YKL044W_p

Protein of unknown function; mRNA identified as translated by ribosome profiling data

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL044W / YKL044W

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:5.36|P-value:6.33E-9 ID:SGTC_134|Compound:0269-0018|FD-Score:-3.77|P-value:3.62E-5 ID:SGTC_135|Compound:0933-0004|FD-Score:2.93|P-value:8.98E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:6.01|P-value:8.78E-11 ID:SGTC_163|Compound:1327-0036|FD-Score:3.13|P-value:4.24E-4 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:4.40|P-value:1.47E-6 ID:SGTC_342|Compound:k048-0088|FD-Score:4.36|P-value:1.80E-6 ID:SGTC_364|Compound:0083-0097|FD-Score:-3.66|P-value:5.92E-5 ID:SGTC_398|Compound:bronopol|FD-Score:3.62|P-value:5.94E-5 ID:SGTC_559|Compound:1550-0661|FD-Score:3.07|P-value:5.31E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:3.20|P-value:3.22E-4 ID:SGTC_827|Compound:3253-0474|FD-Score:3.61|P-value:6.23E-5 ID:SGTC_839|Compound:0122-0028|FD-Score:2.97|P-value:7.69E-4 ID:SGTC_858|Compound:0438-0351|FD-Score:4.13|P-value:5.58E-6 ID:SGTC_1070|Compound:indatraline|FD-Score:-3.09|P-value:5.85E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.81|P-value:3.01E-5 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:2.92|P-value:9.19E-4 ID:SGTC_1115|Compound:galangin|FD-Score:3.00|P-value:7.09E-4 ID:SGTC_1169|Compound:aniline yellow|FD-Score:3.52|P-value:8.85E-5 ID:SGTC_1219|Compound:1469-0211|FD-Score:4.08|P-value:7.24E-6 ID:SGTC_1264|Compound:0783-0040|FD-Score:4.00|P-value:1.03E-5 ID:SGTC_1447|Compound:4239-0816|FD-Score:3.06|P-value:5.49E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:4.23|P-value:3.52E-6 ID:SGTC_1461|Compound:k072-0203|FD-Score:3.50|P-value:9.89E-5 ID:SGTC_1545|Compound:lovastatin|FD-Score:3.39|P-value:1.51E-4 ID:SGTC_1605|Compound:st000082|FD-Score:-4.93|P-value:1.07E-7 ID:SGTC_1606|Compound:st000094|FD-Score:4.99|P-value:5.64E-8 ID:SGTC_1607|Compound:st000305|FD-Score:3.77|P-value:3.06E-5 ID:SGTC_1624|Compound:st003710|FD-Score:3.51|P-value:9.26E-5 ID:SGTC_1728|Compound:st035614|FD-Score:-3.06|P-value:6.50E-4 ID:SGTC_1729|Compound:st035615|FD-Score:-4.40|P-value:1.82E-6 ID:SGTC_1730|Compound:st033808|FD-Score:-5.37|P-value:7.95E-9 ID:SGTC_1736|Compound:st036774|FD-Score:4.38|P-value:1.66E-6 ID:SGTC_1794|Compound:st048918|FD-Score:2.93|P-value:9.00E-4 ID:SGTC_1948|Compound:st076329|FD-Score:4.09|P-value:6.86E-6 ID:SGTC_1955|Compound:wogonin|FD-Score:-3.34|P-value:2.24E-4 ID:SGTC_2077|Compound:5212015|FD-Score:2.92|P-value:9.35E-4 ID:SGTC_2151|Compound:5563267|FD-Score:3.09|P-value:5.06E-4 ID:SGTC_2324|Compound:6149169|FD-Score:7.79|P-value:7.02E-17 ID:SGTC_2325|Compound:6158266|FD-Score:3.36|P-value:1.77E-4 ID:SGTC_2327|Compound:6189656|FD-Score:5.92|P-value:1.70E-10 ID:SGTC_2345|Compound:9052315|FD-Score:3.66|P-value:5.02E-5 ID:SGTC_2347|Compound:9049783|FD-Score:3.12|P-value:4.53E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-6.14|P-value:4.74E-11 ID:SGTC_2412|Compound:st077135|FD-Score:3.92|P-value:1.53E-5 ID:SGTC_2415|Compound:st077333|FD-Score:3.89|P-value:1.74E-5 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:3.12|P-value:4.41E-4 ID:SGTC_2523|Compound:spermine|FD-Score:3.41|P-value:1.44E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:6.32|P-value:1.01E-11 ID:SGTC_2533|Compound:agelasine|FD-Score:3.11|P-value:4.64E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:-3.45|P-value:1.45E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:-3.24|P-value:3.28E-4 ID:SGTC_2856|Compound:9022925|FD-Score:3.45|P-value:1.23E-4 