YKL162C-A_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL162C-A / YKL162C-A

Click on Significant Values for Screen Details ID:SGTC_16|Compound:erodoxin|FD-Score:2.97|P-value:9.14E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:3.28|P-value:2.85E-4 ID:SGTC_97|Compound:0535-0701|FD-Score:3.13|P-value:5.03E-4 ID:SGTC_98|Compound:0074-0023|FD-Score:-2.94|P-value:9.70E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:3.27|P-value:2.98E-4 ID:SGTC_605|Compound:1315-0399|FD-Score:3.41|P-value:1.71E-4 ID:SGTC_776|Compound:4476-4378|FD-Score:-5.45|P-value:4.70E-9 ID:SGTC_899|Compound:1083-0020|FD-Score:3.31|P-value:2.48E-4 ID:SGTC_918|Compound:glabranin|FD-Score:-3.44|P-value:1.43E-4 ID:SGTC_936|Compound:3005-4620|FD-Score:3.00|P-value:8.10E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:3.01|P-value:7.84E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:4.03|P-value:1.15E-5 ID:SGTC_1231|Compound:0242-0792|FD-Score:3.04|P-value:7.01E-4 ID:SGTC_1314|Compound:1222-0010|FD-Score:3.49|P-value:1.19E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:4.59|P-value:6.76E-7 ID:SGTC_1455|Compound:4262-0120|FD-Score:-3.78|P-value:3.42E-5 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.16|P-value:4.27E-4 ID:SGTC_1513|Compound:0337-0559|FD-Score:2.94|P-value:9.98E-4 ID:SGTC_1545|Compound:lovastatin|FD-Score:-3.13|P-value:4.91E-4 ID:SGTC_1619|Compound:st003326|FD-Score:-3.03|P-value:6.92E-4 ID:SGTC_1689|Compound:st020265|FD-Score:-3.26|P-value:2.94E-4 ID:SGTC_1812|Compound:st052057|FD-Score:3.42|P-value:1.62E-4 ID:SGTC_1917|Compound:st066507|FD-Score:2.96|P-value:9.40E-4 ID:SGTC_1919|Compound:st067113|FD-Score:3.14|P-value:4.74E-4 ID:SGTC_1987|Compound:st072290|FD-Score:3.31|P-value:2.48E-4 ID:SGTC_1995|Compound:st072814|FD-Score:3.31|P-value:2.46E-4 ID:SGTC_2053|Compound:5265679|FD-Score:3.15|P-value:4.65E-4 ID:SGTC_2067|Compound:5224629|FD-Score:-3.15|P-value:4.49E-4 ID:SGTC_2078|Compound:5212016|FD-Score:-4.46|P-value:1.34E-6 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.49|P-value:1.22E-4 ID:SGTC_2136|Compound:5328288|FD-Score:2.98|P-value:8.81E-4 ID:SGTC_2141|Compound:5621638|FD-Score:3.28|P-value:2.85E-4 ID:SGTC_2154|Compound:5570129|FD-Score:3.07|P-value:6.36E-4 ID:SGTC_2237|Compound:6667747|FD-Score:3.53|P-value:1.05E-4 ID:SGTC_2271|Compound:7849410|FD-Score:-4.41|P-value:1.73E-6 ID:SGTC_2304|Compound:7443016|FD-Score:-3.36|P-value:1.97E-4 ID:SGTC_2307|Compound:7538926|FD-Score:4.08|P-value:8.82E-6 ID:SGTC_2311|Compound:7694451|FD-Score:3.39|P-value:1.84E-4 ID:SGTC_2360|Compound:9040895|FD-Score:3.58|P-value:8.50E-5 ID:SGTC_2448|Compound:5185112|FD-Score:3.69|P-value:5.19E-5 ID:SGTC_2462|Compound:5162487|FD-Score:-2.96|P-value:9.02E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:-4.62|P-value:5.77E-7 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:-3.76|P-value:3.66E-5 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.82|P-value:2.99E-5 ID:SGTC_2800|Compound:7887935|FD-Score:-3.12|P-value:5.11E-4 ID:SGTC_2825|Compound:7998094|FD-Score:3.10|P-value:5.60E-4 ID:SGTC_2832|Compound:7992762|FD-Score:-3.61|P-value:6.97E-5 ID:SGTC_2835|Compound:9006588|FD-Score:-4.31|P-value:2.83E-6 ID:SGTC_2911|Compound:7942208|FD-Score:4.09|P-value:8.70E-6 ID:SGTC_2951|Compound:9072950|FD-Score:3.00|P-value:8.13E-4 ID:SGTC_3129|Compound:9127257|FD-Score:4.26|P-value:3.80E-6 ID:SGTC_3158|Compound:9100007|FD-Score:-3.36|P-value:1.98E-4 ID:SGTC_3178|Compound:9107506|FD-Score:3.16|P-value:4.52E-4 ID:SGTC_3332|Compound:9141069|FD-Score:3.03|P-value:7.27E-4 ID:SGTC_16|Compound:erodoxin|FD-Score:2.97|P-value:9.14E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:3.28|P-value:2.85E-4 ID:SGTC_97|Compound:0535-0701|FD-Score:3.13|P-value:5.03E-4 