HIPHOP chemogenomics database
YKL189W / HYM1 
Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with Kic1p and Sog2p, localizes to sites of polarized growth during budding and during the mating response
Zygosity: Heterozygous strain
fixedexpanded
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Top fitness defect scores for YKL189W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.148 | 7.08E-18 | YGR087C | PDC6 | hom | Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation |
| 0.136 | 2.42E-15 | YKL179C | COY1 | hom | Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function |
| 0.131 | 2.32E-14 | YBL036C | YBL036C | hom | Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS |
| 0.130 | 3.94E-14 | YLR223C | IFH1 | het | Coactivator that regulates transcription of ribosomal protein (RP) genes; recruited to RP gene promoters during optimal growth conditions via Fhl1p; subunit of CURI, a complex that coordinates RP production and pre-rRNA processing |
| 0.125 | 3.28E-13 | YJL002C | OST1 | het | Alpha subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins |
| 0.124 | 5.40E-13 | YGR117C_p | YGR117C_p | hom | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm |
| 0.120 | 3.10E-12 | YMR182W-A_p | YMR182W-A_p | hom | Putative protein of unknown function |
| 0.118 | 7.52E-12 | YGR032W | GSC2 | hom | Catalytic subunit of 1,3-beta-glucan synthase, involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; has similarity to an alternate catalytic subunit, Fks1p (Gsc1p) |
| 0.116 | 1.79E-11 | YKL022C | CDC16 | het | Subunit of the anaphase-promoting complex/cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; required for sporulation |
| 0.114 | 3.09E-11 | YBR263W | SHM1 | hom | Mitochondrial serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis; reverse reaction generates serine |
| 0.114 | 3.78E-11 | YKL220C | FRE2 | hom | Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels |
| 0.114 | 4.21E-11 | YLR016C | PML1 | hom | Subunit of the RES complex, which is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p |
| 0.113 | 5.13E-11 | YLL038C | ENT4 | hom | Protein of unknown function, contains an N-terminal epsin-like domain; proposed to be involved in the trafficking of Arn1p in the absence of ferrichrome |
| 0.113 | 5.36E-11 | YLL035W | GRC3 | het | Polynucleotide kinase present on rDNA that is required for efficient transcription termination by RNA polymerase I; required for cell growth; mRNA is cell-cycle regulated |
| 0.111 | 1.05E-10 | YOR203W_d | YOR203W_d | het | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps 5' end of essential DED1 gene required for translation initiation |