YKL197C / PEX1

AAA-peroxin that heterodimerizes with AAA-peroxin Pex6p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol; induced by oleic acid and upregulated during anaerobiosis

Zygosity: Homozygous strain
fixedexpanded
Profile for YKL197C / PEX1

Click on Significant Values for Screen Details ID:SGTC_70|Compound:0141-0289|FD-Score:-4.33|P-value:4.93E-6 ID:SGTC_71|Compound:0417-1750|FD-Score:3.50|P-value:1.79E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:5.02|P-value:1.51E-7 ID:SGTC_76|Compound:0433-0009|FD-Score:-3.49|P-value:1.85E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:3.34|P-value:3.32E-4 ID:SGTC_172|Compound:1112-0046|FD-Score:-3.21|P-value:5.27E-4 ID:SGTC_251|Compound:melphalan|FD-Score:4.05|P-value:1.82E-5 ID:SGTC_382|Compound:3229-0966|FD-Score:3.51|P-value:1.68E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:3.47|P-value:1.97E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:3.50|P-value:1.77E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-3.16|P-value:6.29E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:3.23|P-value:4.86E-4 ID:SGTC_883|Compound:0850-0245|FD-Score:3.28|P-value:4.08E-4 ID:SGTC_899|Compound:1083-0020|FD-Score:5.31|P-value:2.98E-8 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.11|P-value:7.50E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:-3.09|P-value:8.12E-4 ID:SGTC_1637|Compound:st007924|FD-Score:3.56|P-value:1.43E-4 ID:SGTC_1880|Compound:MG-132|FD-Score:-3.19|P-value:5.65E-4 ID:SGTC_1917|Compound:st066507|FD-Score:3.43|P-value:2.34E-4 ID:SGTC_1923|Compound:st058458|FD-Score:3.20|P-value:5.45E-4 ID:SGTC_1989|Compound:st071868|FD-Score:3.09|P-value:8.17E-4 ID:SGTC_2316|Compound:5844804|FD-Score:-3.82|P-value:4.89E-5 ID:SGTC_2322|Compound:7413319|FD-Score:3.94|P-value:2.84E-5 ID:SGTC_2328|Compound:6201408|FD-Score:-3.13|P-value:6.94E-4 ID:SGTC_2427|Compound:5545055|FD-Score:-3.38|P-value:2.85E-4 ID:SGTC_2428|Compound:5615643|FD-Score:3.36|P-value:3.07E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-3.09|P-value:7.98E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:-3.94|P-value:2.94E-5 ID:SGTC_2756|Compound:carbadox|FD-Score:3.43|P-value:2.37E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:-3.84|P-value:4.36E-5 ID:SGTC_2932|Compound:9016711|FD-Score:-3.54|P-value:1.51E-4 ID:SGTC_2935|Compound:9038016|FD-Score:-3.50|P-value:1.75E-4 ID:SGTC_2939|Compound:9044578|FD-Score:-4.92|P-value:2.56E-7 ID:SGTC_3099|Compound:9120367|FD-Score:4.80|P-value:4.93E-7 ID:SGTC_3224|Compound:9130643|FD-Score:-4.04|P-value:1.83E-5 ID:SGTC_3235|Compound:9132602|FD-Score:3.88|P-value:3.83E-5 ID:SGTC_3264|Compound:9137442|FD-Score:-5.79|P-value:1.74E-9 ID:SGTC_3273|Compound:9137859|FD-Score:-3.36|P-value:3.05E-4 ID:SGTC_3274|Compound:9138298|FD-Score:3.35|P-value:3.15E-4 ID:SGTC_3327|Compound:9140648|FD-Score:3.96|P-value:2.67E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:-4.33|P-value:4.93E-6 ID:SGTC_71|Compound:0417-1750|FD-Score:3.50|P-value:1.79E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:5.02|P-value:1.51E-7 ID:SGTC_76|Compound:0433-0009|FD-Score:-3.49|P-value:1.85E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:3.34|P-value:3.32E-4 ID:SGTC_172|Compound:1112-0046|FD-Score:-3.21|P-value:5.27E-4 ID:SGTC_251|Compound:melphalan|FD-Score:4.05|P-value:1.82E-5 ID:SGTC_382|Compound:3229-0966|FD-Score:3.51|P-value:1.68E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:3.47|P-value:1.97E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:3.50|P-value:1.77E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-3.16|P-value:6.29E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:3.23|P-value:4.86E-4 