HIPHOP chemogenomics database
YKL098W / MTC2 
Protein of unknown function; mtc2 is synthetically sick with cdc13-1
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YKL098W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.558 | 4.12E-274 | YMR126C_p | DLT1_p | hom | Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA) |
| 0.497 | 1.22E-208 | YPR153W | YPR153W | hom | Putative protein of unknown function |
| 0.405 | 2.62E-132 | YBR255W | MTC4 | hom | Protein of unknown function, required for normal growth rate at 15 degrees C; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; mtc4 is synthetically sick with cdc13-1 |
| 0.388 | 8.41E-121 | YPL077C_p | YPL077C_p | hom | Putative protein of unknown function; regulates PIS1 expression; mutant displays spore wall assembly defect in ether sensitivity screen; YPL077C is not an essential gene; YPL077C has a paralog, YBR197C, that arose from the whole genome duplication |
| 0.327 | 3.86E-84 | YPR029C | APL4 | hom | Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport |
| 0.314 | 2.09E-77 | YCL046W_d | YCL046W_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YCL045C |
| 0.290 | 4.06E-66 | YML072C | TCB3 | hom | Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localized to the bud via specific mRNA transport; non-tagged protein detected in a phosphorylated state in mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact |
| 0.262 | 1.19E-53 | YLR087C | CSF1 | hom | Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies |
| 0.244 | 1.59E-46 | YJR088C | EMC2 | hom | Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm Y57G7A.10/EMC-2, fly CG17556, human TTC35 |
| 0.239 | 6.44E-45 | YKL190W | CNB1 | hom | Calcineurin B; the regulatory subunit of calcineurin, a Ca++/calmodulin-regulated type 2B protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is encoded by CNA1 and/or CMP1; protein abundance increases in response to DNA replication stress |
| 0.237 | 6.64E-44 | YHR151C | MTC6 | hom | Protein of unknown function; mtc6 is synthetically sick with cdc13-1 |
| 0.225 | 7.45E-40 | YKL135C | APL2 | hom | Beta-adaptin subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; protein abundance increases in response to DNA replication stress |
| 0.222 | 7.93E-39 | YLR169W_d | YLR169W_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| 0.217 | 4.49E-37 | YHL019C | APM2 | hom | Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport |
| 0.206 | 2.05E-33 | YKL136W_d | YKL136W_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF APL2/YKL135C |