YKL189W / HYM1

Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with Kic1p and Sog2p, localizes to sites of polarized growth during budding and during the mating response

Zygosity: Heterozygous strain
fixedexpanded
Profile for YKL189W / HYM1

Click on Significant Values for Screen Details ID:SGTC_18|Compound:0111-0177|FD-Score:2.84|P-value:1.20E-4 ID:SGTC_34|Compound:0469-0683|FD-Score:-2.71|P-value:2.88E-4 ID:SGTC_333|Compound:3486-0131|FD-Score:3.89|P-value:2.74E-7 ID:SGTC_335|Compound:4077-0256|FD-Score:2.77|P-value:1.71E-4 ID:SGTC_337|Compound:1315-0038|FD-Score:2.51|P-value:5.95E-4 ID:SGTC_340|Compound:k038-0059|FD-Score:3.96|P-value:1.64E-7 ID:SGTC_341|Compound:1486-1430|FD-Score:-2.84|P-value:1.47E-4 ID:SGTC_347|Compound:4534-1311|FD-Score:-2.61|P-value:4.58E-4 ID:SGTC_349|Compound:k015-0014|FD-Score:-3.01|P-value:6.38E-5 ID:SGTC_351|Compound:caspofungin|FD-Score:-2.86|P-value:1.39E-4 ID:SGTC_550|Compound:4123-0385|FD-Score:-3.51|P-value:3.91E-6 ID:SGTC_750|Compound:4073-0104|FD-Score:-2.77|P-value:2.10E-4 ID:SGTC_802|Compound:4112-3352|FD-Score:-2.73|P-value:2.58E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:3.25|P-value:1.40E-5 ID:SGTC_870|Compound:0573-2213|FD-Score:-2.45|P-value:9.21E-4 ID:SGTC_877|Compound:0771-0151|FD-Score:-2.78|P-value:2.04E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:2.95|P-value:6.97E-5 ID:SGTC_894|Compound:0960-0238|FD-Score:2.39|P-value:9.91E-4 ID:SGTC_899|Compound:1083-0020|FD-Score:2.57|P-value:4.57E-4 ID:SGTC_990|Compound:3985-0011|FD-Score:2.94|P-value:7.26E-5 ID:SGTC_991|Compound:3996-0057|FD-Score:-5.16|P-value:2.20E-11 ID:SGTC_993|Compound:3909-8757|FD-Score:-3.65|P-value:1.64E-6 ID:SGTC_995|Compound:3931-2021|FD-Score:-2.79|P-value:1.91E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:-3.00|P-value:6.54E-5 ID:SGTC_1003|Compound:4049-0218|FD-Score:-3.63|P-value:1.90E-6 ID:SGTC_1038|Compound:k292-0204|FD-Score:-2.91|P-value:1.08E-4 ID:SGTC_1042|Compound:0350-0096|FD-Score:-3.66|P-value:1.57E-6 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:2.80|P-value:1.49E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.61|P-value:2.11E-6 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.55|P-value:2.43E-6 ID:SGTC_1123|Compound:mangostin|FD-Score:-3.25|P-value:1.71E-5 ID:SGTC_1125|Compound:tnp00248|FD-Score:-2.59|P-value:4.91E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:4.00|P-value:1.26E-7 ID:SGTC_1290|Compound:0986-0249|FD-Score:-4.05|P-value:1.18E-7 ID:SGTC_1322|Compound:1348-1070|FD-Score:2.41|P-value:9.33E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:2.59|P-value:4.15E-4 ID:SGTC_1882|Compound:5615643|FD-Score:2.53|P-value:5.43E-4 ID:SGTC_1895|Compound:st058434|FD-Score:3.15|P-value:2.47E-5 ID:SGTC_1968|Compound:st069590|FD-Score:2.49|P-value:6.46E-4 ID:SGTC_2052|Compound:5265182|FD-Score:2.74|P-value:2.00E-4 