YKL115C_d

Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL115C / YKL115C

Click on Significant Values for Screen Details ID:SGTC_56|Compound:0957-0365|FD-Score:-4.37|P-value:4.58E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:18.80|P-value:5.24E-82 ID:SGTC_164|Compound:4100-3994|FD-Score:-3.62|P-value:1.24E-4 ID:SGTC_416|Compound:estradiol valerate|FD-Score:3.72|P-value:7.05E-5 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:4.50|P-value:2.06E-6 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:3.23|P-value:4.71E-4 ID:SGTC_509|Compound:pifithrin|FD-Score:3.13|P-value:6.60E-4 ID:SGTC_588|Compound:3970-1144|FD-Score:3.86|P-value:3.91E-5 ID:SGTC_736|Compound:0958-0254|FD-Score:4.57|P-value:1.46E-6 ID:SGTC_829|Compound:1635-0120|FD-Score:3.94|P-value:2.77E-5 ID:SGTC_896|Compound:0964-0007|FD-Score:3.09|P-value:7.60E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:-3.76|P-value:6.79E-5 ID:SGTC_998|Compound:3996-0085|FD-Score:-4.17|P-value:1.16E-5 ID:SGTC_1014|Compound:4130-3005|FD-Score:4.02|P-value:1.94E-5 ID:SGTC_1019|Compound:4262-0212|FD-Score:3.58|P-value:1.23E-4 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:4.81|P-value:4.27E-7 ID:SGTC_1154|Compound:4088-0362|FD-Score:3.11|P-value:7.20E-4 ID:SGTC_1215|Compound:3852-0577|FD-Score:5.08|P-value:1.03E-7 ID:SGTC_1234|Compound:0326-0494|FD-Score:4.78|P-value:5.20E-7 ID:SGTC_1250|Compound:0485-0349|FD-Score:4.65|P-value:9.78E-7 ID:SGTC_1472|Compound:k841-0093|FD-Score:3.17|P-value:5.77E-4 ID:SGTC_1527|Compound:coumarin|FD-Score:3.43|P-value:2.22E-4 ID:SGTC_1692|Compound:fluoroquinolonic acid|FD-Score:3.14|P-value:6.54E-4 ID:SGTC_1717|Compound:st033143|FD-Score:3.39|P-value:2.63E-4 ID:SGTC_1729|Compound:st035615|FD-Score:3.60|P-value:1.14E-4 ID:SGTC_1757|Compound:st041620|FD-Score:3.12|P-value:6.93E-4 ID:SGTC_1809|Compound:st050081|FD-Score:3.18|P-value:5.70E-4 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:3.34|P-value:3.12E-4 ID:SGTC_1901|Compound:st060216|FD-Score:3.69|P-value:8.04E-5 ID:SGTC_1904|Compound:st060225|FD-Score:4.44|P-value:2.85E-6 ID:SGTC_2020|Compound:4017018|FD-Score:-3.81|P-value:5.59E-5 ID:SGTC_2070|Compound:5230947|FD-Score:3.42|P-value:2.35E-4 ID:SGTC_2136|Compound:5328288|FD-Score:5.34|P-value:2.48E-8 ID:SGTC_2141|Compound:5621638|FD-Score:3.32|P-value:3.32E-4 ID:SGTC_2146|Compound:5545642|FD-Score:3.36|P-value:2.90E-4 ID:SGTC_2299|Compound:7976368|FD-Score:3.17|P-value:5.89E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:3.21|P-value:4.99E-4 ID:SGTC_2437|Compound:5741531|FD-Score:5.20|P-value:5.37E-8 ID:SGTC_2440|Compound:5628896|FD-Score:7.12|P-value:1.80E-13 ID:SGTC_2441|Compound:5730946|FD-Score:3.16|P-value:5.94E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:3.75|P-value:6.17E-5 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:3.45|P-value:2.08E-4 ID:SGTC_2763|Compound:lisinopril|FD-Score:-3.06|P-value:9.79E-4 ID:SGTC_2797|Compound:7859098|FD-Score:3.14|P-value:6.50E-4 ID:SGTC_2816|Compound:7982706|FD-Score:3.67|P-value:8.74E-5 ID:SGTC_2851|Compound:9015922|FD-Score:-3.77|P-value:6.52E-5 ID:SGTC_2856|Compound:9022925|FD-Score:-4.70|P-value:9.14E-7 ID:SGTC_2958|Compound:9077254|FD-Score:5.38|P-value:1.88E-8 ID:SGTC_3002|Compound:9075603|FD-Score:3.41|P-value:2.43E-4 ID:SGTC_3311|Compound:9131146|FD-Score:3.57|P-value:1.26E-4 ID:SGTC_3320|Compound:9137005|FD-Score:3.18|P-value:5.66E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:-4.37|P-value:4.58E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:18.80|P-value:5.24E-82 ID:SGTC_164|Compound:4100-3994|FD-Score:-3.62|P-value:1.24E-4 ID:SGTC_416|Compound:estradiol valerate|FD-Score:3.72|P-value:7.05E-5 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:4.50|P-value:2.06E-6 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:3.23|P-value:4.71E-4 ID:SGTC_509|Compound:pifithrin|FD-Score:3.13|P-value:6.60E-4 ID:SGTC_588|Compound:3970-1144|FD-Score:3.86|P-value:3.91E-5 ID:SGTC_736|Compound:0958-0254|FD-Score:4.57|P-value:1.46E-6 ID:SGTC_829|Compound:1635-0120|FD-Score:3.94|P-value:2.77E-5 ID:SGTC_896|Compound:0964-0007|FD-Score:3.09|P-value:7.60E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:-3.76|P-value:6.79E-5 ID:SGTC_998|Compound:3996-0085|FD-Score:-4.17|P-value:1.16E-5 ID:SGTC_1014|Compound:4130-3005|FD-Score:4.02|P-value:1.94E-5 ID:SGTC_1019|Compound:4262-0212|FD-Score:3.58|P-value:1.23E-4 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:4.81|P-value:4.27E-7 ID:SGTC_1154|Compound:4088-0362|FD-Score:3.11|P-value:7.20E-4 ID:SGTC_1215|Compound:3852-0577|FD-Score:5.08|P-value:1.03E-7 ID:SGTC_1234|Compound:0326-0494|FD-Score:4.78|P-value:5.20E-7 ID:SGTC_1250|Compound:0485-0349|FD-Score:4.65|P-value:9.78E-7 ID:SGTC_1472|Compound:k841-0093|FD-Score:3.17|P-value:5.77E-4 ID:SGTC_1527|Compound:coumarin|FD-Score:3.43|P-value:2.22E-4 ID:SGTC_1692|Compound:fluoroquinolonic acid|FD-Score:3.14|P-value:6.54E-4 ID:SGTC_1717|Compound:st033143|FD-Score:3.39|P-value:2.63E-4 ID:SGTC_1729|Compound:st035615|FD-Score:3.60|P-value:1.14E-4 ID:SGTC_1757|Compound:st041620|FD-Score:3.12|P-value:6.93E-4 ID:SGTC_1809|Compound:st050081|FD-Score:3.18|P-value:5.70E-4 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:3.34|P-value:3.12E-4 ID:SGTC_1901|Compound:st060216|FD-Score:3.69|P-value:8.04E-5 ID:SGTC_1904|Compound:st060225|FD-Score:4.44|P-value:2.85E-6 ID:SGTC_2020|Compound:4017018|FD-Score:-3.81|P-value:5.59E-5 ID:SGTC_2070|Compound:5230947|FD-Score:3.42|P-value:2.35E-4 ID:SGTC_2136|Compound:5328288|FD-Score:5.34|P-value:2.48E-8 ID:SGTC_2141|Compound:5621638|FD-Score:3.32|P-value:3.32E-4 ID:SGTC_2146|Compound:5545642|FD-Score:3.36|P-value:2.90E-4 ID:SGTC_2299|Compound:7976368|FD-Score:3.17|P-value:5.89E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:3.21|P-value:4.99E-4 ID:SGTC_2437|Compound:5741531|FD-Score:5.20|P-value:5.37E-8 ID:SGTC_2440|Compound:5628896|FD-Score:7.12|P-value:1.80E-13 ID:SGTC_2441|Compound:5730946|FD-Score:3.16|P-value:5.94E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:3.75|P-value:6.17E-5 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:3.45|P-value:2.08E-4 ID:SGTC_2763|Compound:lisinopril|FD-Score:-3.06|P-value:9.79E-4 ID:SGTC_2797|Compound:7859098|FD-Score:3.14|P-value:6.50E-4 ID:SGTC_2816|Compound:7982706|FD-Score:3.67|P-value:8.74E-5 ID:SGTC_2851|Compound:9015922|FD-Score:-3.77|P-value:6.52E-5 ID:SGTC_2856|Compound:9022925|FD-Score:-4.70|P-value:9.14E-7 ID:SGTC_2958|Compound:9077254|FD-Score:5.38|P-value:1.88E-8 ID:SGTC_3002|Compound:9075603|FD-Score:3.41|P-value:2.43E-4 ID:SGTC_3311|Compound:9131146|FD-Score:3.57|P-value:1.26E-4 ID:SGTC_3320|Compound:9137005|FD-Score:3.18|P-value:5.66E-4