ID:SGTC_883|Compound:0850-0245|FD-Score:3.28|P-value:4.08E-4 ID:SGTC_899|Compound:1083-0020|FD-Score:5.31|P-value:2.98E-8 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.11|P-value:7.50E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:-3.09|P-value:8.12E-4 ID:SGTC_1637|Compound:st007924|FD-Score:3.56|P-value:1.43E-4 ID:SGTC_1880|Compound:MG-132|FD-Score:-3.19|P-value:5.65E-4 ID:SGTC_1917|Compound:st066507|FD-Score:3.43|P-value:2.34E-4 ID:SGTC_1923|Compound:st058458|FD-Score:3.20|P-value:5.45E-4 ID:SGTC_1989|Compound:st071868|FD-Score:3.09|P-value:8.17E-4 ID:SGTC_2316|Compound:5844804|FD-Score:-3.82|P-value:4.89E-5 ID:SGTC_2322|Compound:7413319|FD-Score:3.94|P-value:2.84E-5 ID:SGTC_2328|Compound:6201408|FD-Score:-3.13|P-value:6.94E-4 ID:SGTC_2427|Compound:5545055|FD-Score:-3.38|P-value:2.85E-4 ID:SGTC_2428|Compound:5615643|FD-Score:3.36|P-value:3.07E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-3.09|P-value:7.98E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:-3.94|P-value:2.94E-5 ID:SGTC_2756|Compound:carbadox|FD-Score:3.43|P-value:2.37E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:-3.84|P-value:4.36E-5 ID:SGTC_2932|Compound:9016711|FD-Score:-3.54|P-value:1.51E-4 ID:SGTC_2935|Compound:9038016|FD-Score:-3.50|P-value:1.75E-4 ID:SGTC_2939|Compound:9044578|FD-Score:-4.92|P-value:2.56E-7 ID:SGTC_3099|Compound:9120367|FD-Score:4.80|P-value:4.93E-7 ID:SGTC_3224|Compound:9130643|FD-Score:-4.04|P-value:1.83E-5 ID:SGTC_3235|Compound:9132602|FD-Score:3.88|P-value:3.83E-5 ID:SGTC_3264|Compound:9137442|FD-Score:-5.79|P-value:1.74E-9 ID:SGTC_3273|Compound:9137859|FD-Score:-3.36|P-value:3.05E-4 ID:SGTC_3274|Compound:9138298|FD-Score:3.35|P-value:3.15E-4 ID:SGTC_3327|Compound:9140648|FD-Score:3.96|P-value:2.67E-5

Top fitness defect scores for YKL197C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_899 1083-0020 5.31 478.0 µM 2.98E-8 3 5.45E-8
2 SGTC_73 0327-0325 5.02 16.2 µM 1.51E-7 DNA damage response 24 2.60E-7
3 SGTC_3099 9120367 4.80 49.5 µM 4.93E-7 4 8.10E-7
4 SGTC_251 melphalan 4.05 456.5 µM 1.82E-5 DNA damage response 21 2.61E-5
5 SGTC_3327 9140648 3.96 26.9 µM 2.67E-5 11 3.77E-5
6 SGTC_2322 7413319 3.94 38.2 µM 2.84E-5 ERAD & cell cycle 150 3.99E-5
7 SGTC_3235 9132602 3.88 49.5 µM 3.83E-5 26 5.32E-5
8 SGTC_1637 st007924 3.56 17.4 µM 1.43E-4 39 1.89E-4
9 SGTC_382 3229-0966 3.51 23.2 µM 1.68E-4 36 2.21E-4
10 SGTC_733 4069-0007 3.50 56.1 µM 1.77E-4 ERAD & cell cycle 106 2.32E-4
11 SGTC_71 0417-1750 3.50 47.8 µM 1.79E-4 Golgi 69 2.35E-4
12 SGTC_690 glyoxal 3.47 20.3 µM 1.97E-4 107 2.57E-4
13 SGTC_1917 st066507 3.43 28.5 µM 2.34E-4 Golgi 65 3.03E-4
14 SGTC_2756 carbadox 3.43 75.1 µM 2.37E-4 78 3.07E-4
15 SGTC_2428 5615643 3.36 7.8 µM 3.07E-4 46 3.94E-4
16 SGTC_3274 9138298 3.35 49.5 µM 3.15E-4 39 4.05E-4
17 SGTC_103 0844-0104 3.34 51.8 µM 3.32E-4 ERAD & cell cycle 180 4.25E-4
18 SGTC_883 0850-0245 3.28 24.6 µM 4.08E-4 cell wall 56 5.19E-4
19 SGTC_770 0389-1121 3.23 67.2 µM 4.86E-4 RPP1 & pyrimidine depletion 60 6.14E-4
20 SGTC_1923 st058458 3.20 19.1 µM 5.45E-4 68 6.86E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.133 1.05E-14 YMR221C_p YMR221C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; physical interaction with Atg27p suggests a possible role in autophagy
0.128 9.19E-14 YOL002C IZH2 hom Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc
0.123 9.07E-13 YGL133W ITC1 hom Subunit of the ATP-dependent Isw2p-Itc1p chromatin remodeling complex, required for repression of a-specific genes, repression of early meiotic genes during mitotic growth, and repression of INO1; similar to mammalian Acf1p, the regulatory subunit of the mammalian ATP-utilizing chromatin assembly and modifying factor (ACF) complex
0.118 7.32E-12 YML014W TRM9 hom tRNA methyltransferase; catalyzes modification of wobble bases in tRNA anticodons to 2, 5-methoxycarbonylmethyluridine and 5-methoxycarbonylmethyl-2-thiouridine; may act as part of a complex with Trm112p; deletion mutation increases translational infidelity, including amino acid misincorporation and -1 frameshifting, and also confers resistance to zymocin; null mutant displays activation of stress responses
0.113 6.05E-11 YPL246C RBD2 hom Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p
0.112 6.87E-11 YIL030C SSM4 hom Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation
0.108 3.68E-10 YKL213C DOA1 hom WD repeat protein required for ubiquitin-mediated protein degradation; forms a complex with Cdc48p; plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase; protein increases in abundance and relocalizes from nucleus to nuclear periphery upon DNA replication stress
0.108 3.56E-10 YNR031C SSK2 hom MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; interacts with Ssk1p, leading to autophosphorylation and activation of Ssk2p which phosphorylates Pbs2p; also mediates actin cytoskeleton recovery from osmotic stress
0.106 6.84E-10 YLR186W EMG1 het Methyltransferase for rRNA; catalyzes methylation of the pseudouridine residue 1191 of 18S rRNA; member of the SPOUT methyltransferase family; required for maturation of 18S rRNA and for 40S ribosomal subunit production independently of methyltransferase activity; forms homodimers; human ortholog is mutated in Bowen-Conradi syndrome, and the equivalent mutation in yeast affects Emg1p dimerization and localization but not its methyltransferase activity
0.106 7.12E-10 YLR380W CSR1 hom Phosphatidylinositol transfer protein; has a potential role in regulating lipid and fatty acid metabolism under heme-depleted conditions; interacts specifically with thioredoxin peroxidase; may have a role in oxidative stress resistance; protein abundance increases in response to DNA replication stress
0.105 9.38E-10 YKR008W RSC4 het Component of the RSC chromatin remodeling complex; found in close proximity to nucleosomal DNA; displaced from the surface of nucleosomal DNA after chromatin remodeling; acetylated (K25) by Gcn5p, altering replication stress tolerance; contains tandem bromodomains that recognize histone H3 acetylated on K14 (H3K14ac) by Gcn5p
0.102 3.61E-9 YOR246C ENV9 hom Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and defects in vacuolar morphology; has similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts
0.102 3.69E-9 YDR186C YDR186C hom Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.100 5.97E-9 YMR264W CUE1 hom Ubiquitin-binding protein; endoplasmic reticulum membrane protein that recruits the ubiquitin-conjugating enzyme Ubc7p to the ER where it functions in protein degradation; contains a CUE domain that binds ubiquitin to facilitate intramolecular monoubiquitination; CUE1 has a paralog, CUE4, that arose from the whole genome duplication
0.098 1.35E-8 YKL124W SSH4 hom Specificity factor required for Rsp5p-dependent ubiquitination and sorting of cargo proteins at the multivesicular body; identified as a high-copy suppressor of a SHR3 deletion, increasing steady-state levels of amino acid permeases