ID:SGTC_2053|Compound:5265679|FD-Score:-4.28|P-value:2.34E-8 ID:SGTC_2056|Compound:5235370|FD-Score:8.07|P-value:1.76E-25 ID:SGTC_2099|Compound:5377090|FD-Score:-3.89|P-value:3.53E-7 ID:SGTC_2252|Compound:omeprazole|FD-Score:2.71|P-value:2.35E-4 ID:SGTC_2254|Compound:7938975|FD-Score:3.51|P-value:3.08E-6 ID:SGTC_2255|Compound:7941087|FD-Score:4.63|P-value:1.25E-9 ID:SGTC_2262|Compound:9014885|FD-Score:3.40|P-value:5.77E-6 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-2.83|P-value:1.60E-4 ID:SGTC_2421|Compound:5690543|FD-Score:2.78|P-value:1.69E-4 ID:SGTC_2424|Compound:5537928|FD-Score:-2.78|P-value:2.01E-4 ID:SGTC_2430|Compound:5571206|FD-Score:3.24|P-value:1.50E-5 ID:SGTC_2618|Compound:avocadyne|FD-Score:-2.52|P-value:6.81E-4 ID:SGTC_2624|Compound:nerol|FD-Score:-2.93|P-value:9.72E-5 ID:SGTC_2629|Compound:bisabolol|FD-Score:3.23|P-value:1.53E-5 ID:SGTC_2831|Compound:7999036|FD-Score:3.66|P-value:1.23E-6 ID:SGTC_2832|Compound:7992762|FD-Score:-2.96|P-value:8.08E-5 ID:SGTC_2842|Compound:9000675|FD-Score:-2.56|P-value:5.56E-4 ID:SGTC_2933|Compound:9026794|FD-Score:3.32|P-value:9.18E-6 ID:SGTC_2943|Compound:9068529|FD-Score:2.48|P-value:6.88E-4 ID:SGTC_3168|Compound:9103419|FD-Score:4.52|P-value:3.04E-9 ID:SGTC_3307|Compound:9126885|FD-Score:2.77|P-value:1.71E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:2.84|P-value:1.20E-4 ID:SGTC_34|Compound:0469-0683|FD-Score:-2.71|P-value:2.88E-4 ID:SGTC_333|Compound:3486-0131|FD-Score:3.89|P-value:2.74E-7 ID:SGTC_335|Compound:4077-0256|FD-Score:2.77|P-value:1.71E-4 ID:SGTC_337|Compound:1315-0038|FD-Score:2.51|P-value:5.95E-4 ID:SGTC_340|Compound:k038-0059|FD-Score:3.96|P-value:1.64E-7 ID:SGTC_341|Compound:1486-1430|FD-Score:-2.84|P-value:1.47E-4 ID:SGTC_347|Compound:4534-1311|FD-Score:-2.61|P-value:4.58E-4 ID:SGTC_349|Compound:k015-0014|FD-Score:-3.01|P-value:6.38E-5 ID:SGTC_351|Compound:caspofungin|FD-Score:-2.86|P-value:1.39E-4 ID:SGTC_550|Compound:4123-0385|FD-Score:-3.51|P-value:3.91E-6 ID:SGTC_750|Compound:4073-0104|FD-Score:-2.77|P-value:2.10E-4 ID:SGTC_802|Compound:4112-3352|FD-Score:-2.73|P-value:2.58E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:3.25|P-value:1.40E-5 ID:SGTC_870|Compound:0573-2213|FD-Score:-2.45|P-value:9.21E-4 ID:SGTC_877|Compound:0771-0151|FD-Score:-2.78|P-value:2.04E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:2.95|P-value:6.97E-5 ID:SGTC_894|Compound:0960-0238|FD-Score:2.39|P-value:9.91E-4 ID:SGTC_899|Compound:1083-0020|FD-Score:2.57|P-value:4.57E-4 ID:SGTC_990|Compound:3985-0011|FD-Score:2.94|P-value:7.26E-5 ID:SGTC_991|Compound:3996-0057|FD-Score:-5.16|P-value:2.20E-11 ID:SGTC_993|Compound:3909-8757|FD-Score:-3.65|P-value:1.64E-6 ID:SGTC_995|Compound:3931-2021|FD-Score:-2.79|P-value:1.91E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:-3.00|P-value:6.54E-5 ID:SGTC_1003|Compound:4049-0218|FD-Score:-3.63|P-value:1.90E-6 ID:SGTC_1038|Compound:k292-0204|FD-Score:-2.91|P-value:1.08E-4 ID:SGTC_1042|Compound:0350-0096|FD-Score:-3.66|P-value:1.57E-6 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:2.80|P-value:1.49E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.61|P-value:2.11E-6 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.55|P-value:2.43E-6 ID:SGTC_1123|Compound:mangostin|FD-Score:-3.25|P-value:1.71E-5 ID:SGTC_1125|Compound:tnp00248|FD-Score:-2.59|P-value:4.91E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:4.00|P-value:1.26E-7 ID:SGTC_1290|Compound:0986-0249|FD-Score:-4.05|P-value:1.18E-7 ID:SGTC_1322|Compound:1348-1070|FD-Score:2.41|P-value:9.33E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:2.59|P-value:4.15E-4 ID:SGTC_1882|Compound:5615643|FD-Score:2.53|P-value:5.43E-4 ID:SGTC_1895|Compound:st058434|FD-Score:3.15|P-value:2.47E-5 ID:SGTC_1968|Compound:st069590|FD-Score:2.49|P-value:6.46E-4 ID:SGTC_2052|Compound:5265182|FD-Score:2.74|P-value:2.00E-4 ID:SGTC_2053|Compound:5265679|FD-Score:-4.28|P-value:2.34E-8 ID:SGTC_2056|Compound:5235370|FD-Score:8.07|P-value:1.76E-25 ID:SGTC_2099|Compound:5377090|FD-Score:-3.89|P-value:3.53E-7 ID:SGTC_2252|Compound:omeprazole|FD-Score:2.71|P-value:2.35E-4 ID:SGTC_2254|Compound:7938975|FD-Score:3.51|P-value:3.08E-6 ID:SGTC_2255|Compound:7941087|FD-Score:4.63|P-value:1.25E-9 ID:SGTC_2262|Compound:9014885|FD-Score:3.40|P-value:5.77E-6 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-2.83|P-value:1.60E-4 ID:SGTC_2421|Compound:5690543|FD-Score:2.78|P-value:1.69E-4 ID:SGTC_2424|Compound:5537928|FD-Score:-2.78|P-value:2.01E-4 ID:SGTC_2430|Compound:5571206|FD-Score:3.24|P-value:1.50E-5 ID:SGTC_2618|Compound:avocadyne|FD-Score:-2.52|P-value:6.81E-4 ID:SGTC_2624|Compound:nerol|FD-Score:-2.93|P-value:9.72E-5 ID:SGTC_2629|Compound:bisabolol|FD-Score:3.23|P-value:1.53E-5 ID:SGTC_2831|Compound:7999036|FD-Score:3.66|P-value:1.23E-6 ID:SGTC_2832|Compound:7992762|FD-Score:-2.96|P-value:8.08E-5 ID:SGTC_2842|Compound:9000675|FD-Score:-2.56|P-value:5.56E-4 ID:SGTC_2933|Compound:9026794|FD-Score:3.32|P-value:9.18E-6 ID:SGTC_2943|Compound:9068529|FD-Score:2.48|P-value:6.88E-4 ID:SGTC_3168|Compound:9103419|FD-Score:4.52|P-value:3.04E-9 ID:SGTC_3307|Compound:9126885|FD-Score:2.77|P-value:1.71E-4

Top fitness defect scores for YKL189W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2056 5235370 8.07 200.0 µM 1.76E-25 1 3.58E-16 2.22
2 SGTC_2255 7941087 4.63 197.4 µM 1.25E-9 2 1.82E-6 0.47
3 SGTC_3168 9103419 4.52 49.5 µM 3.04E-9 60S ribosome export 2 3.15E-6 0.07
4 SGTC_1136 pergolide 4.00 1.1 µM 1.26E-7 15 3.14E-5 0.05
5 SGTC_340 k038-0059 3.96 454.0 µM 1.64E-7 ubiquinone biosynthesis & proteasome 9 3.69E-5 0.30
6 SGTC_333 3486-0131 3.89 40.1 µM 2.74E-7 amide catabolism 1 5.06E-5 0.15
7 SGTC_2831 7999036 3.66 19.5 µM 1.23E-6 7 1.28E-4 0.02
8 SGTC_1119 parthenolide 3.55 318.5 nM 2.43E-6 TSC3-RPN4 11 1.96E-4 0.03
9 SGTC_2254 7938975 3.51 95.2 µM 3.08E-6 13 2.27E-4 0.01
10 SGTC_2262 9014885 3.40 67.5 µM 5.77E-6 1 3.35E-4 0.43
11 SGTC_2933 9026794 3.32 32.5 µM 9.18E-6 9 4.47E-4 0.08
12 SGTC_807 1315-0151 3.25 48.0 µM 1.40E-5 17 5.81E-4 0.01
13 SGTC_2430 5571206 3.24 200.0 µM 1.50E-5 25 6.07E-4 0.10
14 SGTC_2629 bisabolol 3.23 100.0 µM 1.53E-5 18 6.14E-4 0.10
15 SGTC_1895 st058434 3.15 18.3 µM 2.47E-5 10 8.28E-4 0.00
16 SGTC_892 0929-0076 2.95 29.0 µM 6.97E-5 TRP & mitochondrial translation 14 0.00158 0.05
17 SGTC_990 3985-0011 2.94 41.3 µM 7.26E-5 amide catabolism 13 0.00162 0.05
18 SGTC_18 0111-0177 2.84 500.0 nM 1.20E-4 15 0.00222 0.03
19 SGTC_1071 trifluoperazine 2.80 6.3 µM 1.49E-4 15 0.00255 0.03
20 SGTC_2421 5690543 2.78 90.7 µM 1.69E-4 18 0.00275 0.00

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.148 7.08E-18 YGR087C PDC6 hom Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation
0.136 2.42E-15 YKL179C COY1 hom Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function
0.131 2.32E-14 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.130 3.94E-14 YLR223C IFH1 het Coactivator that regulates transcription of ribosomal protein (RP) genes; recruited to RP gene promoters during optimal growth conditions via Fhl1p; subunit of CURI, a complex that coordinates RP production and pre-rRNA processing
0.125 3.28E-13 YJL002C OST1 het Alpha subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins
0.124 5.40E-13 YGR117C_p YGR117C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.120 3.10E-12 YMR182W-A_p YMR182W-A_p hom Putative protein of unknown function
0.118 7.52E-12 YGR032W GSC2 hom Catalytic subunit of 1,3-beta-glucan synthase, involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; has similarity to an alternate catalytic subunit, Fks1p (Gsc1p)
0.116 1.79E-11 YKL022C CDC16 het Subunit of the anaphase-promoting complex/cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; required for sporulation
0.114 3.09E-11 YBR263W SHM1 hom Mitochondrial serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis; reverse reaction generates serine
0.114 3.78E-11 YKL220C FRE2 hom Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels
0.114 4.21E-11 YLR016C PML1 hom Subunit of the RES complex, which is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p
0.113 5.13E-11 YLL038C ENT4 hom Protein of unknown function, contains an N-terminal epsin-like domain; proposed to be involved in the trafficking of Arn1p in the absence of ferrichrome
0.113 5.36E-11 YLL035W GRC3 het Polynucleotide kinase present on rDNA that is required for efficient transcription termination by RNA polymerase I; required for cell growth; mRNA is cell-cycle regulated
0.111 1.05E-10 YOR203W_d YOR203W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps 5' end of essential DED1 gene required for translation initiation