YKL050C

Protein of unknown function; the YKL050W protein is a target of the SCFCdc4 ubiquitin ligase complex and YKL050W transcription is regulated by Azf1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL050C / YKL050C

Click on Significant Values for Screen Details ID:SGTC_613|Compound:3914-0030|FD-Score:-3.35|P-value:6.35E-5 ID:SGTC_770|Compound:0389-1121|FD-Score:-3.05|P-value:2.49E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:-3.43|P-value:4.28E-5 ID:SGTC_903|Compound:1134-0042|FD-Score:-3.45|P-value:3.94E-5 ID:SGTC_906|Compound:1165-0455|FD-Score:-3.45|P-value:3.92E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-2.93|P-value:4.20E-4 ID:SGTC_1115|Compound:galangin|FD-Score:3.95|P-value:1.71E-6 ID:SGTC_1178|Compound:0988-0033|FD-Score:2.70|P-value:6.92E-4 ID:SGTC_1268|Compound:0828-0275|FD-Score:-3.28|P-value:8.65E-5 ID:SGTC_1327|Compound:1436-0082|FD-Score:2.80|P-value:4.66E-4 ID:SGTC_1448|Compound:4255-0083|FD-Score:2.87|P-value:3.51E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-2.82|P-value:6.56E-4 ID:SGTC_1460|Compound:k062-0059|FD-Score:-2.91|P-value:4.47E-4 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:2.69|P-value:7.28E-4 ID:SGTC_1715|Compound:st032160|FD-Score:2.81|P-value:4.40E-4 ID:SGTC_1747|Compound:st037496|FD-Score:-3.02|P-value:2.84E-4 ID:SGTC_1878|Compound:temozolomide|FD-Score:2.77|P-value:5.22E-4 ID:SGTC_1959|Compound:st077091|FD-Score:-2.72|P-value:9.75E-4 ID:SGTC_2005|Compound:4024620|FD-Score:-3.03|P-value:2.75E-4 ID:SGTC_2022|Compound:5136654|FD-Score:-2.89|P-value:4.97E-4 ID:SGTC_2029|Compound:5175081|FD-Score:-3.13|P-value:1.74E-4 ID:SGTC_2037|Compound:5169046|FD-Score:-2.87|P-value:5.25E-4 ID:SGTC_2038|Compound:4100038|FD-Score:4.04|P-value:9.76E-7 ID:SGTC_2046|Compound:4110841|FD-Score:3.25|P-value:6.39E-5 ID:SGTC_2115|Compound:tiliquinol|FD-Score:2.71|P-value:6.82E-4 ID:SGTC_2220|Compound:6782180|FD-Score:2.64|P-value:8.98E-4 ID:SGTC_2238|Compound:6671620|FD-Score:3.27|P-value:5.70E-5 ID:SGTC_2247|Compound:cerulenin|FD-Score:2.81|P-value:4.40E-4 ID:SGTC_2305|Compound:7443522|FD-Score:2.63|P-value:9.38E-4 ID:SGTC_2321|Compound:7390090|FD-Score:-4.03|P-value:1.88E-6 ID:SGTC_2325|Compound:6158266|FD-Score:-3.82|P-value:6.04E-6 ID:SGTC_2358|Compound:9037157|FD-Score:-2.99|P-value:3.28E-4 ID:SGTC_2359|Compound:9039622|FD-Score:2.70|P-value:6.96E-4 ID:SGTC_2363|Compound:9053361|FD-Score:-3.71|P-value:1.07E-5 ID:SGTC_2415|Compound:st077333|FD-Score:3.69|P-value:7.01E-6 ID:SGTC_2537|Compound:larixol|FD-Score:3.06|P-value:1.51E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:-3.31|P-value:7.73E-5 ID:SGTC_2834|Compound:9001755|FD-Score:3.15|P-value:1.01E-4 ID:SGTC_2848|Compound:9016370|FD-Score:3.26|P-value:5.91E-5 ID:SGTC_2917|Compound:7979103|FD-Score:2.87|P-value:3.52E-4 ID:SGTC_2919|Compound:7978188|FD-Score:3.06|P-value:1.53E-4 ID:SGTC_2922|Compound:7999257|FD-Score:-3.20|P-value:1.28E-4 ID:SGTC_2992|Compound:9074591|FD-Score:-2.79|P-value:7.37E-4 ID:SGTC_3016|Compound:9080866|FD-Score:-2.85|P-value:5.68E-4 ID:SGTC_3085|Compound:9117376|FD-Score:-3.04|P-value:2.61E-4 ID:SGTC_3088|Compound:9117578|FD-Score:-2.84|P-value:5.96E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-3.35|P-value:6.35E-5 ID:SGTC_770|Compound:0389-1121|FD-Score:-3.05|P-value:2.49E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:-3.43|P-value:4.28E-5 ID:SGTC_903|Compound:1134-0042|FD-Score:-3.45|P-value:3.94E-5 ID:SGTC_906|Compound:1165-0455|FD-Score:-3.45|P-value:3.92E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-2.93|P-value:4.20E-4 ID:SGTC_1115|Compound:galangin|FD-Score:3.95|P-value:1.71E-6 ID:SGTC_1178|Compound:0988-0033|FD-Score:2.70|P-value:6.92E-4 ID:SGTC_1268|Compound:0828-0275|FD-Score:-3.28|P-value:8.65E-5 ID:SGTC_1327|Compound:1436-0082|FD-Score:2.80|P-value:4.66E-4 ID:SGTC_1448|Compound:4255-0083|FD-Score:2.87|P-value:3.51E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-2.82|P-value:6.56E-4 ID:SGTC_1460|Compound:k062-0059|FD-Score:-2.91|P-value:4.47E-4 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:2.69|P-value:7.28E-4 ID:SGTC_1715|Compound:st032160|FD-Score:2.81|P-value:4.40E-4 ID:SGTC_1747|Compound:st037496|FD-Score:-3.02|P-value:2.84E-4 ID:SGTC_1878|Compound:temozolomide|FD-Score:2.77|P-value:5.22E-4 ID:SGTC_1959|Compound:st077091|FD-Score:-2.72|P-value:9.75E-4 ID:SGTC_2005|Compound:4024620|FD-Score:-3.03|P-value:2.75E-4 ID:SGTC_2022|Compound:5136654|FD-Score:-2.89|P-value:4.97E-4 ID:SGTC_2029|Compound:5175081|FD-Score:-3.13|P-value:1.74E-4 ID:SGTC_2037|Compound:5169046|FD-Score:-2.87|P-value:5.25E-4 ID:SGTC_2038|Compound:4100038|FD-Score:4.04|P-value:9.76E-7 ID:SGTC_2046|Compound:4110841|FD-Score:3.25|P-value:6.39E-5 ID:SGTC_2115|Compound:tiliquinol|FD-Score:2.71|P-value:6.82E-4 ID:SGTC_2220|Compound:6782180|FD-Score:2.64|P-value:8.98E-4 ID:SGTC_2238|Compound:6671620|FD-Score:3.27|P-value:5.70E-5 ID:SGTC_2247|Compound:cerulenin|FD-Score:2.81|P-value:4.40E-4 ID:SGTC_2305|Compound:7443522|FD-Score:2.63|P-value:9.38E-4 ID:SGTC_2321|Compound:7390090|FD-Score:-4.03|P-value:1.88E-6 ID:SGTC_2325|Compound:6158266|FD-Score:-3.82|P-value:6.04E-6 ID:SGTC_2358|Compound:9037157|FD-Score:-2.99|P-value:3.28E-4 ID:SGTC_2359|Compound:9039622|FD-Score:2.70|P-value:6.96E-4 ID:SGTC_2363|Compound:9053361|FD-Score:-3.71|P-value:1.07E-5 ID:SGTC_2415|Compound:st077333|FD-Score:3.69|P-value:7.01E-6 ID:SGTC_2537|Compound:larixol|FD-Score:3.06|P-value:1.51E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:-3.31|P-value:7.73E-5 ID:SGTC_2834|Compound:9001755|FD-Score:3.15|P-value:1.01E-4 ID:SGTC_2848|Compound:9016370|FD-Score:3.26|P-value:5.91E-5 ID:SGTC_2917|Compound:7979103|FD-Score:2.87|P-value:3.52E-4 ID:SGTC_2919|Compound:7978188|FD-Score:3.06|P-value:1.53E-4 ID:SGTC_2922|Compound:7999257|FD-Score:-3.20|P-value:1.28E-4 ID:SGTC_2992|Compound:9074591|FD-Score:-2.79|P-value:7.37E-4 ID:SGTC_3016|Compound:9080866|FD-Score:-2.85|P-value:5.68E-4 ID:SGTC_3085|Compound:9117376|FD-Score:-3.04|P-value:2.61E-4 ID:SGTC_3088|Compound:9117578|FD-Score:-2.84|P-value:5.96E-4

Top fitness defect scores for YKL050C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2038 4100038 4.04 31.0 µM 9.76E-7 plasma membrane duress 49 2.62E-5
2 SGTC_1115 galangin 3.95 695.7 nM 1.71E-6 RPP1 & pyrimidine depletion 14 3.97E-5
3 SGTC_2415 st077333 3.69 57.7 µM 7.01E-6 61 1.13E-4
4 SGTC_2238 6671620 3.27 73.2 µM 5.70E-5 53 5.37E-4
5 SGTC_2848 9016370 3.26 26.0 µM 5.91E-5 57 5.52E-4
6 SGTC_2046 4110841 3.25 106.0 µM 6.39E-5 iron homeostasis 50 5.85E-4
7 SGTC_2834 9001755 3.15 58.4 µM 1.01E-4 73 8.21E-4
