060 2.82 59.9 µM 0.00353 25 0.00243 0.07
15 SGTC_3245 9134821 2.73 49.5 µM 0.00452 21 0.00317 0.02
16 SGTC_327 1273-0057 2.66 4.0 µM 0.00545 azole & statin 21 0.00388 0.01
17 SGTC_3288 9119690 2.62 36.2 µM 0.00611 38 0.00438 0.06
18 SGTC_1728 st035614 2.59 33.8 µM 0.00670 29 0.00484 0.02
19 SGTC_285 1486-1325 2.57 46.0 µM 0.00698 28 0.00505 0.02
20 SGTC_1819 st053448 2.56 58.6 µM 0.00714 amide catabolism 25 0.00517 0.04

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.127 1.93E-13 YLR084C RAX2 hom N-glycosylated protein involved in the maintenance of bud site selection during bipolar budding; localization requires Rax1p; RAX2 mRNA stability is regulated by Mpt5p
0.125 3.50E-13 YGR245C SDA1 het Highly conserved nuclear protein required for actin cytoskeleton organization and passage through Start, plays a critical role in G1 events, binds Nap1p, also involved in 60S ribosome biogenesis
0.119 3.93E-12 YDR452W PPN1 hom Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer; relocalizes from vacuole to cytoplasm upon DNA replication stress
0.119 4.03E-12 YDL153C SAS10 het Essential subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit; disrupts silencing when overproduced; mutant has increased aneuploidy tolerance
0.109 2.63E-10 YGL125W MET13 hom Major isozyme of methylenetetrahydrofolate reductase, catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway
0.107 4.46E-10 YKL156W RPS27A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S27, no bacterial homolog; RPS27A has a paralog, RPS27B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.098 1.31E-8 YJL001W PRE3 het Beta 1 subunit of the 20S proteasome, responsible for cleavage after acidic residues in peptides
0.095 3.00E-8 YIL083C CAB2 het Probable phosphopantothenoylcysteine synthetase (PPCS), which catalyzes the second step of coenzyme A biosynthesis from pantothenate; null mutant lethality is complemented by E. coli coaBC (encoding a bifunctional enzyme with PPCS activity)
0.091 1.49E-7 YGR242W_d YGR242W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YAP1802/YGR241C
0.090 1.98E-7 YDR302W GPI11 het ER membrane protein involved in a late step of glycosylphosphatidylinositol (GPI) anchor assembly; involved in the addition of phosphoethanolamine to the multiply mannosylated GPI intermediate; human PIG-Fp is a functional homolog
0.088 3.29E-7 YPR085C ASA1 het Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1
0.088 3.75E-7 YDR023W SES1 het Cytosolic seryl-tRNA synthetase, class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p
0.087 4.21E-7 YPR110C RPC40 het RNA polymerase subunit AC40, common to RNA polymerase I and III
0.085 9.06E-7 YMR304W UBP15 hom Ubiquitin-specific protease involved in protein deubiquitination; catalytic activity regulated by an N-terminal TRAF-like domain and and C-terminal sequences; physically interacts with anaphase-promoting complex/cyclosome (APC/C) activator, Cdh1p; forms a complex with AAA peroxins Pex1p and Pex6p
0.085 9.19E-7 YLR195C NMT1 het N-myristoyl transferase, catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction