YKL079W / SMY1

Protein that interacts with Myo2p, proposed to be involved in exocytosis; N-terminal domain is related to the motor domain of kinesins

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL079W / SMY1

Click on Significant Values for Screen Details ID:SGTC_263|Compound:alizarin|FD-Score:2.88|P-value:9.86E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:-3.20|P-value:3.96E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:6.32|P-value:7.70E-12 ID:SGTC_431|Compound:k089-0097|FD-Score:3.42|P-value:1.23E-4 ID:SGTC_493|Compound:zm226600|FD-Score:-3.08|P-value:6.11E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:3.25|P-value:2.43E-4 ID:SGTC_610|Compound:4215-0184|FD-Score:-4.04|P-value:1.09E-5 ID:SGTC_637|Compound:1181-0519|FD-Score:3.26|P-value:2.35E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:3.02|P-value:5.98E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:4.43|P-value:1.06E-6 ID:SGTC_699|Compound:0375-0592|FD-Score:3.30|P-value:1.97E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:3.29|P-value:2.12E-4 ID:SGTC_793|Compound:0488-0545|FD-Score:4.45|P-value:9.91E-7 ID:SGTC_813|Compound:k007-0158|FD-Score:3.44|P-value:1.12E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:3.10|P-value:4.45E-4 ID:SGTC_866|Compound:0495-0101|FD-Score:3.08|P-value:4.68E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:3.05|P-value:5.39E-4 ID:SGTC_980|Compound:1473-0395|FD-Score:-3.20|P-value:3.93E-4 ID:SGTC_1015|Compound:4130-4525|FD-Score:-2.96|P-value:9.45E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:2.93|P-value:8.27E-4 ID:SGTC_1293|Compound:1000-1278|FD-Score:3.04|P-value:5.53E-4 ID:SGTC_1306|Compound:1185-0270|FD-Score:5.64|P-value:8.44E-10 ID:SGTC_1474|Compound:0330-0125|FD-Score:-3.75|P-value:4.14E-5 ID:SGTC_1485|Compound:3909-9022|FD-Score:-3.30|P-value:2.71E-4 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:-3.38|P-value:1.95E-4 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:5.47|P-value:2.56E-9 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.27|P-value:2.23E-4 ID:SGTC_1603|Compound:st002045|FD-Score:-3.22|P-value:3.67E-4 ID:SGTC_1617|Compound:st002906|FD-Score:-3.74|P-value:4.19E-5 ID:SGTC_1909|Compound:st060837|FD-Score:5.27|P-value:8.96E-9 ID:SGTC_1956|Compound:st077085|FD-Score:-3.43|P-value:1.55E-4 ID:SGTC_1961|Compound:st076550|FD-Score:3.67|P-value:4.29E-5 ID:SGTC_2013|Compound:4024628|FD-Score:4.70|P-value:2.51E-7 ID:SGTC_2021|Compound:4019055|FD-Score:4.56|P-value:5.45E-7 ID:SGTC_2111|Compound:5486399|FD-Score:-4.67|P-value:4.41E-7 ID:SGTC_2244|Compound:6635614|FD-Score:-3.23|P-value:3.51E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:2.91|P-value:8.92E-4 ID:SGTC_2329|Compound:6138490|FD-Score:2.92|P-value:8.69E-4 ID:SGTC_2335|Compound:9018011|FD-Score:5.58|P-value:1.28E-9 ID:SGTC_2584|Compound:androsterone|FD-Score:4.24|P-value:2.79E-6 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:4.85|P-value:1.06E-7 ID:SGTC_2716|Compound:st080858|FD-Score:3.32|P-value:1.83E-4 ID:SGTC_2918|Compound:7977171|FD-Score:3.10|P-value:4.44E-4 ID:SGTC_2919|Compound:7978188|FD-Score:4.03|P-value:8.10E-6 ID:SGTC_2921|Compound:7974240|FD-Score:5.09|P-value:2.62E-8 ID:SGTC_2926|Compound:9010726|FD-Score:3.30|P-value:1.98E-4 ID:SGTC_2932|Compound:9016711|FD-Score:4.99|P-value:4.72E-8 ID:SGTC_2938|Compound:9059746|FD-Score:-7.06|P-value:4.67E-14 ID:SGTC_3133|Compound:9127736|FD-Score:5.18|P-value:1.56E-8 ID:SGTC_263|Compound:alizarin|FD-Score:2.88|P-value:9.86E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:-3.20|P-value:3.96E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:6.32|P-value:7.70E-12 ID:SGTC_431|Compound:k089-0097|FD-Score:3.42|P-value:1.23E-4 ID:SGTC_493|Compound:zm226600|FD-Score:-3.08|P-value:6.11E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:3.25|P-value:2.43E-4 