ID:SGTC_3026|Compound:9090633|FD-Score:-3.02|P-value:7.64E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-3.06|P-value:6.65E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:5.36|P-value:6.33E-9 ID:SGTC_134|Compound:0269-0018|FD-Score:-3.77|P-value:3.62E-5 ID:SGTC_135|Compound:0933-0004|FD-Score:2.93|P-value:8.98E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:6.01|P-value:8.78E-11 ID:SGTC_163|Compound:1327-0036|FD-Score:3.13|P-value:4.24E-4 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:4.40|P-value:1.47E-6 ID:SGTC_342|Compound:k048-0088|FD-Score:4.36|P-value:1.80E-6 ID:SGTC_364|Compound:0083-0097|FD-Score:-3.66|P-value:5.92E-5 ID:SGTC_398|Compound:bronopol|FD-Score:3.62|P-value:5.94E-5 ID:SGTC_559|Compound:1550-0661|FD-Score:3.07|P-value:5.31E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:3.20|P-value:3.22E-4 ID:SGTC_827|Compound:3253-0474|FD-Score:3.61|P-value:6.23E-5 ID:SGTC_839|Compound:0122-0028|FD-Score:2.97|P-value:7.69E-4 ID:SGTC_858|Compound:0438-0351|FD-Score:4.13|P-value:5.58E-6 ID:SGTC_1070|Compound:indatraline|FD-Score:-3.09|P-value:5.85E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.81|P-value:3.01E-5 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:2.92|P-value:9.19E-4 ID:SGTC_1115|Compound:galangin|FD-Score:3.00|P-value:7.09E-4 ID:SGTC_1169|Compound:aniline yellow|FD-Score:3.52|P-value:8.85E-5 ID:SGTC_1219|Compound:1469-0211|FD-Score:4.08|P-value:7.24E-6 ID:SGTC_1264|Compound:0783-0040|FD-Score:4.00|P-value:1.03E-5 ID:SGTC_1447|Compound:4239-0816|FD-Score:3.06|P-value:5.49E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:4.23|P-value:3.52E-6 ID:SGTC_1461|Compound:k072-0203|FD-Score:3.50|P-value:9.89E-5 ID:SGTC_1545|Compound:lovastatin|FD-Score:3.39|P-value:1.51E-4 ID:SGTC_1605|Compound:st000082|FD-Score:-4.93|P-value:1.07E-7 ID:SGTC_1606|Compound:st000094|FD-Score:4.99|P-value:5.64E-8 ID:SGTC_1607|Compound:st000305|FD-Score:3.77|P-value:3.06E-5 ID:SGTC_1624|Compound:st003710|FD-Score:3.51|P-value:9.26E-5 ID:SGTC_1728|Compound:st035614|FD-Score:-3.06|P-value:6.50E-4 ID:SGTC_1729|Compound:st035615|FD-Score:-4.40|P-value:1.82E-6 ID:SGTC_1730|Compound:st033808|FD-Score:-5.37|P-value:7.95E-9 ID:SGTC_1736|Compound:st036774|FD-Score:4.38|P-value:1.66E-6 ID:SGTC_1794|Compound:st048918|FD-Score:2.93|P-value:9.00E-4 ID:SGTC_1948|Compound:st076329|FD-Score:4.09|P-value:6.86E-6 ID:SGTC_1955|Compound:wogonin|FD-Score:-3.34|P-value:2.24E-4 ID:SGTC_2077|Compound:5212015|FD-Score:2.92|P-value:9.35E-4 ID:SGTC_2151|Compound:5563267|FD-Score:3.09|P-value:5.06E-4 ID:SGTC_2324|Compound:6149169|FD-Score:7.79|P-value:7.02E-17 ID:SGTC_2325|Compound:6158266|FD-Score:3.36|P-value:1.77E-4 ID:SGTC_2327|Compound:6189656|FD-Score:5.92|P-value:1.70E-10 ID:SGTC_2345|Compound:9052315|FD-Score:3.66|P-value:5.02E-5 ID:SGTC_2347|Compound:9049783|FD-Score:3.12|P-value:4.53E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-6.14|P-value:4.74E-11 ID:SGTC_2412|Compound:st077135|FD-Score:3.92|P-value:1.53E-5 ID:SGTC_2415|Compound:st077333|FD-Score:3.89|P-value:1.74E-5 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:3.12|P-value:4.41E-4 ID:SGTC_2523|Compound:spermine|FD-Score:3.41|P-value:1.44E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:6.32|P-value:1.01E-11 ID:SGTC_2533|Compound:agelasine|FD-Score:3.11|P-value:4.64E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:-3.45|P-value:1.45E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:-3.24|P-value:3.28E-4 ID:SGTC_2856|Compound:9022925|FD-Score:3.45|P-value:1.23E-4 ID:SGTC_3026|Compound:9090633|FD-Score:-3.02|P-value:7.64E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-3.06|P-value:6.65E-4