ID:SGTC_98|Compound:0074-0023|FD-Score:-2.94|P-value:9.70E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:3.27|P-value:2.98E-4 ID:SGTC_605|Compound:1315-0399|FD-Score:3.41|P-value:1.71E-4 ID:SGTC_776|Compound:4476-4378|FD-Score:-5.45|P-value:4.70E-9 ID:SGTC_899|Compound:1083-0020|FD-Score:3.31|P-value:2.48E-4 ID:SGTC_918|Compound:glabranin|FD-Score:-3.44|P-value:1.43E-4 ID:SGTC_936|Compound:3005-4620|FD-Score:3.00|P-value:8.10E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:3.01|P-value:7.84E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:4.03|P-value:1.15E-5 ID:SGTC_1231|Compound:0242-0792|FD-Score:3.04|P-value:7.01E-4 ID:SGTC_1314|Compound:1222-0010|FD-Score:3.49|P-value:1.19E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:4.59|P-value:6.76E-7 ID:SGTC_1455|Compound:4262-0120|FD-Score:-3.78|P-value:3.42E-5 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.16|P-value:4.27E-4 ID:SGTC_1513|Compound:0337-0559|FD-Score:2.94|P-value:9.98E-4 ID:SGTC_1545|Compound:lovastatin|FD-Score:-3.13|P-value:4.91E-4 ID:SGTC_1619|Compound:st003326|FD-Score:-3.03|P-value:6.92E-4 ID:SGTC_1689|Compound:st020265|FD-Score:-3.26|P-value:2.94E-4 ID:SGTC_1812|Compound:st052057|FD-Score:3.42|P-value:1.62E-4 ID:SGTC_1917|Compound:st066507|FD-Score:2.96|P-value:9.40E-4 ID:SGTC_1919|Compound:st067113|FD-Score:3.14|P-value:4.74E-4 ID:SGTC_1987|Compound:st072290|FD-Score:3.31|P-value:2.48E-4 ID:SGTC_1995|Compound:st072814|FD-Score:3.31|P-value:2.46E-4 ID:SGTC_2053|Compound:5265679|FD-Score:3.15|P-value:4.65E-4 ID:SGTC_2067|Compound:5224629|FD-Score:-3.15|P-value:4.49E-4 ID:SGTC_2078|Compound:5212016|FD-Score:-4.46|P-value:1.34E-6 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.49|P-value:1.22E-4 ID:SGTC_2136|Compound:5328288|FD-Score:2.98|P-value:8.81E-4 ID:SGTC_2141|Compound:5621638|FD-Score:3.28|P-value:2.85E-4 ID:SGTC_2154|Compound:5570129|FD-Score:3.07|P-value:6.36E-4 ID:SGTC_2237|Compound:6667747|FD-Score:3.53|P-value:1.05E-4 ID:SGTC_2271|Compound:7849410|FD-Score:-4.41|P-value:1.73E-6 ID:SGTC_2304|Compound:7443016|FD-Score:-3.36|P-value:1.97E-4 ID:SGTC_2307|Compound:7538926|FD-Score:4.08|P-value:8.82E-6 ID:SGTC_2311|Compound:7694451|FD-Score:3.39|P-value:1.84E-4 ID:SGTC_2360|Compound:9040895|FD-Score:3.58|P-value:8.50E-5 ID:SGTC_2448|Compound:5185112|FD-Score:3.69|P-value:5.19E-5 ID:SGTC_2462|Compound:5162487|FD-Score:-2.96|P-value:9.02E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:-4.62|P-value:5.77E-7 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:-3.76|P-value:3.66E-5 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.82|P-value:2.99E-5 ID:SGTC_2800|Compound:7887935|FD-Score:-3.12|P-value:5.11E-4 ID:SGTC_2825|Compound:7998094|FD-Score:3.10|P-value:5.60E-4 ID:SGTC_2832|Compound:7992762|FD-Score:-3.61|P-value:6.97E-5 ID:SGTC_2835|Compound:9006588|FD-Score:-4.31|P-value:2.83E-6 ID:SGTC_2911|Compound:7942208|FD-Score:4.09|P-value:8.70E-6 ID:SGTC_2951|Compound:9072950|FD-Score:3.00|P-value:8.13E-4 ID:SGTC_3129|Compound:9127257|FD-Score:4.26|P-value:3.80E-6 ID:SGTC_3158|Compound:9100007|FD-Score:-3.36|P-value:1.98E-4 ID:SGTC_3178|Compound:9107506|FD-Score:3.16|P-value:4.52E-4 ID:SGTC_3332|Compound:9141069|FD-Score:3.03|P-value:7.27E-4

Top fitness defect scores for YKL162C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1454 4239-0054 4.59 42.6 µM 6.76E-7 18 2.17E-6
2 SGTC_3129 9127257 4.26 49.5 µM 3.80E-6 17 1.04E-5
3 SGTC_2911 7942208 4.09 15.6 µM 8.70E-6 mitochondrial response to ROS 18 2.20E-5
4 SGTC_2307 7538926 4.08 6.3 µM 8.82E-6 39 2.23E-5
5 SGTC_955 1216-0110 4.03 33.0 µM 1.15E-5 sphingolipid biosynthesis & PDR1 60 2.83E-5
6 SGTC_2778 tioconazole 3.82 65.1 nM 2.99E-5 ergosterol depletion effects on membrane 65 6.74E-5
7 SGTC_2448 5185112 3.69 27.2 µM 5.19E-5 17 1.11E-4
8 SGTC_2360 9040895 3.58 200.0 µM 8.50E-5 RPP1 & pyrimidine depletion 25 1.74E-4
9 SGTC_2237 6667747 3.53 47.2 µM 1.05E-4 23 2.10E-4
10 SGTC_1314 1222-0010 3.49 41.1 µM 1.19E-4 22 2.37E-4
11 SGTC_2129 girgensonine 3.49 121.0 µM 1.22E-4 heme biosynthesis & mitochondrial translocase 52 2.42E-4
12 SGTC_1812 st052057 3.42 4.3 µM 1.62E-4 calcium & mitochondrial duress 48 3.12E-4
13 SGTC_605 1315-0399 3.41 119.0 µM 1.71E-4 Golgi 42 3.29E-4
14 SGTC_2311 7694451 3.39 200.0 µM 1.84E-4 43 3.51E-4
15 SGTC_1995 st072814 3.31 61.1 µM 2.46E-4 28 4.59E-4
16 SGTC_1987 st072290 3.31 61.9 µM 2.48E-4 32 4.61E-4
17 SGTC_899 1083-0020 3.31 478.0 µM 2.48E-4 45 4.61E-4
18 SGTC_2141 5621638 3.28 7.7 µM 2.85E-4 tubulin folding & SWR complex 51 5.23E-4
19 SGTC_44 0929-0055 3.28 61.2 µM 2.85E-4 56 5.24E-4
20 SGTC_151 3013-0144 3.27 2.3 µM 2.98E-4 iron homeostasis 56 5.45E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.100 5.67E-9 YBR043C QDR3 hom Multidrug transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; has a role in polyamine homeostasis; expression is upregulated under polyamine stress; required for resistance to quinidine, barban, cisplatin, and bleomycin
0.099 7.74E-9 YBR236C ABD1 het Methyltransferase, catalyzes the transfer of a methyl group from S-adenosylmethionine to the GpppN terminus of capped mRNA
0.094 5.23E-8 YPR193C HPA2 hom Tetrameric histone acetyltransferase with similarity to Gcn5p, Hat1p, Elp3p, and Hpa3p; acetylates histones H3 and H4 in vitro and exhibits autoacetylation activity
0.088 3.05E-7 YOL050C_d YOL050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified gene GAL11; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
0.087 5.23E-7 YPR042C PUF2 hom Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding membrane-associated proteins
0.083 1.54E-6 YNL226W_d YNL226W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene JJJ1/YNL227C
0.081 2.75E-6 YJL064W_d YJL064W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL065C/DLS1
0.080 3.10E-6 YMR193C-A_d YMR193C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.079 4.75E-6 YMR152W YIM1 hom Protein of unknown function; null mutant displays sensitivity to DNA damaging agents; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress
0.079 5.14E-6 YJL097W PHS1 het Essential 3-hydroxyacyl-CoA dehydratase of the ER membrane, involved in elongation of very long-chain fatty acids; evolutionarily conserved, similar to mammalian PTPLA and PTPLB; involved in sphingolipid biosynthesis and protein trafficking
0.078 5.72E-6 YOL114C_p YOL114C_p hom Putative protein of unknown function with similarity to human ICT1 and prokaryotic factors that may function in translation termination; YOL114C is not an essential gene
0.074 1.91E-5 YHR160C PEX18 hom Peroxin required for targeting of peroxisomal matrix proteins containing PTS2; interacts with Pex7p; partially redundant with Pex21p
0.073 2.07E-5 YCL054W SPB1 het AdoMet-dependent methyltransferase involved in rRNA processing and 60S ribosomal subunit maturation; methylates G2922 in the tRNA docking site of the large subunit rRNA and in the absence of snR52, U2921; suppressor of PAB1 mutants
0.073 2.18E-5 YPR028W YOP1 hom Membrane protein that interacts with Yip1p to mediate membrane traffic; interacts with Sey1p to maintain ER morphology; overexpression leads to cell death and accumulation of internal cell membranes; mutants have reduced phosphatidylserine transfer between the ER and mitochondria; forms ER foci upon DNA replication stress
0.072 3.11E-5 YNL250W RAD50 hom Subunit of MRX complex with Mre11p and Xrs2p; complex is involved in processing double-strand DNA breaks in vegetative cells, initiation of meiotic DSBs, telomere maintenance, and nonhomologous end joining; forms nuclear foci upon DNA replication stress