YKL147C_d

Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene AVT3

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL147C / YKL147C

Click on Significant Values for Screen Details ID:SGTC_165|Compound:k038-0023|FD-Score:3.36|P-value:1.93E-5 ID:SGTC_572|Compound:0960-0087|FD-Score:2.68|P-value:5.06E-4 ID:SGTC_648|Compound:0375-0473|FD-Score:3.08|P-value:8.13E-5 ID:SGTC_745|Compound:0469-0705|FD-Score:2.91|P-value:1.81E-4 ID:SGTC_890|Compound:0929-0006|FD-Score:-3.09|P-value:8.66E-5 ID:SGTC_934|Compound:2950-0684|FD-Score:3.00|P-value:1.17E-4 ID:SGTC_935|Compound:2996-0153|FD-Score:3.43|P-value:1.30E-5 ID:SGTC_1015|Compound:4130-4525|FD-Score:-2.75|P-value:4.07E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:3.99|P-value:5.26E-7 ID:SGTC_1048|Compound:3161-0300|FD-Score:-2.79|P-value:3.48E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:3.49|P-value:9.39E-6 ID:SGTC_1058|Compound:3448-5425|FD-Score:5.33|P-value:3.49E-11 ID:SGTC_1079|Compound:idarubicin|FD-Score:2.89|P-value:1.93E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:-2.78|P-value:3.65E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:3.23|P-value:3.77E-5 ID:SGTC_1126|Compound:isoteolin|FD-Score:3.86|P-value:1.14E-6 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.15|P-value:5.54E-5 ID:SGTC_1295|Compound:1013-0063|FD-Score:3.60|P-value:5.03E-6 ID:SGTC_1300|Compound:1094-0077|FD-Score:-3.24|P-value:4.06E-5 ID:SGTC_1355|Compound:1499-0035|FD-Score:2.53|P-value:9.62E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:-3.09|P-value:8.37E-5 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:-2.55|P-value:9.75E-4 ID:SGTC_1725|Compound:st036284|FD-Score:-2.55|P-value:9.48E-4 ID:SGTC_1868|Compound:st057644|FD-Score:-3.06|P-value:9.74E-5 ID:SGTC_1870|Compound:st057514|FD-Score:-2.88|P-value:2.26E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:-3.16|P-value:6.15E-5 ID:SGTC_1925|Compound:st057770|FD-Score:-3.28|P-value:3.26E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.83|P-value:1.57E-6 ID:SGTC_2010|Compound:4012422|FD-Score:2.92|P-value:1.75E-4 ID:SGTC_2055|Compound:5235184|FD-Score:4.73|P-value:3.61E-9 ID:SGTC_2145|Compound:5634607|FD-Score:-2.59|P-value:8.16E-4 ID:SGTC_2158|Compound:5657123|FD-Score:2.92|P-value:1.72E-4 ID:SGTC_2175|Compound:5807670|FD-Score:3.56|P-value:6.51E-6 ID:SGTC_2238|Compound:6671620|FD-Score:2.82|P-value:2.76E-4 ID:SGTC_2318|Compound:6029776|FD-Score:4.09|P-value:2.70E-7 ID:SGTC_2350|Compound:9023895|FD-Score:3.20|P-value:4.31E-5 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-3.56|P-value:7.28E-6 ID:SGTC_2447|Compound:5741742|FD-Score:3.39|P-value:1.62E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:2.67|P-value:5.18E-4 ID:SGTC_2667|Compound:digitoxin|FD-Score:2.65|P-value:5.76E-4 ID:SGTC_2732|Compound:terfenadine|FD-Score:-2.73|P-value:4.55E-4 ID:SGTC_2797|Compound:7859098|FD-Score:3.62|P-value:4.62E-6 ID:SGTC_2954|Compound:9074818|FD-Score:5.09|P-value:2.29E-10 ID:SGTC_2957|Compound:9076800|FD-Score:-2.75|P-value:4.16E-4 ID:SGTC_2965|Compound:9082772|FD-Score:2.61|P-value:6.98E-4 ID:SGTC_3002|Compound:9075603|FD-Score:2.62|P-value:6.59E-4 ID:SGTC_3191|Compound:9110352|FD-Score:-2.86|P-value:2.47E-4 ID:SGTC_3232|Compound:9132874|FD-Score:3.25|P-value:3.38E-5 ID:SGTC_3291|Compound:9121177|FD-Score:2.70|P-value:4.66E-4 ID:SGTC_3293|Compound:9120939|FD-Score:4.36|P-value:4.59E-8 ID:SGTC_3331|Compound:9141060|FD-Score:-2.86|P-value:2.45E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:3.36|P-value:1.93E-5 ID:SGTC_572|Compound:0960-0087|FD-Score:2.68|P-value:5.06E-4 ID:SGTC_648|Compound:0375-0473|FD-Score:3.08|P-value:8.13E-5 ID:SGTC_745|Compound:0469-0705|FD-Score:2.91|P-value:1.81E-4 ID:SGTC_890|Compound:0929-0006|FD-Score:-3.09|P-value:8.66E-5 ID:SGTC_934|Compound:2950-0684|FD-Score:3.00|P-value:1.17E-4 ID:SGTC_935|Compound:2996-0153|FD-Score:3.43|P-value:1.30E-5 ID:SGTC_1015|Compound:4130-4525|FD-Score:-2.75|P-value:4.07E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:3.99|P-value:5.26E-7 ID:SGTC_1048|Compound:3161-0300|FD-Score:-2.79|P-value:3.48E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:3.49|P-value:9.39E-6 ID:SGTC_1058|Compound:3448-5425|FD-Score:5.33|P-value:3.49E-11 ID:SGTC_1079|Compound:idarubicin|FD-Score:2.89|P-value:1.93E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:-2.78|P-value:3.65E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:3.23|P-value:3.77E-5 ID:SGTC_1126|Compound:isoteolin|FD-Score:3.86|P-value:1.14E-6 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.15|P-value:5.54E-5 ID:SGTC_1295|Compound:1013-0063|FD-Score:3.60|P-value:5.03E-6 ID:SGTC_1300|Compound:1094-0077|FD-Score:-3.24|P-value:4.06E-5 ID:SGTC_1355|Compound:1499-0035|FD-Score:2.53|P-value:9.62E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:-3.09|P-value:8.37E-5 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:-2.55|P-value:9.75E-4 ID:SGTC_1725|Compound:st036284|FD-Score:-2.55|P-value:9.48E-4 ID:SGTC_1868|Compound:st057644|FD-Score:-3.06|P-value:9.74E-5 ID:SGTC_1870|Compound:st057514|FD-Score:-2.88|P-value:2.26E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:-3.16|P-value:6.15E-5 ID:SGTC_1925|Compound:st057770|FD-Score:-3.28|P-value:3.26E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.83|P-value:1.57E-6 ID:SGTC_2010|Compound:4012422|FD-Score:2.92|P-value:1.75E-4 ID:SGTC_2055|Compound:5235184|FD-Score:4.73|P-value:3.61E-9 ID:SGTC_2145|Compound:5634607|FD-Score:-2.59|P-value:8.16E-4 ID:SGTC_2158|Compound:5657123|FD-Score:2.92|P-value:1.72E-4 ID:SGTC_2175|Compound:5807670|FD-Score:3.56|P-value:6.51E-6 ID:SGTC_2238|Compound:6671620|FD-Score:2.82|P-value:2.76E-4 ID:SGTC_2318|Compound:6029776|FD-Score:4.09|P-value:2.70E-7 ID:SGTC_2350|Compound:9023895|FD-Score:3.20|P-value:4.31E-5 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-3.56|P-value:7.28E-6 ID:SGTC_2447|Compound:5741742|FD-Score:3.39|P-value:1.62E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:2.67|P-value:5.18E-4 ID:SGTC_2667|Compound:digitoxin|FD-Score:2.65|P-value:5.76E-4 ID:SGTC_2732|Compound:terfenadine|FD-Score:-2.73|P-value:4.55E-4 ID:SGTC_2797|Compound:7859098|FD-Score:3.62|P-value:4.62E-6 ID:SGTC_2954|Compound:9074818|FD-Score:5.09|P-value:2.29E-10 ID:SGTC_2957|Compound:9076800|FD-Score:-2.75|P-value:4.16E-4 ID:SGTC_2965|Compound:9082772|FD-Score:2.61|P-value:6.98E-4 ID:SGTC_3002|Compound:9075603|FD-Score:2.62|P-value:6.59E-4 ID:SGTC_3191|Compound:9110352|FD-Score:-2.86|P-value:2.47E-4 ID:SGTC_3232|Compound:9132874|FD-Score:3.25|P-value:3.38E-5 ID:SGTC_3291|Compound:9121177|FD-Score:2.70|P-value:4.66E-4 ID:SGTC_3293|Compound:9120939|FD-Score:4.36|P-value:4.59E-8 ID:SGTC_3331|Compound:9141060|FD-Score:-2.86|P-value:2.45E-4