Top fitness defect scores for YKL044W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2324 6149169 7.79 200.0 µM 7.02E-17 1 3.30E-15
2 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 6.32 63.6 µM 1.01E-11 11 1.33E-10
3 SGTC_138 0850-0259 6.01 40.9 µM 8.78E-11 cell wall 105 9.19E-10
4 SGTC_2327 6189656 5.92 200.0 µM 1.70E-10 4 1.66E-9
5 SGTC_58 0957-0393 5.36 9.0 µM 6.33E-9 cell wall 250 4.19E-8
6 SGTC_1606 st000094 4.99 49.2 µM 5.64E-8 60S ribosome export 4 2.96E-7
7 SGTC_238 5hr heat shock (37°C) + nsc-638432 4.40 8.9 µM 1.47E-6 heat shock/prefoldin 29 5.44E-6
8 SGTC_1736 st036774 4.38 51.0 µM 1.66E-6 22 6.07E-6
9 SGTC_342 k048-0088 4.36 23.3 µM 1.80E-6 RSC & ERG11 12 6.55E-6
10 SGTC_1459 k035-0031 4.23 35.7 µM 3.52E-6 DNA intercalators 18 1.19E-5
11 SGTC_858 0438-0351 4.13 2.8 µM 5.58E-6 copper-dependent oxidative stress 17 1.80E-5
12 SGTC_1948 st076329 4.09 66.6 µM 6.86E-6 24 2.16E-5
13 SGTC_1219 1469-0211 4.08 33.1 µM 7.24E-6 19 2.27E-5
14 SGTC_1264 0783-0040 4.00 158.0 µM 1.03E-5 27 3.12E-5
15 SGTC_2412 st077135 3.92 33.4 µM 1.53E-5 25 4.43E-5
16 SGTC_2415 st077333 3.89 57.7 µM 1.74E-5 47 4.97E-5
17 SGTC_1607 st000305 3.77 50.6 µM 3.06E-5 17 8.24E-5
18 SGTC_2345 9052315 3.66 157.4 µM 5.02E-5 22 1.28E-4
19 SGTC_398 bronopol 3.62 33.3 µM 5.94E-5 RNA processing & uracil transport 27 1.49E-4
20 SGTC_827 3253-0474 3.61 693.0 µM 6.23E-5 27 1.55E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.204 5.86E-33 YAL015C NTG1 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication
0.174 2.34E-24 YNL233W BNI4 hom Targeting subunit for Glc7p protein phosphatase, localized to the bud neck, required for localization of chitin synthase III to the bud neck via interaction with the chitin synthase III regulatory subunit Skt5p
0.173 4.80E-24 YLR150W STM1 hom Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure; protein abundance increases in response to DNA replication stress; serves as a ribosome preservation factor both during quiescence and recovery
0.169 8.22E-23 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.156 1.11E-19 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.151 1.43E-18 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.150 1.95E-18 YJL080C SCP160 hom Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins
0.145 3.06E-17 YOR051C ETT1 hom Nuclear protein that inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts; deletion increases stop codon readthrough
0.142 1.23E-16 YML057C-A_d YML057C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene CMP2/YML057W
0.141 2.68E-16 YPL269W KAR9 hom Karyogamy protein required for correct positioning of the mitotic spindle and for orienting cytoplasmic microtubules, localizes at the shmoo tip in mating cells and at the tip of the growing bud in small-budded cells through anaphase
0.140 4.53E-16 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.137 1.39E-15 YBL031W SHE1 hom Mitotic spindle protein; interacts with components of the Dam1 (DASH) complex, its effector Sli15p, and microtubule-associated protein Bim1p; also localizes to nuclear microtubules and to the bud neck in a ring-shaped structure; inhibits dynein function
0.137 1.83E-15 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.136 2.18E-15 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.134 5.51E-15 YCL005W LDB16 hom Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria