YKL094W / YJU3

Monoglyceride lipase (MGL), functional ortholog of mammalian MGL, localizes to lipid particles and membranes, also member of the eukaryotic serine hydrolase family

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL094W / YJU3

Click on Significant Values for Screen Details ID:SGTC_37|Compound:0566-0070|FD-Score:3.76|P-value:7.53E-5 ID:SGTC_42|Compound:0133-0086|FD-Score:-4.53|P-value:2.52E-6 ID:SGTC_784|Compound:4579-0127|FD-Score:-3.69|P-value:1.02E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:-4.09|P-value:1.90E-5 ID:SGTC_831|Compound:k061-1017|FD-Score:-3.79|P-value:6.73E-5 ID:SGTC_944|Compound:3370-0224|FD-Score:3.49|P-value:2.20E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:-3.44|P-value:2.66E-4 ID:SGTC_1029|Compound:k015-0030|FD-Score:4.25|P-value:9.20E-6 ID:SGTC_1041|Compound:0206-0046|FD-Score:-4.12|P-value:1.65E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.86|P-value:5.14E-5 ID:SGTC_1161|Compound:k007-0610|FD-Score:3.24|P-value:5.39E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.19|P-value:6.37E-4 ID:SGTC_1340|Compound:1486-1359|FD-Score:-3.37|P-value:3.45E-4 ID:SGTC_1412|Compound:3909-8563|FD-Score:3.32|P-value:4.11E-4 ID:SGTC_1431|Compound:4049-0260|FD-Score:3.22|P-value:5.83E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:3.63|P-value:1.25E-4 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:3.41|P-value:2.98E-4 ID:SGTC_1628|Compound:st004252|FD-Score:5.97|P-value:8.78E-10 ID:SGTC_1633|Compound:st005664|FD-Score:-3.95|P-value:3.51E-5 ID:SGTC_1637|Compound:st007924|FD-Score:-3.56|P-value:1.70E-4 ID:SGTC_1638|Compound:st008370|FD-Score:-4.54|P-value:2.44E-6 ID:SGTC_1643|Compound:st009866|FD-Score:3.61|P-value:1.36E-4 ID:SGTC_1743|Compound:st037606|FD-Score:3.07|P-value:9.87E-4 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:-3.30|P-value:4.45E-4 ID:SGTC_1905|Compound:st060207|FD-Score:3.14|P-value:7.84E-4 ID:SGTC_1906|Compound:st060206|FD-Score:3.87|P-value:4.82E-5 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.26|P-value:4.98E-4 ID:SGTC_2394|Compound:5221648|FD-Score:3.22|P-value:5.93E-4 ID:SGTC_2404|Compound:5161160|FD-Score:4.26|P-value:8.78E-6 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.72|P-value:8.89E-5 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:3.27|P-value:4.79E-4 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:-4.71|P-value:1.04E-6 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:4.03|P-value:2.39E-5 ID:SGTC_2611|Compound:pyromycin|FD-Score:-3.91|P-value:4.13E-5 ID:SGTC_2774|Compound:tamoxifen|FD-Score:3.16|P-value:7.16E-4 ID:SGTC_2781|Compound:5567276|FD-Score:4.26|P-value:8.65E-6 ID:SGTC_2784|Compound:7567673|FD-Score:-4.09|P-value:1.94E-5 ID:SGTC_2955|Compound:9076254|FD-Score:-3.28|P-value:4.82E-4 ID:SGTC_2960|Compound:9079389|FD-Score:-4.48|P-value:3.21E-6 ID:SGTC_3147|Compound:9097027|FD-Score:3.14|P-value:7.80E-4 ID:SGTC_3302|Compound:9125395|FD-Score:3.59|P-value:1.48E-4 ID:SGTC_37|Compound:0566-0070|FD-Score:3.76|P-value:7.53E-5 ID:SGTC_42|Compound:0133-0086|FD-Score:-4.53|P-value:2.52E-6 ID:SGTC_784|Compound:4579-0127|FD-Score:-3.69|P-value:1.02E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:-4.09|P-value:1.90E-5 ID:SGTC_831|Compound:k061-1017|FD-Score:-3.79|P-value:6.73E-5 ID:SGTC_944|Compound:3370-0224|FD-Score:3.49|P-value:2.20E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:-3.44|P-value:2.66E-4 ID:SGTC_1029|Compound:k015-0030|FD-Score:4.25|P-value:9.20E-6 ID:SGTC_1041|Compound:0206-0046|FD-Score:-4.12|P-value:1.65E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.86|P-value:5.14E-5 ID:SGTC_1161|Compound:k007-0610|FD-Score:3.24|P-value:5.39E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.19|P-value:6.37E-4 ID:SGTC_1340|Compound:1486-1359|FD-Score:-3.37|P-value:3.45E-4 ID:SGTC_1412|Compound:3909-8563|FD-Score:3.32|P-value:4.11E-4 ID:SGTC_1431|Compound:4049-0260|FD-Score:3.22|P-value:5.83E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:3.63|P-value:1.25E-4 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:3.41|P-value:2.98E-4 ID:SGTC_1628|Compound:st004252|FD-Score:5.97|P-value:8.78E-10 ID:SGTC_1633|Compound:st005664|FD-Score:-3.95|P-value:3.51E-5 ID:SGTC_1637|Compound:st007924|FD-Score:-3.56|P-value:1.70E-4 ID:SGTC_1638|Compound:st008370|FD-Score:-4.54|P-value:2.44E-6 ID:SGTC_1643|Compound:st009866|FD-Score:3.61|P-value:1.36E-4 ID:SGTC_1743|Compound:st037606|FD-Score:3.07|P-value:9.87E-4 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:-3.30|P-value:4.45E-4 ID:SGTC_1905|Compound:st060207|FD-Score:3.14|P-value:7.84E-4 ID:SGTC_1906|Compound:st060206|FD-Score:3.87|P-value:4.82E-5 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.26|P-value:4.98E-4 ID:SGTC_2394|Compound:5221648|FD-Score:3.22|P-value:5.93E-4 ID:SGTC_2404|Compound:5161160|FD-Score:4.26|P-value:8.78E-6 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.72|P-value:8.89E-5 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:3.27|P-value:4.79E-4 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:-4.71|P-value:1.04E-6 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:4.03|P-value:2.39E-5 ID:SGTC_2611|Compound:pyromycin|FD-Score:-3.91|P-value:4.13E-5 ID:SGTC_2774|Compound:tamoxifen|FD-Score:3.16|P-value:7.16E-4 ID:SGTC_2781|Compound:5567276|FD-Score:4.26|P-value:8.65E-6 ID:SGTC_2784|Compound:7567673|FD-Score:-4.09|P-value:1.94E-5 ID:SGTC_2955|Compound:9076254|FD-Score:-3.28|P-value:4.82E-4 ID:SGTC_2960|Compound:9079389|FD-Score:-4.48|P-value:3.21E-6 ID:SGTC_3147|Compound:9097027|FD-Score:3.14|P-value:7.80E-4 ID:SGTC_3302|Compound:9125395|FD-Score:3.59|P-value:1.48E-4

Top fitness defect scores for YKL094W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1628 st004252 5.97 77.7 µM 8.78E-10 3 1.17E-9
2 SGTC_2781 5567276 4.26 71.4 µM 8.65E-6 40 1.01E-5
3 SGTC_2404 5161160 4.26 200.0 µM 8.78E-6 11 1.03E-5
4 SGTC_1029 k015-0030 4.25 64.7 µM 9.20E-6 20 1.07E-5
5 SGTC_2598 perillyl alcohol 4.03 100.0 µM 2.39E-5 27 2.75E-5
6 SGTC_1906 st060206 3.87 94.7 µM 4.82E-5 20 5.50E-5
7 SGTC_37 0566-0070 3.76 1.6 µM 7.53E-5 32 8.53E-5
8 SGTC_2419 paclitaxel 3.72 166.5 µM 8.89E-5 53 1.00E-4
9 SGTC_1512 0259-0544 3.63 12.2 µM 1.25E-4 24 1.41E-4
10 SGTC_1643 st009866 3.61 20.2 µM 1.36E-4 39 1.52E-4
11 SGTC_3302 9125395 3.59 16.4 µM 1.48E-4 23 1.66E-4
12 SGTC_944 3370-0224 3.49 231.0 µM 2.20E-4 43 2.46E-4
13 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 3.41 85.4 µM 2.98E-4 38 3.30E-4
14 SGTC_1412 3909-8563 3.32 178.0 µM 4.11E-4 23 4.54E-4
15 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 3.27 100.0 µM 4.79E-4 44 5.28E-4
16 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 3.26 70.1 µM 4.98E-4 61 5.49E-4
17 SGTC_1161 k007-0610 3.24 110.0 µM 5.39E-4 ERAD & cell cycle 155 5.93E-4
18 SGTC_1431 4049-0260 3.22 9.1 µM 5.83E-4 20 6.40E-4
19 SGTC_2394 5221648 3.22 200.0 µM 5.93E-4 55 6.52E-4
20 SGTC_1212 0520-0165 3.19 585.0 µM 6.37E-4 70 6.99E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.207 7.92E-34 YFL042C_p YFL042C_p hom Putative protein of unknown function; YFL042C is not an essential gene
0.196 2.51E-30 YGL156W AMS1 hom Vacuolar alpha mannosidase, involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway
0.186 1.73E-27 YJR098C_p YJR098C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.182 2.23E-26 YGR025W_d YGR025W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.175 1.93E-24 YDR234W LYS4 hom Homoaconitase, catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway
0.148 5.50E-18 YER068C-A_d YER068C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.147 1.16E-17 YDR222W_p YDR222W_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.133 1.13E-14 YPL249C GYP5 hom GTPase-activating protein (GAP) for yeast Rab family members; involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.132 1.69E-14 YGL203C KEX1 hom Protease involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteins
0.128 1.20E-13 YKL030W_d YKL030W_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene MAE1
0.121 2.07E-12 YGR036C CAX4 hom Dolichyl pyrophosphate (Dol-P-P) phosphatase with a luminally oriented active site in the ER, cleaves the anhydride linkage in Dol-P-P, required for Dol-P-P-linked oligosaccharide intermediate synthesis and protein N-glycosylation
0.116 1.58E-11 YBR088C POL30 het Proliferating cell nuclear antigen (PCNA), functions as the sliding clamp for DNA polymerase delta; may function as a docking site for other proteins required for mitotic and meiotic chromosomal DNA replication and for DNA repair
0.116 1.75E-11 YDR411C DFM1 hom Endoplasmic reticulum (ER) localized protein involved in ER-associated protein degradation (ERAD), ER stress and homeostasis; interacts with components of ERAD-L and ERAD-C and Cdc48p; derlin-like family member similar to Der1p
0.115 2.30E-11 YGL165C_d YGL165C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CUP2/YGL166W
0.113 4.82E-11 YGR075C PRP38 het Unique component of the U4/U6.U5 tri-snRNP particle, required for conformational changes which result in the catalytic activation of the spliceosome; dispensible for spliceosome assembly