ID:SGTC_610|Compound:4215-0184|FD-Score:-4.04|P-value:1.09E-5 ID:SGTC_637|Compound:1181-0519|FD-Score:3.26|P-value:2.35E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:3.02|P-value:5.98E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:4.43|P-value:1.06E-6 ID:SGTC_699|Compound:0375-0592|FD-Score:3.30|P-value:1.97E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:3.29|P-value:2.12E-4 ID:SGTC_793|Compound:0488-0545|FD-Score:4.45|P-value:9.91E-7 ID:SGTC_813|Compound:k007-0158|FD-Score:3.44|P-value:1.12E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:3.10|P-value:4.45E-4 ID:SGTC_866|Compound:0495-0101|FD-Score:3.08|P-value:4.68E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:3.05|P-value:5.39E-4 ID:SGTC_980|Compound:1473-0395|FD-Score:-3.20|P-value:3.93E-4 ID:SGTC_1015|Compound:4130-4525|FD-Score:-2.96|P-value:9.45E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:2.93|P-value:8.27E-4 ID:SGTC_1293|Compound:1000-1278|FD-Score:3.04|P-value:5.53E-4 ID:SGTC_1306|Compound:1185-0270|FD-Score:5.64|P-value:8.44E-10 ID:SGTC_1474|Compound:0330-0125|FD-Score:-3.75|P-value:4.14E-5 ID:SGTC_1485|Compound:3909-9022|FD-Score:-3.30|P-value:2.71E-4 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:-3.38|P-value:1.95E-4 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:5.47|P-value:2.56E-9 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.27|P-value:2.23E-4 ID:SGTC_1603|Compound:st002045|FD-Score:-3.22|P-value:3.67E-4 ID:SGTC_1617|Compound:st002906|FD-Score:-3.74|P-value:4.19E-5 ID:SGTC_1909|Compound:st060837|FD-Score:5.27|P-value:8.96E-9 ID:SGTC_1956|Compound:st077085|FD-Score:-3.43|P-value:1.55E-4 ID:SGTC_1961|Compound:st076550|FD-Score:3.67|P-value:4.29E-5 ID:SGTC_2013|Compound:4024628|FD-Score:4.70|P-value:2.51E-7 ID:SGTC_2021|Compound:4019055|FD-Score:4.56|P-value:5.45E-7 ID:SGTC_2111|Compound:5486399|FD-Score:-4.67|P-value:4.41E-7 ID:SGTC_2244|Compound:6635614|FD-Score:-3.23|P-value:3.51E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:2.91|P-value:8.92E-4 ID:SGTC_2329|Compound:6138490|FD-Score:2.92|P-value:8.69E-4 ID:SGTC_2335|Compound:9018011|FD-Score:5.58|P-value:1.28E-9 ID:SGTC_2584|Compound:androsterone|FD-Score:4.24|P-value:2.79E-6 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:4.85|P-value:1.06E-7 ID:SGTC_2716|Compound:st080858|FD-Score:3.32|P-value:1.83E-4 ID:SGTC_2918|Compound:7977171|FD-Score:3.10|P-value:4.44E-4 ID:SGTC_2919|Compound:7978188|FD-Score:4.03|P-value:8.10E-6 ID:SGTC_2921|Compound:7974240|FD-Score:5.09|P-value:2.62E-8 ID:SGTC_2926|Compound:9010726|FD-Score:3.30|P-value:1.98E-4 ID:SGTC_2932|Compound:9016711|FD-Score:4.99|P-value:4.72E-8 ID:SGTC_2938|Compound:9059746|FD-Score:-7.06|P-value:4.67E-14 ID:SGTC_3133|Compound:9127736|FD-Score:5.18|P-value:1.56E-8

Top fitness defect scores for YKL079W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_312 4092-0653 6.32 6.8 µM 7.70E-12 ergosterol depletion effects on membrane 35 1.31E-10
2 SGTC_1306 1185-0270 5.64 9.0 µM 8.44E-10 Golgi 31 8.40E-9
3 SGTC_2335 9018011 5.58 154.2 µM 1.28E-9 7 1.22E-8
4 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 5.47 66.5 µM 2.56E-9 4 2.24E-8
5 SGTC_1909 st060837 5.27 51.5 µM 8.96E-9 23 6.80E-8
6 SGTC_3133 9127736 5.18 49.5 µM 1.56E-8 3 1.11E-7
7 SGTC_2921 7974240 5.09 10.7 µM 2.62E-8 24 1.76E-7
8 SGTC_2932 9016711 4.99 44.5 µM 4.72E-8 23 2.96E-7
9 SGTC_2588 indole-3-carbinol 4.85 100.0 µM 1.06E-7 22 6.07E-7
10 SGTC_2013 4024628 4.70 200.0 µM 2.51E-7 27 1.30E-6
11 SGTC_2021 4019055 4.56 173.0 µM 5.45E-7 endomembrane recycling 85 2.59E-6
12 SGTC_793 0488-0545 4.45 106.0 µM 9.91E-7 10 4.39E-6
13 SGTC_658 3253-0951 4.43 102.0 µM 1.06E-6 calcium & mitochondrial duress 43 4.66E-6
14 SGTC_2584 androsterone 4.24 48.7 µM 2.79E-6 cell wall 112 1.10E-5
15 SGTC_2919 7978188 4.03 46.4 µM 8.10E-6 17 2.82E-5
16 SGTC_1961 st076550 3.67 68.7 µM 4.29E-5 19 1.24E-4
17 SGTC_813 k007-0158 3.44 173.0 µM 1.12E-4 fatty acid desaturase (OLE1) 66 2.90E-4
18 SGTC_431 k089-0097 3.42 107.0 µM 1.23E-4 iron homeostasis 66 3.13E-4
19 SGTC_2716 st080858 3.32 38.6 µM 1.83E-4 60S ribosome export 34 4.47E-4
20 SGTC_699 0375-0592 3.30 111.0 µM 1.97E-4 iron homeostasis 44 4.77E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.137 1.70E-15 YPL259C APM1 hom Mu1-like medium subunit of the clathrin-associated protein complex (AP-1); binds clathrin; involved in clathrin-dependent Golgi protein sorting
0.124 5.68E-13 YGL116W CDC20 het Activator of anaphase-promoting complex/cyclosome (APC/C); APC/C is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; cell-cycle regulated; potential Cdc28p substrate; relative distribution to the nucleus increases upon DNA replication stress
0.116 1.75E-11 YNL070W TOM7 hom Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex
0.115 2.87E-11 YNL219C ALG9 hom Mannosyltransferase, involved in N-linked glycosylation; catalyzes both the transfer of seventh mannose residue on B-arm and ninth mannose residue on the C-arm from Dol-P-Man to lipid-linked oligosaccharides; mutation of the human ortholog causes type 1 congenital disorders of glycosylation
0.114 3.26E-11 YPR055W SEC8 het Essential 121 kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; involved in ER and Golgi inheritance in small buds; relocalizes away from bud neck upon DNA replication stress
0.113 5.25E-11 YKL051W SFK1 hom Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
0.112 7.94E-11 YLR380W CSR1 hom Phosphatidylinositol transfer protein; has a potential role in regulating lipid and fatty acid metabolism under heme-depleted conditions; interacts specifically with thioredoxin peroxidase; may have a role in oxidative stress resistance; protein abundance increases in response to DNA replication stress
0.111 1.24E-10 YDR310C SUM1 hom Transcriptional repressor required for mitotic repression of middle sporulation-specific genes; also acts as general replication initiation factor; involved in telomere maintenance, chromatin silencing; regulated by pachytene checkpoint
0.108 3.50E-10 YJL165C HAL5 hom Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters; HAL5 has a paralog, KKQ8, that arose from the whole genome duplication
0.107 4.80E-10 YOR115C TRS33 hom One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
0.107 5.82E-10 YLR190W MMR1 hom Phosphorylated protein of the mitochondrial outer membrane, localizes only to mitochondria of the bud; interacts with Myo2p to mediate mitochondrial distribution to buds; mRNA is targeted to the bud via the transport system involving She2p
0.105 1.04E-9 YBL046W PSY4 hom Regulatory subunit of protein phosphatase PP4; presence of Psy4p in the PP4 complex (along with catalytic subunit Pph3p and Psy2p) is required for dephosphorylation of the histone variant H2AX, but not for dephosphorylation of Rad53p, during recovery from the DNA damage checkpoint; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; required for cisplatin resistance; homolog of mammalian R2
0.104 1.64E-9 YIL068C SEC6 het Essential 88kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; anchors the assembled complex to sites of secretion; interacts with SM-like protein and SNARE regulator Sec1p and may recruit it to sites of secretion; interacts with Sec9p and inhibits formation of the t-SNARE complex between Sec9p and Sso1p
0.104 1.82E-9 YDL133W SRF1 hom Regulator of phospholipase D (Spo14p); interacts with Spo14p and regulates its catalytic activity; capable of buffering the toxicity of C16:0 platelet activating factor, a lipid that accumulates intraneuronally in Alzheimer's patients
0.103 2.33E-9 YGR149W_p YGR149W_p hom Putative protein of unknown function; predicted to be an integal membrane protein