Top fitness defect scores for YKL115C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_58 0957-0393 18.80 9.0 µM 5.24E-82 cell wall 16 5.66E-79
2 SGTC_2440 5628896 7.12 157.8 µM 1.80E-13 6 5.42E-13
3 SGTC_2958 9077254 5.38 16.7 µM 1.88E-8 9 3.65E-8
4 SGTC_2136 5328288 5.34 199.3 µM 2.48E-8 6 4.78E-8
5 SGTC_2437 5741531 5.20 144.2 µM 5.37E-8 18 1.00E-7
6 SGTC_1215 3852-0577 5.08 11.2 µM 1.03E-7 5 1.87E-7
7 SGTC_1116 jasmonic acid 4.81 1.6 µM 4.27E-7 7 7.37E-7
8 SGTC_1234 0326-0494 4.78 15.5 µM 5.20E-7 6 8.90E-7
9 SGTC_1250 0485-0349 4.65 40.2 µM 9.78E-7 13 1.64E-6
10 SGTC_736 0958-0254 4.57 92.6 µM 1.46E-6 Golgi 17 2.40E-6
11 SGTC_436 n,n-dimethylsphingosine 4.50 3.3 µM 2.06E-6 17 3.35E-6
12 SGTC_1904 st060225 4.44 78.0 µM 2.85E-6 11 4.58E-6
13 SGTC_1014 4130-3005 4.02 69.3 µM 1.94E-5 19 2.90E-5
14 SGTC_829 1635-0120 3.94 117.0 µM 2.77E-5 DNA damage response 40 4.07E-5
15 SGTC_588 3970-1144 3.86 52.9 µM 3.91E-5 30 5.67E-5
16 SGTC_2592 piperlongumine 3.75 83.3 µM 6.17E-5 TSC3-RPN4 49 8.81E-5
17 SGTC_416 estradiol valerate 3.72 100.0 µM 7.05E-5 18 1.00E-4
18 SGTC_1901 st060216 3.69 58.6 µM 8.04E-5 28 1.14E-4
19 SGTC_2816 7982706 3.67 58.4 µM 8.74E-5 azole & statin 65 1.23E-4
20 SGTC_1729 st035615 3.60 46.0 µM 1.14E-4 46 1.59E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.388 1.52E-120 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.359 1.28E-102 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.334 1.77E-88 YBR120C CBP6 hom Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.324 5.05E-83 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.318 7.99E-80 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.313 5.14E-77 YNL314W DAL82 hom Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain
0.308 1.22E-74 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.291 1.42E-66 YAL015C NTG1 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication
0.279 4.98E-61 YCL005W LDB16 hom Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria
0.269 7.85E-57 YIL123W SIM1 hom Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that may participate in DNA replication, promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated
0.267 6.85E-56 YIL148W RPL40A hom Ubiquitin-ribosomal 60S subunit protein L40A fusion protein; cleaved to yield ubiquitin and ribosomal protein L40A; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40, no bacterial homolog; RPL40A has a paralog, RPL40B, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.267 8.50E-56 YKL033W-A_p YKL033W-A_p hom Putative protein of unknown function; similar to uncharacterized proteins from other fungi
0.265 5.56E-55 YMR111C YMR111C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR111C is not an essential gene; forms nuclear foci upon DNA replication stress
0.261 2.73E-53 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.256 3.55E-51 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together