Top fitness defect scores for YKL147C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1058 3448-5425 5.33 97.3 µM 3.49E-11 19 4.96E-8
2 SGTC_2954 9074818 5.09 52.7 µM 2.29E-10 19 1.77E-7
3 SGTC_2055 5235184 4.73 200.0 µM 3.61E-9 ERG2 15 1.15E-6
4 SGTC_3293 9120939 4.36 62.0 µM 4.59E-8 11 6.43E-6
5 SGTC_2318 6029776 4.09 164.0 µM 2.70E-7 27 2.14E-5
6 SGTC_1047 2043-3044 3.99 82.0 µM 5.26E-7 32 3.36E-5
7 SGTC_1126 isoteolin 3.86 1.0 µM 1.14E-6 30 5.70E-5
8 SGTC_2797 7859098 3.62 81.8 µM 4.62E-6 39 1.48E-4
9 SGTC_1295 1013-0063 3.60 9.8 µM 5.03E-6 20 1.57E-4
10 SGTC_2175 5807670 3.56 165.3 µM 6.51E-6 29 1.87E-4
11 SGTC_1050 3232-1156 3.49 69.3 µM 9.39E-6 RSC complex & mRNA processing 35 2.40E-4
12 SGTC_935 2996-0153 3.43 430.0 µM 1.30E-5 PDR1 36 2.98E-4
13 SGTC_2447 5741742 3.39 33.8 µM 1.62E-5 44 3.47E-4
14 SGTC_165 k038-0023 3.36 64.4 µM 1.93E-5 ubiquinone biosynthesis & proteasome 115 3.91E-4
15 SGTC_3232 9132874 3.25 49.5 µM 3.38E-5 RPP1 & pyrimidine depletion 36 5.75E-4
16 SGTC_1123 mangostin 3.23 811.3 nM 3.77E-5 mitochondrial response to ROS 66 6.19E-4
17 SGTC_2350 9023895 3.20 38.9 µM 4.31E-5 ergosterol biosynthesis 56 6.78E-4
18 SGTC_1132 3456-3614 3.15 2.5 µM 5.54E-5 tubulin folding & SWR complex 102 8.05E-4
19 SGTC_648 0375-0473 3.08 33.3 µM 8.13E-5 52 0.00105
20 SGTC_934 2950-0684 3.00 338.0 µM 1.17E-4 57 0.00135

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.116 1.79E-11 YKR009C FOX2 hom Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities
0.114 4.27E-11 YLR300W EXG1 hom Major exo-1,3-beta-glucanase of the cell wall, involved in cell wall beta-glucan assembly; exists as three differentially glycosylated isoenzymes
0.110 1.59E-10 YLR225C_p YLR225C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR225C is not an essential gene
0.105 9.29E-10 YOR023C AHC1 hom Subunit of the Ada histone acetyltransferase complex, required for structural integrity of the complex
0.105 9.78E-10 YHR047C AAP1 hom Arginine/alanine amino peptidase; overproduction stimulates glycogen accumulation; AAP1 has a paralog, APE2, that arose from the whole genome duplication
0.105 1.08E-9 YIR019C FLO11 hom GPI-anchored cell surface glycoprotein (flocculin); required for pseudohyphal formation, invasive growth, flocculation, and biofilms; transcriptionally regulated by the MAPK pathway (via Ste12p and Tec1p) and the cAMP pathway (via Flo8p); required for the formation of fibrous interconnections between cells in a colony of a wild S. cerevisiae strain
0.100 6.76E-9 YNL209W SSB2 hom Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in the folding of newly-synthesized polypeptide chains; member of the HSP70 family; SSB2 has a paralog, SSB1, that arose from the whole genome duplication
0.097 2.03E-8 YPL250C ICY2 hom Protein of unknown function; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate
0.093 6.93E-8 YBR205W KTR3 hom Putative alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; Svp26p mediates uptake of Ktr3p into COPII vesicles; relocalizes from nucleus to vacuole upon DNA replication stress
0.093 7.00E-8 YKL117W SBA1 hom Co-chaperone that binds to and regulates Hsp90 family chaperones; important for pp60v-src activity in yeast; homologous to the mammalian p23 proteins, and like p23 can regulate telomerase activity; protein abundance increases in response to DNA replication stress
0.092 8.34E-8 YDL010W GRX6 hom Cis-golgi localized monothiol glutaredoxin, binds Fe-S cluster; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; GRX6 has a paralog, GRX7, that arose from the whole genome duplication
0.089 2.51E-7 YHR155W YSP1 hom Mitochondrial protein; potential role in promoting mitochondrial fragmentation during programmed cell death in response to high levels of alpha-factor mating pheromone or the drug amiodarone; YSP1 has a paralog, SIP3, that arose from the whole genome duplication
0.089 2.52E-7 YGL010W_p YGL010W_p hom Putative protein of unknown function; YGL010W is not an essential gene
0.089 2.56E-7 YOL011W PLB3 hom Phospholipase B (lysophospholipase) involved in phospholipid metabolism; hydrolyzes phosphatidylinositol and phosphatidylserine and displays transacylase activity in vitro
0.088 3.73E-7 YER026C CHO1 hom Phosphatidylserine synthase, functions in phospholipid biosynthesis; catalyzes the reaction CDP-diaclyglycerol + L-serine = CMP + L-1-phosphatidylserine, transcriptionally repressed by myo-inositol and choline