8 SGTC_2537 larixol 3.06 68.9 µM 1.51E-4 67 0.00111
9 SGTC_2919 7978188 3.06 46.4 µM 1.53E-4 62 0.00112
10 SGTC_1448 4255-0083 2.87 152.0 µM 3.51E-4 ERG2 71 0.00208
11 SGTC_2917 7979103 2.87 53.8 µM 3.52E-4 91 0.00208
12 SGTC_2247 cerulenin 2.81 830.0 nM 4.40E-4 72 0.00246
13 SGTC_1715 st032160 2.81 10.2 µM 4.40E-4 102 0.00246
14 SGTC_1327 1436-0082 2.80 2.2 µM 4.66E-4 72 0.00257
15 SGTC_1878 temozolomide 2.77 1.0 mM 5.22E-4 52 0.00280
16 SGTC_2115 tiliquinol 2.71 12.8 µM 6.82E-4 56 0.00341
17 SGTC_1178 0988-0033 2.70 191.0 µM 6.92E-4 117 0.00345
18 SGTC_2359 9039622 2.70 200.0 µM 6.96E-4 endomembrane recycling 103 0.00347
19 SGTC_1586 deoxycorticosterone acetate 2.69 53.7 µM 7.28E-4 70 0.00358
20 SGTC_2220 6782180 2.64 200.0 µM 8.98E-4 RNA processing & uracil transport 41 0.00419

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.152 7.87E-19 YEL058W PCM1 het Essential N-acetylglucosamine-phosphate mutase; converts GlcNAc-6-P to GlcNAc-1-P, which is a precursor for the biosynthesis of chitin and for the formation of N-glycosylated mannoproteins and glycosylphosphatidylinositol anchors
0.117 1.18E-11 YOR062C_p YOR062C_p hom Protein of unknown function; similar to YKR075Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
0.114 3.13E-11 YGL235W_p YGL235W_p hom Putative protein of unknown function; potential Cdc28p substrate; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
0.108 3.75E-10 YMR112C MED11 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential protein
0.104 1.76E-9 YGL081W_p YGL081W_p hom Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis
0.102 3.28E-9 YOR093C_p YOR093C_p hom Putative protein of unknown function; deletion causes sensitivity to unfolded protein response-inducing agents
0.099 9.93E-9 YDL174C DLD1 hom D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane
0.098 1.39E-8 YJR116W_p TDA4_p hom Putative protein of unknown function; null mutant is sensitive to expression of the top1-T722A allele
0.098 1.49E-8 YKL166C TPK3 hom cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk2p; localizes to P-bodies during stationary phase; TPK3 has a paralog, TPK1, that arose from the whole genome duplication
0.097 2.04E-8 YML083C YML083C hom Protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions
0.096 2.42E-8 YDR422C SIP1 hom Alternate beta-subunit of the Snf1p kinase complex, may confer substrate specificity; vacuolar protein containing KIS (Kinase-Interacting Sequence) and ASC (Association with Snf1 kinase Complex) domains involved in protein interactions
0.096 2.90E-8 YNR039C ZRG17 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Msc2p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; zinc-regulated directly through Zap1p; transcription induced under conditions of zinc deficiency
0.095 3.08E-8 YOR079C ATX2 hom Golgi membrane protein involved in manganese homeostasis; overproduction suppresses the sod1 (copper, zinc superoxide dismutase) null mutation
0.093 5.78E-8 YGR189C CRH1 hom Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar and functionally redundant to Utr2; localizes to sites of polarized growth; expression induced by cell wall stress
0.093 6.92E-8 YLL006W-A_p YLL006W-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR